NCT05528718View on ClinicalTrials.gov

SMILE Trial - Imaging Sub-Study

CompletedOBSERVATIONAL
Enrollment

11

Participants

Timeline

Start Date

March 7, 2023

Primary Completion Date

March 30, 2024

Study Completion Date

June 14, 2024

Conditions
Major Depressive Disorder
Interventions
DRUG

Nitrous oxide gas for inhalation

This sub-study does not have an intervention and based on the main study the participants who have received N2O will be compared with the midazolam placebo group.

DRUG

Midazolam injection

This sub-study does not have an intervention and based on the main study the participants who have received N2O will be compared with the midazolam placebo group.

Trial Locations (1)

M5B 1M8

St. Michael's Hospital, Toronto

All Listed Sponsors
lead

Unity Health Toronto

OTHER