Testing the Use of Fulvestrant and Binimetinib Targeted Treatment for NF1 Mutation in Hormone Receptor-Positive Metastatic Breast Cancer (A ComboMATCH Treatment Trial)

PHASE2TerminatedINTERVENTIONAL
Enrollment

1

Participants

Timeline

Start Date

September 13, 2024

Primary Completion Date

April 4, 2025

Study Completion Date

April 4, 2025

Conditions
Anatomic Stage IV Breast Cancer AJCC v8Metastatic HER2-Negative Breast CarcinomaMetastatic Hormone Receptor-Positive Breast Carcinoma
Interventions
DRUG

Binimetinib

Given PO

PROCEDURE

Biopsy Procedure

Undergo tumor biopsy

PROCEDURE

Biospecimen Collection

Undergo blood sample collection

PROCEDURE

Bone Scan

Undergo bone scan

PROCEDURE

Computed Tomography

Undergo CT scan

PROCEDURE

Echocardiography Test

Undergo ECHO

DRUG

Fulvestrant

Given IM

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

PROCEDURE

Multigated Acquisition Scan

Undergo MUGA

Trial Locations (196)

10461

Montefiore Medical Center-Einstein Campus, The Bronx

15146

UPMC Hillman Cancer Center - Monroeville, Monroeville

15232

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

15237

UPMC-Passavant Hospital, Pittsburgh

15601

UPMC Cancer Centers - Arnold Palmer Pavilion, Greensburg

16505

UPMC Hillman Cancer Center Erie, Erie

16601

UPMC Altoona, Altoona

17050

UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion, Mechanicsburg

19010

Bryn Mawr Hospital, Bryn Mawr

19063

Riddle Memorial Hospital, Media

19090

Asplundh Cancer Pavilion, Willow Grove

19096

Lankenau Medical Center, Wynnewood

19107

Thomas Jefferson University Hospital, Philadelphia

19301

Paoli Memorial Hospital, Paoli

20892

National Institutes of Health Clinical Center, Bethesda

21201

University of Maryland/Greenebaum Cancer Center, Baltimore

21502

UPMC Western Maryland, Cumberland

23229

Virginia Cancer Institute, Richmond

23235

VCU Massey Cancer Center at Stony Point, Richmond

23298

Virginia Commonwealth University/Massey Cancer Center, Richmond

23970

VCU Community Memorial Health Center, South Hill

33136

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33146

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables

33176

UM Sylvester Comprehensive Cancer Center at Kendall, Miami

33180

UM Sylvester Comprehensive Cancer Center at Aventura, Aventura

33324

UM Sylvester Comprehensive Cancer Center at Plantation, Plantation

33442

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

35233

University of Alabama at Birmingham Cancer Center, Birmingham

39502

Gulfport Memorial Hospital, Gulfport

40536

University of Kentucky/Markey Cancer Center, Lexington

43040

Memorial Hospital, Marysville

43050

Knox Community Hospital, Mount Vernon

43055

Licking Memorial Hospital, Newark

43081

Saint Ann's Hospital, Westerville

43130

Fairfield Medical Center, Lancaster

43210

Ohio State University Comprehensive Cancer Center, Columbus

43213

Mount Carmel East Hospital, Columbus

43219

The Mark H Zangmeister Center, Columbus

43551

Mercy Health - Perrysburg Hospital, Perrysburg

43623

Mercy Health - Saint Anne Hospital, Toledo

43701

Genesis Healthcare System Cancer Care Center, Zanesville

44710

Aultman Health Foundation, Canton

45331

Miami Valley Cancer Care and Infusion, Greenville

45373

Upper Valley Medical Center, Troy

45409

Miami Valley Hospital, Dayton

Premier Blood and Cancer Center, Dayton

45415

Dayton Physician LLC - Englewood, Dayton

Miami Valley Hospital North, Dayton

45429

Kettering Medical Center, Kettering

45459

Miami Valley Hospital South, Centerville

45504

Springfield Regional Cancer Center, Springfield

Springfield Regional Medical Center, Springfield

45601

Adena Regional Medical Center, Chillicothe

45662

Southern Ohio Medical Center, Portsmouth

45714

Strecker Cancer Center-Belpre, Belpre

45750

Marietta Memorial Hospital, Marietta

48044

