1,170
Participants
Start Date
January 11, 2023
Primary Completion Date
August 1, 2027
Study Completion Date
August 1, 2027
Datopotamab Deruxtecan
Dato-DXd will be administered as an intravenous (IV) infusion every 3 weeks on Day 1 of each 21-day cycle.
Pembrolizumab
Pembrolizumab will be administered as an intravenous (IV) infusion every 3 weeks on Day 1 of each 21-day cycle.
Pemetrexed
Pemetrexed will be administered as an intravenous (IV) infusion every 3 weeks on Day 1 of each 21-day cycle.
Carboplatin
Carboplatin will be administered an intravenous (IV) infusion every 3 weeks on Day 1 of each 21-day cycle for up to 4 cycles.
Cisplatin
Cisplatin will be administered an intravenous (IV) infusion every 3 weeks on Day 1 of each 21-day cycle for up to 4 cycles.
COMPLETED
Koo Foundation Sun Yat-Sen Cancer Center, Taipei
COMPLETED
Taipei Veterans General Hospital, Taipei
COMPLETED
Linkou Chang Gung Memorial Hospital, Taoyuan District
COMPLETED
Changhua Christian Hospital, Changhua
COMPLETED
National Cheng Kung University Hospital, Tainan City
RECRUITING
National Koranyi Institute For Pulmonology, Budapest
RECRUITING
Fundacion CENIT para la investigacion en Neurociencias, Ciudad Autonoma de Buenos Aire
RECRUITING
Karl Landsteiner Institut Fã¼R Lungenforschung Und Pneumologische Onkologie C/O Klinik Floridsdorf, Vienna
RECRUITING
Baskent University, Adana
RECRUITING
St George Public Hospital, Kogarah
RECRUITING
Southern Medical Day Care Centre, Wollongong
RECRUITING
PSEHOG (Peninsula and South Eastern Haematology and Oncology Group), Frankston
RECRUITING
Jessa Hospital, Hasselt
RECRUITING
Spital Sts Ag, Thun
COMPLETED
Yonsei University Health System - Severance Hospital, Seoul
RECRUITING
Kantonsspital Baselland, Liestal
TERMINATED
CRSA/ St Andrews Hospital, Adelaide
RECRUITING
Hetenyi G Korhaz, Onkologiai Kozpont, Szolnok
RECRUITING
Flinders Medical Centre (Fmc), Bedford Park
RECRUITING
Centro Polivalente de Asistencia E Investigacion Clinica Cer San Juan, San Juan
RECRUITING
Bkmk Hospital, KecskemĂŠt
COMPLETED
Samsung Medical Center, Gangnam-Gu
RECRUITING
Memorial Ankara Hospital, Cankaya/Ankara
COMPLETED
The Catholic Univ. of Korea, Seoul St. Marys Hospital, Seoul
RECRUITING
Landeskrankenhaus Feldkirch, Feldkirch
RECRUITING
Ankara Bilkent City Hospital, Ankara
RECRUITING
Akdeniz University Hospital, Antalya
RECRUITING
Hospital de La Comunidad, Mar del Plata
RECRUITING
Fejer Megyei Szent Gyorgy Korhaz Pulmonologiai Osztaly, Székesfehérvár
RECRUITING
Hospital Clinic I Provincial de Barcelona, Barcelona
RECRUITING
Centro de Investigaciones Clinicas. Clinica Viedma S.A., Viedma
RECRUITING
Veszprem Megyei Tudogyogyintezet Farkasgyepu, Farkasgyepű
RECRUITING
Az Maria Middelares - Campus Maria Middelares, Ghent
RECRUITING
Kantonsspital St. Gallen, Sankt Gallen
RECRUITING
Klinikum Klagenfurt Pulmologie, Klagenfurt
RECRUITING
Az Nikolaas, Sint-Niklaas
TERMINATED
Klinikum Chemnitz, Chemnitz
RECRUITING
Azienda Ospedaliero - Universitaria San Luigi Gonzaga, Orbassano
COMPLETED
National Taiwan University Hospital, Taipei
RECRUITING
Istituto Di Candiolo Irccs, Candiolo
