165
Participants
Start Date
April 25, 2023
Primary Completion Date
October 1, 2028
Study Completion Date
October 1, 2028
Biopsy Procedure
Undergo tumor biopsy
Biospecimen Collection
Undergo blood collection
Bone Marrow Aspiration and Biopsy
Undergo bone marrow aspiration or biopsy
Computed Tomography
Undergo CT scan
Echocardiography Test
Undergo ECHO
Multigated Acquisition Scan
Undergo MUGA
Olaparib
Given PO
Selumetinib Sulfate
Given PO
RECRUITING
Memorial Sloan Kettering Cancer Center, New York
RECRUITING
Memorial Sloan Kettering Westchester, Harrison
RECRUITING
Memorial Sloan Kettering Commack, Commack
RECRUITING
State University of New York Upstate Medical University, Syracuse
RECRUITING
Roswell Park Cancer Institute, Buffalo
RECRUITING
UPMC Hillman Cancer Center - Monroeville, Monroeville
RECRUITING
UPMC-Magee Womens Hospital, Pittsburgh
RECRUITING
University of Pittsburgh Cancer Institute (UPCI), Pittsburgh
RECRUITING
UPMC-Passavant Hospital, Pittsburgh
RECRUITING
UPMC Cancer Centers - Arnold Palmer Pavilion, Greensburg
RECRUITING
UPMC Hillman Cancer Center Erie, Erie
RECRUITING
UPMC Altoona, Altoona
RECRUITING
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion, Mechanicsburg
RECRUITING
Lehigh Valley Hospital - Muhlenberg, Bethlehem
RECRUITING
Lehigh Valley Hospital-Cedar Crest, Allentown
RECRUITING
Pocono Medical Center, East Stroudsburg
RECRUITING
Bryn Mawr Hospital, Bryn Mawr
RECRUITING
Riddle Memorial Hospital, Media
RECRUITING
Asplundh Cancer Pavilion, Willow Grove
RECRUITING
Lankenau Medical Center, Wynnewood
RECRUITING
Pennsylvania Hospital, Philadelphia
RECRUITING
Thomas Jefferson University Hospital, Philadelphia
RECRUITING
Fox Chase Cancer Center, Philadelphia
RECRUITING
Paoli Memorial Hospital, Paoli
RECRUITING
National Institutes of Health Clinical Center, Bethesda
RECRUITING
University of Maryland/Greenebaum Cancer Center, Baltimore
RECRUITING
UPMC Western Maryland, Cumberland
RECRUITING
Henrico Doctor's Hospital, Richmond
RECRUITING
Virginia Cancer Institute, Richmond
RECRUITING
VCU Massey Cancer Center at Stony Point, Richmond
RECRUITING
VCU Massey Comprehensive Cancer Center, Richmond
RECRUITING
VCU Community Memorial Health Center, South Hill
RECRUITING
Carilion Roanoke Memorial Hospital, Roanoke
RECRUITING
Edwards Comprehensive Cancer Center, Huntington
RECRUITING
West Virginia University Healthcare, Morgantown
RECRUITING
Duke Women's Cancer Care Raleigh, Raleigh
RECRUITING
Duke University Medical Center, Durham
RECRUITING
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami
RECRUITING
UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables
RECRUITING
UM Sylvester Comprehensive Cancer Center at Kendall, Miami
RECRUITING
UM Sylvester Comprehensive Cancer Center at Aventura, Aventura
RECRUITING
UM Sylvester Comprehensive Cancer Center at Plantation, Plantation
RECRUITING
UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach
RECRUITING
University of Alabama at Birmingham Cancer Center, Birmingham
RECRUITING
University of South Alabama Mitchell Cancer Institute, Mobile
RECRUITING
University of Kentucky/Markey Cancer Center, Lexington
RECRUITING
Dublin Methodist Hospital, Dublin
RECRUITING
Memorial Hospital, Marysville
RECRUITING
Knox Community Hospital, Mount Vernon
RECRUITING
Licking Memorial Hospital, Newark
RECRUITING
