199
Participants
Start Date
December 13, 2023
Primary Completion Date
August 26, 2026
Study Completion Date
August 26, 2026
Binimetinib
Given PO
Biopsy Procedure
Undergo biopsy
Biospecimen Collection
Undergo collection of blood samples
Bone Scan
Undergo bone scan
Computed Tomography
Undergo CT
Magnetic Resonance Imaging
Undergo MRI
Palbociclib
Given PO
Mount Sinai Hospital, New York
Upstate Cancer Center at Oswego, Oswego
State University of New York Upstate Medical University, Syracuse
Upstate Cancer Center at Verona, Verona
Roswell Park Cancer Institute, Buffalo
UPMC Hillman Cancer Center - Monroeville, Monroeville
University of Pittsburgh Cancer Institute (UPCI), Pittsburgh
UPMC-Passavant Hospital, Pittsburgh
UPMC Cancer Centers - Arnold Palmer Pavilion, Greensburg
UPMC Hillman Cancer Center Erie, Erie
UPMC Altoona, Altoona
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion, Mechanicsburg
Bryn Mawr Hospital, Bryn Mawr
Riddle Memorial Hospital, Media
Lankenau Medical Center, Wynnewood
Paoli Memorial Hospital, Paoli
National Institutes of Health Clinical Center, Bethesda
University of Maryland/Greenebaum Cancer Center, Baltimore
UPMC Western Maryland, Cumberland
Inova Schar Cancer Institute, Fairfax
Inova Fairfax Hospital, Falls Church
University of Virginia Cancer Center, Charlottesville
VCU Massey Comprehensive Cancer Center, Richmond
West Virginia University Healthcare, Morgantown
Duke University Medical Center, Durham
Prisma Health Cancer Institute - Spartanburg, Boiling Springs
Prisma Health Cancer Institute - Butternut, Greenville
Prisma Health Cancer Institute - Faris, Greenville
Prisma Health Cancer Institute - Eastside, Greenville
Prisma Health Cancer Institute - Easley, Easley
Prisma Health Cancer Institute - Greer, Greer
Prisma Health Cancer Institute - Seneca, Seneca
University of Florida Health Science Center - Gainesville, Gainesville
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami
UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables
UM Sylvester Comprehensive Cancer Center at Kendall, Miami
UM Sylvester Comprehensive Cancer Center at Aventura, Aventura
UM Sylvester Comprehensive Cancer Center at Plantation, Plantation
UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach
University of Alabama at Birmingham Cancer Center, Birmingham
University of South Alabama Mitchell Cancer Institute, Mobile
Vanderbilt University/Ingram Cancer Center, Nashville
University of Kentucky/Markey Cancer Center, Lexington
Delaware Health Center-Grady Cancer Center, Delaware
Grady Memorial Hospital, Delaware
Columbus Oncology and Hematology Associates, Dublin
Dublin Methodist Hospital, Dublin
Ohio State University Comprehensive Cancer Center, Columbus
Columbus Oncology and Hematology Associates Inc, Columbus
Riverside Methodist Hospital, Columbus
Grant Medical Center, Columbus
Doctors Hospital, Columbus
OhioHealth Marion General Hospital, Marion
OhioHealth Mansfield Hospital, Mansfield
Good Samaritan Hospital - Cincinnati, Cincinnati
Miami Valley Cancer Care and Infusion, Greenville
Upper Valley Medical Center, Troy
Miami Valley Hospital, Dayton
Premier Blood and Cancer Center, Dayton
Dayton Physician LLC - Englewood, Dayton
Miami Valley Hospital North, Dayton
Kettering Medical Center, Kettering
Miami Valley Hospital South, Centerville
Corewell Health William Beaumont University Hospital, Royal Oak
Corewell Health Beaumont Troy Hospital, Troy
Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor
Huron Gastroenterology PC, Ypsilanti
Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton
Trinity Health Medical Center - Brighton, Brighton
Chelsea Hospital, Chelsea
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea
Corewell Health Dearborn Hospital, Dearborn
Trinity Health Saint Mary Mercy Livonia Hospital, Livonia
Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton
Trinity Health Medical Center - Canton, Canton
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti
Corewell Health Farmington Hills Hospital, Farmington Hills
Michigan Healthcare Professionals Pontiac, Pontiac
Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac
Cancer Hematology Centers - Flint, Flint
Genesee Hematology Oncology PC, Flint
Genesys Hurley Cancer Institute, Flint
Hurley Medical Center, Flint
University of Michigan Health - Sparrow Lansing, Lansing
Bronson Methodist Hospital, Kalamazoo
West Michigan Cancer Center, Kalamazoo
Beacon Kalamazoo Cancer Center, Kalamazoo
Bronson Battle Creek, Battle Creek
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph
Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph
Corewell Health Lakeland Hospitals - Niles Hospital, Niles
Trinity Health Muskegon Hospital, Muskegon
Cancer and Hematology Centers of Western Michigan - Norton Shores, Norton Shores
Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids
Trinity Health Grand Rapids Hospital, Grand Rapids
University of Michigan Health - West, Wyoming
Corewell Health Reed City Hospital, Reed City
Munson Medical Center, Traverse City
OSF Saint Francis Hospital and Medical Group, Escanaba
UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny
UI Health Care Mission Cancer and Blood - Waukee Clinic, Waukee
UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines
Mercy Hospital, Cedar Rapids
Oncology Associates at Mercy Medical Center, Cedar Rapids
Aurora Health Care Germantown Health Center, Germantown
Aurora Cancer Care-Grafton, Grafton
Aurora Medical Center in Summit, Summit
Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan
Aurora Cancer Care-Southern Lakes VLCC, Burlington
Aurora Saint Luke's South Shore, Cudahy
Aurora Cancer Care-Kenosha South, Kenosha
Aurora Cancer Care-Milwaukee, Milwaukee
Aurora Saint Luke's Medical Center, Milwaukee
Aurora Cancer Care-Milwaukee West, Wauwatosa
Aurora West Allis Medical Center, West Allis
Aurora Sinai Medical Center, Milwaukee
Aurora Cancer Care-Racine, Racine
Mercyhealth Hospital and Cancer Center - Janesville, Janesville
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison
University of Wisconsin Carbone Cancer Center - University Hospital, Madison
Aurora Bay Area Medical Group-Marinette, Marinette
Saint Vincent Hospital Cancer Center at Oconto Falls, Oconto Falls
Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers
Saint Vincent Hospital Cancer Center Green Bay, Green Bay
Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay
Aurora BayCare Medical Center, Green Bay
Marshfield Medical Center-Marshfield, Marshfield
Marshfield Medical Center - Weston, Weston
Marshfield Medical Center-River Region at Stevens Point, Stevens Point
Marshfield Medical Center - Minocqua, Minocqua
Gundersen Lutheran Medical Center, La Crosse
Marshfield Medical Center-EC Cancer Center, Eau Claire
Duluth Clinic Ashland, Ashland
Marshfield Medical Center-Rice Lake, Rice Lake
Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh
ThedaCare Regional Cancer Center, Appleton
Essentia Health Sandstone, Sandstone
Hennepin County Medical Center, Minneapolis
Essentia Health Hibbing Clinic, Hibbing
Essentia Health Virginia Clinic, Virginia
Essentia Health Cancer Center, Duluth
Sanford Joe Lueken Cancer Center, Bemidji
Essentia Health - Deer River Clinic, Deer River
Sanford Cancer Center Oncology Clinic, Sioux Falls
Sanford Broadway Medical Center, Fargo
Sanford Roger Maris Cancer Center, Fargo
Sanford Bismarck Medical Center, Bismarck
Billings Clinic Cancer Center, Billings
Benefis Sletten Cancer Institute, Great Falls
Community Hospital of Anaconda, Anaconda
Bozeman Health Deaconess Hospital, Bozeman
Community Medical Center, Missoula
Logan Health Medical Center, Kalispell
Advocate Good Shepherd Hospital, Barrington
AMG Crystal Lake - Oncology, Crystal Lake
Northwestern Medicine Glenview Outpatient Center, Glenview
Northwestern Medicine Grayslake Outpatient Center, Grayslake
Northwestern Medicine Lake Forest Hospital, Lake Forest
AMG Libertyville - Oncology, Libertyville
Condell Memorial Hospital, Libertyville
Advocate Lutheran General Hospital, Park Ridge
Northwestern Medicine Cancer Center Kishwaukee, DeKalb
Advocate Sherman Hospital, Elgin
Northwestern Medicine Cancer Center Delnor, Geneva
Advocate South Suburban Hospital, Hazel Crest
UC Comprehensive Cancer Center at Silver Cross, New Lenox
Advocate Outpatient Center - Oak Lawn, Oak Lawn
Northwestern Medicine Orland Park, Orland Park
University of Chicago Medicine-Orland Park, Orland Park
Advocate High Tech Medical Park, Palos Heights
Advocate Good Samaritan Hospital, Downers Grove
Northwestern Medicine Cancer Center Warrenville, Warrenville
Northwestern University, Chicago
John H Stroger Jr Hospital of Cook County, Chicago