COMPLETED
Faculty of Medicine Chulalongkorn University, Bangkok
COMPLETED
Ramathibodi Hospital, Bangkok
COMPLETED
National Cancer Center, Goyang-si
TERMINATED
North Shore Hematology Oncology Associates dba NY Cancer and Blood Specialists - Bronx, The Bronx
COMPLETED
Siriraj Hospital, Bangkok
TERMINATED
North Shore Hematology Oncology Associates dba NY Cancer and Blood Specialists- New Hyde Park, New Hyde Park
COMPLETED
Tri-Service General Hospital, Taipei
RECRUITING
Sotiria General Hospital of Chest Diseases, Athens
TERMINATED
North Shore Hematology Oncology Associates, Patchogue
TERMINATED
North Shore Hematology Oncology Associates DBA NY Cancer and Blood Specialists, Port Jefferson Station
RECRUITING
Institut Paoli Calmettes, Marseille
RECRUITING
Aphm - Hopital Nord, Marseille
TERMINATED
Evangelische Lungenklinik Berlin, Berlin
COMPLETED
Seoul National University Bundang Hospital, Seongnam-si
RECRUITING
Metropolitan Hospital, Neo Faliro
RECRUITING
American Oncology Partners of Maryland, Bethesda
RECRUITING
Maryland Oncology Heamtology P.A., Columbia
RECRUITING
Asst Sette Laghi, Varese
RECRUITING
Hopital Jean Minjoz - CHU de Besancon, Besançon
RECRUITING
Hospital Universitario Arnau de Vilanova, Lleida
RECRUITING
Olympion Hospital, Pátrai
RECRUITING
Hospital General Universitario Gregorio Marañon, Madrid
RECRUITING
Hospital Clinico San Carlos, Madrid
RECRUITING
Hospital Universitario Fundacion Jimenez Diaz, Madrid
COMPLETED
Chungbuk National University Hospital, Cheongju-si
RECRUITING
Hospital Regional Universitario Malaga, Málaga
RECRUITING
CHUO, Ourense
RECRUITING
Cancer Specialist of North Florida, Jacksonville
RECRUITING
Woodlands Medical Specialists, Pa, Pensacola
RECRUITING
Cancer Care Centers of Brevard, Inc., Palm Bay
RECRUITING
Chu de Bordeaux - Hopital Saint Andre, Bordeaux
RECRUITING
Ospedale S. Maria Della Misericordia, Udine
RECRUITING
Florida Cancer Specialists-North, St. Petersburg
RECRUITING
Florida Cancer Specialists - South, Fort Myers
RECRUITING
Istanbul Medeniyet University Medical Faculty, Istanbul
RECRUITING
Medipol Mega University Hospital, Bağcılar
RECRUITING
Chu de Montpellier, Montpellier
RECRUITING
CHU de Rennes - Hopital Pontchaillou, Rennes
RECRUITING
Southern Cancer Center Pc, Daphne
RECRUITING
Azienda Ospedaliera Universitaria Integrata Verona Ospedale Borgo Roma Crc - Centro Ricerche Clinich, Verona
COMPLETED
Khon Kaen University - Faculty of Medicine-Srinagarind Hospital, Nonthaburi
COMPLETED
Taichung Veterans General Hospital, Taichung
RECRUITING
Hosp Univ Virgen Macarena, Seville
RECRUITING
Hospital Universitario Virgen de Valme, Seville
COMPLETED
Kyungpook National University Chilgok Hospital, Daegu
RECRUITING
Chu de Nantes, Nantes
RECRUITING
Hopital Prive Du Confluent, Nantes
RECRUITING
Universitaetsklinikum Essen, Essen
RECRUITING
University Hospital of Ioannina Uhi, Ioannina
RECRUITING
Hospital Universitario y Politecnico de La Fe, Valenica
RECRUITING
University Hospital Mă Nster, Münster
RECRUITING
Hospital Universitario Miguel Servet, Zaragoza
COMPLETED
Chiang Mai University CMU - Maharaj Nakhon Chiang Mai Hospital Nakorn Chiang Mai Hospital, Chiang Mai
