379
Participants
Start Date
September 16, 2022
Primary Completion Date
August 12, 2028
Study Completion Date
August 12, 2028
M5049 low dose
Participants will receive film-coated tablets of M5049 at a low dose orally, twice a day (BID) for up to 194 weeks.
M5049 medium dose
Participants will receive film-coated tablets of M5049 at a medium dose orally, BID for up to 194 weeks.
M5049 high dose
Participants will receive film-coated tablets of M5049 at a high dose orally, BID for up to 194 weeks.
Placebo
Participants will receive M5049 matching placebo orally, BID for up to 194 weeks.
Advance Medical Research Center, Miami
Bay Area Arthritis and Osteoporosis, Brandon
Ramesh C Gupta, MD, Memphis
Ohio State University - CTMO Parent, Columbus
Dawes Fretzin Dermatology Group, LLC, Indianapolis
AA MRC LLC Ahmed Arif Medical Research Center, Grand Blanc
University of Minnesota, Minneapolis
The Lundquist Institute at Harbor-UCLA Medical Center, Torrance
Centro de Investigaciones Medicas Mar del Plata - CIM, Buenos Aires
CINME - Centro De Investigaciones Metabolicas, Buenos Aires
Buenos Aires Skin, Ciudad Autonoma Buenos Aires
Hospital Militar Central Dr. Cosme Argerich, Ciudad Autonoma Buenos Aires
Centro de Investigaciones Medicas Mar del Plata - CIM, Mar del Plata
Instituto de Reumatologia, Mendoza
Instituto Medico de alta Complejidad San Isidro S.A (IMAC), San Fernando
CER San Juan Centro Polivalente de Asistencia e Inv. Clinica, San Juan
Centro Dermatologico Schejtman, San Miguel
PSORIAHUE-Medicina Interdisciplinar, San Miguel
Centro de Investigaciones Medicas Tucuman, San Miguel de Tucumán
Investigaciones Clinicas Tucuman, San Miguel de Tucumán
Monash Medical Centre Clayton, Clayton
Veracity Clinical Research, Woolloongabba
Santa Casa de Misericórdia de Belo Horizonte, Belo Horizonte
Oncovida - Centro de Onco-Hematologia de Mato Grosso, Cuiabá
Clínica SER da Bahia, Graça
CMiP - Centro Mineiro de Pesquisa, Juiz de Fora
Hospital Moinhos de Vento, Moinhos de Vento
Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto - CIP - Centro Integrado de Pesquisa, São José
CEPIC - Centro Paulista de Investigação Clínica e Serviços Médicos, São Paulo
DCC 'Sveti Georgi' EOOD - Cardiology Office, Haskovo
MC Artmed OOD, Plovdiv
DCC 1 Sevlievo EOOD, Sevlievo
DCC Focus 5 - MEOH OOD, Sofia
Military Medical Academy - MHAT - Sofia, Sofia
"UMHAT Sv. Ivan Rilski, EAD - Clinic of Rheumatology", Sofia
"UMHAT Sv. Ivan Rilski, EAD - Clinica of Rheumatology", Sofia
Clinica Alemana de Osorno - Corporacion de Beneficencia Osorno, Los Lagos
BioMedica Research Group - Psicomedica Clinical and Research Group, Santiago
CeCim Biocinetic, Santiago
Centro Medico Prosalud, Santiago
CIEC- Centro Internacional de Estudios Clinicos - Valenzuela Y Compania Ltda, Santiago
Dermacross, Santiago
The First Affiliated Hospital of Baotou Medical College, Baotou
Peking Union Medical College Hospital - Beijing Union Medical College Hospital, Beijing
The First Hospital of Jilin University, Changchun
Guangdong Provincial People's Hospital, Guangzhou
Hainan General Hospital, Haikou
The First Affiliated Hospital of Henan University of Science and Technology, Luoyang
The Second Affiliated Hospital of Nanchang University, Nanchang
The Affiliated Drum Tower Hospital of Nanjing University, Nanjing
Huashan Hospital, Fudan University - Neurology, Shanghai
Renji Hospital Shanghai Jiaotong University School of Medicine - West Branch, Shanghai
Shanghai Skin Disease Hospital, Shanghai
West China Hospital, Sichuan University, Sichuan
The First Affiliated Hospital of Soochow University, Suzhou
Tianjin Medical University General Hospital, Tianjin
The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an
Centro de Investigacion Medico Asistencial S.A.S, Barranquilla
