Study of Chemotherapy Plus Ipatasertib for People With Solid Tumors With PTEN/AKT Mutations, A ComboMATCH Treatment Trial

PHASE2RecruitingINTERVENTIONAL
Enrollment

33

Participants

Timeline

Start Date

September 22, 2023

Primary Completion Date

August 31, 2026

Study Completion Date

August 31, 2026

Conditions
Locally Advanced Malignant Solid NeoplasmMetastatic Malignant Solid NeoplasmUnresectable Malignant Solid Neoplasm
Interventions
PROCEDURE

Biopsy Procedure

Undergo tumor biopsy

PROCEDURE

Biospecimen Collection

Undergo blood collection

PROCEDURE

Computed Tomography

Undergo CT scan

DRUG

Ipatasertib

Given PO

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

DRUG

Paclitaxel

Given IV

Trial Locations (210)

10029

ACTIVE_NOT_RECRUITING

Mount Sinai Hospital, New York

14263

ACTIVE_NOT_RECRUITING

Roswell Park Cancer Institute, Buffalo

15146

RECRUITING

UPMC Hillman Cancer Center - Monroeville, Monroeville

15213

RECRUITING

UPMC-Magee Womens Hospital, Pittsburgh

15232

RECRUITING

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

15237

RECRUITING

UPMC-Passavant Hospital, Pittsburgh

15601

RECRUITING

UPMC Cancer Centers - Arnold Palmer Pavilion, Greensburg

16505

RECRUITING

UPMC Hillman Cancer Center Erie, Erie

16601

RECRUITING

UPMC Altoona, Altoona

17050

RECRUITING

UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion, Mechanicsburg

18017

RECRUITING

Lehigh Valley Hospital - Muhlenberg, Bethlehem

18103

RECRUITING

Lehigh Valley Hospital-Cedar Crest, Allentown

18201

RECRUITING

Lehigh Valley Hospital-Hazleton, Hazleton

18301

RECRUITING

Pocono Medical Center, East Stroudsburg

19010

RECRUITING

Bryn Mawr Hospital, Bryn Mawr

19063

RECRUITING

Riddle Memorial Hospital, Media

19096

RECRUITING

Lankenau Medical Center, Wynnewood

19107

RECRUITING

Thomas Jefferson University Hospital, Philadelphia

19301

RECRUITING

Paoli Memorial Hospital, Paoli

20892

RECRUITING

National Institutes of Health Clinical Center, Bethesda

21201

ACTIVE_NOT_RECRUITING

University of Maryland/Greenebaum Cancer Center, Baltimore

21502

RECRUITING

UPMC Western Maryland, Cumberland

22031

RECRUITING

Inova Schar Cancer Institute, Fairfax

22042

RECRUITING

Inova Fairfax Hospital, Falls Church

22908

RECRUITING

University of Virginia Cancer Center, Charlottesville

23229

RECRUITING

Virginia Cancer Institute, Richmond

23235

RECRUITING

VCU Massey Cancer Center at Stony Point, Richmond

23298

RECRUITING

VCU Massey Comprehensive Cancer Center, Richmond

23970

RECRUITING

VCU Community Memorial Health Center, South Hill

24033

RECRUITING

Carilion Roanoke Memorial Hospital, Roanoke

27710

RECRUITING

Duke University Medical Center, Durham

33136

ACTIVE_NOT_RECRUITING

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33146

ACTIVE_NOT_RECRUITING

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables

33176

ACTIVE_NOT_RECRUITING

UM Sylvester Comprehensive Cancer Center at Kendall, Miami

33180

ACTIVE_NOT_RECRUITING

UM Sylvester Comprehensive Cancer Center at Aventura, Aventura

33324

ACTIVE_NOT_RECRUITING

UM Sylvester Comprehensive Cancer Center at Plantation, Plantation

33442

ACTIVE_NOT_RECRUITING

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

35233

RECRUITING

University of Alabama at Birmingham Cancer Center, Birmingham

36688

RECRUITING

University of South Alabama Mitchell Cancer Institute, Mobile

40536

RECRUITING

University of Kentucky/Markey Cancer Center, Lexington

43015

ACTIVE_NOT_RECRUITING

Delaware Health Center-Grady Cancer Center, Delaware

ACTIVE_NOT_RECRUITING

Grady Memorial Hospital, Delaware

43016

ACTIVE_NOT_RECRUITING

Columbus Oncology and Hematology Associates, Dublin

ACTIVE_NOT_RECRUITING

Dublin Methodist Hospital, Dublin

43040

RECRUITING

Memorial Hospital, Marysville

43050

RECRUITING

Knox Community Hospital, Mount Vernon

43055

RECRUITING

Licking Memorial Hospital, Newark

43081

RECRUITING

Saint Ann's Hospital, Westerville

43082

ACTIVE_NOT_RECRUITING

OhioHealth Westerville Medical Campus/Westerville Cancer Center, Westerville

43130

RECRUITING

Fairfield Medical Center, Lancaster

43213

RECRUITING

Mount Carmel East Hospital, Columbus

43214

ACTIVE_NOT_RECRUITING

Columbus Oncology and Hematology Associates Inc, Columbus

ACTIVE_NOT_RECRUITING

Riverside Methodist Hospital, Columbus

43215

ACTIVE_NOT_RECRUITING

Grant Medical Center, Columbus

43219

RECRUITING

The Mark H Zangmeister Center, Columbus

43228

ACTIVE_NOT_RECRUITING

Doctors Hospital, Columbus

43302

ACTIVE_NOT_RECRUITING

OhioHealth Marion General Hospital, Marion

43551

RECRUITING

Mercy Health - Perrysburg Hospital, Perrysburg

43623

RECRUITING

Mercy Health - Saint Anne Hospital, Toledo

43701

RECRUITING

Genesis Healthcare System Cancer Care Center, Zanesville

44011

RECRUITING

UH Seidman Cancer Center at UH Avon Health Center, Avon

44060

RECRUITING

UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor

44106

RECRUITING

Case Western Reserve University, Cleveland

44122

RECRUITING

UHHS-Chagrin Highlands Medical Center, Beachwood

44710

RECRUITING

Aultman Health Foundation, Canton

44903

ACTIVE_NOT_RECRUITING

OhioHealth Mansfield Hospital, Mansfield

45415

ACTIVE_NOT_RECRUITING

Dayton Physician LLC - Englewood, Dayton

45429

ACTIVE_NOT_RECRUITING

Kettering Medical Center, Kettering

45504

RECRUITING

Springfield Regional Cancer Center, Springfield

RECRUITING

Springfield Regional Medical Center, Springfield

45601

RECRUITING

Adena Regional Medical Center, Chillicothe

45662

RECRUITING

Southern Ohio Medical Center, Portsmouth

45714

RECRUITING

Strecker Cancer Center-Belpre, Belpre

48044

RECRUITING

Henry Ford Saint John Hospital - Macomb Medical, Macomb

48073

RECRUITING

Corewell Health William Beaumont University Hospital, Royal Oak

48085

RECRUITING

Corewell Health Beaumont Troy Hospital, Troy

48106

RECRUITING

Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor

RECRUITING

Huron Gastroenterology PC, Ypsilanti

48114

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton

RECRUITING

Trinity Health Medical Center - Brighton, Brighton

48118

RECRUITING

Chelsea Hospital, Chelsea

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea

48124

RECRUITING

Corewell Health Dearborn Hospital, Dearborn

48154

RECRUITING

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia

48188

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton

RECRUITING

Trinity Health Medical Center - Canton, Canton

48197

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti

48336

RECRUITING

Corewell Health Farmington Hills Hospital, Farmington Hills

48341

RECRUITING

Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac

48503

RECRUITING

Cancer Hematology Centers - Flint, Flint

SUSPENDED

Genesee Hematology Oncology PC, Flint

RECRUITING

Genesys Hurley Cancer Institute, Flint

RECRUITING

Hurley Medical Center, Flint

48601

RECRUITING

MyMichigan Medical Center Saginaw, Saginaw

48604

SUSPENDED

Oncology Hematology Associates of Saginaw Valley PC, Saginaw

48661

SUSPENDED

Saint Mary's Oncology/Hematology Associates of West Branch, West Branch

48764

RECRUITING

MyMichigan Medical Center Tawas, Tawas City

48912

RECRUITING

University of Michigan Health - Sparrow Lansing, Lansing

50023

RECRUITING

UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny

50263

RECRUITING

UI Health Care Mission Cancer and Blood - Waukee Clinic, Waukee

50309

RECRUITING

UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines

50314

RECRUITING

Mercy Medical Center - Des Moines, Des Moines

53022

RECRUITING

Aurora Health Care Germantown Health Center, Germantown

53024

RECRUITING

Aurora Cancer Care-Grafton, Grafton

53066

RECRUITING

Aurora Medical Center in Summit, Summit

53081

RECRUITING

Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan

53105

RECRUITING

Aurora Cancer Care-Southern Lakes VLCC, Burlington

53110

RECRUITING

Aurora Saint Luke's South Shore, Cudahy

53142

RECRUITING

Aurora Cancer Care-Kenosha South, Kenosha

53209

RECRUITING

Aurora Cancer Care-Milwaukee, Milwaukee

53215

RECRUITING

Aurora Saint Luke's Medical Center, Milwaukee

53226

RECRUITING

Aurora Cancer Care-Milwaukee West, Wauwatosa

53227

RECRUITING

Aurora West Allis Medical Center, West Allis

53233

RECRUITING

Aurora Sinai Medical Center, Milwaukee

53406

RECRUITING

Aurora Cancer Care-Racine, Racine

53718

RECRUITING

University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison

53792

RECRUITING

University of Wisconsin Carbone Cancer Center - University Hospital, Madison

54143

RECRUITING

Aurora Bay Area Medical Group-Marinette, Marinette

54241

RECRUITING

Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers

54311

RECRUITING

Aurora BayCare Medical Center, Green Bay

54601

ACTIVE_NOT_RECRUITING

Gundersen Lutheran Medical Center, La Crosse

54806

RECRUITING

Duluth Clinic Ashland, Ashland

54904

RECRUITING

Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh

55072

RECRUITING

Essentia Health Sandstone, Sandstone

55101

ACTIVE_NOT_RECRUITING

Regions Hospital, Saint Paul

55102

ACTIVE_NOT_RECRUITING

United Hospital, Saint Paul

55407

ACTIVE_NOT_RECRUITING

Abbott-Northwestern Hospital, Minneapolis

55416

ACTIVE_NOT_RECRUITING

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55433

ACTIVE_NOT_RECRUITING

Mercy Hospital, Coon Rapids

55435

ACTIVE_NOT_RECRUITING

Fairview Southdale Hospital, Edina

55746

RECRUITING

Essentia Health Hibbing Clinic, Hibbing

55792

RECRUITING

Essentia Health Virginia Clinic, Virginia

55805

RECRUITING

Essentia Health Cancer Center, Duluth

55905

RECRUITING

Mayo Clinic in Rochester, Rochester

56601

RECRUITING

Sanford Joe Lueken Cancer Center, Bemidji

56636

RECRUITING

Essentia Health - Deer River Clinic, Deer River

57104

RECRUITING

Sanford Cancer Center Oncology Clinic, Sioux Falls

57701

ACTIVE_NOT_RECRUITING

Rapid City Regional Hospital, Rapid City

58122

RECRUITING

Sanford Broadway Medical Center, Fargo

RECRUITING

Sanford Roger Maris Cancer Center, Fargo

58501

RECRUITING

Sanford Bismarck Medical Center, Bismarck

59101

RECRUITING

Billings Clinic Cancer Center, Billings

59405

RECRUITING

Benefis Sletten Cancer Institute, Great Falls

59711

RECRUITING

Community Hospital of Anaconda, Anaconda

59715

RECRUITING

Bozeman Health Deaconess Hospital, Bozeman

59804

RECRUITING

Community Medical Center, Missoula

59901

RECRUITING

Logan Health Medical Center, Kalispell

60010

RECRUITING

Advocate Good Shepherd Hospital, Barrington

60014

RECRUITING

AMG Crystal Lake - Oncology, Crystal Lake

60048

RECRUITING

AMG Libertyville - Oncology, Libertyville

RECRUITING

Condell Memorial Hospital, Libertyville

60068

RECRUITING

Advocate Lutheran General Hospital, Park Ridge

60123

RECRUITING

Advocate Sherman Hospital, Elgin

60429

RECRUITING

Advocate South Suburban Hospital, Hazel Crest

60451

RECRUITING

UC Comprehensive Cancer Center at Silver Cross, New Lenox

60462

RECRUITING

University of Chicago Medicine-Orland Park, Orland Park

60515

RECRUITING

Advocate Good Samaritan Hospital, Downers Grove

60612

RECRUITING

John H Stroger Jr Hospital of Cook County, Chicago

60637

RECRUITING

University of Chicago Comprehensive Cancer Center, Chicago

60657

RECRUITING

Advocate Illinois Masonic Medical Center, Chicago

61801

RECRUITING

Carle Cancer Center, Urbana

61832

RECRUITING

Carle at The Riverfront, Danville

61938

RECRUITING

Carle Physician Group-Mattoon/Charleston, Mattoon

62401

RECRUITING

Carle Physician Group-Effingham, Effingham

73104

RECRUITING

University of Oklahoma Health Sciences Center, Oklahoma City

77030

RECRUITING

M D Anderson Cancer Center, Houston

83301

RECRUITING

Saint Luke's Cancer Institute - Twin Falls, Twin Falls

83605

RECRUITING

Saint Alphonsus Cancer Care Center-Caldwell, Caldwell

83619

RECRUITING

Saint Luke's Cancer Institute - Fruitland, Fruitland

83642

RECRUITING

Saint Luke's Cancer Institute - Meridian, Meridian

83687

RECRUITING

Saint Alphonsus Cancer Care Center-Nampa, Nampa

RECRUITING

Saint Luke's Cancer Institute - Nampa, Nampa

83706

RECRUITING

Saint Alphonsus Cancer Care Center-Boise, Boise

83712

RECRUITING

Saint Luke's Cancer Institute - Boise, Boise

83814

RECRUITING

Kootenai Health - Coeur d'Alene, Coeur d'Alene

83854

RECRUITING

Kootenai Clinic Cancer Services - Post Falls, Post Falls

83864

RECRUITING

Kootenai Clinic Cancer Services - Sandpoint, Sandpoint

86401

RECRUITING

Kingman Regional Medical Center, Kingman

89052

RECRUITING

OptumCare Cancer Care at Seven Hills, Henderson

89102

RECRUITING

OptumCare Cancer Care at Charleston, Las Vegas

89148

RECRUITING

OptumCare Cancer Care at Fort Apache, Las Vegas

90025

RECRUITING

The Angeles Clinic and Research Institute - West Los Angeles Office, Los Angeles

90048

RECRUITING

Cedars Sinai Medical Center, Los Angeles

90404

RECRUITING

Saint John's Cancer Institute, Santa Monica

92093

ACTIVE_NOT_RECRUITING

UC San Diego Moores Cancer Center, La Jolla

92868

RECRUITING

Saint Joseph Hospital - Orange, Orange

93420

RECRUITING

PCR Oncology, Arroyo Grande

94304

RECRUITING

Stanford Cancer Institute Palo Alto, Palo Alto

97045

RECRUITING

Providence Willamette Falls Medical Center, Oregon City

97132

RECRUITING

Providence Newberg Medical Center, Newberg

97213

RECRUITING

Providence Portland Medical Center, Portland

97225

RECRUITING

Providence Saint Vincent Medical Center, Portland

97914

RECRUITING

Saint Alphonsus Cancer Care Center-Ontario, Ontario

98026

RECRUITING

Swedish Cancer Institute-Edmonds, Edmonds

98029

RECRUITING

Swedish Cancer Institute-Issaquah, Issaquah

98055

RECRUITING

Valley Medical Center, Renton

98122

RECRUITING

Swedish Medical Center-First Hill, Seattle

98902

RECRUITING

North Star Lodge Cancer Center at Yakima Valley Memorial Hospital, Yakima

99508

RECRUITING

Alaska Women's Cancer Care, Anchorage

32224-9980

RECRUITING

Mayo Clinic in Florida, Jacksonville

60453-2699

RECRUITING

Advocate Christ Medical Center, Oak Lawn

04330

RECRUITING

Harold Alfond Center for Cancer Care, Augusta

04412

RECRUITING

Lafayette Family Cancer Center-EMMC, Brewer

04074

RECRUITING

MaineHealth Maine Medical Center- Scarborough, Scarborough

02111

RECRUITING

Tufts Medical Center, Boston

08903

RECRUITING

Rutgers Cancer Institute of New Jersey, New Brunswick

02905

RECRUITING

Women and Infants Hospital, Providence

57117-5134

RECRUITING

Sanford USD Medical Center - Sioux Falls, Sioux Falls

00961

RECRUITING

Puerto Rico Hematology Oncology Group, Bayamón

00927

RECRUITING

Centro Comprensivo de Cancer de UPR, San Juan

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH