Testing the Effects of Novel Therapeutics for Newly Diagnosed, Untreated Patients With High-Risk Acute Myeloid Leukemia (A MyeloMATCH Treatment Trial)

PHASE2RecruitingINTERVENTIONAL
Enrollment

335

Participants

Timeline

Start Date

September 25, 2024

Primary Completion Date

March 31, 2027

Study Completion Date

March 31, 2027

Conditions
Acute Myeloid LeukemiaAcute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative NeoplasmAcute Myeloid Leukemia Post Cytotoxic TherapyAcute Myeloid Leukemia, Myelodysplasia-Related
Interventions
DRUG

Azacitidine

Given SC or IV

PROCEDURE

Biospecimen Collection

Undergo collection of blood

PROCEDURE

Bone Marrow Aspiration

Undergo bone marrow aspiration

DRUG

Cytarabine

Given IV

DRUG

Daunorubicin Hydrochloride

Given IV

PROCEDURE

Echocardiography Test

Undergo ECHO

DRUG

Liposome-encapsulated Daunorubicin-Cytarabine

Given IV

PROCEDURE

Multigated Acquisition Scan

Undergo MUGA

DRUG

Venetoclax

Given PO

Trial Locations (189)

10029

RECRUITING

Mount Sinai Hospital, New York

10467

RECRUITING

Montefiore Medical Center - Moses Campus, The Bronx

11030

RECRUITING

North Shore University Hospital, Manhasset

11042

RECRUITING

Northwell Health/Center for Advanced Medicine, Lake Success

13210

RECRUITING

State University of New York Upstate Medical University, Syracuse

14263

RECRUITING

Roswell Park Cancer Institute, Buffalo

14642

RECRUITING

University of Rochester, Rochester

15232

RECRUITING

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

17044

RECRUITING

Lewistown Hospital, Lewistown

17822

RECRUITING

Geisinger Medical Center, Danville

18103

RECRUITING

Lehigh Valley Hospital-Cedar Crest, Allentown

19104

RECRUITING

University of Pennsylvania/Abramson Cancer Center, Philadelphia

19107

RECRUITING

Thomas Jefferson University Hospital, Philadelphia

19611

RECRUITING

Reading Hospital, West Reading

21287

RECRUITING

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore

22031

RECRUITING

Inova Schar Cancer Institute, Fairfax

22042

RECRUITING

Inova Fairfax Hospital, Falls Church

22908

RECRUITING

University of Virginia Cancer Center, Charlottesville

27157

RECRUITING

Wake Forest University Health Sciences, Winston-Salem

27710

RECRUITING

Duke University Medical Center, Durham

28203

RECRUITING

Carolinas Medical Center/Levine Cancer Institute, Charlotte

29316

RECRUITING

Prisma Health Cancer Institute - Spartanburg, Boiling Springs

29605

RECRUITING

Prisma Health Cancer Institute - Butternut, Greenville

RECRUITING

Prisma Health Cancer Institute - Faris, Greenville

29615

RECRUITING

Prisma Health Cancer Institute - Eastside, Greenville

29640

RECRUITING

Prisma Health Cancer Institute - Easley, Easley

29650

RECRUITING

Prisma Health Cancer Institute - Greer, Greer

29672

RECRUITING

Prisma Health Cancer Institute - Seneca, Seneca

30912

RECRUITING

Augusta University Medical Center, Augusta

31701

RECRUITING

Phoebe Putney Memorial Hospital, Albany

35233

RECRUITING

University of Alabama at Birmingham Cancer Center, Birmingham

37920

RECRUITING

University of Tennessee - Knoxville, Knoxville

38017

RECRUITING

Baptist Memorial Hospital and Cancer Center-Collierville, Collierville

38120

RECRUITING

Baptist Memorial Hospital and Cancer Center-Memphis, Memphis

38652

RECRUITING

Baptist Memorial Hospital and Cancer Center-Union County, New Albany

