Palbociclib and Binimetinib in RAS-Mutant Cancers, A ComboMATCH Treatment Trial

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

199

Participants

Timeline

Start Date

December 13, 2023

Primary Completion Date

August 26, 2026

Study Completion Date

August 26, 2026

Conditions
Exocrine Pancreas CarcinomaMalignant Solid NeoplasmOvarian Low Grade Serous AdenocarcinomaStage IV Ovarian Cancer AJCC v8Stage IV Pancreatic Cancer AJCC v8
Interventions
DRUG

Binimetinib

Given PO

PROCEDURE

Biopsy Procedure

Undergo biopsy

PROCEDURE

Biospecimen Collection

Undergo collection of blood samples

PROCEDURE

Bone Scan

Undergo bone scan

PROCEDURE

Computed Tomography

Undergo CT

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

DRUG

Palbociclib

Given PO

Trial Locations (267)

10029

Mount Sinai Hospital, New York

13126

Upstate Cancer Center at Oswego, Oswego

13210

State University of New York Upstate Medical University, Syracuse

13478

Upstate Cancer Center at Verona, Verona

14263

Roswell Park Cancer Institute, Buffalo

15146

UPMC Hillman Cancer Center - Monroeville, Monroeville

15232

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

15237

UPMC-Passavant Hospital, Pittsburgh

15601

UPMC Cancer Centers - Arnold Palmer Pavilion, Greensburg

16505

UPMC Hillman Cancer Center Erie, Erie

16601

UPMC Altoona, Altoona

17050

UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion, Mechanicsburg

19010

Bryn Mawr Hospital, Bryn Mawr

19063

Riddle Memorial Hospital, Media

19096

Lankenau Medical Center, Wynnewood

19301

Paoli Memorial Hospital, Paoli

20892

National Institutes of Health Clinical Center, Bethesda

21201

University of Maryland/Greenebaum Cancer Center, Baltimore

21502

UPMC Western Maryland, Cumberland

22031

Inova Schar Cancer Institute, Fairfax

22042

Inova Fairfax Hospital, Falls Church

22908

University of Virginia Cancer Center, Charlottesville

23298

VCU Massey Comprehensive Cancer Center, Richmond

26506

West Virginia University Healthcare, Morgantown

27710

Duke University Medical Center, Durham

29316

Prisma Health Cancer Institute - Spartanburg, Boiling Springs

29605

Prisma Health Cancer Institute - Butternut, Greenville

Prisma Health Cancer Institute - Faris, Greenville

29615

Prisma Health Cancer Institute - Eastside, Greenville

29640

Prisma Health Cancer Institute - Easley, Easley

29650

Prisma Health Cancer Institute - Greer, Greer

29672

Prisma Health Cancer Institute - Seneca, Seneca

32610

University of Florida Health Science Center - Gainesville, Gainesville

33136

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33146

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables

33176

UM Sylvester Comprehensive Cancer Center at Kendall, Miami

33180

UM Sylvester Comprehensive Cancer Center at Aventura, Aventura

33324

UM Sylvester Comprehensive Cancer Center at Plantation, Plantation

33442

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

35233

University of Alabama at Birmingham Cancer Center, Birmingham

36688

University of South Alabama Mitchell Cancer Institute, Mobile

37232

Vanderbilt University/Ingram Cancer Center, Nashville

40536

University of Kentucky/Markey Cancer Center, Lexington

43015

Delaware Health Center-Grady Cancer Center, Delaware

Grady Memorial Hospital, Delaware

43016

Columbus Oncology and Hematology Associates, Dublin

Dublin Methodist Hospital, Dublin

43210

Ohio State University Comprehensive Cancer Center, Columbus

43214

Columbus Oncology and Hematology Associates Inc, Columbus

Riverside Methodist Hospital, Columbus

43215

Grant Medical Center, Columbus

43228

Doctors Hospital, Columbus

43302

OhioHealth Marion General Hospital, Marion

44903

OhioHealth Mansfield Hospital, Mansfield

45220

Good Samaritan Hospital - Cincinnati, Cincinnati

45331

Miami Valley Cancer Care and Infusion, Greenville