Saint Ann's Hospital, Westerville
SUSPENDED
OhioHealth Westerville Medical Campus/Westerville Cancer Center, Westerville
RECRUITING
Fairfield Medical Center, Lancaster
SUSPENDED
OhioHealth Pickerington Methodist Hospital, Pickerington
RECRUITING
Ohio State University Comprehensive Cancer Center, Columbus
RECRUITING
Mount Carmel East Hospital, Columbus
RECRUITING
Riverside Methodist Hospital, Columbus
RECRUITING
The Mark H Zangmeister Center, Columbus
RECRUITING
Mercy Health - Perrysburg Hospital, Perrysburg
RECRUITING
Mercy Health - Saint Anne Hospital, Toledo
RECRUITING
Genesis Healthcare System Cancer Care Center, Zanesville
RECRUITING
UH Seidman Cancer Center at UH Avon Health Center, Avon
RECRUITING
UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor
RECRUITING
Case Western Reserve University, Cleveland
RECRUITING
UHHS-Chagrin Highlands Medical Center, Beachwood
RECRUITING
UH Seidman Cancer Center at Saint John Medical Center, Westlake
RECRUITING
Aultman Health Foundation, Canton
RECRUITING
OhioHealth Mansfield Hospital, Mansfield
RECRUITING
Good Samaritan Hospital - Cincinnati, Cincinnati
RECRUITING
Miami Valley Cancer Care and Infusion, Greenville
RECRUITING
Upper Valley Medical Center, Troy
RECRUITING
Miami Valley Hospital, Dayton
SUSPENDED
Dayton Physician LLC - Englewood, Dayton
RECRUITING
Miami Valley Hospital North, Dayton
SUSPENDED
Kettering Medical Center, Kettering
RECRUITING
Miami Valley Hospital South, Centerville
RECRUITING
Springfield Regional Cancer Center, Springfield
RECRUITING
Springfield Regional Medical Center, Springfield
RECRUITING
Adena Regional Medical Center, Chillicothe
RECRUITING
Southern Ohio Medical Center, Portsmouth
RECRUITING
Strecker Cancer Center-Belpre, Belpre
RECRUITING
Marietta Memorial Hospital, Marietta
RECRUITING
UChicago Medicine Northwest Indiana, Crown Point
RECRUITING
Henry Ford Saint John Hospital - Macomb Medical, Macomb
RECRUITING
Corewell Health William Beaumont University Hospital, Royal Oak
RECRUITING
Corewell Health Beaumont Troy Hospital, Troy
RECRUITING
Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor
RECRUITING
Huron Gastroenterology PC, Ypsilanti
RECRUITING
University of Michigan Comprehensive Cancer Center, Ann Arbor
RECRUITING
Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton
RECRUITING
Trinity Health Medical Center - Brighton, Brighton
RECRUITING
University of Michigan - Brighton Center for Specialty Care, Brighton
RECRUITING
Chelsea Hospital, Chelsea
RECRUITING
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea
RECRUITING
Corewell Health Dearborn Hospital, Dearborn
RECRUITING
Trinity Health Saint Mary Mercy Livonia Hospital, Livonia
RECRUITING
Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton
RECRUITING
Trinity Health Medical Center - Canton, Canton
RECRUITING
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti
RECRUITING
Corewell Health Farmington Hills Hospital, Farmington Hills
RECRUITING
Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac
RECRUITING
Cancer Hematology Centers - Flint, Flint
SUSPENDED
Genesee Hematology Oncology PC, Flint
RECRUITING
Genesys Hurley Cancer Institute, Flint
RECRUITING
Hurley Medical Center, Flint
RECRUITING
University of Michigan Health - Sparrow Lansing, Lansing
RECRUITING
UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny
RECRUITING