38655

RECRUITING

Baptist Memorial Hospital and Cancer Center-Oxford, Oxford

38671

RECRUITING

Baptist Memorial Hospital and Cancer Center-Desoto, Southhaven

38901

RECRUITING

Baptist Cancer Center-Grenada, Grenada

39705

RECRUITING

Baptist Memorial Hospital and Cancer Center-Golden Triangle, Columbus

40202

RECRUITING

The James Graham Brown Cancer Center at University of Louisville, Louisville

40245

RECRUITING

UofL Health Medical Center Northeast, Louisville

40536

RECRUITING

University of Kentucky/Markey Cancer Center, Lexington

43210

RECRUITING

Ohio State University Comprehensive Cancer Center, Columbus

46202

RECRUITING

Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis

48106

RECRUITING

Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor

48114

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton

48118

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea

48154

RECRUITING

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia

48188

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton

48197

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti

48201

RECRUITING

Wayne State University/Karmanos Cancer Institute, Detroit

48202

RECRUITING

Henry Ford Hospital, Detroit

48322

RECRUITING

Henry Ford West Bloomfield Hospital, West Bloomfield

48334

RECRUITING

Weisberg Cancer Treatment Center, Farmington Hills

48377

RECRUITING

Henry Ford Medical Center-Columbus, Novi

48503

RECRUITING

Cancer Hematology Centers - Flint, Flint

SUSPENDED

Genesee Hematology Oncology PC, Flint

RECRUITING

Genesys Hurley Cancer Institute, Flint

RECRUITING

Hurley Medical Center, Flint

52242

RECRUITING

University of Iowa/Holden Comprehensive Cancer Center, Iowa City

53226

RECRUITING

Medical College of Wisconsin, Milwaukee

54301

RECRUITING

Saint Vincent Hospital Cancer Center Green Bay, Green Bay

54303

RECRUITING

Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay

54601

RECRUITING

Gundersen Lutheran Medical Center, La Crosse

54806

RECRUITING

Duluth Clinic Ashland, Ashland

54911

RECRUITING

ThedaCare Regional Cancer Center, Appleton

55072

RECRUITING

Essentia Health Sandstone, Sandstone

55101

RECRUITING

Regions Hospital, Saint Paul

55102

RECRUITING

United Hospital, Saint Paul

55407

RECRUITING

Abbott-Northwestern Hospital, Minneapolis

55416

RECRUITING

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55433

RECRUITING

Mercy Hospital, Coon Rapids

55435

RECRUITING

Fairview Southdale Hospital, Edina

55746

RECRUITING

Essentia Health Hibbing Clinic, Hibbing

55792

RECRUITING

Essentia Health Virginia Clinic, Virginia

55805

RECRUITING

Essentia Health Cancer Center, Duluth

55905

RECRUITING

Mayo Clinic in Rochester, Rochester

56636

RECRUITING

Essentia Health - Deer River Clinic, Deer River

59101

RECRUITING

Billings Clinic Cancer Center, Billings

59405

RECRUITING

Benefis Sletten Cancer Institute, Great Falls

59711

RECRUITING

Community Hospital of Anaconda, Anaconda

59715

RECRUITING

Bozeman Health Deaconess Hospital, Bozeman

59804

RECRUITING

Community Medical Center, Missoula

59901

RECRUITING

Logan Health Medical Center, Kalispell

60026

RECRUITING

NorthShore University HealthSystem-Glenbrook Hospital, Glenview

60035

RECRUITING

NorthShore University HealthSystem-Highland Park Hospital, Highland Park

60153

RECRUITING