45373

Upper Valley Medical Center, Troy

45409

Miami Valley Hospital, Dayton

Premier Blood and Cancer Center, Dayton

45415

Dayton Physician LLC - Englewood, Dayton

Miami Valley Hospital North, Dayton

45429

Kettering Medical Center, Kettering

45459

Miami Valley Hospital South, Centerville

48073

Corewell Health William Beaumont University Hospital, Royal Oak

48085

Corewell Health Beaumont Troy Hospital, Troy

48106

Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor

Huron Gastroenterology PC, Ypsilanti

48114

Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton

Trinity Health Medical Center - Brighton, Brighton

48118

Chelsea Hospital, Chelsea

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea

48124

Corewell Health Dearborn Hospital, Dearborn

48154

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia

48188

Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton

Trinity Health Medical Center - Canton, Canton

48197

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti

48336

Corewell Health Farmington Hills Hospital, Farmington Hills

48341

Michigan Healthcare Professionals Pontiac, Pontiac

Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac

48503

Cancer Hematology Centers - Flint, Flint

Genesee Hematology Oncology PC, Flint

Genesys Hurley Cancer Institute, Flint

Hurley Medical Center, Flint

48912

University of Michigan Health - Sparrow Lansing, Lansing

49007

Bronson Methodist Hospital, Kalamazoo

West Michigan Cancer Center, Kalamazoo

49009

Beacon Kalamazoo Cancer Center, Kalamazoo

49017

Bronson Battle Creek, Battle Creek

49085

Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph

Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph

49120

Corewell Health Lakeland Hospitals - Niles Hospital, Niles

49444

Trinity Health Muskegon Hospital, Muskegon

Cancer and Hematology Centers of Western Michigan - Norton Shores, Norton Shores

49503

Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids

Trinity Health Grand Rapids Hospital, Grand Rapids

49519

University of Michigan Health - West, Wyoming

49677

Corewell Health Reed City Hospital, Reed City

49684

Munson Medical Center, Traverse City

49829

OSF Saint Francis Hospital and Medical Group, Escanaba

50023

UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny

50263

UI Health Care Mission Cancer and Blood - Waukee Clinic, Waukee

50309

UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines

52403

Mercy Hospital, Cedar Rapids

Oncology Associates at Mercy Medical Center, Cedar Rapids

53022

Aurora Health Care Germantown Health Center, Germantown

53024

Aurora Cancer Care-Grafton, Grafton

53066

Aurora Medical Center in Summit, Summit

53081

Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan

53105

Aurora Cancer Care-Southern Lakes VLCC, Burlington

53110

Aurora Saint Luke's South Shore, Cudahy

53142

Aurora Cancer Care-Kenosha South, Kenosha

53209

Aurora Cancer Care-Milwaukee, Milwaukee

53215

Aurora Saint Luke's Medical Center, Milwaukee

53226

Aurora Cancer Care-Milwaukee West, Wauwatosa

53227

Aurora West Allis Medical Center, West Allis

53233

Aurora Sinai Medical Center, Milwaukee

53406

Aurora Cancer Care-Racine, Racine

53548

Mercyhealth Hospital and Cancer Center - Janesville, Janesville

53718

University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison

53792

University of Wisconsin Carbone Cancer Center - University Hospital, Madison

54143

Aurora Bay Area Medical Group-Marinette, Marinette

54154

Saint Vincent Hospital Cancer Center at Oconto Falls, Oconto Falls

54241

Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers

54301

Saint Vincent Hospital Cancer Center Green Bay, Green Bay

54303

Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay

54311

Aurora BayCare Medical Center, Green Bay

54449

