Testing the Use of the Combination of Selumetinib and Olaparib or Selumetinib Alone Targeted Treatment for RAS Pathway Mutant Recurrent or Persistent Ovarian and Endometrial Cancers, A ComboMATCH Treatment Trial

PHASE2RecruitingINTERVENTIONAL
Enrollment

165

Participants

Timeline

Start Date

April 25, 2023

Primary Completion Date

October 1, 2028

Study Completion Date

October 1, 2028

Conditions
Recurrent Endometrial CarcinomaRecurrent Fallopian Tube CarcinomaRecurrent Ovarian CarcinomaRecurrent Primary Peritoneal Carcinoma
Interventions
PROCEDURE

Biopsy Procedure

Undergo tumor biopsy

PROCEDURE

Biospecimen Collection

Undergo blood collection

PROCEDURE

Bone Marrow Aspiration and Biopsy

Undergo bone marrow aspiration or biopsy

PROCEDURE

Computed Tomography

Undergo CT scan

PROCEDURE

Echocardiography Test

Undergo ECHO

PROCEDURE

Multigated Acquisition Scan

Undergo MUGA

DRUG

Olaparib

Given PO

DRUG

Selumetinib Sulfate

Given PO

Trial Locations (282)

10065

RECRUITING

Memorial Sloan Kettering Cancer Center, New York

10604

RECRUITING

Memorial Sloan Kettering Westchester, Harrison

11725

RECRUITING

Memorial Sloan Kettering Commack, Commack

13210

RECRUITING

State University of New York Upstate Medical University, Syracuse

14263

RECRUITING

Roswell Park Cancer Institute, Buffalo

15146

RECRUITING

UPMC Hillman Cancer Center - Monroeville, Monroeville

15213

RECRUITING

UPMC-Magee Womens Hospital, Pittsburgh

15232

RECRUITING

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

15237

RECRUITING

UPMC-Passavant Hospital, Pittsburgh

15601

RECRUITING

UPMC Cancer Centers - Arnold Palmer Pavilion, Greensburg

16505

RECRUITING

UPMC Hillman Cancer Center Erie, Erie

16601

RECRUITING

UPMC Altoona, Altoona

17050

RECRUITING

UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion, Mechanicsburg

18017

RECRUITING

Lehigh Valley Hospital - Muhlenberg, Bethlehem

18103

RECRUITING

Lehigh Valley Hospital-Cedar Crest, Allentown

18301

RECRUITING

Pocono Medical Center, East Stroudsburg

19010

RECRUITING

Bryn Mawr Hospital, Bryn Mawr

19063

RECRUITING

Riddle Memorial Hospital, Media

19090

RECRUITING

Asplundh Cancer Pavilion, Willow Grove

19096

RECRUITING

Lankenau Medical Center, Wynnewood

19107

RECRUITING

Pennsylvania Hospital, Philadelphia

RECRUITING

Thomas Jefferson University Hospital, Philadelphia

19111

RECRUITING

Fox Chase Cancer Center, Philadelphia

19301

RECRUITING

Paoli Memorial Hospital, Paoli

20892

RECRUITING

National Institutes of Health Clinical Center, Bethesda

21201

RECRUITING

University of Maryland/Greenebaum Cancer Center, Baltimore

21502

RECRUITING

UPMC Western Maryland, Cumberland

23229

RECRUITING

Henrico Doctor's Hospital, Richmond

RECRUITING

Virginia Cancer Institute, Richmond

23235

RECRUITING

VCU Massey Cancer Center at Stony Point, Richmond

23298

RECRUITING

VCU Massey Comprehensive Cancer Center, Richmond

23970

RECRUITING

VCU Community Memorial Health Center, South Hill

24033

RECRUITING

Carilion Roanoke Memorial Hospital, Roanoke

25701

RECRUITING

Edwards Comprehensive Cancer Center, Huntington

26506

RECRUITING

West Virginia University Healthcare, Morgantown

27607

RECRUITING

Duke Women's Cancer Care Raleigh, Raleigh

27710

RECRUITING

Duke University Medical Center, Durham

33136

RECRUITING

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33146

RECRUITING

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables

33176

RECRUITING

UM Sylvester Comprehensive Cancer Center at Kendall, Miami

33180

RECRUITING

UM Sylvester Comprehensive Cancer Center at Aventura, Aventura

33324

RECRUITING

UM Sylvester Comprehensive Cancer Center at Plantation, Plantation

33442

RECRUITING

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

35233

RECRUITING

University of Alabama at Birmingham Cancer Center, Birmingham

36688

RECRUITING

University of South Alabama Mitchell Cancer Institute, Mobile

