2,000
Participants
Start Date
June 18, 2024
Primary Completion Date
May 15, 2029
Study Completion Date
May 15, 2029
Allogeneic Hematopoietic Stem Cell Transplantation
Given IV
Azacitidine
Given IV or SC
Best Practice
Receive SOC treatment
Biopsy Procedure
Undergo biopsy
Biospecimen Collection
Undergo collection of blood, urine, and/or buccal swab samples
Bone Marrow Aspiration
Undergo bone marrow aspiration
Bone Marrow Biopsy
Undergo bone marrow biopsy
Busulfan
Given IV
Chest Radiography
Undergo chest x-ray
Computed Tomography
Undergo CT
Cytarabine
Given
Daunorubicin Hydrochloride
Given IV
Decitabine and Cedazuridine
Given PO
Echocardiography Test
Undergo ECHO
Enasidenib
Given PO
Fludarabine
Given IV
Gemtuzumab Ozogamicin
Given IV
Gilteritinib
Given PO
Liposome-encapsulated Daunorubicin-Cytarabine
Given IV
Melphalan
Given IV
Multigated Acquisition Scan
Undergo MUGA
Mutation Carrier Screening
Undergo rapid genetic testing
Olutasidenib
Given PO
Placebo Administration
Given PO
Positron Emission Tomography
Undergo PET
Total-Body Irradiation
Undergo total body irradiation
Venetoclax
Given PO
RECRUITING
Mount Sinai Hospital, New York
RECRUITING
Memorial Sloan Kettering Cancer Center, New York
RECRUITING
Montefiore Medical Center - Moses Campus, The Bronx
RECRUITING
North Shore University Hospital, Manhasset
RECRUITING
Northwell Health/Center for Advanced Medicine, Lake Success
RECRUITING
Memorial Sloan Kettering Nassau, Uniondale
RECRUITING
Memorial Sloan Kettering Commack, Commack
RECRUITING
State University of New York Upstate Medical University, Syracuse
RECRUITING
Roswell Park Cancer Institute, Buffalo
RECRUITING
Rochester General Hospital, Rochester
RECRUITING
University of Rochester, Rochester
RECRUITING
University of Pittsburgh Cancer Institute (UPCI), Pittsburgh
RECRUITING
Lewistown Hospital, Lewistown
RECRUITING
Geisinger Medical Center, Danville
RECRUITING
Lehigh Valley Hospital-Cedar Crest, Allentown
RECRUITING
Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre
RECRUITING
University of Pennsylvania/Abramson Cancer Center, Philadelphia
RECRUITING
Thomas Jefferson University Hospital, Philadelphia
RECRUITING
Reading Hospital, West Reading
RECRUITING
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore
RECRUITING
Inova Schar Cancer Institute, Fairfax
RECRUITING
Inova Fairfax Hospital, Falls Church
RECRUITING
University of Virginia Cancer Center, Charlottesville
RECRUITING
VCU Massey Comprehensive Cancer Center, Richmond
RECRUITING
Novant Health Forsyth Medical Center, Winston-Salem
RECRUITING
Wake Forest University Health Sciences, Winston-Salem
RECRUITING
UNC Lineberger Comprehensive Cancer Center, Chapel Hill
RECRUITING
Duke University Medical Center, Durham
RECRUITING
Carolinas Medical Center/Levine Cancer Institute, Charlotte
RECRUITING
Novant Health Presbyterian Medical Center, Charlotte
RECRUITING
Novant Health New Hanover Regional Medical Center, Wilmington
RECRUITING
Prisma Health Cancer Institute - Spartanburg, Boiling Springs
RECRUITING
Medical University of South Carolina, Charleston
RECRUITING
Prisma Health Cancer Institute - Butternut, Greenville
RECRUITING
Prisma Health Cancer Institute - Faris, Greenville
RECRUITING
Prisma Health Cancer Institute - Eastside, Greenville
RECRUITING
Prisma Health Cancer Institute - Easley, Easley
RECRUITING
Prisma Health Cancer Institute - Greer, Greer
RECRUITING
Prisma Health Cancer Institute - Seneca, Seneca
RECRUITING
Augusta University Medical Center, Augusta
RECRUITING
Phoebe Putney Memorial Hospital, Albany
RECRUITING
University of Alabama at Birmingham Cancer Center, Birmingham
RECRUITING
University of Tennessee - Knoxville, Knoxville
RECRUITING
Baptist Memorial Hospital and Cancer Center-Collierville, Collierville
RECRUITING
Baptist Memorial Hospital and Cancer Center-Memphis, Memphis
RECRUITING
Baptist Memorial Hospital and Cancer Center-Union County, New Albany
RECRUITING
Baptist Memorial Hospital and Cancer Center-Oxford, Oxford
RECRUITING
Baptist Memorial Hospital and Cancer Center-Desoto, Southhaven
RECRUITING
Baptist Cancer Center-Grenada, Grenada
RECRUITING
Baptist Memorial Hospital and Cancer Center-Golden Triangle, Columbus
RECRUITING
The James Graham Brown Cancer Center at University of Louisville, Louisville
RECRUITING
UofL Health Medical Center Northeast, Louisville
RECRUITING
University of Kentucky/Markey Cancer Center, Lexington
RECRUITING
Ohio State University Comprehensive Cancer Center, Columbus
RECRUITING
Case Western Reserve University, Cleveland
RECRUITING
Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis
RECRUITING
Henry Ford Macomb Hospital-Clinton Township, Clinton Township
RECRUITING
Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor
RECRUITING
Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton
RECRUITING
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea
RECRUITING
Trinity Health Saint Mary Mercy Livonia Hospital, Livonia
RECRUITING
Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton
RECRUITING
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti
RECRUITING
Wayne State University/Karmanos Cancer Institute, Detroit
RECRUITING
Henry Ford Hospital, Detroit
RECRUITING
Henry Ford West Bloomfield Hospital, West Bloomfield
RECRUITING
Weisberg Cancer Treatment Center, Farmington Hills
RECRUITING
Henry Ford Medical Center-Columbus, Novi
RECRUITING
Cancer Hematology Centers - Flint, Flint
SUSPENDED
Genesee Hematology Oncology PC, Flint
RECRUITING
Genesys Hurley Cancer Institute, Flint
RECRUITING
Hurley Medical Center, Flint
RECRUITING
Mercy Medical Center - Des Moines, Des Moines
SUSPENDED
UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines
SUSPENDED
UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive
RECRUITING
University of Iowa/Holden Comprehensive Cancer Center, Iowa City
RECRUITING
Aurora Health Care Germantown Health Center, Germantown
RECRUITING
Aurora Cancer Care-Grafton, Grafton
RECRUITING
ProHealth Oconomowoc Memorial Hospital, Oconomowoc
RECRUITING
Aurora Medical Center in Summit, Summit
RECRUITING
Saint Vincent Hospital Cancer Center at Sheboygan, Sheboygan
RECRUITING
Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan
RECRUITING
Aurora Cancer Care-Southern Lakes VLCC, Burlington
RECRUITING
Aurora Saint Luke's South Shore, Cudahy
RECRUITING
Aurora Cancer Care-Kenosha South, Kenosha
RECRUITING
ProHealth D N Greenwald Center, Mukwonago
RECRUITING
ProHealth Waukesha Memorial Hospital, Waukesha
RECRUITING
UW Cancer Center at ProHealth Care, Waukesha
RECRUITING
Aurora Cancer Care-Milwaukee, Milwaukee
RECRUITING
Aurora Saint Luke's Medical Center, Milwaukee
RECRUITING
Medical College of Wisconsin, Milwaukee
RECRUITING
Aurora Cancer Care-Milwaukee West, Wauwatosa
RECRUITING
Aurora West Allis Medical Center, West Allis
RECRUITING
Aurora Sinai Medical Center, Milwaukee
RECRUITING
Aurora Cancer Care-Racine, Racine
RECRUITING
Mercyhealth Hospital and Cancer Center - Janesville, Janesville
RECRUITING
William S Middleton VA Medical Center, Madison
RECRUITING
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison
RECRUITING
University of Wisconsin Carbone Cancer Center - University Hospital, Madison
RECRUITING
Aurora Bay Area Medical Group-Marinette, Marinette
RECRUITING
Saint Vincent Hospital Cancer Center at Oconto Falls, Oconto Falls
RECRUITING
Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers
RECRUITING
Saint Vincent Hospital Cancer Center Green Bay, Green Bay
RECRUITING
Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay
RECRUITING
Aurora BayCare Medical Center, Green Bay
RECRUITING
Marshfield Medical Center-Marshfield, Marshfield
RECRUITING
Marshfield Medical Center - Weston, Weston
RECRUITING
Marshfield Medical Center-River Region at Stevens Point, Stevens Point
RECRUITING
Marshfield Medical Center - Minocqua, Minocqua
RECRUITING
Gundersen Lutheran Medical Center, La Crosse
RECRUITING
Marshfield Medical Center-EC Cancer Center, Eau Claire
RECRUITING
Duluth Clinic Ashland, Ashland
RECRUITING
Marshfield Medical Center-Rice Lake, Rice Lake
RECRUITING
Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh
RECRUITING
ThedaCare Regional Cancer Center, Appleton
RECRUITING
Regions Hospital, Saint Paul
RECRUITING
United Hospital, Saint Paul
RECRUITING
Abbott-Northwestern Hospital, Minneapolis
RECRUITING
Park Nicollet Clinic - Saint Louis Park, Saint Louis Park
RECRUITING
Mercy Hospital, Coon Rapids
RECRUITING
Fairview Southdale Hospital, Edina
RECRUITING
Essentia Health Hibbing Clinic, Hibbing
RECRUITING
Essentia Health Virginia Clinic, Virginia
RECRUITING
Essentia Health Cancer Center, Duluth
RECRUITING
Mayo Clinic in Rochester, Rochester
RECRUITING
Essentia Health - Deer River Clinic, Deer River
RECRUITING
Sanford Cancer Center Oncology Clinic, Sioux Falls
RECRUITING
Billings Clinic Cancer Center, Billings
RECRUITING
Benefis Sletten Cancer Institute, Great Falls
RECRUITING
Community Hospital of Anaconda, Anaconda
RECRUITING
Bozeman Health Deaconess Hospital, Bozeman
RECRUITING
Saint Patrick Hospital - Community Hospital, Missoula
RECRUITING
Community Medical Center, Missoula
RECRUITING
Logan Health Medical Center, Kalispell
RECRUITING
NorthShore University HealthSystem-Glenbrook Hospital, Glenview
RECRUITING
Northwestern Medicine Glenview Outpatient Center, Glenview
RECRUITING
Northwestern Medicine Grayslake Outpatient Center, Grayslake
RECRUITING
NorthShore University HealthSystem-Highland Park Hospital, Highland Park
RECRUITING
Northwestern Medicine Lake Forest Hospital, Lake Forest
RECRUITING
Northwestern Medicine Cancer Center Kishwaukee, DeKalb
RECRUITING
Northwestern Medicine Cancer Center Delnor, Geneva
RECRUITING
Edward Hines Jr VA Hospital, Hines
RECRUITING
Loyola University Medical Center, Maywood
RECRUITING
NorthShore University HealthSystem-Evanston Hospital, Evanston
RECRUITING
Northwestern Medicine Orland Park, Orland Park
RECRUITING
Northwestern Medicine Cancer Center Warrenville, Warrenville
RECRUITING
Northwestern University, Chicago
RECRUITING
University of Illinois, Chicago
RECRUITING
University of Chicago Comprehensive Cancer Center, Chicago
RECRUITING
Illinois CancerCare-Dixon, Dixon
RECRUITING
Illinois CancerCare-Ottawa Clinic, Ottawa
RECRUITING
Illinois CancerCare-Peru, Peru
RECRUITING
Illinois CancerCare-Princeton, Princeton
RECRUITING
Illinois CancerCare-Galesburg, Galesburg
RECRUITING
Illinois CancerCare-Kewanee Clinic, Kewanee
RECRUITING
Illinois CancerCare-Macomb, Macomb
RECRUITING
Illinois CancerCare-Canton, Canton
RECRUITING
Illinois CancerCare-Eureka, Eureka
RECRUITING
Illinois CancerCare-Pekin, Pekin
RECRUITING
Illinois CancerCare - Washington, Washington
RECRUITING
Illinois CancerCare-Peoria, Peoria
RECRUITING
Methodist Medical Center of Illinois, Peoria
RECRUITING
OSF Saint Francis Medical Center, Peoria
RECRUITING
OSF Saint Joseph Medical Center, Bloomington
RECRUITING
Illinois CancerCare-Bloomington, Bloomington
RECRUITING
Carle Cancer Center, Urbana
RECRUITING
Carle at The Riverfront, Danville
RECRUITING
Carle Physician Group-Mattoon/Charleston, Mattoon
RECRUITING
Cancer Care Center of O'Fallon, O'Fallon
RECRUITING
Illinois CancerCare-Carthage, Carthage
RECRUITING
Carle Physician Group-Effingham, Effingham
RECRUITING
Crossroads Cancer Center, Effingham
RECRUITING
Cancer Care Specialists of Illinois - Decatur, Decatur
RECRUITING
Decatur Memorial Hospital, Decatur
RECRUITING
Southern Illinois University School of Medicine, Springfield
RECRUITING
Springfield Clinic, Springfield
RECRUITING
Springfield Memorial Hospital, Springfield
RECRUITING
Missouri Baptist Sullivan Hospital, Sullivan
RECRUITING
Washington University School of Medicine, St Louis
RECRUITING
BJC Outpatient Center at Sunset Hills, Sunset Hills
RECRUITING
Mercy Hospital South, St Louis
RECRUITING
Siteman Cancer Center-South County, St Louis
RECRUITING
Missouri Baptist Medical Center, St Louis
RECRUITING
Siteman Cancer Center at Christian Hospital, St Louis
RECRUITING
Siteman Cancer Center at West County Hospital, Creve Coeur
RECRUITING
Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters
RECRUITING
Parkland Health Center - Farmington, Farmington
RECRUITING
Sainte Genevieve County Memorial Hospital, Sainte Genevieve
RECRUITING
University of Kansas Cancer Center - Lee's Summit, Lee's Summit
RECRUITING
University Health Truman Medical Center, Kansas City
RECRUITING
University of Kansas Cancer Center - North, Kansas City
RECRUITING
Heartland Regional Medical Center, Saint Joseph
RECRUITING
Lawrence Memorial Hospital, Lawrence
RECRUITING
The University of Kansas Cancer Center - Olathe, Olathe
RECRUITING
University of Kansas Cancer Center, Kansas City
RECRUITING
University of Kansas Clinical Research Center, Fairway
RECRUITING
University of Kansas Hospital-Westwood Cancer Center, Westwood
RECRUITING
University of Kansas Cancer Center-Overland Park, Overland Park
RECRUITING
University of Kansas Hospital-Indian Creek Campus, Overland Park
SUSPENDED
Cotton O'Neil Cancer Center / Stormont Vail Health, Topeka
RECRUITING
University of Kansas Health System Saint Francis Campus, Topeka
SUSPENDED
Salina Regional Health Center, Salina
RECRUITING
HaysMed, Hays
RECRUITING
Nebraska Medicine-Village Pointe, Omaha
RECRUITING
Nebraska Medicine-Bellevue, Bellevue
RECRUITING
University of Nebraska Medical Center, Omaha
RECRUITING
LSU Health Baton Rouge-North Clinic, Baton Rouge
RECRUITING
Our Lady of the Lake Physician Group, Baton Rouge
SUSPENDED
Our Lady of The Lake, Baton Rouge
RECRUITING
University of Arkansas for Medical Sciences, Little Rock
RECRUITING
University of Oklahoma Health Sciences Center, Oklahoma City
RECRUITING
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston
RECRUITING
Ben Taub General Hospital, Houston
RECRUITING
Saint Alphonsus Cancer Care Center-Caldwell, Caldwell
RECRUITING
Saint Luke's Cancer Institute - Fruitland, Fruitland
RECRUITING
Saint Luke's Cancer Institute - Meridian, Meridian
RECRUITING
Saint Alphonsus Cancer Care Center-Nampa, Nampa
RECRUITING
Saint Luke's Cancer Institute - Nampa, Nampa
RECRUITING
Saint Alphonsus Cancer Care Center-Boise, Boise
RECRUITING
Saint Luke's Cancer Institute - Boise, Boise
RECRUITING
Kootenai Health - Coeur d'Alene, Coeur d'Alene
RECRUITING
Kootenai Clinic Cancer Services - Post Falls, Post Falls
RECRUITING
Kootenai Clinic Cancer Services - Sandpoint, Sandpoint
RECRUITING
Huntsman Cancer Institute/University of Utah, Salt Lake City
RECRUITING
George E Wahlen Department of Veterans Affairs Medical Center, Salt Lake City
RECRUITING
Mayo Clinic Hospital in Arizona, Phoenix
RECRUITING
Banner University Medical Center - Tucson, Tucson
RECRUITING
University of Arizona Cancer Center-North Campus, Tucson
RECRUITING
University of New Mexico Cancer Center, Albuquerque
RECRUITING
OptumCare Cancer Care at Seven Hills, Henderson
RECRUITING
OptumCare Cancer Care at Charleston, Las Vegas
RECRUITING
OptumCare Cancer Care at Fort Apache, Las Vegas
RECRUITING
Cedars Sinai Medical Center, Los Angeles
ACTIVE_NOT_RECRUITING
Tibor Rubin VA Medical Center, Long Beach
RECRUITING
Kaiser Permanente Fresno Orchard Plaza, Fresno
RECRUITING
Kaiser Permanente-Fresno, Fresno
RECRUITING
Kaiser Permanente-South San Francisco, South San Francisco
RECRUITING
Kaiser Permanente-San Francisco, San Francisco
RECRUITING
UCSF Medical Center-Parnassus, San Francisco
RECRUITING
Kaiser Permanente-Fremont, Fremont
RECRUITING
Kaiser Permanente Dublin, Dublin
RECRUITING
Kaiser Permanente San Leandro, San Leandro
RECRUITING
Kaiser Permanente-Vallejo, Vallejo
RECRUITING
Kaiser Permanente-Walnut Creek, Walnut Creek
RECRUITING
Kaiser Permanente-Oakland, Oakland
RECRUITING
Alta Bates Summit Medical Center-Herrick Campus, Berkeley
RECRUITING
Kaiser San Rafael-Gallinas, San Rafael
RECRUITING
Kaiser Permanente Medical Center - Santa Clara, Santa Clara
RECRUITING
Kaiser Permanente-Santa Teresa-San Jose, San Jose
RECRUITING
Kaiser Permanente-Modesto, Modesto
RECRUITING
Kaiser Permanente-Santa Rosa, Santa Rosa
RECRUITING
Kaiser Permanente-Roseville, Roseville
RECRUITING
Kaiser Permanente Downtown Commons, Sacramento
RECRUITING
University of California Davis Comprehensive Cancer Center, Sacramento
RECRUITING
Kaiser Permanente-South Sacramento, Sacramento
RECRUITING
Hawaii Cancer Care - Westridge, ‘Aiea
RECRUITING
Pali Momi Medical Center, ‘Aiea
RECRUITING
Hawaii Cancer Care Inc - Waterfront Plaza, Honolulu
RECRUITING
Straub Clinic and Hospital, Honolulu
RECRUITING
Kaiser Permanente Moanalua Medical Center, Honolulu
RECRUITING
Kapiolani Medical Center for Women and Children, Honolulu
RECRUITING
Providence Willamette Falls Medical Center, Oregon City
RECRUITING
Providence Newberg Medical Center, Newberg
RECRUITING
Providence Portland Medical Center, Portland
RECRUITING
Providence Saint Vincent Medical Center, Portland
RECRUITING
Oregon Health and Science University, Portland
RECRUITING
Saint Alphonsus Cancer Care Center-Ontario, Ontario
RECRUITING
Swedish Cancer Institute-Edmonds, Edmonds
RECRUITING
Swedish Cancer Institute-Issaquah, Issaquah
RECRUITING
Fred Hutchinson Cancer Center, Seattle
RECRUITING
Swedish Medical Center-First Hill, Seattle
RECRUITING
University of Washington Medical Center - Montlake, Seattle
RECRUITING
Yale University, New Haven
SUSPENDED
Veterans Affairs Connecticut Healthcare System-West Haven Campus, West Haven
RECRUITING
Mayo Clinic in Florida, Jacksonville
RECRUITING
MaineHealth Cancer Care and IV Therapy - Brunswick, Brunswick
RECRUITING
Mid Coast Hospital, Brunswick
RECRUITING
MaineHealth Maine Medical Center - Portland, Portland
RECRUITING
MaineHealth Cancer Care and IV Therapy - South Portland, South Portland
RECRUITING
Walter Reed National Military Medical Center, Bethesda
RECRUITING
Tufts Medical Center, Boston
RECRUITING
Dana-Farber Cancer Institute, Boston
RECRUITING
UMass Memorial Medical Center - University Campus, Worcester
RECRUITING
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon
RECRUITING
Memorial Sloan Kettering Basking Ridge, Basking Ridge
RECRUITING
Cooper Hospital University Medical Center, Camden
RECRUITING
Saint Barnabas Medical Center, Livingston
RECRUITING
Monmouth Medical Center, Long Branch
RECRUITING
Memorial Sloan Kettering Monmouth, Middletown
RECRUITING
Memorial Sloan Kettering Bergen, Montvale
RECRUITING
Rutgers Cancer Institute of New Jersey, New Brunswick
RECRUITING
The Valley Hospital - Luckow Pavilion, Paramus
RECRUITING
Valley Health System Ridgewood Campus, Ridgewood
RECRUITING
Community Medical Center, Toms River
RECRUITING
Penn State Milton S Hershey Medical Center, Hershey
RECRUITING
Rhode Island Hospital, Providence
RECRUITING
Sanford USD Medical Center - Sioux Falls, Sioux Falls
RECRUITING
University of Vermont Medical Center, Burlington
RECRUITING
University of Vermont and State Agricultural College, Burlington
RECRUITING
Saint Vincent Hospital Cancer Center at Sturgeon Bay, Sturgeon Bay
RECRUITING
Arthur J E Child Comprehensive Cancer Centre, Calgary
RECRUITING
University of Alberta Hospital, Edmonton
RECRUITING
CancerCare Manitoba, Winnipeg
RECRUITING
QEII Health Sciences Centre/Nova Scotia Health Authority, Halifax
RECRUITING
Juravinski Cancer Centre at Hamilton Health Sciences, Hamilton
RECRUITING
Odette Cancer Centre- Sunnybrook Health Sciences Centre, Toronto
RECRUITING
CSSS Champlain-Charles Le Moyne, Greenfield Park
RECRUITING
CIUSSSEMTL-Hopital Maisonneuve-Rosemont, Montreal
RECRUITING
Jewish General Hospital, Montreal
RECRUITING
Centro Comprensivo de Cancer de UPR, San Juan
RECRUITING
San Juan City Hospital, San Juan
National Cancer Institute (NCI)
NIH