Marshfield Medical Center-Marshfield, Marshfield

54476

Marshfield Medical Center - Weston, Weston

54482

Marshfield Medical Center-River Region at Stevens Point, Stevens Point

54548

Marshfield Medical Center - Minocqua, Minocqua

54601

Gundersen Lutheran Medical Center, La Crosse

54701

Marshfield Medical Center-EC Cancer Center, Eau Claire

54806

Duluth Clinic Ashland, Ashland

54868

Marshfield Medical Center-Rice Lake, Rice Lake

54904

Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh

54911

ThedaCare Regional Cancer Center, Appleton

55072

Essentia Health Sandstone, Sandstone

55415

Hennepin County Medical Center, Minneapolis

55746

Essentia Health Hibbing Clinic, Hibbing

55792

Essentia Health Virginia Clinic, Virginia

55805

Essentia Health Cancer Center, Duluth

56601

Sanford Joe Lueken Cancer Center, Bemidji

56636

Essentia Health - Deer River Clinic, Deer River

57104

Sanford Cancer Center Oncology Clinic, Sioux Falls

58122

Sanford Broadway Medical Center, Fargo

Sanford Roger Maris Cancer Center, Fargo

58501

Sanford Bismarck Medical Center, Bismarck

59101

Billings Clinic Cancer Center, Billings

59405

Benefis Sletten Cancer Institute, Great Falls

59711

Community Hospital of Anaconda, Anaconda

59715

Bozeman Health Deaconess Hospital, Bozeman

59804

Community Medical Center, Missoula

59901

Logan Health Medical Center, Kalispell

60010

Advocate Good Shepherd Hospital, Barrington

60014

AMG Crystal Lake - Oncology, Crystal Lake

60026

Northwestern Medicine Glenview Outpatient Center, Glenview

60030

Northwestern Medicine Grayslake Outpatient Center, Grayslake

60045

Northwestern Medicine Lake Forest Hospital, Lake Forest

60048

AMG Libertyville - Oncology, Libertyville

Condell Memorial Hospital, Libertyville

60068

Advocate Lutheran General Hospital, Park Ridge

60115

Northwestern Medicine Cancer Center Kishwaukee, DeKalb

60123

Advocate Sherman Hospital, Elgin

60134

Northwestern Medicine Cancer Center Delnor, Geneva

60429

Advocate South Suburban Hospital, Hazel Crest

60451

UC Comprehensive Cancer Center at Silver Cross, New Lenox

60453

Advocate Outpatient Center - Oak Lawn, Oak Lawn

60462

Northwestern Medicine Orland Park, Orland Park

University of Chicago Medicine-Orland Park, Orland Park

60463

Advocate High Tech Medical Park, Palos Heights

60515

Advocate Good Samaritan Hospital, Downers Grove

60555

Northwestern Medicine Cancer Center Warrenville, Warrenville

60611

Northwestern University, Chicago

60612

John H Stroger Jr Hospital of Cook County, Chicago

60637

University of Chicago Comprehensive Cancer Center, Chicago

60657

Advocate Illinois Masonic Medical Center, Chicago

61021

Illinois CancerCare-Dixon, Dixon

61114

Mercyhealth Cancer Institute - Rockford, Rockford

61350

Illinois CancerCare-Ottawa Clinic, Ottawa

61354

Illinois CancerCare-Peru, Peru

61356

Illinois CancerCare-Princeton, Princeton

61401

Illinois CancerCare-Galesburg, Galesburg

61443

Illinois CancerCare-Kewanee Clinic, Kewanee

61455

Illinois CancerCare-Macomb, Macomb

61520

Illinois CancerCare-Canton, Canton

61530

Illinois CancerCare-Eureka, Eureka

61554

Illinois CancerCare-Pekin, Pekin

61571

Illinois CancerCare - Washington, Washington

61615

Illinois CancerCare-Peoria, Peoria

61704

Illinois CancerCare-Bloomington, Bloomington

61801

Carle Cancer Center, Urbana

61832

Carle at The Riverfront, Danville

61938

Carle Physician Group-Mattoon/Charleston, Mattoon

62269

Cancer Care Center of O'Fallon, O'Fallon

62321

Illinois CancerCare-Carthage, Carthage

62401

Carle Physician Group-Effingham, Effingham

Crossroads Cancer Center, Effingham

62526

Cancer Care Specialists of Illinois - Decatur, Decatur

Decatur Memorial Hospital, Decatur

62702

Southern Illinois University School of Medicine, Springfield

Springfield Clinic, Springfield

62781