UI Health Care Mission Cancer and Blood - Waukee Clinic, Waukee
RECRUITING
UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines
RECRUITING
Mercy Medical Center - Des Moines, Des Moines
RECRUITING
UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines
RECRUITING
UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive
RECRUITING
Aurora Health Care Germantown Health Center, Germantown
RECRUITING
Aurora Cancer Care-Grafton, Grafton
RECRUITING
Aurora Medical Center in Summit, Summit
RECRUITING
Saint Vincent Hospital Cancer Center at Sheboygan, Sheboygan
RECRUITING
Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan
RECRUITING
Aurora Cancer Care-Southern Lakes VLCC, Burlington
RECRUITING
Aurora Saint Luke's South Shore, Cudahy
RECRUITING
Aurora Cancer Care-Kenosha South, Kenosha
RECRUITING
Aurora Cancer Care-Milwaukee, Milwaukee
RECRUITING
Aurora Saint Luke's Medical Center, Milwaukee
RECRUITING
Aurora Cancer Care-Milwaukee West, Wauwatosa
RECRUITING
Aurora West Allis Medical Center, West Allis
RECRUITING
Aurora Sinai Medical Center, Milwaukee
RECRUITING
Aurora Cancer Care-Racine, Racine
RECRUITING
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison
RECRUITING
University of Wisconsin Carbone Cancer Center - University Hospital, Madison
RECRUITING
Aurora Bay Area Medical Group-Marinette, Marinette
RECRUITING
Saint Vincent Hospital Cancer Center at Oconto Falls, Oconto Falls
RECRUITING
Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers
RECRUITING
Saint Vincent Hospital Cancer Center Green Bay, Green Bay
RECRUITING
Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay
RECRUITING
Aurora BayCare Medical Center, Green Bay
RECRUITING
Gundersen Lutheran Medical Center, La Crosse
RECRUITING
Duluth Clinic Ashland, Ashland
RECRUITING
Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh
RECRUITING
Essentia Health Sandstone, Sandstone
RECRUITING
Regions Hospital, Saint Paul
RECRUITING
United Hospital, Saint Paul
RECRUITING
Fairview Clinics and Surgery Center Maple Grove, Maple Grove
RECRUITING
Abbott-Northwestern Hospital, Minneapolis
RECRUITING
Park Nicollet Clinic - Saint Louis Park, Saint Louis Park
RECRUITING
Mercy Hospital, Coon Rapids
RECRUITING
Fairview Southdale Hospital, Edina
RECRUITING
Essentia Health Hibbing Clinic, Hibbing
RECRUITING
Essentia Health Virginia Clinic, Virginia
RECRUITING
Essentia Health Cancer Center, Duluth
RECRUITING
Mayo Clinic in Rochester, Rochester
RECRUITING
Essentia Health - Deer River Clinic, Deer River
SUSPENDED
Sanford Cancer Center Oncology Clinic, Sioux Falls
ACTIVE_NOT_RECRUITING
Rapid City Regional Hospital, Rapid City
RECRUITING
Sanford Broadway Medical Center, Fargo
RECRUITING
Sanford Roger Maris Cancer Center, Fargo
RECRUITING
Sanford Bismarck Medical Center, Bismarck
RECRUITING
Billings Clinic Cancer Center, Billings
RECRUITING
Benefis Sletten Cancer Institute, Great Falls
RECRUITING
Community Hospital of Anaconda, Anaconda
RECRUITING
Bozeman Health Deaconess Hospital, Bozeman
RECRUITING
Community Medical Center, Missoula
RECRUITING
Logan Health Medical Center, Kalispell
RECRUITING
Advocate Good Shepherd Hospital, Barrington
RECRUITING
AMG Crystal Lake - Oncology, Crystal Lake
RECRUITING
NorthShore University HealthSystem-Glenbrook Hospital, Glenview
RECRUITING
NorthShore University HealthSystem-Highland Park Hospital, Highland Park