COMPLETED
Gyeongsang National University Hospital, Jinju-si Gyeongsangnam-do
RECRUITING
Bioclinic Thessaloniki (Galinos Clinic), Thessalonki
RECRUITING
Illinois Cancer Specialists, Niles
RECRUITING
FN Brno Klinika Nemoci Plicnich a TBC, Brno
RECRUITING
Hopital Lyon Sud, Lyon
RECRUITING
Centre Leon Berard, Lyon
RECRUITING
University General Hospital of Heraklion, Heraklion
RECRUITING
Klinikum Esslingen Gmbh, Esslingen am Neckar
RECRUITING
Institut Curie, Paris
RECRUITING
Tenon Hospital, Paris
RECRUITING
Texas Oncology-Tyler, Tyler
RECRUITING
Texas Oncology, P.A., Sugar Land
RECRUITING
Ut Health San Antonio, San Antonio
RECRUITING
Texas Oncology, P.A., McAllen
RECRUITING
Universitaetsklinikum Freiburg, Freiburg im Breisgau
RECRUITING
Ludwig-Maximilians University Hospital of Munich, Munich
RECRUITING
UCHealth Memorial Hospital, Colorado Springs
RECRUITING
Utah Cancer Specialists IHO Corp, Salt Lake City
RECRUITING
Ironwood Cancer and Research Centers, Chandler
RECRUITING
Centre Hospitalier Universitaire, CHU, de Poitiers, France
RECRUITING
Arizona Oncology Associates, Pc - Nahoa, Prescott Valley
COMPLETED
Prince of Songkla University PSU - Faculty of Medicine, Hat Yai
RECRUITING
Ronald Reagan UCLA Medical Center, Santa Monica
RECRUITING
Hôpital Foch, Suresnes
RECRUITING
Compassionate Cancer Care Medical Group, Riverside
RECRUITING
Hoag Memorial Hospital Prebyterian, Newport Beach
RECRUITING
Sansum Clinic, Santa Barbara
RECRUITING
VA Puget Sound Health Care System, Seattle
RECRUITING
Providence Regional Cancer System, Lacey
COMPLETED
Prince of Wales Hospital / The Chinese University of Hong Kong, Hong Kong
COMPLETED
Peking University Peoples Hospital, Beijing
COMPLETED
Peking University Cancer Hospital Beijing Cancer Hospital Beijing Institute For Cancer Research, Beijing Sheng
COMPLETED
Liaoning Cancer Hospital & Institute, Shenyang
COMPLETED
First Affiliated Hospital of Medical College of Jilin University, Changchun
COMPLETED
Jilin Cancer Hospital, Changchun
COMPLETED
Harbin Medical University Cancer Hospital, Harbin
COMPLETED
Jiamusi Cancer Hospital, Jiamusi
COMPLETED
Shanghai Chest Hospital, Shanghai
COMPLETED
Fudan University Shanghai Cancer Center, Shanghai
RECRUITING
Onco Clinic Consult Sa, Craiova
RECRUITING
Centrul de Oncologie Sfantu Nectarie, Craiova
COMPLETED
Zhongda Hospital, Southeast University, Nanjing
COMPLETED
Linyi Cancer Hospital, Linyi
RECRUITING
Oncocenter Oncologie Clinica S.R.L, Timișoara
COMPLETED
Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou
COMPLETED
The First Affiliated Hospital of College of Medicine Zhejiang University, Hangzhou
COMPLETED
The First Affiliated Hospital of Nanchang University, Nanchang
COMPLETED
Fujian Medical University - Union Hospital Foochow Christian Union Hospital, Fuzhou
RECRUITING
Institute of Oncology Prof. Dr. Ion Chiricuta, Cluj-Napoca
COMPLETED
Chongqing University Cancer Hospital, Chongqing
COMPLETED
Hunan Cancer Hospital, Changsha
COMPLETED
Union Hospital of Tongji Medical College Huazhong University of Science and Technology, Wuhan
COMPLETED
Xiangyang Central Hospital, Xianyang
COMPLETED
Henan Cancer Hospital, Zhengzhou
COMPLETED
The First Affiliated Hospital Sun Yat-Sen University, Guangzhou
COMPLETED
Affiliated Cancer Hospital and Insititute of Guangzhou Medical University, Guangzhou
COMPLETED
The First Affiliated Hospital of Guangzhou Medical University, Guangzhou
COMPLETED
University of Electronic Science Technology of China UESTC - Sichuan Cancer Hospital Institute SIC, Chengdu
COMPLETED
The First Affiliate Hospital of Xi'An Jiaotong University, Xi'an
COMPLETED
The First Affiliated Hosptial of Xinjiang Medical University, Ürümqi
COMPLETED
Tuen Mun Hospital, Hong Kong
COMPLETED
Queen Mary Hospital, Pok Fu Lam
RECRUITING
ONCOVIDA, Santiago
RECRUITING
Centro de Estudios Clinicos Saga Spa, Santiago
RECRUITING
Orlandi Oncologia, Santiago
RECRUITING
Emory University - Winship Cancer Institute Wci, Atlanta
RECRUITING
Beth Israel Deaconess Medical Center, Boston
RECRUITING
Dana Farber Cancer Institute; Inv Drg Svc Pharm, Boston
RECRUITING
Dana Farber Cancer Institute At St. Elizabeth'S Medical Center, Brighton
RECRUITING
Dana Farber Brigham Cancer Center, Foxborough
RECRUITING
Dana Farber At Milford Regional Cancer Center, Milford
RECRUITING
Dana Farber/Bwcc in Affiliation With South Shore Hospital, South Weymouth
RECRUITING
Astera Cancer Care, East Brunswick
RECRUITING
Regional Cancer Care Associates LLC, Hackensack
RECRUITING
Instituto Alexander Fleming, Buenos Aires
RECRUITING
Sanatorio Britanico, Rosario
RECRUITING
Centre hospitalier Jolimont-Lobbes, Haine-Saint-Paul
RECRUITING
Cliniques Saint Pierre Ottignies (CSPO), Ottignies
RECRUITING
Fundacion Arturo Lopez Perez, Santiago
RECRUITING
Oncocentro Apys, Viña del Mar
WITHDRAWN
An Hui Cancer Hospital, Hefei
RECRUITING
Sainte-Catherine Institut du Cancer Avignon-Provence, Avignon
RECRUITING
University Hospital Giessen, ZIM IV, Giessen
RECRUITING
External pharmacy Fortuna Herstellung GmbH of main site Universitaetsmedizin Mannheim, Mannheim
RECRUITING
Metropolitan Hospital - Athens, Athens
RECRUITING
St. Luke's Hospital, Thessaloniki
RECRUITING
Reformatus Pulmonologiai Centrum, Törökbálint
RECRUITING
Ospedale San Luca, Lucca
RECRUITING
IFO Regina Elena, Rome
COMPLETED
NHO Shikoku Cancer Center, Ehime
RECRUITING
Cryptex Investigacion Clinica Sa de Cv, Cuauhtémoc
RECRUITING
Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara
RECRUITING
Instituto Nacional de Cancerologia, Mexico City
RECRUITING
Centro de Investigacion Clinica de Oaxaca CICLO, Oaxaca City
RECRUITING
Hospital CUF Porto, Porto
RECRUITING
SC Oncomed SRL, Jud Timis
COMPLETED
China Medical University Hospital, Hsia
RECRUITING
Ege Universitesi Gogus Hastaliklari Poliklinigi, Bornova-Izmir
RECRUITING
Adana Acibadem Hospital, Seyhan
RECRUITING
Centro de Investigacion Pergamino Sa, Pergamino
RECRUITING
Instituto de Oncologia de Rosario, Rosario
RECRUITING
Sanatorio Parque, Rosario
RECRUITING
Princess Alexandra Hospital, Woolloongabba
RECRUITING
Personal Oncologia de Precisao - Cenantron, Belo Horizonte
RECRUITING
Fundaco Universidade de Caxias Do Sul- Instituto de Pesquisas Em Saude Ips-Ucs, Caxias do Sul
