A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)

PHASE3RecruitingINTERVENTIONAL
Enrollment

810

Participants

Timeline

Start Date

September 20, 2022

Primary Completion Date

November 3, 2025

Study Completion Date

November 30, 2033

Conditions
Relapsed or Refractory Multiple Myeloma
Interventions
DRUG

mezigdomide

Specified dose on specified days

DRUG

Pomalidomide

Specified dose on specified days

DRUG

Bortezomib

Specified dose on specified days

DRUG

Dexamethasone

Specified dose on specified days

Trial Locations (266)

0

RECRUITING

Centro de Investigaciones, Viña del Mar

RECRUITING

Liuzhou Worker's Hospital - Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou

RECRUITING

Erciyes Universitesi Tıp Fakultesi Hastaneleri, Kayseri

1023

RECRUITING

Auckland City Hospital, Auckland

1140

RECRUITING

Hanusch-Krankenhaus, Vienna

1160

RECRUITING

Klinik Ottakring, Vienna

1425

RECRUITING

Centro Medico Barrio Parque, Buenos Aires

2000

RECRUITING

Hospital Privado de Rosario, Rosario

2025

WITHDRAWN

Local Institution - 0334, Auckland

2030

RECRUITING

ZNA Cadix, Antwerp

2170

RECRUITING

Liverpool Hospital, Liverpool

2298

RECRUITING

Calvary Mater Newcastle, Waratah

2500

RECRUITING

Wollongong Hospital-Illawarra Cancer Care Centre, Wollongong

3000

RECRUITING

Clínica de Nefrología, Urología y Enfermedades Cardiovasculares, S3000epv

3004

RECRUITING

The Alfred Hospital, Melbourne

3065

RECRUITING

St Vincent's Hospital, Melbourne

3100

RECRUITING

Universitätsklinikum St. Pölten, Sankt Pölten

3112

RECRUITING

Tauranga Hospital, Tauranga

3128

RECRUITING

Box Hill Hospital, Box Hill

3500

RECRUITING

Universitätsklinikum Krems, Krems

3600

RECRUITING

Ziekenhuis Oost-Limburg, Campus St.-Jan, Genk

4575

RECRUITING

Sunshine Coast University Hospital, Birtinya

5016

RECRUITING

Hospital Privado Universitario de Córdoba, Córdoba

6009

RECRUITING

Sir Charles Gairdner Hospital, Nedlands

6620

RECRUITING

Sanatorio Chivilcoy, Chivilcoy

7580

RECRUITING

Haemalife, Kuilsriver

7800

NOT_YET_RECRUITING

Local Institution - 0406, Plumstead

7925

NOT_YET_RECRUITING

Local Institution - 0404, Cape Town

8700

RECRUITING

LKH Hochsteiermark - Standort Leoben, Leoben

9000

RECRUITING

UZ Gent, Ghent

9016

RECRUITING

Dunedin Hospital, Dunedin

10003

RECRUITING

Hospital San Pedro de Alcantara, Cáceres

10028

COMPLETED

Local Institution - 0371, New York

10469

COMPLETED

Local Institution - 0372, The Bronx

11042

RECRUITING

Northwell Health/ RJ Zuckerberg Cancer Center, Lake Success

COMPLETED

Local Institution - 0373, New Hyde Park

11967

RECRUITING

New York Cancer and Blood Specialists, Shirley

12808

RECRUITING

Vseobecna fakultni nemocnice v Praze, Prague

13620

WITHDRAWN

Local Institution - 0102, Seongnam

RECRUITING

Seoul National University Bundang Hospital, Seongnam

14215

WITHDRAWN

Local Institution - 0245, Buffalo

14221

WITHDRAWN

Local Institution - 0274, Williamsville

14621

RECRUITING

Rochester General Hospital, Rochester

17403

COMPLETED

Local Institution - 0264, York

18103

RECRUITING

Lehigh Valley Health Network, Allentown

20251

RECRUITING

Universitaetsklinikum Hamburg-Eppendorf, Hamburg

21215

RECRUITING

Sinai Hospital Of Baltimore, Baltimore

22408

RECRUITING

Hematology Oncology Associates of Fredericksburg, Fredericksburg

22763

RECRUITING

Asklepios Altona, Hamburg

23502

RECRUITING

Virginia Oncology Associates, Norfolk

24014

RECRUITING

Blue Ridge Cancer Care, Roanoke

24071

RECRUITING

Complejo Asistencial Universitario de León - Hospital de León, León

24105

RECRUITING

Universitaetsklinikum Schleswig-Holstein Campus Kiel, Kiel

27100

RECRUITING

Fondazione IRCCS Policlinico San Matteo, Pavia

27710

RECRUITING

Duke Cancer Institute, Durham

28041

RECRUITING

Hospital Universitario 12 de Octubre, Madrid

29603

RECRUITING

Hospital Costa del Sol, Marbella

WITHDRAWN

Local Institution - 0182, Marbella

30008

RECRUITING

Hospital General Universitario Morales Meseguer, Murcia

30029

RECRUITING

Centre Hospitalier Universitaire de Nîmes - Institut de Cancérologie du Gard - Hôpital Universitaire Carémeau, Nîmes

