A Study of Venoarterial ECMO vs Off-Pump Bilateral Orthotopic Lung Transplantation

NARecruitingINTERVENTIONAL
Enrollment

228

Participants

Timeline

Start Date

September 17, 2022

Primary Completion Date

September 30, 2026

Study Completion Date

September 30, 2027

Conditions
Lung Transplant
Interventions
PROCEDURE

Off-pump lung transplantation

General anesthesia, intubation with double lumen tube, thoracotomies or clamshell incision, pneumonectomy starting by the less perfused lung in the scan, stump preparation, lung implantation, reperfusion, gradual release of the pulmonary artery clamp, deairing, ventilation of the 1st implanted lung. The process is repeated at the contralateral side. Ventilation of both lungs, chest closure.

PROCEDURE

Venoarterial ECMO lung transplantation

General anesthesia, intubation with double lumen tube, thoracotomies or clamshell incision, heparin, peripheral or central venoarterial ECMO cannulation, first pneumonectomy, stump preparation, lung implantation, reperfusion, release of the pulmonary artery clamp, deairing, ventilation of the 1st implanted lung. The process is repeated at the contralateral side. Ventilation of both lungs, ECMO decannulation, chest closure.

Trial Locations (5)

19104

RECRUITING

University of Pennsylvania, Philadelphia

19140

RECRUITING

Temple University Hospital, Philadelphia

40202

RECRUITING

University Of Louisville, Louisville

55905

RECRUITING

Mayo Clinic Rochester, Rochester

77030

RECRUITING

Baylor College of Medicine, Houston

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Mayo Clinic

OTHER

NCT05547698 - A Study of Venoarterial ECMO vs Off-Pump Bilateral Orthotopic Lung Transplantation | Biotech Hunter | Biotech Hunter