The Maximizing Extubation Outcomes Through Educational and Organizational Research (METEOR) Trial

NAEnrolling by invitationINTERVENTIONAL
Enrollment

13,018

Participants

Timeline

Start Date

March 1, 2023

Primary Completion Date

January 31, 2026

Study Completion Date

April 30, 2026

Conditions
Acute Respiratory FailureAirway Extubation
Interventions
BEHAVIORAL

Traditional online education

A 30-60 minute, online, interactive, educational video that is customized to each provider type and offered with provider-specific continuing education credits

BEHAVIORAL

Interprofessional education

Interprofessional education (IPE) consists of both classroom-based IPE and just-in-time IPE. In classroom-based IPE, a trained physician educator with content expertise who works in the ICU leads a 60-to-90-minute, in-person, IPE workshop consisting of a 30-minute didactic session and a 30-to-60-minute small group session, during which participants work together to apply the content to authentic cases. The workshops, which are designed according to modern principles of adult learning and IPE, present the rationale and evidence supporting the preventive, post-extubation therapies. They are specifically designed to foster authenticity, reinforce role identity, and relate the content to life experience. In just-in-time IPE, trained local champions meet with the interprofessional ICU team each morning to identify eligible patients and, as needed, briefly review the evidence supporting proper use of the assigned preventive, post-extubation strategy.

BEHAVIORAL

Clinical protocol

"An adequately explicit protocol provides specific rules for use of the preventive, post-extubation therapy based on patient data. A ready-to-customize version of the protocol with instructions to work with key local stakeholders to revise the protocol, accounting for local needs and resources, is provided. After local customization, a local champion then disseminates the protocol based on local practices."

OTHER

Risk-stratified preventive post-extubation noninvasive ventilation (NIV) or high-flow nasal cannula oxygen (HFNC)

Preventive post-extubation NIV for high-risk patients and preventive post-extubation HFNC for low-risk patients

OTHER

Preventive post-extubation high-flow nasal cannula oxygen (HFNC)

Preventive post-extubation HFNC for all eligible patients (without risk stratification)

Trial Locations (15)

15146

UPMC East, Monroeville

15213

University of Pittsburgh, Pittsburgh

UPMC Magee-Womens Hospital, Pittsburgh

UPMC Presbyterian, Pittsburgh

15215

UPMC St. Margaret, Pittsburgh

15219

UPMC Mercy, Pittsburgh

15232

UPMC Shadyside, Pittsburgh

15237

UPMC Passavant, Pittsburgh

16105

UPMC Jameson, New Castle

17015

UPMC Carlisle, Carlisle

17050

UPMC West Shore, Mechanicsburg

17101

UPMC Harrisburg, Harrisburg

17109

UPMC Community Osteopathic, Harrisburg

17331

UPMC Hanover, Hanover

17408

UPMC Memorial, York

All Listed Sponsors
collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

lead

University of Pittsburgh

OTHER