446
Participants
Start Date
August 31, 2022
Primary Completion Date
December 17, 2024
Study Completion Date
September 12, 2025
Olezarsen
Olezarsen will be administered by SC injection.
Placebo
Olezarsen-matching placebo will be administered by SC injection.
Medical Center for Specialized Medical Help in Cardiovascular Diseases OOD, Sofia
Hôpital Erasme, Brussels
Acibadem City Clinic Tokuda University Hospital, Sofia
Medico Dental Center ISUL Tsaritsa Yoanna EOOD, Sofia
Medical Centre Synexus Sofia EOOD, Sofia
UZ Leuven, Leuven
Virga Jessa Hospital, Hasselt
UMHAT - Kaspela EOOD, Plovdiv
University Multiprofile Hospital for Active Treatment Pulmed OOD, Plovdiv
MHAT Pazardzhik AD, Pazardzhik
Medical Center Smolyan Clinical Research OOD, Smolyan
"Medical Centre Nevromedics EOOD", Veliko Tarnovo
Medical Center Zara - Med, Stara Zagora
MHAT Haskovo AD, Haskovo
Medical Center Diamedical EOOD, Dimitrovgrad
UMHAT Kanev AD, Rousse
AZ Sint-Jan Brugge, Bruges
Hospital Vall d'Hebron, Barcelona
MHAT Sliven to MMA Sofia, Sliven
Hospital Germans Trias i Pujol, Badalona
DCC Equita, Varna
Specialized Hospital for Active Treatment of Cardiology, Varna
S.C. SAL MED S.R.L., Cardiologie, Piteşti
Pulau Pinang Hospital, George Town
Centrul Medical Medicover Victoria, Bucharest
AHEPA Building of Evaggelismos, Athens
NYU Langone Hospital - Long Island, Mineola
University General Hospital ATTIKON, Athens
Orchard Park Family Practice, Orchard Park
Hygeia Hospital, Athens
Hospital Provincial de Conxo, Santiago de Compostela
University of Pennsylvania, Philadelphia
Centro de Investigación Cardiométabolica de Aguascalientes S.A. de C.V., Aguascalientes
Hospital Comarcal Infanta Elena, Huelva
University of Maryland School of Medicine, Baltimore
Maryland Cardiovascular Specialists, Baltimore
Hospital Universitario de Jaen, Jaén
Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo
"Fondazione I.R.C.C.S. Policlinico San Matteo c/o C.U.R.M.", Pavia
Hospital Universitario 12 de Octubre, Madrid
OnSite Clinical Solutions, LLC, Salisbury
Diabetes and Endocrinology Consultants, P.C., Morehead City
Clinical Trials of America, LLC, Lenoir
Hospital Regional de Malaga, Málaga
Unidad de Ensayos Clinicos, Málaga
Medical University of South Carolina (MUSC), Charleston
Main Street Physicians Care Waterway, Little River
Randomize Now, Newnan
Emory University, Atlanta
Northeast Georgia Medical Center, Gainesville
Accel Clinical Research, Eatonton
Cientia Investigacion Clinica Sc, Chihuahua City
University of Florida Jacksonville, Jacksonville
Accel Research Sites, DeLand
Meridien Research, Maitland
Combined Research Orlando Phase I-IV, Orlando
Columbus Clinical Services, Miami
Harmony Clinical Research, Inc, North Miami Beach
Chang Gung Medical Foundation - Linkou Branch, Taoyuan District
3Sync Research, Sunrise
Metabolic Research Institute, West Palm Beach
Finlay Medical Research, Greenacres City
R & B Medical Center LLC, Tampa
JSV Clinical Research Study, Inc., Tampa
Hospital Taiping, Taiping
Central Research Associates, Inc., Birmingham
Alabama Clinical Therapeutics, LLC Alabaster, Birmingham
The Jackson Clinic, Jackson
Stern Cardiovascular, Southaven
University of Louisville, Louisville
Louisville Metabolic and Atherosclerosis Research Center (L-MARC), Louisville
The Research Group of Lexington, LLC, Lexington
Taichung Veterans General Hospital, Taichung
Hospital Universitario Virgen Macarena, Seville
The Ohio State University (OSU), Columbus
SV Research LLC, Marion
Azienda Ospedaliero-Universitaria di Ferrara-Arcispedale Sant'Anna, Cona
Hospital Clinico Universitario de Valencia, Valencia
St. Vincent Medical Group, Carmel
Onyx Clinical Research, Rochester Hills
Onyx Clinical Research, Flint
Saules seimons medicinos centras, Kaunas
Hospital Universitario Miguel Servet, Zaragoza
Clinical Investigation Specialists Inc., Kenosha
Clinical Research Institute S.C., Tlanepantla
AHEPA University General Hospital of Thessaloniki, Thessaloniki
Monument Health Clinical Research, Rapid City
University Malaya Medical Centre (UMMC), Kuala Lumpur
ELSAN - Polyclinique Vauban, Valenciennes
University of Kansas Medical Center (KUMC), Kansas City
Hopital de Hautepierre, Strasbourg
University General Hospital of Alexandroupoli, Alexandroupoli
GHM les Portes du Sud, Vénissieux
Grace Research, LLC, Bossier City
Clinical Trials of America LA, LLC, Monroe
Oklahoma Heart Institute, Tulsa
Texas Institute of Cardiology, McKinney