Springfield Memorial Hospital, Springfield

63080

Missouri Baptist Sullivan Hospital, Sullivan

63110

Washington University School of Medicine, St Louis

63127

BJC Outpatient Center at Sunset Hills, Sunset Hills

63129

Siteman Cancer Center-South County, St Louis

63131

Missouri Baptist Medical Center, St Louis

63136

Siteman Cancer Center at Christian Hospital, St Louis

63141

Siteman Cancer Center at West County Hospital, Creve Coeur

63376

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

63640

Parkland Health Center - Farmington, Farmington

63670

Sainte Genevieve County Memorial Hospital, Sainte Genevieve

63703

Saint Francis Medical Center, Cape Girardeau

73104

University of Oklahoma Health Sciences Center, Oklahoma City

77030

Houston Methodist Hospital, Houston

M D Anderson Cancer Center, Houston

77058

Houston Methodist Saint John Hospital, Nassau Bay

77070

Methodist Willowbrook Hospital, Houston

77094

Houston Methodist West Hospital, Houston

77385

Houston Methodist The Woodlands Hospital, The Woodlands

77479

Houston Methodist Sugar Land Hospital, Sugar Land

79601

Hendrick Medical Center, Abilene

80045

UCHealth University of Colorado Hospital, Aurora

80524

Poudre Valley Hospital, Fort Collins

80528

Cancer Care and Hematology-Fort Collins, Fort Collins

80538

Medical Center of the Rockies, Loveland

80631

UCHealth Greeley Hospital, Greeley

83605

Saint Alphonsus Cancer Care Center-Caldwell, Caldwell

83619

Saint Luke's Cancer Institute - Fruitland, Fruitland

83642

Saint Luke's Cancer Institute - Meridian, Meridian

83687

Saint Alphonsus Cancer Care Center-Nampa, Nampa

Saint Luke's Cancer Institute - Nampa, Nampa

83706

Saint Alphonsus Cancer Care Center-Boise, Boise

83712

Saint Luke's Cancer Institute - Boise, Boise

83814

Kootenai Health - Coeur d'Alene, Coeur d'Alene

83854

Kootenai Clinic Cancer Services - Post Falls, Post Falls

83864

Kootenai Clinic Cancer Services - Sandpoint, Sandpoint

87106

University of New Mexico Cancer Center, Albuquerque

89052

OptumCare Cancer Care at Seven Hills, Henderson

89102

OptumCare Cancer Care at Charleston, Las Vegas

89148

OptumCare Cancer Care at Fort Apache, Las Vegas

92024

UC San Diego Health System - Encinitas, Encinitas

92093

UC San Diego Moores Cancer Center, La Jolla

92103

UC San Diego Medical Center - Hillcrest, San Diego

94304

VA Palo Alto Health Care System, Palo Alto

97045

Providence Willamette Falls Medical Center, Oregon City

97132

Providence Newberg Medical Center, Newberg

97213

Providence Portland Medical Center, Portland

97225

Providence Saint Vincent Medical Center, Portland

97914

Saint Alphonsus Cancer Care Center-Ontario, Ontario

98026

Swedish Cancer Institute-Edmonds, Edmonds

98029

Swedish Cancer Institute-Issaquah, Issaquah

98122

Swedish Medical Center-First Hill, Seattle

99508

Providence Alaska Medical Center, Anchorage

60453-2699

Advocate Christ Medical Center, Oak Lawn

04330

Harold Alfond Center for Cancer Care, Augusta

04412

Lafayette Family Cancer Center-EMMC, Brewer

04074

MaineHealth Maine Medical Center- Scarborough, Scarborough

04106

MaineHealth Cancer Care and IV Therapy - South Portland, South Portland

20889-5600

Walter Reed National Military Medical Center, Bethesda

02215

Dana-Farber Cancer Institute, Boston

08903

Rutgers Cancer Institute of New Jersey, New Brunswick

45005-1066

Atrium Medical Center-Middletown Regional Hospital, Franklin

02905

Women and Infants Hospital, Providence

57117-5134

Sanford USD Medical Center - Sioux Falls, Sioux Falls

54235-1495

Saint Vincent Hospital Cancer Center at Sturgeon Bay, Sturgeon Bay

00927

Centro Comprensivo de Cancer de UPR, San Juan

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH

NCT05554367 - Palbociclib and Binimetinib in RAS-Mutant Cancers, A ComboMATCH Treatment Trial | Biotech Hunter | Biotech Hunter