Loyola University Medical Center, Maywood

60201

RECRUITING

NorthShore University HealthSystem-Evanston Hospital, Evanston

60611

RECRUITING

Northwestern University, Chicago

60637

RECRUITING

University of Chicago Comprehensive Cancer Center, Chicago

61021

RECRUITING

Illinois CancerCare-Dixon, Dixon

61350

RECRUITING

Illinois CancerCare-Ottawa Clinic, Ottawa

61354

RECRUITING

Illinois CancerCare-Peru, Peru

61356

RECRUITING

Illinois CancerCare-Princeton, Princeton

61401

RECRUITING

Illinois CancerCare-Galesburg, Galesburg

61443

RECRUITING

Illinois CancerCare-Kewanee Clinic, Kewanee

61455

RECRUITING

Illinois CancerCare-Macomb, Macomb

61520

RECRUITING

Illinois CancerCare-Canton, Canton

61530

RECRUITING

Illinois CancerCare-Eureka, Eureka

61554

RECRUITING

Illinois CancerCare-Pekin, Pekin

61571

RECRUITING

Illinois CancerCare - Washington, Washington

61615

RECRUITING

Illinois CancerCare-Peoria, Peoria

61636

RECRUITING

Methodist Medical Center of Illinois, Peoria

61637

RECRUITING

OSF Saint Francis Medical Center, Peoria

61701

RECRUITING

OSF Saint Joseph Medical Center, Bloomington

61704

RECRUITING

Illinois CancerCare-Bloomington, Bloomington

62269

RECRUITING

Cancer Care Center of O'Fallon, O'Fallon

62321

RECRUITING

Illinois CancerCare-Carthage, Carthage

62401

RECRUITING

Crossroads Cancer Center, Effingham

62526

RECRUITING

Cancer Care Specialists of Illinois - Decatur, Decatur

RECRUITING

Decatur Memorial Hospital, Decatur

62702

RECRUITING

Southern Illinois University School of Medicine, Springfield

RECRUITING

Springfield Clinic, Springfield

62781

RECRUITING

Springfield Memorial Hospital, Springfield

63110

RECRUITING

Washington University School of Medicine, St Louis

63129

RECRUITING

Siteman Cancer Center-South County, St Louis

63136

RECRUITING

Siteman Cancer Center at Christian Hospital, St Louis

63141

RECRUITING

Siteman Cancer Center at West County Hospital, Creve Coeur

63376

RECRUITING

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

66160

RECRUITING

University of Kansas Cancer Center, Kansas City

66205

RECRUITING

University of Kansas Clinical Research Center, Fairway

RECRUITING

University of Kansas Hospital-Westwood Cancer Center, Westwood

66211

RECRUITING

University of Kansas Hospital-Indian Creek Campus, Overland Park

68118

RECRUITING

Nebraska Medicine-Village Pointe, Omaha

68123

RECRUITING

Nebraska Medicine-Bellevue, Bellevue

68198

RECRUITING

University of Nebraska Medical Center, Omaha

70805

RECRUITING

LSU Health Baton Rouge-North Clinic, Baton Rouge

70808

RECRUITING

Our Lady of the Lake Physician Group, Baton Rouge

RECRUITING

Our Lady of The Lake, Baton Rouge

72205

RECRUITING

University of Arkansas for Medical Sciences, Little Rock

73104

RECRUITING

University of Oklahoma Health Sciences Center, Oklahoma City

83605

RECRUITING

Saint Alphonsus Cancer Care Center-Caldwell, Caldwell

83619

RECRUITING

Saint Luke's Cancer Institute - Fruitland, Fruitland

83642

RECRUITING

Saint Luke's Cancer Institute - Meridian, Meridian

83687

RECRUITING

Saint Alphonsus Cancer Care Center-Nampa, Nampa

RECRUITING

Saint Luke's Cancer Institute - Nampa, Nampa

83706

RECRUITING

Saint Alphonsus Cancer Care Center-Boise, Boise

83712

RECRUITING

Saint Luke's Cancer Institute - Boise, Boise

83814

RECRUITING