SMS Clinical Research, LLC, Mesquite
Southern Endocrinology Associates, Mesquite
Texas Health Family Care, Fort Worth
FMC Science, Lampasas
Vilo Research Group, Houston
Juno Research, Houston
Juno Research, Houston
Clinical Trial Network, Houston
Pioneer Research Solutions, Inc, Houston
Tranquil Research, Webster
Sante Clinical Research, LLC, Kerrville
Diabetes & Glandular Disease Clinic, P.A., San Antonio
DCT - McAllen Primary Care, LLC, McAllen
Permian Research Foundation, Odessa
Kaohsiung Medical University Chung-Ho Memorial Hospital (KMUH), Kaohsiung City
AORN S. Anna e S. Sebastiano UOC FARMACIA, Caserta
Ambulancia diabetologicka a poruch latkovej premeny a vyzivy, Bratislava
Aspen Clinical Research, Orem
Ogden Clinic Grandview, Roy
Onyx Clinical Research, Peoria
NRC Research Institute, Los Angeles
Medical Care and Research S.A de C.V., Mérida
Interna a diabetologicka ambulancia - IN-DIA s.r.o., Lučenec
Max Super Specialty Hospital, New Delhi
Sir Ganga Ram Hospital, Delhi
Shin Kong Wu Ho-Su Memorial Hospital, Taipei
Mackay Memorial Hospital, New Taipei City
Eternal Hospital, Jaipur
Bhatia Hospital, Mumbai
Cardioplus Center SRL, Baia Mare
Centrul Medical de Diagnostic si Tratament Ambulatoriu Neomed S.R.L, Brasov
Cabinet Medical Individual SC DIANA BARBONTA SRL, Alba
Cardio Med SRL, Târgu Mureş
S.C. Mediab Srl, Târgu Mureş
Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bengaluru
Manipal Hospital Mysore, Mysore
Vinaya Hospital and Research Centre (A Unit of Karnataka Institute of Medical Sciences), Mangaluru
IPGMER, Kolkata
B. M. Birla Heart Research Centre A Unit of the Calcutta Medical Research Institute, Kolkata
National Cheng Kung University Hospital, Tainan City
KEM Hospital, Mumbai
Massachusetts General Hospital, Boston
CIPREC - Centro de Investigación y Prevención Cardiovascular, Buenos Aires
Fundacion Favaloro, Buenos Aires
Centro Médico Dra. Laura Maffei, Buenos Aires
Glenny Corp SA, Buenos Aires
Instituto de Cardiología Corrientes, Corrientes
Instituto Médico DAMIC, Córdoba
Centro Medico San Luis, San Luis
Clínica FUSAVIM Privada, Villa María
NUPEC - Nucleo de Pesquisa Clinica, Belo Horizonte
Núcleo de Pesquisa Clínica, Curitiba
Hospital Universitario Walter Cantidio - UFC, Fortaleza
Nucleo de Pesquisa em Cirurgia Vascular, Porto Alegre
IBPClin Pesquisa Clinica, Rio de Janeiro
CPQuali Pesquisa Clinica, São Paulo
Instituto do Coração - HCFMUSP, São Paulo
Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo - FMUSP, São Paulo
i9 Pesquisas Clínicas/Loema - Instituto de Pesquisas Clínica & Consultores, São Paulo
NL Health Services, St. John's
Aggarwal and Associates Ltd., Brampton
Joanne F. Liutkus Medicine Professional Corporation, Cambridge
Bluewater Clinical Research Group, Sarnia
Toronto General Hospital, Toronto
Unite de Recherche Clinique, Saint-Jérôme
CTC Hodonin s.r.o., Hodonín
KardioBusak s.r.o., Louny
Fakultni nemocnice v Motole, Prague
Endokrinologie Cerny Most s.r.o., Prague
Diabetologická a endokrinologická ambulance Milan Kvapil, Příbram
AeskuLab k.s, Teplice
Lausmed Kft., Baja
DRC Gyogyszervizsgalo Kozpont Kft, Balatonfüred
Obudai Egeszsegugyi Centrum, Budapest
Clinexpert Kft., Budapest
Pharma4 Trial Kft., Gyöngyös
Somogy Varmegyei Kaposi Mor Oktato Korhaz Diabetologiai szakrendeles, Kaposvár
Klinikiniai sprendimai, Kaunas
Clinic of Cardiology and Rehabilitation, Klaipėda
Republican Panevezys Hospital, Panevezys
Pirmoji viltis, Šiauliai
Sultanah Bahiyah Hospital, Alor Star
Clinstile, S.A. de C.V., Mexico City
Vumc Amsterdam Medical Center, Amsterdam
Gelre Ziekenhuizen Apeldoorn, Apeldoorn
Reinier de Graaf Ziekenhuis, Delft
Het Van Weel Bethesda ziekenhuis, Dirksland
Albert Schweitzer Ziekenhuis, Dordrecht
Bethesda Diabetes Research Center, Hoogeveen
Canisius-Wilhelmina Ziekenhuis (CWZ), Nijmegen
UCK, I Klinika Kardiologii, Gdansk
Biokinetica, Józefów
Centrum Medyczne Pratia, Katowice
Centra Medyczne Medyceusz, Lodz
Clinical Best Solutions, Lublin
Etg Lublin, Lublin
Centrum Zdrowia Metabolicznego, Poznan
Clinical Best Solutions Sp. Z.o.o Spolka Komandytowa, Warsaw
Centrum Medycnze AMED, Warsaw
Narodowy Instytut Kardiologii im. S. Wyszyńskiego - PIB, Warsaw
ETG Zamosc / Pro Life Medica Sp. z o.o., Zamość
Hospital CUF Tejo, Lisbon
Centro Hospitalar de Entre Douro e Vouga, Santa Maria da Feira
Alian s.r.o., Bardejov
Diab sro, Rožňava
Interna SK, s.r.o., Svidník
Areteus s.r.o, Trebišov
Acardo MedSite, Solna
Lead Sponsor
Ionis Pharmaceuticals, Inc.
INDUSTRY