40536

RECRUITING

University of Kentucky/Markey Cancer Center, Lexington

43016

RECRUITING

Dublin Methodist Hospital, Dublin

43040

RECRUITING

Memorial Hospital, Marysville

43050

RECRUITING

Knox Community Hospital, Mount Vernon

43055

RECRUITING

Licking Memorial Hospital, Newark

43081

RECRUITING

Saint Ann's Hospital, Westerville

43082

SUSPENDED

OhioHealth Westerville Medical Campus/Westerville Cancer Center, Westerville

43130

RECRUITING

Fairfield Medical Center, Lancaster

43147

SUSPENDED

OhioHealth Pickerington Methodist Hospital, Pickerington

43210

RECRUITING

Ohio State University Comprehensive Cancer Center, Columbus

43213

RECRUITING

Mount Carmel East Hospital, Columbus

43214

RECRUITING

Riverside Methodist Hospital, Columbus

43219

RECRUITING

The Mark H Zangmeister Center, Columbus

43551

RECRUITING

Mercy Health - Perrysburg Hospital, Perrysburg

43623

RECRUITING

Mercy Health - Saint Anne Hospital, Toledo

43701

RECRUITING

Genesis Healthcare System Cancer Care Center, Zanesville

44011

RECRUITING

UH Seidman Cancer Center at UH Avon Health Center, Avon

44060

RECRUITING

UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor

44106

RECRUITING

Case Western Reserve University, Cleveland

44122

RECRUITING

UHHS-Chagrin Highlands Medical Center, Beachwood

44145

RECRUITING

UH Seidman Cancer Center at Saint John Medical Center, Westlake

44710

RECRUITING

Aultman Health Foundation, Canton

44903

RECRUITING

OhioHealth Mansfield Hospital, Mansfield

45220

RECRUITING

Good Samaritan Hospital - Cincinnati, Cincinnati

45331

RECRUITING

Miami Valley Cancer Care and Infusion, Greenville

45373

RECRUITING

Upper Valley Medical Center, Troy

45409

RECRUITING

Miami Valley Hospital, Dayton

45415

SUSPENDED

Dayton Physician LLC - Englewood, Dayton

RECRUITING

Miami Valley Hospital North, Dayton

45429

SUSPENDED

Kettering Medical Center, Kettering

45459

RECRUITING

Miami Valley Hospital South, Centerville

45504

RECRUITING

Springfield Regional Cancer Center, Springfield

RECRUITING

Springfield Regional Medical Center, Springfield

45601

RECRUITING

Adena Regional Medical Center, Chillicothe

45662

RECRUITING

Southern Ohio Medical Center, Portsmouth

45714

RECRUITING

Strecker Cancer Center-Belpre, Belpre

45750

RECRUITING

Marietta Memorial Hospital, Marietta

46307

RECRUITING

UChicago Medicine Northwest Indiana, Crown Point

48044

RECRUITING

Henry Ford Saint John Hospital - Macomb Medical, Macomb

48073

RECRUITING

Corewell Health William Beaumont University Hospital, Royal Oak

48085

RECRUITING

Corewell Health Beaumont Troy Hospital, Troy

48106

RECRUITING

Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor

RECRUITING

Huron Gastroenterology PC, Ypsilanti

48109

RECRUITING

University of Michigan Comprehensive Cancer Center, Ann Arbor

48114

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton

RECRUITING

Trinity Health Medical Center - Brighton, Brighton

48116

RECRUITING

University of Michigan - Brighton Center for Specialty Care, Brighton

48118

RECRUITING

Chelsea Hospital, Chelsea

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea

48124

RECRUITING

Corewell Health Dearborn Hospital, Dearborn

48154

RECRUITING

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia

48188

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton

RECRUITING

Trinity Health Medical Center - Canton, Canton

48197

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti

48336

RECRUITING

Corewell Health Farmington Hills Hospital, Farmington Hills

48341

RECRUITING

Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac

48503

RECRUITING

Cancer Hematology Centers - Flint, Flint

SUSPENDED

Genesee Hematology Oncology PC, Flint

RECRUITING

Genesys Hurley Cancer Institute, Flint

RECRUITING

Hurley Medical Center, Flint

48912

RECRUITING

University of Michigan Health - Sparrow Lansing, Lansing

50023

RECRUITING

UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny

50263

RECRUITING

UI Health Care Mission Cancer and Blood - Waukee Clinic, Waukee

50309

RECRUITING

UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines

50314

RECRUITING

Mercy Medical Center - Des Moines, Des Moines

RECRUITING

UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines

50325

RECRUITING

UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive

53022

RECRUITING

Aurora Health Care Germantown Health Center, Germantown

53024

RECRUITING

Aurora Cancer Care-Grafton, Grafton

53066

RECRUITING

Aurora Medical Center in Summit, Summit

53081

RECRUITING

Saint Vincent Hospital Cancer Center at Sheboygan, Sheboygan

RECRUITING

Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan

53105

RECRUITING

Aurora Cancer Care-Southern Lakes VLCC, Burlington

53110

RECRUITING

Aurora Saint Luke's South Shore, Cudahy

53142

RECRUITING

Aurora Cancer Care-Kenosha South, Kenosha

53209

RECRUITING

Aurora Cancer Care-Milwaukee, Milwaukee

53215

RECRUITING

Aurora Saint Luke's Medical Center, Milwaukee

53226

RECRUITING

Aurora Cancer Care-Milwaukee West, Wauwatosa

53227

RECRUITING

Aurora West Allis Medical Center, West Allis

53233

RECRUITING

Aurora Sinai Medical Center, Milwaukee

53406

RECRUITING

Aurora Cancer Care-Racine, Racine

53718

RECRUITING

University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison

53792

RECRUITING

University of Wisconsin Carbone Cancer Center - University Hospital, Madison

54143

RECRUITING

Aurora Bay Area Medical Group-Marinette, Marinette

54154

RECRUITING

Saint Vincent Hospital Cancer Center at Oconto Falls, Oconto Falls

54241

RECRUITING

Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers

54301

RECRUITING

Saint Vincent Hospital Cancer Center Green Bay, Green Bay

54303

RECRUITING

Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay

54311

RECRUITING

Aurora BayCare Medical Center, Green Bay

54601

RECRUITING

Gundersen Lutheran Medical Center, La Crosse

54806

RECRUITING

Duluth Clinic Ashland, Ashland

54904

RECRUITING

Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh

55072

RECRUITING

Essentia Health Sandstone, Sandstone

55101

RECRUITING

Regions Hospital, Saint Paul

55102

RECRUITING

United Hospital, Saint Paul

55369

RECRUITING

Fairview Clinics and Surgery Center Maple Grove, Maple Grove

55407

RECRUITING

Abbott-Northwestern Hospital, Minneapolis

55416

RECRUITING

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55433

RECRUITING

Mercy Hospital, Coon Rapids

55435

RECRUITING

Fairview Southdale Hospital, Edina

55746

RECRUITING

Essentia Health Hibbing Clinic, Hibbing

55792

RECRUITING

Essentia Health Virginia Clinic, Virginia

55805

RECRUITING

Essentia Health Cancer Center, Duluth

55905

RECRUITING

Mayo Clinic in Rochester, Rochester

56636

RECRUITING

Essentia Health - Deer River Clinic, Deer River

57104

SUSPENDED

Sanford Cancer Center Oncology Clinic, Sioux Falls

57701

ACTIVE_NOT_RECRUITING

Rapid City Regional Hospital, Rapid City

58122

RECRUITING

Sanford Broadway Medical Center, Fargo

RECRUITING

Sanford Roger Maris Cancer Center, Fargo

58501

RECRUITING

Sanford Bismarck Medical Center, Bismarck

59101

RECRUITING

Billings Clinic Cancer Center, Billings

59405

RECRUITING

Benefis Sletten Cancer Institute, Great Falls

59711

RECRUITING

Community Hospital of Anaconda, Anaconda

59715

RECRUITING

Bozeman Health Deaconess Hospital, Bozeman

59804

RECRUITING

Community Medical Center, Missoula

59901

RECRUITING

Logan Health Medical Center, Kalispell

60010

RECRUITING

Advocate Good Shepherd Hospital, Barrington

60014

RECRUITING

AMG Crystal Lake - Oncology, Crystal Lake

60026

RECRUITING

NorthShore University HealthSystem-Glenbrook Hospital, Glenview

60035

RECRUITING

NorthShore University HealthSystem-Highland Park Hospital, Highland Park

60048

RECRUITING

AMG Libertyville - Oncology, Libertyville