Kootenai Health - Coeur d'Alene, Coeur d'Alene

83854

RECRUITING

Kootenai Clinic Cancer Services - Post Falls, Post Falls

83864

RECRUITING

Kootenai Clinic Cancer Services - Sandpoint, Sandpoint

84112

RECRUITING

Huntsman Cancer Institute/University of Utah, Salt Lake City

85054

RECRUITING

Mayo Clinic Hospital in Arizona, Phoenix

85719

RECRUITING

Banner University Medical Center - Tucson, Tucson

RECRUITING

University of Arizona Cancer Center-North Campus, Tucson

87106

RECRUITING

University of New Mexico Cancer Center, Albuquerque

89052

RECRUITING

OptumCare Cancer Care at Seven Hills, Henderson

89102

RECRUITING

OptumCare Cancer Care at Charleston, Las Vegas

89148

RECRUITING

OptumCare Cancer Care at Fort Apache, Las Vegas

90048

RECRUITING

Cedars Sinai Medical Center, Los Angeles

94143

RECRUITING

UCSF Medical Center-Parnassus, San Francisco

94401

RECRUITING

Mills Health Center, San Mateo

94704

RECRUITING

Alta Bates Summit Medical Center-Herrick Campus, Berkeley

95817

RECRUITING

University of California Davis Comprehensive Cancer Center, Sacramento

96701

RECRUITING

Hawaii Cancer Care - Westridge, ‘Aiea

RECRUITING

Pali Momi Medical Center, ‘Aiea

96813

RECRUITING

Hawaii Cancer Care Inc - Waterfront Plaza, Honolulu

RECRUITING

Straub Clinic and Hospital, Honolulu

96826

RECRUITING

Kapiolani Medical Center for Women and Children, Honolulu

97213

RECRUITING

Providence Portland Medical Center, Portland

97225

RECRUITING

Providence Saint Vincent Medical Center, Portland

97239

RECRUITING

Oregon Health and Science University, Portland

97914

RECRUITING

Saint Alphonsus Cancer Care Center-Ontario, Ontario

98026

RECRUITING

Swedish Cancer Institute-Edmonds, Edmonds

98029

RECRUITING

Swedish Cancer Institute-Issaquah, Issaquah

98122

RECRUITING

Swedish Medical Center-First Hill, Seattle

06520

RECRUITING

Yale University, New Haven

32224-9980

RECRUITING

Mayo Clinic in Florida, Jacksonville

04102

RECRUITING

MaineHealth Maine Medical Center - Portland, Portland

04106

RECRUITING

MaineHealth Cancer Care and IV Therapy - South Portland, South Portland

02111

RECRUITING

Tufts Medical Center, Boston

02215

RECRUITING

Dana-Farber Cancer Institute, Boston

01805

RECRUITING

Lahey Hospital and Medical Center, Burlington

01960

RECRUITING

Lahey Medical Center-Peabody, Peabody

08103

RECRUITING

Cooper Hospital University Medical Center, Camden

07039

RECRUITING

Saint Barnabas Medical Center, Livingston

07740

RECRUITING

Monmouth Medical Center, Long Branch

08903

RECRUITING

Rutgers Cancer Institute of New Jersey, New Brunswick

07652

RECRUITING

The Valley Hospital - Luckow Pavilion, Paramus

07450

RECRUITING

Valley Health System Ridgewood Campus, Ridgewood

08755

RECRUITING

Community Medical Center, Toms River

17033-0850

RECRUITING

Penn State Milton S Hershey Medical Center, Hershey

05401

RECRUITING

University of Vermont Medical Center, Burlington

05405

RECRUITING

University of Vermont and State Agricultural College, Burlington

T2N 5G2

RECRUITING

Arthur J E Child Comprehensive Cancer Centre, Calgary

T6G 2B7

RECRUITING

University of Alberta Hospital, Edmonton

R3E 0V9

RECRUITING

CancerCare Manitoba, Winnipeg

00927

RECRUITING

Centro Comprensivo de Cancer de UPR, San Juan

00936

RECRUITING

San Juan City Hospital, San Juan

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH