Study of Chemotherapy, With or Without Binimetinib in Advanced Biliary Tract Cancers in 2nd Line Setting (A ComboMATCH Treatment Trial)

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

66

Participants

Timeline

Start Date

February 9, 2024

Primary Completion Date

January 21, 2026

Study Completion Date

January 21, 2026

Conditions
Advanced Biliary Tract CarcinomaAdvanced Gallbladder CarcinomaAdvanced Intrahepatic CholangiocarcinomaRecurrent Biliary Tract CarcinomaRecurrent Gallbladder CarcinomaRecurrent Intrahepatic CholangiocarcinomaStage III Distal Bile Duct Cancer AJCC v8Stage III Gallbladder Cancer AJCC v8Stage III Hilar Cholangiocarcinoma AJCC v8Stage III Intrahepatic Cholangiocarcinoma AJCC v8Stage IV Distal Bile Duct Cancer AJCC v8Stage IV Gallbladder Cancer AJCC v8Stage IV Hilar Cholangiocarcinoma AJCC v8Stage IV Intrahepatic Cholangiocarcinoma AJCC v8Unresectable Biliary Tract CarcinomaUnresectable Gallbladder CarcinomaUnresectable Intrahepatic Cholangiocarcinoma
Interventions
DRUG

Binimetinib

Given PO

PROCEDURE

Biopsy Procedure

Undergo biopsy

PROCEDURE

Biospecimen Collection

Undergo collection of blood

PROCEDURE

Bone Scan

Undergo bone scan

PROCEDURE

Computed Tomography

Undergo CT

PROCEDURE

Echocardiography Test

Undergo ECHO

DRUG

Fluorouracil

Given IV

DRUG

Leucovorin Calcium

Given IV

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

PROCEDURE

Multigated Acquisition Scan

Undergo MUGA

DRUG

Oxaliplatin

Given IV

Trial Locations (209)

14263

Roswell Park Cancer Institute, Buffalo

15146

UPMC Hillman Cancer Center - Monroeville, Monroeville

15232

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

15237

UPMC-Passavant Hospital, Pittsburgh

15601

UPMC Cancer Centers - Arnold Palmer Pavilion, Greensburg

16505

UPMC Hillman Cancer Center Erie, Erie

16601

UPMC Altoona, Altoona

17050

UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion, Mechanicsburg

18017

Lehigh Valley Hospital - Muhlenberg, Bethlehem

18103

Lehigh Valley Hospital-Cedar Crest, Allentown

18201

Lehigh Valley Hospital-Hazleton, Hazleton

18301

Pocono Medical Center, East Stroudsburg

20892

National Institutes of Health Clinical Center, Bethesda

21201

University of Maryland/Greenebaum Cancer Center, Baltimore

21502

UPMC Western Maryland, Cumberland

22031

Inova Schar Cancer Institute, Fairfax

22042

Inova Fairfax Hospital, Falls Church

22908

University of Virginia Cancer Center, Charlottesville

23229

Virginia Cancer Institute, Richmond

23235

VCU Massey Cancer Center at Stony Point, Richmond

23298

VCU Massey Comprehensive Cancer Center, Richmond

23970

VCU Community Memorial Health Center, South Hill

26506

West Virginia University Healthcare, Morgantown

32610

University of Florida Health Science Center - Gainesville, Gainesville

33136

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33146

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables

33176

UM Sylvester Comprehensive Cancer Center at Kendall, Miami

33180

UM Sylvester Comprehensive Cancer Center at Aventura, Aventura

33324

UM Sylvester Comprehensive Cancer Center at Plantation, Plantation

33442

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

35233

University of Alabama at Birmingham Cancer Center, Birmingham

36688

University of South Alabama Mitchell Cancer Institute, Mobile

38017

Baptist Memorial Hospital and Cancer Center-Collierville, Collierville

38120

Baptist Memorial Hospital and Cancer Center-Memphis, Memphis

38652

Baptist Memorial Hospital and Cancer Center-Union County, New Albany

38655

Baptist Memorial Hospital and Cancer Center-Oxford, Oxford

38671

Baptist Memorial Hospital and Cancer Center-Desoto, Southhaven

38901

Baptist Cancer Center-Grenada, Grenada

39705

Baptist Memorial Hospital and Cancer Center-Golden Triangle, Columbus

40536

University of Kentucky/Markey Cancer Center, Lexington

45331

Miami Valley Cancer Care and Infusion, Greenville

45373

Upper Valley Medical Center, Troy

45409

Miami Valley Hospital, Dayton

Premier Blood and Cancer Center, Dayton

45415

Dayton Physician LLC - Englewood, Dayton

Miami Valley Hospital North, Dayton

45429

Kettering Medical Center, Kettering

45459

Miami Valley Hospital South, Centerville

48044

Henry Ford Saint John Hospital - Macomb Medical, Macomb

48073

Corewell Health William Beaumont University Hospital, Royal Oak

48085

Corewell Health Beaumont Troy Hospital, Troy

48106

Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor

Huron Gastroenterology PC, Ypsilanti

48109

University of Michigan Comprehensive Cancer Center, Ann Arbor

48114

Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton

Trinity Health Medical Center - Brighton, Brighton

48116

University of Michigan - Brighton Center for Specialty Care, Brighton

48118

Chelsea Hospital, Chelsea

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea

48124

Corewell Health Dearborn Hospital, Dearborn

48154

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia

48188

Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton

Trinity Health Medical Center - Canton, Canton

48197

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti

48336

Corewell Health Farmington Hills Hospital, Farmington Hills

48341

Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac

48503

Cancer Hematology Centers - Flint, Flint

Genesee Hematology Oncology PC, Flint

Genesys Hurley Cancer Institute, Flint

Hurley Medical Center, Flint

48912

University of Michigan Health - Sparrow Lansing, Lansing

50023

UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny

50263

UI Health Care Mission Cancer and Blood - Waukee Clinic, Waukee

50309

UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines

53022

Aurora Health Care Germantown Health Center, Germantown

53024

Aurora Cancer Care-Grafton, Grafton

53066

Aurora Medical Center in Summit, Summit

53081

Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan

53105

Aurora Cancer Care-Southern Lakes VLCC, Burlington

53110

Aurora Saint Luke's South Shore, Cudahy

53142

Aurora Cancer Care-Kenosha South, Kenosha

53209

Aurora Cancer Care-Milwaukee, Milwaukee

53215

Aurora Saint Luke's Medical Center, Milwaukee

53226

Aurora Cancer Care-Milwaukee West, Wauwatosa

53227

Aurora West Allis Medical Center, West Allis

53233

Aurora Sinai Medical Center, Milwaukee

53406

Aurora Cancer Care-Racine, Racine

54143

Aurora Bay Area Medical Group-Marinette, Marinette

54241

Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers

54311

Aurora BayCare Medical Center, Green Bay

54806

Duluth Clinic Ashland, Ashland

54904

Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh

54911

ThedaCare Regional Cancer Center, Appleton

54923

ThedaCare Cancer Care - Berlin, Berlin

54956

ThedaCare Regional Medical Center - Neenah, Neenah

55072

Essentia Health Sandstone, Sandstone

55101

Regions Hospital, Saint Paul

55102

United Hospital, Saint Paul

55109

Saint John's Hospital - Healtheast, Maplewood

55407

Abbott-Northwestern Hospital, Minneapolis

55416

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55433

Mercy Hospital, Coon Rapids

55435

Fairview Southdale Hospital, Edina

55746

Essentia Health Hibbing Clinic, Hibbing

55792

Essentia Health Virginia Clinic, Virginia

55805

Essentia Health Cancer Center, Duluth

55905

Mayo Clinic in Rochester, Rochester

56601

Sanford Joe Lueken Cancer Center, Bemidji

56636

Essentia Health - Deer River Clinic, Deer River

57104

Sanford Cancer Center Oncology Clinic, Sioux Falls

58122

Sanford Broadway Medical Center, Fargo

Sanford Roger Maris Cancer Center, Fargo

58501

Sanford Bismarck Medical Center, Bismarck

59101

Billings Clinic Cancer Center, Billings

59405

Benefis Sletten Cancer Institute, Great Falls

59711

Community Hospital of Anaconda, Anaconda

59715

Bozeman Health Deaconess Hospital, Bozeman

59804

Community Medical Center, Missoula

59901

Logan Health Medical Center, Kalispell

60010

Advocate Good Shepherd Hospital, Barrington

60014

AMG Crystal Lake - Oncology, Crystal Lake

60026

Northwestern Medicine Glenview Outpatient Center, Glenview

60030

Northwestern Medicine Grayslake Outpatient Center, Grayslake

60045

Northwestern Medicine Lake Forest Hospital, Lake Forest

60048

AMG Libertyville - Oncology, Libertyville

Condell Memorial Hospital, Libertyville

60068

Advocate Lutheran General Hospital, Park Ridge

60115

Northwestern Medicine Cancer Center Kishwaukee, DeKalb

60123

Advocate Sherman Hospital, Elgin

60134

Northwestern Medicine Cancer Center Delnor, Geneva

60429

Advocate South Suburban Hospital, Hazel Crest

60451

UC Comprehensive Cancer Center at Silver Cross, New Lenox

60462

Northwestern Medicine Orland Park, Orland Park

University of Chicago Medicine-Orland Park, Orland Park

60515

Advocate Good Samaritan Hospital, Downers Grove

60555

Northwestern Medicine Cancer Center Warrenville, Warrenville

60611

Northwestern University, Chicago

60612

John H Stroger Jr Hospital of Cook County, Chicago

60637

University of Chicago Comprehensive Cancer Center, Chicago

60657

Advocate Illinois Masonic Medical Center, Chicago

61801

Carle Cancer Center, Urbana

61832

Carle at The Riverfront, Danville

61938

Carle Physician Group-Mattoon/Charleston, Mattoon

62269

Cancer Care Center of O'Fallon, O'Fallon

Memorial Hospital East, Shiloh

62401

Carle Physician Group-Effingham, Effingham

Crossroads Cancer Center, Effingham

62526

Cancer Care Specialists of Illinois - Decatur, Decatur

Decatur Memorial Hospital, Decatur

62702

Southern Illinois University School of Medicine, Springfield

Springfield Clinic, Springfield

62781

Springfield Memorial Hospital, Springfield

63080

Missouri Baptist Sullivan Hospital, Sullivan

63110

Washington University School of Medicine, St Louis

63127

BJC Outpatient Center at Sunset Hills, Sunset Hills

63129

Siteman Cancer Center-South County, St Louis

63131

Missouri Baptist Medical Center, St Louis

63136

Siteman Cancer Center at Christian Hospital, St Louis

63141

Siteman Cancer Center at West County Hospital, Creve Coeur

63376

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

63640

Parkland Health Center - Farmington, Farmington

63670

Sainte Genevieve County Memorial Hospital, Sainte Genevieve

63703

Saint Francis Medical Center, Cape Girardeau

68118

Nebraska Medicine-Village Pointe, Omaha

68123

Nebraska Medicine-Bellevue, Bellevue

68198

University of Nebraska Medical Center, Omaha

72401

NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro, Jonesboro

73104

University of Oklahoma Health Sciences Center, Oklahoma City

77030

M D Anderson Cancer Center, Houston

77079

MD Anderson West Houston, Houston

77384

MD Anderson in The Woodlands, Conroe

77478

MD Anderson in Sugar Land, Sugar Land

77573

MD Anderson League City, League City

83605

Saint Alphonsus Cancer Care Center-Caldwell, Caldwell

83619

Saint Luke's Cancer Institute - Fruitland, Fruitland

83642

Saint Luke's Cancer Institute - Meridian, Meridian

83687

Saint Alphonsus Cancer Care Center-Nampa, Nampa

Saint Luke's Cancer Institute - Nampa, Nampa

83706

Saint Alphonsus Cancer Care Center-Boise, Boise

83712

Saint Luke's Cancer Institute - Boise, Boise

83814

Kootenai Health - Coeur d'Alene, Coeur d'Alene

83854

Kootenai Clinic Cancer Services - Post Falls, Post Falls

83864

Kootenai Clinic Cancer Services - Sandpoint, Sandpoint

85054

Mayo Clinic Hospital in Arizona, Phoenix

87106

University of New Mexico Cancer Center, Albuquerque

89052

OptumCare Cancer Care at Seven Hills, Henderson

89102

OptumCare Cancer Care at Charleston, Las Vegas

89148

OptumCare Cancer Care at Fort Apache, Las Vegas

89502

Renown Regional Medical Center, Reno

90048

Cedars Sinai Medical Center, Los Angeles

90602

Presbyterian Intercommunity Hospital, Whittier

92093

UC San Diego Moores Cancer Center, La Jolla

96701

Hawaii Cancer Care - Westridge, ‘Aiea

96706

The Queen's Medical Center - West Oahu, ‘Ewa Beach

96813

Hawaii Cancer Care Inc - Waterfront Plaza, Honolulu

Queen's Cancer Cenrer - POB I, Honolulu

Queen's Medical Center, Honolulu

96817

Queen's Cancer Center - Kuakini, Honolulu

97914

Saint Alphonsus Cancer Care Center-Ontario, Ontario

98026

Swedish Cancer Institute-Edmonds, Edmonds

98029

Swedish Cancer Institute-Issaquah, Issaquah

98055

Valley Medical Center, Renton

98122

Swedish Medical Center-First Hill, Seattle

32224-9980

Mayo Clinic in Florida, Jacksonville

60453-2699

Advocate Christ Medical Center, Oak Lawn

04412

Lafayette Family Cancer Center-EMMC, Brewer

20889-5600

Walter Reed National Military Medical Center, Bethesda

45005-1066

Atrium Medical Center-Middletown Regional Hospital, Franklin

57117-5134

Sanford USD Medical Center - Sioux Falls, Sioux Falls

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH

NCT05564403 - Study of Chemotherapy, With or Without Binimetinib in Advanced Biliary Tract Cancers in 2nd Line Setting (A ComboMATCH Treatment Trial) | Biotech Hunter | Biotech Hunter