Serotonin Release in Premotor and Motor PD

RecruitingOBSERVATIONAL
Enrollment

42

Participants

Timeline

Start Date

July 1, 2022

Primary Completion Date

June 30, 2026

Study Completion Date

June 30, 2026

Conditions
Parkinson DiseaseParkinson'sParkinson's DiseaseNeurodegenerative DiseasesNeurodegenerationPositron Emission Tomography
Interventions
OTHER

Positron Emission Tomography (PET) scan using CIMBI-36 tracer

This scan creates images of regional serotonin release in by using a tracer compound called CIMBI to highlight the brains capacity to release serotonin.

OTHER

Magnetic Resonance Imaging (MRI) Scan

MRI (magnetic resonance imaging) uses magnets alongside radio waves to create pictures of the brain

OTHER

Positron Emission Tomography (PET) scan using DASB tracer

To create images of the brain using a tracer called DASB, which is a highly selective for serotonin transporters, this highlights serotonin terminals and neurons in the brain.

OTHER

FP-CIT Single-photon Emission Computed Tomography (SPECT) scan

A single-photon emission computerized tomography (SPECT) scan allows analysis of brain function by creating 3D Pictures using compounds called tracers.

OTHER

Lumbar puncture

A lumbar puncture invovles a thin needle is inserted between the bones in your lower spine using local anaesthetic. This allows the collection of Cerebrospinal fluid ( CSF)

Trial Locations (1)

EX1 2LU

RECRUITING

University Of Exeter, Exeter

All Listed Sponsors
lead

University of Exeter

OTHER