RECRUITING

Condell Memorial Hospital, Libertyville

60068

RECRUITING

Advocate Lutheran General Hospital, Park Ridge

60123

RECRUITING

Advocate Sherman Hospital, Elgin

60201

RECRUITING

NorthShore University HealthSystem-Evanston Hospital, Evanston

60429

RECRUITING

Advocate South Suburban Hospital, Hazel Crest

60451

RECRUITING

UC Comprehensive Cancer Center at Silver Cross, New Lenox

60462

RECRUITING

University of Chicago Medicine-Orland Park, Orland Park

60515

RECRUITING

Advocate Good Samaritan Hospital, Downers Grove

60612

RECRUITING

John H Stroger Jr Hospital of Cook County, Chicago

RECRUITING

University of Illinois, Chicago

60637

RECRUITING

University of Chicago Comprehensive Cancer Center, Chicago

60657

RECRUITING

Advocate Illinois Masonic Medical Center, Chicago

61021

RECRUITING

Illinois CancerCare-Dixon, Dixon

61350

RECRUITING

Illinois CancerCare-Ottawa Clinic, Ottawa

61354

RECRUITING

Illinois CancerCare-Peru, Peru

61356

RECRUITING

Illinois CancerCare-Princeton, Princeton

61401

RECRUITING

Illinois CancerCare-Galesburg, Galesburg

61443

RECRUITING

Illinois CancerCare-Kewanee Clinic, Kewanee

61455

RECRUITING

Illinois CancerCare-Macomb, Macomb

61520

RECRUITING

Illinois CancerCare-Canton, Canton

61530

RECRUITING

Illinois CancerCare-Eureka, Eureka

61554

RECRUITING

Illinois CancerCare-Pekin, Pekin

61571

RECRUITING

Illinois CancerCare - Washington, Washington

61615

RECRUITING

Illinois CancerCare-Peoria, Peoria

61704

RECRUITING

Illinois CancerCare-Bloomington, Bloomington

61801

RECRUITING

Carle Cancer Center, Urbana

61832

RECRUITING

Carle at The Riverfront, Danville

61938

RECRUITING

Carle Physician Group-Mattoon/Charleston, Mattoon

62269

RECRUITING

Cancer Care Center of O'Fallon, O'Fallon

62321

RECRUITING

Illinois CancerCare-Carthage, Carthage

62401

RECRUITING

Carle Physician Group-Effingham, Effingham

RECRUITING

Crossroads Cancer Center, Effingham

62526

RECRUITING

Cancer Care Specialists of Illinois - Decatur, Decatur

RECRUITING

Decatur Memorial Hospital, Decatur

62702

RECRUITING

Southern Illinois University School of Medicine, Springfield

RECRUITING

Springfield Clinic, Springfield

62781

RECRUITING

Springfield Memorial Hospital, Springfield

62801

RECRUITING

Centralia Oncology Clinic, Centralia

63080

RECRUITING

Missouri Baptist Sullivan Hospital, Sullivan

63110

RECRUITING

Washington University School of Medicine, St Louis

63127

RECRUITING

BJC Outpatient Center at Sunset Hills, Sunset Hills

63131

RECRUITING

Missouri Baptist Medical Center, St Louis

63640

RECRUITING

Parkland Health Center - Farmington, Farmington

63670

RECRUITING

Sainte Genevieve County Memorial Hospital, Sainte Genevieve

63703

RECRUITING

Saint Francis Medical Center, Cape Girardeau

70115

RECRUITING

Ochsner Baptist Medical Center, New Orleans

70121

RECRUITING

Ochsner Medical Center Jefferson, New Orleans

73104

RECRUITING

University of Oklahoma Health Sciences Center, Oklahoma City

77030

RECRUITING

M D Anderson Cancer Center, Houston

77079

RECRUITING

MD Anderson West Houston, Houston

77384

RECRUITING

MD Anderson in The Woodlands, Conroe

77478

RECRUITING

MD Anderson in Sugar Land, Sugar Land

77573

RECRUITING

MD Anderson League City, League City

83301

RECRUITING

Saint Luke's Cancer Institute - Twin Falls, Twin Falls

83605

RECRUITING

Saint Alphonsus Cancer Care Center-Caldwell, Caldwell

83619

RECRUITING

Saint Luke's Cancer Institute - Fruitland, Fruitland

83642

RECRUITING

Saint Luke's Cancer Institute - Meridian, Meridian

83687

RECRUITING

Saint Alphonsus Cancer Care Center-Nampa, Nampa

RECRUITING

Saint Luke's Cancer Institute - Nampa, Nampa

83706

RECRUITING

Saint Alphonsus Cancer Care Center-Boise, Boise

83712

RECRUITING

Saint Luke's Cancer Institute - Boise, Boise

83814

RECRUITING

Kootenai Health - Coeur d'Alene, Coeur d'Alene

83854

RECRUITING

