Testing the Addition of the AKT Inhibitor, Ipatasertib, to Treatment With the Hormonal Agent Megestrol Acetate for Recurrent or Metastatic Endometrial Cancers

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

96

Participants

Timeline

Start Date

March 31, 2023

Primary Completion Date

January 31, 2027

Study Completion Date

January 31, 2027

Conditions
FIGO Grade 1 Endometrial Endometrioid AdenocarcinomaFIGO Grade 2 Endometrial Endometrioid AdenocarcinomaMetastatic Endometrial Endometrioid AdenocarcinomaRecurrent Endometrial Endometrioid Adenocarcinoma
Interventions
PROCEDURE

Biospecimen Collection

Undergo blood sample collection

PROCEDURE

Computed Tomography

Undergo CT scan

DRUG

Ipatasertib

Given PO

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

DRUG

Megestrol Acetate

Given PO

Trial Locations (152)

10461

Montefiore Medical Center-Einstein Campus, The Bronx

Montefiore Medical Center-Weiler Hospital, The Bronx

10467

Montefiore Medical Center - Moses Campus, The Bronx

13210

State University of New York Upstate Medical University, Syracuse

14642

University of Rochester, Rochester

15025

Jefferson Hospital, Jefferson Hills

15090

Wexford Health and Wellness Pavilion, Wexford

15146

Forbes Hospital, Monroeville

15212

Allegheny General Hospital, Pittsburgh

15224

West Penn Hospital, Pittsburgh

19090

Asplundh Cancer Pavilion, Willow Grove

19107

Thomas Jefferson University Hospital, Philadelphia

22908

University of Virginia Cancer Center, Charlottesville

23235

VCU Massey Cancer Center at Stony Point, Richmond

23298

VCU Massey Comprehensive Cancer Center, Richmond

24033

Carilion Roanoke Memorial Hospital, Roanoke

25304

West Virginia University Charleston Division, Charleston

27599

UNC Lineberger Comprehensive Cancer Center, Chapel Hill

28025

Atrium Health Cabarrus/LCI-Concord, Concord

28203

Carolinas Medical Center/Levine Cancer Institute, Charlotte

29425

Medical University of South Carolina, Charleston

30912

Augusta University Medical Center, Augusta

32610

University of Florida Health Science Center - Gainesville, Gainesville

34236

Florida Cancer Specialists - Sarasota Downtown, Sarasota

34239

First Physicians Group-Sarasota, Sarasota

Sarasota Memorial Hospital, Sarasota

34275

Sarasota Memorial Hospital-Venice, N. Venice

Florida Cancer Specialists - Venice Pinebrook, Venice

37232

Vanderbilt University/Ingram Cancer Center, Nashville

43210

Ohio State University Comprehensive Cancer Center, Columbus

43214

Riverside Methodist Hospital, Columbus

44024

Geauga Hospital, Chardon

44060

UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor

44106

Case Western Reserve University, Cleveland

44122

UHHS-Chagrin Highlands Medical Center, Beachwood

44145

UH Seidman Cancer Center at Saint John Medical Center, Westlake

44195

Cleveland Clinic Foundation, Cleveland

44304

Summa Health System - Akron Campus, Akron

45220

Good Samaritan Hospital - Cincinnati, Cincinnati

45331

Miami Valley Cancer Care and Infusion, Greenville

45373

Upper Valley Medical Center, Troy

45409

Miami Valley Hospital, Dayton

45415

Miami Valley Hospital North, Dayton

45459

Miami Valley Hospital South, Centerville

46032

IU Health North Hospital, Carmel

46202

Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis

46526

Goshen Center for Cancer Care, Goshen

46601

Memorial Hospital of South Bend, South Bend

46845

Parkview Regional Medical Center, Fort Wayne

48109

University of Michigan Comprehensive Cancer Center, Ann Arbor

49007

Bronson Methodist Hospital, Kalamazoo

West Michigan Cancer Center, Kalamazoo

49009

Beacon Kalamazoo Cancer Center, Kalamazoo

49017

Bronson Battle Creek, Battle Creek

49085

Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph

Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph

49120

Corewell Health Lakeland Hospitals - Niles Hospital, Niles

49444

Trinity Health Muskegon Hospital, Muskegon

Cancer and Hematology Centers of Western Michigan - Norton Shores, Norton Shores

49503

Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids

Trinity Health Grand Rapids Hospital, Grand Rapids

49519

University of Michigan Health - West, Wyoming

49677

Corewell Health Reed City Hospital, Reed City

49684

Munson Medical Center, Traverse City

50023

UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny

50309

Iowa Methodist Medical Center, Des Moines

UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines

52242

University of Iowa/Holden Comprehensive Cancer Center, Iowa City

53226

Medical College of Wisconsin, Milwaukee

53718

University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison

53792

University of Wisconsin Carbone Cancer Center - University Hospital, Madison

55101

Regions Hospital, Saint Paul