Henry Ford Saint John Hospital - Macomb Medical, Macomb

48073

Corewell Health William Beaumont University Hospital, Royal Oak

48085

Corewell Health Beaumont Troy Hospital, Troy

48106

Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor

Huron Gastroenterology PC, Ypsilanti

48114

Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton

Trinity Health Medical Center - Brighton, Brighton

48118

Chelsea Hospital, Chelsea

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea

48124

Corewell Health Dearborn Hospital, Dearborn

48154

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia

48188

Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton

Trinity Health Medical Center - Canton, Canton

48197

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti

48336

Corewell Health Farmington Hills Hospital, Farmington Hills

48503

Cancer Hematology Centers - Flint, Flint

Genesee Hematology Oncology PC, Flint

Genesys Hurley Cancer Institute, Flint

Hurley Medical Center, Flint

48601

MyMichigan Medical Center Saginaw, Saginaw

48604

Oncology Hematology Associates of Saginaw Valley PC, Saginaw

48661

Saint Mary's Oncology/Hematology Associates of West Branch, West Branch

48764

MyMichigan Medical Center Tawas, Tawas City

48912

University of Michigan Health - Sparrow Lansing, Lansing

50023

UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny

50309

UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines

50314

Mercy Medical Center - Des Moines, Des Moines

53022

Aurora Health Care Germantown Health Center, Germantown

53024

Aurora Cancer Care-Grafton, Grafton

53066

Aurora Medical Center in Summit, Summit

53081

Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan

53105

Aurora Cancer Care-Southern Lakes VLCC, Burlington

53110

Aurora Saint Luke's South Shore, Cudahy

53142

Aurora Cancer Care-Kenosha South, Kenosha

53209

Aurora Cancer Care-Milwaukee, Milwaukee

53215

Aurora Saint Luke's Medical Center, Milwaukee

53226

Aurora Cancer Care-Milwaukee West, Wauwatosa

53227

Aurora West Allis Medical Center, West Allis

53233

Aurora Sinai Medical Center, Milwaukee

53406

Aurora Cancer Care-Racine, Racine

53718

University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison

53792

University of Wisconsin Carbone Cancer Center - University Hospital, Madison

54143

Aurora Bay Area Medical Group-Marinette, Marinette

54241

Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers

54311

Aurora BayCare Medical Center, Green Bay

54601

Gundersen Lutheran Medical Center, La Crosse

54806

Duluth Clinic Ashland, Ashland

54904

Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh

55072

Essentia Health Sandstone, Sandstone

55101

Regions Hospital, Saint Paul

55102

United Hospital, Saint Paul

55109

Saint John's Hospital - Healtheast, Maplewood

55407

Abbott-Northwestern Hospital, Minneapolis

55416

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55433

Mercy Hospital, Coon Rapids

55435

Fairview Southdale Hospital, Edina

55746

Essentia Health Hibbing Clinic, Hibbing

55792

Essentia Health Virginia Clinic, Virginia

55805

Essentia Health Cancer Center, Duluth

55905

Mayo Clinic in Rochester, Rochester

56601

Sanford Joe Lueken Cancer Center, Bemidji

56636

Essentia Health - Deer River Clinic, Deer River

57104

Sanford Cancer Center Oncology Clinic, Sioux Falls

58122

Sanford Broadway Medical Center, Fargo

Sanford Roger Maris Cancer Center, Fargo

58501

Sanford Bismarck Medical Center, Bismarck

59101

Billings Clinic Cancer Center, Billings

59405

Benefis Sletten Cancer Institute, Great Falls

59711

Community Hospital of Anaconda, Anaconda

59715

Bozeman Health Deaconess Hospital, Bozeman

59804

Community Medical Center, Missoula

59901

Logan Health Medical Center, Kalispell

60010

Advocate Good Shepherd Hospital, Barrington

60014

AMG Crystal Lake - Oncology, Crystal Lake