Kootenai Clinic Cancer Services - Post Falls, Post Falls

83864

RECRUITING

Kootenai Clinic Cancer Services - Sandpoint, Sandpoint

85338

RECRUITING

CTCA at Western Regional Medical Center, Goodyear

86401

RECRUITING

Kingman Regional Medical Center, Kingman

87106

RECRUITING

University of New Mexico Cancer Center, Albuquerque

89052

RECRUITING

OptumCare Cancer Care at Seven Hills, Henderson

89102

RECRUITING

OptumCare Cancer Care at Charleston, Las Vegas

89148

RECRUITING

OptumCare Cancer Care at Fort Apache, Las Vegas

90048

RECRUITING

Cedars Sinai Medical Center, Los Angeles

90602

RECRUITING

Presbyterian Intercommunity Hospital, Whittier

92868

RECRUITING

Saint Joseph Hospital - Orange, Orange

93420

RECRUITING

PCR Oncology, Arroyo Grande

94304

RECRUITING

Stanford Cancer Institute Palo Alto, Palo Alto

96706

SUSPENDED

The Queen's Medical Center - West Oahu, ‘Ewa Beach

96813

SUSPENDED

Queen's Cancer Cenrer - POB I, Honolulu

SUSPENDED

Queen's Medical Center, Honolulu

RECRUITING

University of Hawaii Cancer Center, Honolulu

96817

SUSPENDED

Queen's Cancer Center - Kuakini, Honolulu

96826

SUSPENDED

Kapiolani Medical Center for Women and Children, Honolulu

97045

RECRUITING

Providence Willamette Falls Medical Center, Oregon City

97132

RECRUITING

Providence Newberg Medical Center, Newberg

97213

RECRUITING

Providence Portland Medical Center, Portland

97225

RECRUITING

Providence Saint Vincent Medical Center, Portland

97239

RECRUITING

Oregon Health and Science University, Portland

97914

RECRUITING

Saint Alphonsus Cancer Care Center-Ontario, Ontario

98026

RECRUITING

Swedish Cancer Institute-Edmonds, Edmonds

98029

RECRUITING

Swedish Cancer Institute-Issaquah, Issaquah

98055

RECRUITING

Valley Medical Center, Renton

98122

RECRUITING

Swedish Medical Center-First Hill, Seattle

98503

RECRUITING

Providence Regional Cancer System-Lacey, Lacey

98902

RECRUITING

North Star Lodge Cancer Center at Yakima Valley Memorial Hospital, Yakima

99362

RECRUITING

Providence Saint Mary Regional Cancer Center, Walla Walla

99508

RECRUITING

Alaska Women's Cancer Care, Anchorage

32224-9980

RECRUITING

Mayo Clinic in Florida, Jacksonville

60453-2699

RECRUITING

Advocate Christ Medical Center, Oak Lawn

04330

RECRUITING

Harold Alfond Center for Cancer Care, Augusta

04412

RECRUITING

Lafayette Family Cancer Center-EMMC, Brewer

04074

RECRUITING

MaineHealth Maine Medical Center- Scarborough, Scarborough

20889-5600

SUSPENDED

Walter Reed National Military Medical Center, Bethesda

02111

RECRUITING

Tufts Medical Center, Boston

01199

RECRUITING

Baystate Medical Center, Springfield

07302

RECRUITING

Jersey City Medical Center, Jersey City

08701

RECRUITING

Monmouth Medical Center Southern Campus, Lakewood

07740

RECRUITING

Monmouth Medical Center, Long Branch

07748

RECRUITING

Memorial Sloan Kettering Monmouth, Middletown

08903

RECRUITING

Rutgers Cancer Institute of New Jersey, New Brunswick

08080

RECRUITING

Sidney Kimmel Cancer Center Washington Township, Sewell

45005-1066

RECRUITING

Atrium Medical Center-Middletown Regional Hospital, Franklin

02905

RECRUITING

Women and Infants Hospital, Providence

57117-5134

RECRUITING

Sanford USD Medical Center - Sioux Falls, Sioux Falls

77026-1967

RECRUITING

Lyndon Baines Johnson General Hospital, Houston

54235-1495

RECRUITING

Saint Vincent Hospital Cancer Center at Sturgeon Bay, Sturgeon Bay

00961

RECRUITING

Puerto Rico Hematology Oncology Group, Bayamón

00927

RECRUITING

Centro Comprensivo de Cancer de UPR, San Juan

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

NRG Oncology

OTHER

lead

National Cancer Institute (NCI)

NIH

NCT05554328 - Testing the Use of the Combination of Selumetinib and Olaparib or Selumetinib Alone Targeted Treatment for RAS Pathway Mutant Recurrent or Persistent Ovarian and Endometrial Cancers, A ComboMATCH Treatment Trial | Biotech Hunter | Biotech Hunter