RECRUITING
AMG Libertyville - Oncology, Libertyville
RECRUITING
Condell Memorial Hospital, Libertyville
RECRUITING
Advocate Lutheran General Hospital, Park Ridge
RECRUITING
Advocate Sherman Hospital, Elgin
RECRUITING
NorthShore University HealthSystem-Evanston Hospital, Evanston
RECRUITING
Advocate South Suburban Hospital, Hazel Crest
RECRUITING
UC Comprehensive Cancer Center at Silver Cross, New Lenox
RECRUITING
University of Chicago Medicine-Orland Park, Orland Park
RECRUITING
Advocate Good Samaritan Hospital, Downers Grove
RECRUITING
John H Stroger Jr Hospital of Cook County, Chicago
RECRUITING
University of Illinois, Chicago
RECRUITING
University of Chicago Comprehensive Cancer Center, Chicago
RECRUITING
Advocate Illinois Masonic Medical Center, Chicago
RECRUITING
Illinois CancerCare-Dixon, Dixon
RECRUITING
Illinois CancerCare-Ottawa Clinic, Ottawa
RECRUITING
Illinois CancerCare-Peru, Peru
RECRUITING
Illinois CancerCare-Princeton, Princeton
RECRUITING
Illinois CancerCare-Galesburg, Galesburg
RECRUITING
Illinois CancerCare-Kewanee Clinic, Kewanee
RECRUITING
Illinois CancerCare-Macomb, Macomb
RECRUITING
Illinois CancerCare-Canton, Canton
RECRUITING
Illinois CancerCare-Eureka, Eureka
RECRUITING
Illinois CancerCare-Pekin, Pekin
RECRUITING
Illinois CancerCare - Washington, Washington
RECRUITING
Illinois CancerCare-Peoria, Peoria
RECRUITING
Illinois CancerCare-Bloomington, Bloomington
RECRUITING
Carle Cancer Center, Urbana
RECRUITING
Carle at The Riverfront, Danville
RECRUITING
Carle Physician Group-Mattoon/Charleston, Mattoon
RECRUITING
Cancer Care Center of O'Fallon, O'Fallon
RECRUITING
Illinois CancerCare-Carthage, Carthage
RECRUITING
Carle Physician Group-Effingham, Effingham
RECRUITING
Crossroads Cancer Center, Effingham
RECRUITING
Cancer Care Specialists of Illinois - Decatur, Decatur
RECRUITING
Decatur Memorial Hospital, Decatur
RECRUITING
Southern Illinois University School of Medicine, Springfield
RECRUITING
Springfield Clinic, Springfield
RECRUITING
Springfield Memorial Hospital, Springfield
RECRUITING
Centralia Oncology Clinic, Centralia
RECRUITING
Missouri Baptist Sullivan Hospital, Sullivan
RECRUITING
Washington University School of Medicine, St Louis
RECRUITING
BJC Outpatient Center at Sunset Hills, Sunset Hills
RECRUITING
Missouri Baptist Medical Center, St Louis
RECRUITING
Parkland Health Center - Farmington, Farmington
RECRUITING
Sainte Genevieve County Memorial Hospital, Sainte Genevieve
RECRUITING
Saint Francis Medical Center, Cape Girardeau
RECRUITING
Ochsner Baptist Medical Center, New Orleans
RECRUITING
Ochsner Medical Center Jefferson, New Orleans
RECRUITING
University of Oklahoma Health Sciences Center, Oklahoma City
RECRUITING
M D Anderson Cancer Center, Houston
RECRUITING
MD Anderson West Houston, Houston
RECRUITING
MD Anderson in The Woodlands, Conroe
RECRUITING
MD Anderson in Sugar Land, Sugar Land
RECRUITING
MD Anderson League City, League City
RECRUITING
Saint Luke's Cancer Institute - Twin Falls, Twin Falls
RECRUITING
Saint Alphonsus Cancer Care Center-Caldwell, Caldwell
RECRUITING
Saint Luke's Cancer Institute - Fruitland, Fruitland
RECRUITING
Saint Luke's Cancer Institute - Meridian, Meridian
RECRUITING
Saint Alphonsus Cancer Care Center-Nampa, Nampa
RECRUITING
Saint Luke's Cancer Institute - Nampa, Nampa
RECRUITING
