Study of Early Stage Endometrial Cancer Based on Molecular Classification and Traditional Risk Stratification to Guide Adjuvant Radiotherapy Decisions

PHASE3Not yet recruitingINTERVENTIONAL
Enrollment

624

Participants

Timeline

Start Date

December 1, 2022

Primary Completion Date

December 1, 2026

Study Completion Date

June 30, 2027

Conditions
Endometrial CancerAdjuvant RadiotherapyMolecular Classification
Interventions
RADIATION

Vaginal brachytherapy

"High-dose rate vaginal brachytherapy (VBT) was delivered with a vaginal cylinder.For VBT administered alone, the dose is recommended: 3 fractions of 7 Gy or 5 fractions of 6 Gy or 6 fractions of 5 Gy.~For VBT administered after completion of EBRT: 2-3 fractions of 4-6 Gy."

RADIATION

Pelvic external beam radiotherapy

EBRT was delivered to the pelvic area using a total dose of 45-50.4Gy in 25-28 fractions over 5-6 weeks with the intensity-modulated radiotherapy (IMRT) technique, three-dimensional conformal radiotherapy (3D-CRT) modality

OTHER

Observation

No radiotherapy is administrated, but active follow-up and quality of life questionnaires is needed after surgery.

DRUG

Chemotherapy

Intravenous concurrent or sequential adjuvant chemotherapy consists of carboplatin/paclitaxel, cisplatin/doxorubicin or cisplatin/doxorubicin/paclitaxel, etc.

All Listed Sponsors
collaborator

The First Affiliated Hospital of Air Force Medicial University

OTHER

collaborator

The Second Affiliated Hospital of Dalian Medical University

OTHER

collaborator

The second hospital Affiliated by Jilin University

UNKNOWN

collaborator

First Affiliated Hospital Xi'an Jiaotong University

OTHER

collaborator

The Affiliated Hospital of Inner Mongolia Medical University

OTHER

collaborator

Third Affiliated Hospital of Xinjiang Medical University

OTHER

collaborator

Peking University First Hospital

OTHER

collaborator

940 Hospital of the People's Liberation Army Joint Logistic Support Force

OTHER

collaborator

Xiangya Hospital of Central South University

OTHER

collaborator

Cancer Institute and Hospital, Chinese Academy of Medical Sciences

OTHER

lead

Peking Union Medical College Hospital

OTHER

NCT05524389 - Study of Early Stage Endometrial Cancer Based on Molecular Classification and Traditional Risk Stratification to Guide Adjuvant Radiotherapy Decisions | Biotech Hunter | Biotech Hunter