Impact of First-trimester Preeclampsia Screening on Perinatal and Maternal Morbidity (RANSPRE)

NARecruitingINTERVENTIONAL
Enrollment

14,500

Participants

Timeline

Start Date

March 6, 2023

Primary Completion Date

October 31, 2025

Study Completion Date

March 6, 2026

Conditions
Preeclampsia (PE)
Interventions
PROCEDURE

First-trimester preeclampsia screening (FMF triple test)

"An algorithm assessing the risk of developing preeclampsia combining maternal parameters, blood pressure measurement, Doppler measurements of the uterine arteries and maternal PlGF concentrations.~For women in the screening group, a Doppler study of the uterine arteries and a blood test to quantify PlGF concentrations will be performed within 2 days of randomization, allowing the risk to be calculated according to the screening test. For women with a positive screening test (i.e. predicted risk\> 1/100), a treatment with aspirin will be prescribed at 160 mg/day, started as soon as possible and before 15 WG, and taken up to 36 WG, in the absence of contraindications. For women with negative screening, usual pregnancy monitoring without aspirin will be offered."

Trial Locations (22)

Unknown

RECRUITING

CHU Angers, Angers

RECRUITING

CHU de Bordeaux, Bordeaux

RECRUITING

Hôpital Femme Mère Enfant, Bron

RECRUITING

Hôpital Antoine Béclère, Clamart

RECRUITING

CHU Estaing, Clermont-Ferrand

RECRUITING

Hôpital Intercommunal Créteil, Créteil

RECRUITING

CHU Dijon Bourgogne, Dijon

RECRUITING

CHU Lille, Lille

RECRUITING

Hôpital de la conception et de la Timone, Marseille

RECRUITING

Hôpital Nord, Marseille

RECRUITING

CHRU de Nancy, Nancy

RECRUITING

Hôpital Femme - Maternité, Nantes

RECRUITING

Hôpital Armand Trousseau, Paris

RECRUITING

Hôpital Cochin (site Port-Royal), Paris

RECRUITING

Hôpital Saint-Joseph, Paris

RECRUITING

CHI de Poissy, Poissy

RECRUITING

Hôpital Sud Rennes, Rennes

RECRUITING

CHU Charles Nicolle, Rouen

RECRUITING

CHU Strasbourg, CMCO Schiltigheim, Strasbourg

RECRUITING

Hôpital de Hautepierre, Strasbourg

RECRUITING

Hôpital Paule de Viguier, Toulouse

RECRUITING

Hôpital Bretonneau, Tours

All Listed Sponsors
collaborator

URC-CIC Paris Descartes Necker Cochin

OTHER

collaborator

INSERM, Epopé team

UNKNOWN

lead

Assistance Publique - Hôpitaux de Paris

OTHER