55102

United Hospital, Saint Paul

55125

Minnesota Oncology Hematology PA-Woodbury, Woodbury

55407

Abbott-Northwestern Hospital, Minneapolis

55416

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55433

Mercy Hospital, Coon Rapids

55435

Fairview Southdale Hospital, Edina

55455

University of Minnesota/Masonic Cancer Center, Minneapolis

59101

Billings Clinic Cancer Center, Billings

59405

Benefis Sletten Cancer Institute, Great Falls

59711

Community Hospital of Anaconda, Anaconda

59715

Bozeman Health Deaconess Hospital, Bozeman

59804

Community Medical Center, Missoula

60030

Northwestern Medicine Grayslake Outpatient Center, Grayslake

60045

Northwestern Medicine Lake Forest Hospital, Lake Forest

60115

Northwestern Medicine Cancer Center Kishwaukee, DeKalb

60134

Northwestern Medicine Cancer Center Delnor, Geneva

60462

Northwestern Medicine Orland Park, Orland Park

60555

Northwestern Medicine Cancer Center Warrenville, Warrenville

60611

Northwestern University, Chicago

60612

University of Illinois, Chicago

61801

Carle Cancer Center, Urbana

61832

Carle at The Riverfront, Danville

61938

Carle Physician Group-Mattoon/Charleston, Mattoon

62269

Cancer Care Center of O'Fallon, O'Fallon

62401

Carle Physician Group-Effingham, Effingham

Crossroads Cancer Center, Effingham

62526

Cancer Care Specialists of Illinois - Decatur, Decatur

Decatur Memorial Hospital, Decatur

62702

Southern Illinois University School of Medicine, Springfield

Springfield Clinic, Springfield

62781

Springfield Memorial Hospital, Springfield

63128

Mercy Hospital South, St Louis

63141

Mercy Hospital Saint Louis, St Louis

64154

University of Kansas Cancer Center - North, Kansas City

65109

MU Health Care Goldschmidt Cancer Center, Jefferson City

65212

MU Health - University Hospital/Ellis Fischel Cancer Center, Columbia

65804

Mercy Hospital Springfield, Springfield

66160

University of Kansas Cancer Center, Kansas City

66205

University of Kansas Hospital-Westwood Cancer Center, Westwood

66211

University of Kansas Hospital-Indian Creek Campus, Overland Park

72703

Highlands Oncology Group - Fayetteville, Fayetteville

72758

Highlands Oncology Group - Rogers, Rogers

72762

Highlands Oncology Group, Springdale

73104

University of Oklahoma Health Sciences Center, Oklahoma City

74146

Oklahoma Cancer Specialists and Research Institute-Tulsa, Tulsa

75080

UT Southwestern Clinical Center at Richardson/Plano, Richardson

75235

Parkland Memorial Hospital, Dallas

75390

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

76104

UT Southwestern/Simmons Cancer Center-Fort Worth, Fort Worth

77030

M D Anderson Cancer Center, Houston

Memorial Hermann Texas Medical Center, Houston

80045

UCHealth University of Colorado Hospital, Aurora

83605

Saint Alphonsus Cancer Care Center-Caldwell, Caldwell

83619

Saint Luke's Cancer Institute - Fruitland, Fruitland

83642

Saint Luke's Cancer Institute - Meridian, Meridian

83687

Saint Alphonsus Cancer Care Center-Nampa, Nampa

Saint Luke's Cancer Institute - Nampa, Nampa

83706

Saint Alphonsus Cancer Care Center-Boise, Boise

83712

Saint Luke's Cancer Institute - Boise, Boise

83814

Kootenai Health - Coeur d'Alene, Coeur d'Alene

83854

Kootenai Clinic Cancer Services - Post Falls, Post Falls

83864

Kootenai Clinic Cancer Services - Sandpoint, Sandpoint

84112

Huntsman Cancer Institute/University of Utah, Salt Lake City

85719

Banner University Medical Center - Tucson, Tucson

University of Arizona Cancer Center-North Campus, Tucson

87106

University of New Mexico Cancer Center, Albuquerque

95817

University of California Davis Comprehensive Cancer Center, Sacramento

97213

Providence Portland Medical Center, Portland

97225

Providence Saint Vincent Medical Center, Portland

97914

Saint Alphonsus Cancer Care Center-Ontario, Ontario

98026

Swedish Cancer Institute-Edmonds, Edmonds

98029

Swedish Cancer Institute-Issaquah, Issaquah

98122

Swedish Medical Center-First Hill, Seattle

04330

Harold Alfond Center for Cancer Care, Augusta

04074

MaineHealth Maine Medical Center- Scarborough, Scarborough

20889-5600

Walter Reed National Military Medical Center, Bethesda

08103

Cooper Hospital University Medical Center, Camden

45005-1066

Atrium Medical Center-Middletown Regional Hospital, Franklin

02905

Women and Infants Hospital, Providence

77026-1967

Lyndon Baines Johnson General Hospital, Houston

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

NRG Oncology

OTHER

lead

National Cancer Institute (NCI)

NIH

NCT05538897 - Testing the Addition of the AKT Inhibitor, Ipatasertib, to Treatment With the Hormonal Agent Megestrol Acetate for Recurrent or Metastatic Endometrial Cancers | Biotech Hunter | Biotech Hunter