A Study of Vobramitamab Duocarmazine in Participants With Metastatic Castration Resistant Prostate Cancer and Other Solid Tumors

PHASE2CompletedINTERVENTIONAL
Enrollment

192

Participants

Timeline

Start Date

June 13, 2023

Primary Completion Date

July 4, 2024

Study Completion Date

January 23, 2025

Conditions
Castration-Resistant Prostatic CancerAndrogen-Independent Prostatic CancerAndrogen-Insensitive Prostatic CancerAndrogen-Resistant Prostatic CancerHormone Refractory Prostatic CancerAnal CancerAnal NeoplasmCarcinoma, Squamous Cell of Head and NeckHead and Neck Squamous Cell CarcinomaLaryngeal Squamous Cell CarcinomaOral Squamous Cell CarcinomaMalignant MelanomaMelanomaNon-small Cell Lung CancerNon-small Cell CarcinomaSmall-cell Lung CancerSmall Cell Carcinoma
Interventions
BIOLOGICAL

vobramitamab duocarmazine 2.0 mg (Arm A)

2.0 mg/kg intravenous (IV) every 4 weeks

BIOLOGICAL

vobramitamab duocarmazine 2.7 mg (Arm B)

2.7 mg.kg IV every 4 weeks

BIOLOGICAL

vobramitamab duocarmazine

2.7 mg.kg IV every 4 weeks

DRUG

Abiraterone

1000 mg once daily

DRUG

Enzalutamide

160 mg daily

Trial Locations (63)

1200

Cliniques Universitaires Saint-Luc, Woluwe-Saint-Lambert

2145

Ramsay Health Care - Westmead Private Hospital, Westmead

3000

Peter MacCallum Cancer Centre, Melbourne

3144

Cabrini Health- Malvern, Malvern

4102

The University of Queensland (UQ) - Princess Alexandra Hospital (PAH), Woolloongabba

5300

Centre Hospitalier Universitaire (CHU) - Universite Catholique de Louvain (UCL) - Namur - Site Godinne (Cliniques Universitaires UCL de Mont-Godinne), Godinne

5505

Asan Medical Center, Seoul

6000

(Grand Hopital de Charleroi) GHDC, Charleroi

6800

Centre Hospitalier de Ardenne - Libramont - Clinique du Sein, Libramont

9000

Algemeen Ziekenhuis Maria Middelares, Ghent

10049

AOU San Luigi Gonzaga Oncology Department, Orbassano

10408

National Cancer Center, Goyang-si

21231

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore

22031

Virginia Cancer Specalists, Fairfax

22908

University of Virginia Comprehensive Cancer Center, Charlottesville

27002

Hospital Universitario Lucus Augusti, Lugo

28041

Hospital Universitario 12 de Octubre, Madrid

29200

CHRU Brest, Brest

29572

Carolina Urologic Research Center, Myrtle Beach

30174

Ospedale dell'Angelo, Mestre

32209

The University of Florida Health System - UF Health Urology - Jacksonville, Jacksonville

32763

Mid Florida Hematology and Oncology Center, Orange City

33076

Institut Bergonié, Bordeaux

34298

Institut régional du Cancer de Montpellier - ICM Val d'Aurelle, Montpellier

35128

Istituto Oncologico Veneto, Padua

35760

Centre Hospitalier Privé Saint-Grégoire, Saint-Grégoire

38122

Azienda Provinciale per i Servizi Sanitari - Presidio Ospedaliero S. Chiara, Trento

41013

Hospital Universitario Virgen del Rocio, Seville

41404

Kyungpook National University Chilgok Hospital, Bugok

44718

Gabrail Cancer Center, Canton

48201

Barbara Ann Karmanos Cancer Institute - Hudson-Webber Cancer Research Center, Detroit

50134

Radiation Oncology Unit, Azienda Ospedaliera Universitaria Careggi, University of Florence, Florence

55455

Masonic Cancer Center, University of Minnesota, Minneapolis

61469

Chonnam National University Hospital, Gwangju

67200

Institut de Cancerologie Strasbourg Europe (ICANS), Strasbourg

70433

Pontchartrain Cancer Center, Covington

72000

Clinique Victor Hugo, Le Mans

75014

Institut Mutualiste Montsouris, Paris

90095

University of California Los Angeles (UCLA) Community Cancer Care, Los Angeles

92150

Hopital Foch, Suresnes

92708

Compassionate Cancer Care Medical Group, Fountain Valley

94160

Hôpital d'Instruction des Armées Bégin, Saint-Mandé

94800

Gustave Roussy, Villejuif

97239

VA Portland Health Care Services, Portland

98109

Fred Hutchinson Cancer Center, Seattle

06189

Centre Antoine-Lacassagne, Nice

05-400

Szpital im. Fryderyka Chopina, Otwock

01-748

Magodent Szpital Elblaska, Warsaw

02-798

Medical Concierge Centrum Medyczne, Warsaw

04-073

Grochowski Hospital, Warsaw

75-581

Szpital Wojewodzki im. Mikolaja Kopernika, Koszalin

62-500

"Przychodnia Lekarska KOMED", Konin

03080

Seoul National University Hopital, Seoul

03722

Yonsei University Health System, Severance Hospital, Seoul

06351

Samsung Meical Cemter, Seoul

07985

Ewha Womans University Mokdong Hospital, Seoul

08208

Hospital Universitari Parc Taulí, Sabadell

08003

Hospital Del Mar, Barcelona

08036

Hospital Clinic de Barcelona, Barcelona

Hospital de la Santa Creu I Sant Pau, Barcelona

Institut Catala d'Oncologia Hospitalet, Barcelona

SM2 5PT

The Royal Marsden NHS Trust, Sutton

OX3 7LE

Oxford University Hospitals NHS- Churchill Hospital, Oxford

Sponsors

Lead Sponsor

All Listed Sponsors
lead

MacroGenics

INDUSTRY