University of Chicago Comprehensive Cancer Center, Chicago
Advocate Illinois Masonic Medical Center, Chicago
Illinois CancerCare-Dixon, Dixon
Mercyhealth Cancer Institute - Rockford, Rockford
Illinois CancerCare-Ottawa Clinic, Ottawa
Illinois CancerCare-Peru, Peru
Illinois CancerCare-Princeton, Princeton
Illinois CancerCare-Galesburg, Galesburg
Illinois CancerCare-Kewanee Clinic, Kewanee
Illinois CancerCare-Macomb, Macomb
Illinois CancerCare-Canton, Canton
Illinois CancerCare-Eureka, Eureka
Illinois CancerCare-Pekin, Pekin
Illinois CancerCare - Washington, Washington
Illinois CancerCare-Peoria, Peoria
Illinois CancerCare-Bloomington, Bloomington
Carle Cancer Center, Urbana
Carle at The Riverfront, Danville
Carle Physician Group-Mattoon/Charleston, Mattoon
Cancer Care Center of O'Fallon, O'Fallon
Illinois CancerCare-Carthage, Carthage
Carle Physician Group-Effingham, Effingham
Crossroads Cancer Center, Effingham
Cancer Care Specialists of Illinois - Decatur, Decatur
Decatur Memorial Hospital, Decatur
Southern Illinois University School of Medicine, Springfield
Springfield Clinic, Springfield
Springfield Memorial Hospital, Springfield
Missouri Baptist Sullivan Hospital, Sullivan
Washington University School of Medicine, St Louis
BJC Outpatient Center at Sunset Hills, Sunset Hills
Siteman Cancer Center-South County, St Louis
Missouri Baptist Medical Center, St Louis
Siteman Cancer Center at Christian Hospital, St Louis
Siteman Cancer Center at West County Hospital, Creve Coeur
Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters
Parkland Health Center - Farmington, Farmington
Sainte Genevieve County Memorial Hospital, Sainte Genevieve
Saint Francis Medical Center, Cape Girardeau
University of Oklahoma Health Sciences Center, Oklahoma City
Houston Methodist Hospital, Houston
M D Anderson Cancer Center, Houston
Houston Methodist Saint John Hospital, Nassau Bay
Methodist Willowbrook Hospital, Houston
Houston Methodist West Hospital, Houston
Houston Methodist The Woodlands Hospital, The Woodlands
Houston Methodist Sugar Land Hospital, Sugar Land
Hendrick Medical Center, Abilene
UCHealth University of Colorado Hospital, Aurora
Poudre Valley Hospital, Fort Collins
Cancer Care and Hematology-Fort Collins, Fort Collins
Medical Center of the Rockies, Loveland
UCHealth Greeley Hospital, Greeley
Saint Alphonsus Cancer Care Center-Caldwell, Caldwell
Saint Luke's Cancer Institute - Fruitland, Fruitland
Saint Luke's Cancer Institute - Meridian, Meridian
Saint Alphonsus Cancer Care Center-Nampa, Nampa
Saint Luke's Cancer Institute - Nampa, Nampa
Saint Alphonsus Cancer Care Center-Boise, Boise
Saint Luke's Cancer Institute - Boise, Boise
Kootenai Health - Coeur d'Alene, Coeur d'Alene
Kootenai Clinic Cancer Services - Post Falls, Post Falls
Kootenai Clinic Cancer Services - Sandpoint, Sandpoint
University of New Mexico Cancer Center, Albuquerque
OptumCare Cancer Care at Seven Hills, Henderson
OptumCare Cancer Care at Charleston, Las Vegas
OptumCare Cancer Care at Fort Apache, Las Vegas
UC San Diego Health System - Encinitas, Encinitas
UC San Diego Moores Cancer Center, La Jolla
UC San Diego Medical Center - Hillcrest, San Diego
VA Palo Alto Health Care System, Palo Alto
Providence Willamette Falls Medical Center, Oregon City
Providence Newberg Medical Center, Newberg
Providence Portland Medical Center, Portland
Providence Saint Vincent Medical Center, Portland
Saint Alphonsus Cancer Care Center-Ontario, Ontario
Swedish Cancer Institute-Edmonds, Edmonds
Swedish Cancer Institute-Issaquah, Issaquah
Swedish Medical Center-First Hill, Seattle
Providence Alaska Medical Center, Anchorage
Advocate Christ Medical Center, Oak Lawn
Harold Alfond Center for Cancer Care, Augusta
Lafayette Family Cancer Center-EMMC, Brewer
MaineHealth Maine Medical Center- Scarborough, Scarborough
MaineHealth Cancer Care and IV Therapy - South Portland, South Portland
Walter Reed National Military Medical Center, Bethesda
Dana-Farber Cancer Institute, Boston
Rutgers Cancer Institute of New Jersey, New Brunswick
Atrium Medical Center-Middletown Regional Hospital, Franklin
Women and Infants Hospital, Providence
Sanford USD Medical Center - Sioux Falls, Sioux Falls
Saint Vincent Hospital Cancer Center at Sturgeon Bay, Sturgeon Bay
Centro Comprensivo de Cancer de UPR, San Juan
National Cancer Institute (NCI)
NIH