RECRUITING
Hospital Erasto Gaertner, Curitiba
RECRUITING
Oncosite - Centro de Pesquisa Clinica Em Oncologia Ltda, Ijuí
RECRUITING
Clínica de Neoplasias Litoral Ltda, ItajaĂ-
RECRUITING
Clnica Lacks, Pelotas
RECRUITING
Santa Casa de Misericordia de Porto Alegre, Porto Alegre
RECRUITING
Instituto Nacional de Că'Ncer - Inca, Rio de Janeiro
RECRUITING
Centro de Estudos E Pesquisa de Hematologia E Oncologia - Cepho, Santo André
RECRUITING
Instituto de Ensino E Pesquisa Sao Lucas, São Paulo
RECRUITING
Instituto Do Cancer Brasil - Unidade Taubate, Taubaté
RECRUITING
CHU de Quebec -Universite Laval Hopital de L'Enfant-Jesus, Québec
RECRUITING
Centro de Investigaciones Clinicas Vina Del Mar, ViĂąa Del Mar
COMPLETED
Cangzhou Peoples Hospital, Cangzhou
COMPLETED
Inner Mongolia Medical University- the Affiliated Hospital, Hohhot
RECRUITING
Fakultni nemocnice Olomouc FNOL, Olomouc
RECRUITING
Euromedica General Clinic of Thessaloniki, Thessaloniki
COMPLETED
Kurume University Hospital, Fukoka
COMPLETED
Kyushu Cancer Center, Fukuoka
COMPLETED
Kyushu University Hospital, Fukuoka
COMPLETED
Teine Keijinkai Hospital, Hokkaido
COMPLETED
Hyogo Medical University Hospital, Hyōgo
COMPLETED
Kanazawa University Hospital, Ishikawa
COMPLETED
Kanagawa Cancer Center, Kanagawa
COMPLETED
Kitasato University hospital, Kanagawa
COMPLETED
Social Welfare Organization Saiseikai Imperial Gift Foundation, Inc. Saiseikai Kumamoto Hospital, Kumamoto
COMPLETED
University Hospital Kyoto Prefectual University of Medicine, Kyoto
COMPLETED
Matsusaka Municipal Hospital, Mie
COMPLETED
Sendai Kousei Hospital, Miyagi
COMPLETED
Niigata Cancer Center Hospital, Niigata
COMPLETED
Osaka International Cancer Institute, Osaka
COMPLETED
Osaka Toneyama Medical Center, Osaka
COMPLETED
Kansai Medical University Hospital, Osaka
COMPLETED
NHO Kinki-Chuo Chest Medical Center, Osaka
COMPLETED
Dokkyo Medical University Hospital, Tochigi
COMPLETED
Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo
COMPLETED
Juntendo University Hospital, Tokyo
COMPLETED
The Cancer Institute Hospital of JFCR, Tokyo
COMPLETED
Toho University Omori Medical Center, Tokyo
COMPLETED
Iwakuni Clinical Center, Yamaguchi
COMPLETED
Yamaguchi-Ube Medical Center, Yamaguchi
COMPLETED
Yamanashi Prefectural Central Hospital, Yamanashi
RECRUITING
Jeroen Bosch Ziekenhuis Jbz, 's-Hertogenbosch
RECRUITING
Amphia Ziekenhuis, Breda
RECRUITING
Leiden University Medical Center, Leiden
RECRUITING
II Klinika Chorob Pluc i Gruzlicy, Bialystok
RECRUITING
Centrum Terapii Wspolczesnej, Lodz
RECRUITING
Instytut Centrum Zdrowia Matki Polki (Iczmp), Lodz
RECRUITING
SPSK4, Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie, Lublin
RECRUITING
Med Polonia Sp. Z O.O., Poznan
RECRUITING
Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw
RECRUITING
Fundacao Champalimaud, Lisbon
RECRUITING
IPO Porto Francisco Gentil, E.P.E., Porto
COMPLETED
Asan Medical Center, Seoul
RECRUITING
Vall Hebron University Hospital, Barcelona
RECRUITING
Barts Health NHS Trust, London
Lead Sponsor
Collaborators (1)
AstraZeneca
INDUSTRY
Merck Sharp & Dohme LLC
INDUSTRY
Daiichi Sankyo
INDUSTRY