60045

Northwestern Medicine Lake Forest Hospital, Lake Forest

60048

AMG Libertyville - Oncology, Libertyville

Condell Memorial Hospital, Libertyville

60068

Advocate Lutheran General Hospital, Park Ridge

60115

Northwestern Medicine Cancer Center Kishwaukee, DeKalb

60123

Advocate Sherman Hospital, Elgin

60134

Northwestern Medicine Cancer Center Delnor, Geneva

60429

Advocate South Suburban Hospital, Hazel Crest

60462

Northwestern Medicine Orland Park, Orland Park

60555

Northwestern Medicine Cancer Center Warrenville, Warrenville

60611

Northwestern University, Chicago

60612

John H Stroger Jr Hospital of Cook County, Chicago

60657

Advocate Illinois Masonic Medical Center, Chicago

61801

Carle Cancer Center, Urbana

61832

Carle at The Riverfront, Danville

61938

Carle Physician Group-Mattoon/Charleston, Mattoon

62269

Memorial Hospital East, Shiloh

62401

Carle Physician Group-Effingham, Effingham

63110

Washington University School of Medicine, St Louis

63129

Siteman Cancer Center-South County, St Louis

63136

Siteman Cancer Center at Christian Hospital, St Louis

63141

Siteman Cancer Center at West County Hospital, Creve Coeur

63376

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

73104

University of Oklahoma Health Sciences Center, Oklahoma City

77030

M D Anderson Cancer Center, Houston

83301

Saint Luke's Cancer Institute - Twin Falls, Twin Falls

83605

Saint Alphonsus Cancer Care Center-Caldwell, Caldwell

83619

Saint Luke's Cancer Institute - Fruitland, Fruitland

83642

Saint Luke's Cancer Institute - Meridian, Meridian

83687

Saint Alphonsus Cancer Care Center-Nampa, Nampa

Saint Luke's Cancer Institute - Nampa, Nampa

83706

Saint Alphonsus Cancer Care Center-Boise, Boise

83712

Saint Luke's Cancer Institute - Boise, Boise

83814

Kootenai Health - Coeur d'Alene, Coeur d'Alene

83854

Kootenai Clinic Cancer Services - Post Falls, Post Falls

83864

Kootenai Clinic Cancer Services - Sandpoint, Sandpoint

86401

Kingman Regional Medical Center, Kingman

89052

OptumCare Cancer Care at Seven Hills, Henderson

89102

OptumCare Cancer Care at Charleston, Las Vegas

89148

OptumCare Cancer Care at Fort Apache, Las Vegas

90404

Saint John's Cancer Institute, Santa Monica

92868

Saint Joseph Hospital - Orange, Orange

93420

PCR Oncology, Arroyo Grande

94568

Epic Care-Dublin, Dublin

94597

Epic Care Cyberknife Center, Walnut Creek

94608

Epic Care Partners in Cancer Care, Emeryville

97045

Providence Willamette Falls Medical Center, Oregon City

97132

Providence Newberg Medical Center, Newberg

97213

Providence Portland Medical Center, Portland

97225

Providence Saint Vincent Medical Center, Portland

97914

Saint Alphonsus Cancer Care Center-Ontario, Ontario

98026

Swedish Cancer Institute-Edmonds, Edmonds

98029

Swedish Cancer Institute-Issaquah, Issaquah

98055

Valley Medical Center, Renton

98902

North Star Lodge Cancer Center at Yakima Valley Memorial Hospital, Yakima

94553-3156

Contra Costa Regional Medical Center, Martinez

32224-9980

Mayo Clinic in Florida, Jacksonville

60453-2699

Advocate Christ Medical Center, Oak Lawn

04412

Lafayette Family Cancer Center-EMMC, Brewer

02111

Tufts Medical Center, Boston

45005-1066

Atrium Medical Center-Middletown Regional Hospital, Franklin

57117-5134

Sanford USD Medical Center - Sioux Falls, Sioux Falls

00961

Puerto Rico Hematology Oncology Group, Bayamón

00674

Doctors Cancer Center, Manatí

00927

Centro Comprensivo de Cancer de UPR, San Juan

PROncology, San Juan

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

NRG Oncology

OTHER

lead

National Cancer Institute (NCI)

NIH

NCT05554354 - Testing the Use of Fulvestrant and Binimetinib Targeted Treatment for NF1 Mutation in Hormone Receptor-Positive Metastatic Breast Cancer (A ComboMATCH Treatment Trial) | Biotech Hunter | Biotech Hunter