30060

WITHDRAWN

Local Institution - 0048, Marietta

30161

RECRUITING

Praxis Onkologie am Raschplatz, Hanover

30607

RECRUITING

University Cancer Blood Ctr, Athens

32500

RECRUITING

The First Affiliated Hospital of Wenzhou Medical University, Wenzhou

33321

RECRUITING

Advanced Research, Coral Springs

33401

RECRUITING

Florida Cancer Specialists - East, West Palm Beach

33600

RECRUITING

CHU Bordeaux Haut-Leveque, Pessac

33705

RECRUITING

Florida Cancer Specialists - North, St. Petersburg

33901

RECRUITING

Florida Cancer Specialists - South, Fort Myers

34093

RECRUITING

Istanbul University, Istanbul Faculty of Medicine, Istanbul

35033

RECRUITING

Universitätsklinikum Marburg, Marburg

35100

RECRUITING

Ege Universitesi Hastanesi, Izmir

37032

RECRUITING

Centre Hospitalier Régional Universitaire de Tours - Hôpital Bretonneau, Tours

38138

RECRUITING

The West Clinic, PLLC dba West Cancer Center, Germantown

39213

WITHDRAWN

Local Institution - 0242, Jackson

39401

RECRUITING

Hattiesburg Clinic Hematology/Oncology, Hattiesburg

40138

RECRUITING

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola, Bologna

40479

RECRUITING

Marien Hospital Düsseldorf, Düsseldorf

44093

RECRUITING

Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu, Nantes

44111

RECRUITING

Fairview Hospital, Cleveland

44124

RECRUITING

Cleveland Clinic - Hillcrest Hospital, Mayfield Heights

44195

RECRUITING

Cleveland Clinic, Cleveland

45242

RECRUITING

Oncology Hematology Care, Cincinnati

47014

RECRUITING

"IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) Dino Amadori", Meldola

48109

RECRUITING

University of Michigan, Ann Arbor

48202

RECRUITING

Henry Ford Hospital, Detroit

49100

RECRUITING

Rabin Medical Center, Peatch Tikva

49241

WITHDRAWN

Local Institution - 0106, Busan

RECRUITING

Pusan National University Hospital, Busan

52074

RECRUITING

Universitätsklinikum Aachen, Aachen

53127

RECRUITING

Universitätsklinikum Bonn, Bonn

53792

WITHDRAWN

Local Institution - 0220, Madison

55139

RECRUITING

Ondokuz Mayıs Universitesi, Samsun

55404

RECRUITING

Minnesota Oncology Hematology, P.A., Minneapolis

58128

RECRUITING

Chonnam National University Hwasun Hospital, Hwasun

WITHDRAWN

Local Institution - 0103, Hwasun

59000

RECRUITING

Hopital Claude Huriez - CHU de Lille, Lille

63100

RECRUITING

Centre Hospitalier Universitaire Estaing, Clermont-Ferrand

66205

RECRUITING

University of Kansas Medical Center, Westwood

67033

RECRUITING

Institut de cancérologie Strasbourg Europe (ICANS), Strasbourg

67846

COMPLETED

Local Institution - 0330, Garden City

69373

RECRUITING

Centre Leon Berard, Lyon Cedex08

70112

ACTIVE_NOT_RECRUITING

Local Institution - 0255, New Orleans

70210

RECRUITING

Kuopion Yliopistollinen Sairaala, Kuopio

70808

RECRUITING

Our Lady of the Lake RMC, Baton Rouge

71103

NOT_YET_RECRUITING

Local Institution - 0385, Shreveport

72076

RECRUITING

Universitaetsklinikum Tuebingen, Tübingen

75571

RECRUITING

Hôpital Saint Antoine, Paris

77030

RECRUITING

University of Texas MD Anderson Cancer Center, Houston

78229

RECRUITING

Mays Cancer Center, San Antonio

78240

RECRUITING

