The Effects of Increasing Caloric Intake on Diet-Induced Thermogenesis and 24h Energy Expenditure

NARecruitingINTERVENTIONAL
Enrollment

120

Participants

Timeline

Start Date

June 6, 2023

Primary Completion Date

February 2, 2027

Study Completion Date

February 2, 2027

Conditions
ObesityNormal PhysiologyHealthy Volunteers
Interventions
DIETARY_SUPPLEMENT

+200% of dietary requirements, 50% of calories from carbohydrates, 20% from protein, and 30% from fat

+200% of energy balance requirements with standard macronutrient balance of 50% of calories from carbohydrates, 20% from protein, and 30% from fat

DIETARY_SUPPLEMENT

fasting

Fasting for at least 24 hours

DIETARY_SUPPLEMENT

-50% of energy balance requirements. 50% of calories from carbohydrates, 20% from protein, and 30% from fat

-50% of energy balance requirements with standard macronutrient balance of 50% of calories from carbohydrates, 20% from protein, and 30% from fat

DIETARY_SUPPLEMENT

+150% of energy balance requirements, 50% of calories from carbohydrates, 20% from protein, and 30% from fat

+150% of energy balance requirements with standard macronutrient balance of 50% of calories from carbohydrates, 20% from protein, and 30% from fat

DIETARY_SUPPLEMENT

+200% of dietary requirements, 51% of the calories from carbohydrates, 46%, from fat and 3% from protein

+200% of energy balance requirements with low protein macronutrient balance of 51% of the calories from carbohydrates, 46%, from fat and 3% from protein.

DIETARY_SUPPLEMENT

-25% of energy balance requirements, 50% of calories from carbohydrates, 20% from protein, and 30% from fat

-25% of energy balance (EB) requirements with standard macronutrient balance of 50% of calories from carbohydrates, 20% from protein, and 30% from fat

DIETARY_SUPPLEMENT

+150% of dietary requirements, 51% of the calories from carbohydrates, 46%, from fat and 3% from protein

+150% of energy balance requirements with low protein macronutrient balance of 51% of the calories from carbohydrates, 46%, from fat and 3% from protein.

Trial Locations (1)

85014

RECRUITING

NIDDK, Phoenix, Phoenix

All Listed Sponsors
lead

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NIH