Centro de Investigacion en Reumatologia y Especialidades Medicas SAS. CIREEM, Bogotá
Servimed S.A.S., Bucaramanga
Centro Integral de Reumatologia del Caribe SAS CIRCARIBE SAS, Medellín
Healthy Medical Center, Zipaquirá
General Hospital of Athens Laiko, Athens
General Hospital Papageorgiou, Thessaloniki
Chaim Sheba Medical Center - pt, Ramat Gan
NHO Asahikawa Medical Center - Dept of Gastroenterology, Asahikawa-shi
NHO Chibahigashi National Hospital - Dept of Allergy/Rheumatology, Chiba
St. Luke's International Hospital - Dept of Immunology/Allergy, Chūōku
Hiroshima University Hospital, Hiroshima
Eiraku Clinic - Dept of Rheumatology, Kagoshima
Saitama Medical Center - Dept of Rheumatology/Immunology, Kawagoe-shi
Kagawa University Hospital - Dept of Immunology/ Rheumatology, Kita-gun
Hokkaido University Hospital - Dept of Internal Medicine 2(Rheumatology/Immunolog, Sapporo
Tohoku University Hospital - Dept of Hematology/Immunology, Sendai
CAP Research Ltd, Quatre Bornes
Consultorio Privado Dr. Miguel Cortes Hernandez, Cuernavaca
Centro de Estudios de Investigacion Basica y Clinica SC, Guadalajara
Diseno y Planeacion en Investigacion Medica S.C., Guadalajara
Diseño y Planeacion en Investigacion Medica S.C., Guadalajara
Centro Medico del Angel, Mexicali
CAIMED Investigacion en salud S.A de C.V., Mexico City
Clinstile, S.A. de C.V., Mexico City
Medical Care & Research SA de CV, Mérida
Centro de Investigacion Clínica GRAMEL S.C, México
Clinica para el Diagnostico y Tratamiento de las Enfermedades Reumaticas, México
Consultorio de Reumatologia - Hospital Angeles Lindavista Cons. 445B, México
Grupo Medico Camino S.C., México
Centro Regiomontano de Estudios Clínicos Roma S.C., Monterrey
CIMAB S.A. de C.V. - Centro de Investigacion Medica Alberto Bazzoni, Torreón
"ICS ARENSIA Exploratory Medicine SRL - Republican Clinical Hospital Timofei Mosneaga", Chisinau
Davao Doctors Hospital - Medicine, Davao City
Iloilo Doctors Hospital, Iloilo City
Mary Mediatrix Medical Center, Lipa City
Ospital Ng Makati, Makati City
Chinese General Hospital & Medical Center, Manila
Far Eastern University - Dr. Nicanor Reyes Medical Foundation - Department of Child Health, Quezon City
Nova Reuma Domysławska i Rusiłowicz, Spółka Partnerska Lekarza Reumatologa i Fizjoterapeuty, Bialystok
Prywatna Praktyka Lekarska prof Pawel Hrycaj, Kościan
Centrum Medyczne Plejady, Krakow
Centrum Nowoczesnych Terapii Dobry Lekarz, Krakow
Twoja Przychodnia PCM, Poznan
Twoja Przychodnia-Szczecinskie Centrum Medyczne Sp. z o. o, Szczecin
Clinical Best Solutions - Warszawa, Warsaw
Centrul Medical Monza SRL - Arensia Exploratory Medicine, Bucharest
S.C Delta Health Care S.R.L - Ponderas Academic Hospital, Bucharest
"Spitalul Clinic Sf. Maria - Clinica de Medicina Interna si Reumatologie", Bucharest
"Spitalul Clinic Sf. Maria - parent", Bucharest
Institute of Rheumatology - Rheumatology, Belgrade
Institute of Rheumatology, Belgrade
University Clinical Center of Serbia - Clinic of Alergology and Imunology, Belgrade
Arthritis Clinical Research Trial Unit - Dr CE Spargo and Dr RB Bhorat, Cape Town
University of Pretoria Clinical Research Unit - Parent, Pretoria
Naidoo, A - Netcare Umhlanga Hospital, Umhlanga
Gachon University Gil Medical Center, Incheon
Seoul National University Hospital, Seoul
Ajou University Hospital, Suwon
Hospital General de Castellon - Servicio de Reumatologia, Castelló
Hospital Regional Universitario de Malaga - Reumatology Dept, Málaga
Hospital Universitario Marques de Valdecilla - Servicio de Reumatologia, Santander
Hospital Universitario Rio Hortega - Servicio de Medicina Interna, Valladolid
Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City
Taipei Veterans General Hospital, Taipei
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
INDUSTRY