Texas Oncology - San Antonio, San Antonio

80045

NOT_YET_RECRUITING

Local Institution - 0381, Aurora

81675

RECRUITING

TUM Klinikum, München

83278

RECRUITING

Klinikum Traunstein, Traunstein

84106

RECRUITING

Utah Cancer Specialists, Salt Lake City

87042

RECRUITING

Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren, Limoges

87131

RECRUITING

University of New Mexico Comprehensive Cancer Center, Albuquerque

90069

COMPLETED

Local Institution - 0273, West Hollywood

90720

RECRUITING

Cancer and Blood Specialty Clinic, Los Alamitos

91220

RECRUITING

Hadassah Medical Center - Do Not Use - Duplicate Facility, Jerusalem

92123

RECRUITING

Sharp Memorial Hospital, San Diego

92367

RECRUITING

Medizinisches Versorgungszentrum, Weiden

95123

RECRUITING

"Policlinico G. Rodolico", Catania

96049

RECRUITING

Sozialstiftung Bamberg, Bamberg

97080

RECRUITING

Gemeinschaftspraxis Dres. med. Björn Schöttker & Dominik Pretscher, Würzburg

98108

RECRUITING

VA Puget Sound Health Care System, Seattle

98109

WITHDRAWN

Local Institution - 0293, Seattle

98684

RECRUITING

Northwest Cancer Specialists, P.C., Vancouver

99085

NOT_YET_RECRUITING

Local Institution - 0396, Erfurt

99208

WITHDRAWN

Local Institution - 0097, Spokane

100034

RECRUITING

Peking University First Hospital, Beijing

100043

RECRUITING

Beijing Chaoyang Hospital, Capital Medical University, Beijing

COMPLETED

Local Institution - 0165, Beijing

100091

COMPLETED

Local Institution - 0141, Beijing

110004

RECRUITING

Shengjing Hospital of China Medical University, Shenyang

122011

RECRUITING

Marengo Asia Hospitals Gurugram, Gurugram

141008

RECRUITING

Christian Medical College & Hospital, Ludhiana

200030

RECRUITING

Shanghai 6th people's hospital, Shanghai

200434

RECRUITING

Tongji University - Shanghai Fourth People's Hospital, Shanghai

210000

RECRUITING

Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School, Nanjing

214023

RECRUITING

Wuxi People's Hospital, Wuxi

221002

NOT_YET_RECRUITING

Local Institution - 0341, Varanasi

266000

RECRUITING

The Affiliated Hospital of Qingdao University, Qingdao

300060

RECRUITING

Tianjin Medical University Cancer Institute and Hospital, Tianjin

310003

WITHDRAWN

Local Institution - 0151, Hangzhou

315010

RECRUITING

Ningbo First Hospital, Ningbo

317000

RECRUITING

Taizhou Hospital of Zhejiang Province, Linhai

361003

RECRUITING

The First Affiliated hospital of Xiamen University, Xiamen

380060

RECRUITING

HCG Aastha Cancer Centre, Ahmedabad

400016

RECRUITING

The First Afffiliated Hospital of Chongqing Medical University, Chongqing

400036

RECRUITING

Mumbai Oncocare Centre - Nanachowk, Mumbai

400124

RECRUITING

Institutul Oncologic Cluj, Cluj-Napoca

410008

RECRUITING

Xiangya Hospital Central South University, Changsha

410013

RECRUITING

The Third Xiangya Hospital of Central South University, Changsha

430022

RECRUITING

Wuhan Union Hospital, Wuhan

450003

RECRUITING

People's Hospital of Henan Province, Zhengzhou

450008

RECRUITING

Henan Cancer Hospital, Guangzhou

471003

RECRUITING

The First Affiliated Hospital of Henan University of Science &Technology, Luoyang

510060

RECRUITING

Sun Yat-sen University Cancer Center, Guangzhou

510080

WITHDRAWN

Local Institution - 0168, Guangzhou

518039

RECRUITING

Shenzhen Second People's Hospital, Shenzhen

530007

RECRUITING

Guangxi Medical University No.1 Affiliated Hospital, Nanning

590010

RECRUITING

KLES Dr. Prabhakar Kore Hospital & M.R.C, Belagavi

605006

RECRUITING

Jawaharlal Institute Of Postgraduate Medical Education And Research, Puducherry

618000

NOT_YET_RECRUITING

Local Institution - 0356, Deyang

625107

RECRUITING

Meenakshi Mission Hospital and Research Centre, Madurai

650032

RECRUITING

First Affiliated Hospital of Kunming Medical University, Kunming

700483

RECRUITING

Institutul Regional de Oncologie Iasi, Iași

710004

RECRUITING

The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an

710126

COMPLETED

Local Institution - 0110, Xi'an

830001

NOT_YET_RECRUITING

Local Institution - 0353, Ürümqi

3109601

RECRUITING

Rambam Health Care Campus, Haifa

3113117

RECRUITING

Mito Medical Center, Higashiibaraki

4428164

RECRUITING

Meir Medical Center, Kfar Saba

5262100

RECRUITING

Sheba Medical Center, Ramat Gan

6423906

RECRUITING

Sourasky Medical Center, Tel Aviv

7580206

RECRUITING

Clínica Inmunocel, Santiago

8420383

RECRUITING

Bradfordhill, Santiago

22793080

RECRUITING

Americas Centro de Oncologia Integrado, Rio de Janeiro

06030

RECRUITING

UConn Health, Farmington

06510

WITHDRAWN

Local Institution - 0208, New Haven

02215

RECRUITING

Dana-Farber Cancer Institute, Boston

08816

RECRUITING

Astera Cancer Care, East Brunswick

07450

NOT_YET_RECRUITING

Local Institution - 0363, Ridgewood

79606-5208

RECRUITING

Texas Oncology - West Texas, Abilene

R8500ACE

RECRUITING

Clinica Viedma S. A, Viedma

CP1280AEB

RECRUITING

Hospital Británico de Buenos Aires, Buenos Aires

B-9100

RECRUITING

AZ Nikolaas, Sint-Niklaas

40301-155

RECRUITING

Instituto D'Or de Pesquisa e Ensino (IDOR) - Filial Salvador, Salvador

90110-270

RECRUITING

Centro Gaucho Integrado De Oncologia, Hematologia, Ensino E Pesquisa, Porto Alegre

89202-050

RECRUITING

Instituto Joinvilense de Hematologia e Oncologia, Joinville

17210-080

RECRUITING

Hospital Amaral Carvalho, Jaú

04537-080

RECRUITING

Clínica Médica São Germano S/S Ltda, São Paulo

05652-900

RECRUITING

Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein, São Paulo

J4V 2H1

RECRUITING

Centre Intégré de Santé et de Services Sociaux de la Montérégie-Centre, Greenfield Park

H4J 1C5

RECRUITING

Centre intégré universitaire de santé et de services sociaux du Nord-de-l'Île-de-Montréal (CIUSSS NÎM) - Hôpital du Sacré-Coeur, Montreal

G1J 1Z4

RECRUITING

Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus, Québec

050030

RECRUITING

The First Hospital of Hebei Medical University, Shijiazhuang

030001

RECRUITING

First Affiliated Hospital of Shanxi Medical University, Taiyuan

030032

RECRUITING

Shanxi Bethune Hospital, Taiyuan

625 00

RECRUITING

Fakultní nemocnice Brno Bohunice, Brno

100 34

RECRUITING

Fakultni nemocnice Kralovske Vinohrady, Prague

00029

RECRUITING

Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus), Helsinki

01307

RECRUITING

Gemeinschaftspraxis Hämatologie - Onkologie Freiberg-Richter, Jacobasch, Illmer, Wolf, Dresden

106 76

RECRUITING

Evangelismos General Hospital of Athens, Athens

115 28

RECRUITING

Alexandra General Hospital of Athens, Athens

570 10

RECRUITING

G. Papanikolaou General Hospital, Thessaloniki

H91 YR71

RECRUITING

University College Hospital - Galway, Galway

T12 E8YV

RECRUITING

Cork University Hospital, Cork

D08 E9P6

RECRUITING

St. James's Hospital, Dublin

V94 F858

WITHDRAWN

Local Institution - 0251, Limerick

00189

RECRUITING

Azienda Ospedaliera Sant'Andrea, Roma

277-8577

RECRUITING

National Cancer Center Hospital East, Kashiwa

806-8501

RECRUITING

Japan Community Healthcare Organization Kyushu Hospital, Kitakyushu-shi

003-0804

RECRUITING

National Hospital Organization Hokkaido Cancer Center, Sapporo

028-3695

RECRUITING

Iwate Medical University Hospital, Shiwa-gun Yahaba-cho

247-8533

RECRUITING

Shonan Kamakura General Hospital, Kamakura

350-0495

RECRUITING

Saitama Medical University Hospital, Iruma

343-8555

RECRUITING

Dokkyo Medical University Saitama Medical Center, Koshigaya

411-8777

RECRUITING

Shizuoka Cancer Center, Nagaizumi-cho,Sunto-gun

173-8610

RECRUITING

Nihon University Itabashi Hospital, Itabashiku

260-8677

RECRUITING

Chiba University Hospital, Chiba

810-8563

RECRUITING

National Hospital Organization Kyushu Medical Center, Fukuoka

815-8555

RECRUITING

Japanese Red Cross Fukuoka Hospital, Fukuoka

730-0052

RECRUITING

Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital, Hiroshima

860-8556

RECRUITING

Kumamoto University, Kumamoto

852-8104

RECRUITING

The Japanese Red Cross Nagasaki Genbaku Hospital, Nagasaki

105-8461

RECRUITING

The Jikei University Hospital, Tokyo

150-8935

RECRUITING

Japanese Red Cross Medical Center, Tokyo

60-185

WITHDRAWN

Local Institution - 0346, Skórzewo

87-100

RECRUITING

MICS Centrum Medyczne Torun, Torun

30-727

NOT_YET_RECRUITING

Local Institution - 0325, Krakow

02-776

RECRUITING

Instytut Hematologii i Transfuzjologii, Warsaw

76-200

COMPLETED

Local Institution - 0292, Słupsk

40-519

RECRUITING

Pratia Onkologia Katowice, Katowice

4710-243

RECRUITING

Hospital de Braga, Braga

1400-038

RECRUITING

Champalimaud Foundation, Lisbon

4200-072

RECRUITING

Instituto Português de Oncologia do Porto Francisco Gentil, EPE, Porto

00909

WITHDRAWN

Local Institution - 0355, San Juan

022328

RECRUITING

Fundeni Clinical Institute, Bucharest

0044

RECRUITING

Netcare Pretoria East Hospital, Centurion

03080

WITHDRAWN

Local Institution - 0101, Seoul

RECRUITING

Seoul National University Hospital, Seoul

06351

RECRUITING

Samsung Medical Center, Seoul

06591

WITHDRAWN

Local Institution - 0104, Seoul

RECRUITING

The Catholic Univ. of Korea Seoul St. Mary's Hospital, Seoul

05505

RECRUITING

Asan Medical Center, Seoul

WITHDRAWN

Local Institution - 0105, Seoul

03722

WITHDRAWN

Local Institution - 0100, Seoul

RECRUITING

Severance Hospital, Yonsei University Health System, Seoul

138-736

NOT_YET_RECRUITING

Local Institution, Seoul

07120

WITHDRAWN

Local Institution - 0183, Palma

RECRUITING

Hospital Universitari Son Espases, Palma

08036

RECRUITING

Hospital Clínic de Barcelona, Barcelona

WITHDRAWN

Local Institution - 0073, Barcelona

06620

RECRUITING

Ankara University Health Practice and Research Hospitals, Ankara

06680

RECRUITING

Liv Hospital Ankara, Ankara

CB2 0QQ

RECRUITING

Addenbrooke's Hospital, Cambridge

TR1 3LJ

RECRUITING

The Royal Cornwall Hospital, Truro

ML6 OJS

RECRUITING

Lanarkshire NHS Trust - Monklands Hospital, Airdrie

SE5 9RS

RECRUITING

King's College Hospital, London

LE1 5WW

RECRUITING

Leicester Royal Infirmary, Leicester

W12 0HS

RECRUITING

Hammersmith Hospital, London

EN5 3DJ

RECRUITING

Barnet Hospital, Barnet

NE7 7DN

RECRUITING

Freeman Hospital, Newcastle upon Tyne

ST4 6QG

RECRUITING

Royal Stoke University Hospital, Stoke-on-Trent

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Celgene

INDUSTRY

NCT05519085 - A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM) | Biotech Hunter | Biotech Hunter