Saint Alphonsus Cancer Care Center-Boise, Boise
RECRUITING
Saint Luke's Cancer Institute - Boise, Boise
RECRUITING
Kootenai Health - Coeur d'Alene, Coeur d'Alene
RECRUITING
Kootenai Clinic Cancer Services - Post Falls, Post Falls
RECRUITING
Kootenai Clinic Cancer Services - Sandpoint, Sandpoint
RECRUITING
CTCA at Western Regional Medical Center, Goodyear
RECRUITING
Kingman Regional Medical Center, Kingman
RECRUITING
University of New Mexico Cancer Center, Albuquerque
RECRUITING
OptumCare Cancer Care at Seven Hills, Henderson
RECRUITING
OptumCare Cancer Care at Charleston, Las Vegas
RECRUITING
OptumCare Cancer Care at Fort Apache, Las Vegas
RECRUITING
Cedars Sinai Medical Center, Los Angeles
RECRUITING
Presbyterian Intercommunity Hospital, Whittier
RECRUITING
Saint Joseph Hospital - Orange, Orange
RECRUITING
PCR Oncology, Arroyo Grande
RECRUITING
Stanford Cancer Institute Palo Alto, Palo Alto
SUSPENDED
The Queen's Medical Center - West Oahu, ‘Ewa Beach
SUSPENDED
Queen's Cancer Cenrer - POB I, Honolulu
SUSPENDED
Queen's Medical Center, Honolulu
RECRUITING
University of Hawaii Cancer Center, Honolulu
SUSPENDED
Queen's Cancer Center - Kuakini, Honolulu
SUSPENDED
Kapiolani Medical Center for Women and Children, Honolulu
RECRUITING
Providence Willamette Falls Medical Center, Oregon City
RECRUITING
Providence Newberg Medical Center, Newberg
RECRUITING
Providence Portland Medical Center, Portland
RECRUITING
Providence Saint Vincent Medical Center, Portland
RECRUITING
Oregon Health and Science University, Portland
RECRUITING
Saint Alphonsus Cancer Care Center-Ontario, Ontario
RECRUITING
Swedish Cancer Institute-Edmonds, Edmonds
RECRUITING
Swedish Cancer Institute-Issaquah, Issaquah
RECRUITING
Valley Medical Center, Renton
RECRUITING
Swedish Medical Center-First Hill, Seattle
RECRUITING
Providence Regional Cancer System-Lacey, Lacey
RECRUITING
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital, Yakima
RECRUITING
Providence Saint Mary Regional Cancer Center, Walla Walla
RECRUITING
Alaska Women's Cancer Care, Anchorage
RECRUITING
Mayo Clinic in Florida, Jacksonville
RECRUITING
Advocate Christ Medical Center, Oak Lawn
RECRUITING
Harold Alfond Center for Cancer Care, Augusta
RECRUITING
Lafayette Family Cancer Center-EMMC, Brewer
RECRUITING
MaineHealth Maine Medical Center- Scarborough, Scarborough
SUSPENDED
Walter Reed National Military Medical Center, Bethesda
RECRUITING
Tufts Medical Center, Boston
RECRUITING
Baystate Medical Center, Springfield
RECRUITING
Jersey City Medical Center, Jersey City
RECRUITING
Monmouth Medical Center Southern Campus, Lakewood
RECRUITING
Monmouth Medical Center, Long Branch
RECRUITING
Memorial Sloan Kettering Monmouth, Middletown
RECRUITING
Rutgers Cancer Institute of New Jersey, New Brunswick
RECRUITING
Sidney Kimmel Cancer Center Washington Township, Sewell
RECRUITING
Atrium Medical Center-Middletown Regional Hospital, Franklin
RECRUITING
Women and Infants Hospital, Providence
RECRUITING
Sanford USD Medical Center - Sioux Falls, Sioux Falls
RECRUITING
Lyndon Baines Johnson General Hospital, Houston
RECRUITING
Saint Vincent Hospital Cancer Center at Sturgeon Bay, Sturgeon Bay
RECRUITING
Puerto Rico Hematology Oncology Group, Bayamón
RECRUITING
Centro Comprensivo de Cancer de UPR, San Juan
Collaborators (1)
NRG Oncology
OTHER
National Cancer Institute (NCI)
NIH