Effect of Single vs Multiple Prophylactic Antibiotic Doses on PJI Following Primary THA in Patients With a Fracture

NAActive, not recruitingINTERVENTIONAL
Enrollment

2,000

Participants

Timeline

Start Date

September 1, 2022

Primary Completion Date

April 1, 2025

Study Completion Date

April 1, 2025

Conditions
Fracture of HipTotal Hip ArthroplastyProsthetic-joint InfectionFracture Acetabular
Interventions
OTHER

Antibiotic dosage practice

"Patient inclusion starts day one, cross-over of departments from treatment A (single-dose) to B (multiple-dose) or vice versa after one year and end of inclusion happens after 2 years.~All centers in Denmark use either Cloxacillin/Dicloxacillin, Cefuroxime or both drugs as standard prophylactic antibiotic practice for THA. In cases of cephalosporin allergy or general beta lactam allergy, the antibiotic clindamycin may be administered.~In this trial, patients will be administered the standard prophylactic antibiotic practice of either single-dose (A) or multiple-doses (B) of antibiotics administered at each respective cluster that respective year. Both practices of dose administration for antibiotic prophylaxis (i.e. single- or multiple-dose) follow current standards of treatment and are based on present clinical practice guidelines."

Trial Locations (36)

2100

Adeas Private Hospital, Parken, Copenhagen Ø

2400

Department of Orthopedic Surgery and Traumatology, Bispebjerg, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen NV

2605

Capio Private Hospital, Gildhøj, Brøndby

2650

Department of Orthopedic Surgery, Hvidovre, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre

2730

Department of Orthopaedic Surgery, Herlev, Copenhagen University Hospital - Herlev and Gentofte, Herlev

2800

Acure Private Hospital, Kongens Lyngby

2860

Aleris Private Hospital, Søborg, Søborg

2900

Department of Orthopaedic Surgery, Gentofte, Copenhagen University Hospital - Herlev and Gentofte, Hellerup

3400

Department of Orthopedic Surgery, Hillerød, Copenhagen University Hospital - North Zealand, Hillerød

3520

CPH Private Hospital, Farum

3700

Department of Surgery, Copenhagen University Hospital - Bornholm, Rønne

4100

Aleris Private Hospital, Ringsted, Ringsted

4300

Department of Orthopedic Surgery, Copenhagen University Hospital - Holbæk, Holbæk

4600

Department of Orthopedic Surgery, Zealand University Hospital, Køge, Køge

4700

Department for Planned Orthopaedic Surgery, Næstved, Copenhagen University Hospital - Næstved, Slagelse and Ringsted, Næstved

4800

Department of Orthopedic Surgery, Copenahegn University Hospital - Nykøbing F., Nykøbing Falster

6340

Kollund Private Hospital, Kollund, Kruså

6700

Department of Orthopedic Surgery, Esbjerg, Hospital of South West Jutland, Esbjerg

7100

Department of Orthopedics, Lillebaelt Hospital, Vejle, Vejle

Mølholm Private Hospital, Vejle, Vejle

7200

Department of Orthopedic Surgery, Grindsted, Hospital of South West Jutland, Grindsted

7400

Department of Orthopedic Surgery, Gødstrup Regional Hospital, Herning

8000

Capio Private Hospital, Aarhus, Aarhus C

8200

Aleris Private Hospital, Aarhus, Aarhus

Deaprtment of Orthopaedic Surgery, Aarhus University Hospital, Aarhus

8600

Center for Planned Surgery, Silkeborg Regional Hospital, Silkeborg

8700

Department of Orthopedic Surgery, Horsens Regional Hospital, Denmark, Horsens

8800

Deparmtent of Orthopedic Sugery, Viborg Regional Hospital, Viborg

8930

Deparmtent of Orthopedic Surgery, Randers Regional Hospital, Randers

9000

Capio Private Hospital, Aalborg, Aalborg

Department of Orthopedic Surgery, Aalborg, Aalborg University Hospital, Aalborg

9640

Department of Orthopedic Surgery, Farsø, Aalborg University Hospital, Farsø

9900

Department of Orthopedic Surgery, Frederikshavn, Aalborg University Hospital, Frederikshavn

6200/6400

Department of Orthopedic Surgery, Aabenraa and Sønderborg, Hospital of Southern Jutland, Aabenraa

2900/5000

Capio Private Hospital, Hellerup and Odense, Hellerup

5000/5700

Department of Orthopedic Surgery and Traumatology, Odense University Hospital and Svendborg Hospital, Odense

All Listed Sponsors
collaborator

University of Copenhagen

OTHER

collaborator

University Hospital Bispebjerg and Frederiksberg

OTHER

collaborator

Odense University Hospital

OTHER

collaborator

Aarhus University Hospital

OTHER

collaborator

University of Aarhus

OTHER

collaborator

Sygehus Lillebaelt

OTHER

lead

Soren Overgaard

OTHER