Zibotentan and Dapagliflozin Combination, EvAluated in Liver Cirrhosis (ZEAL Study)

PHASE2TerminatedINTERVENTIONAL
Enrollment

205

Participants

Timeline

Start Date

October 31, 2022

Primary Completion Date

May 22, 2025

Study Completion Date

July 17, 2025

Conditions
Liver Cirrhosis
Interventions
DRUG

Part A: Placebo (matching zibotentan capsule & matching dapagliflozin tablet)

"placebo capsule (matching zibotentan capsule)~placebo tablet (matching dapagliflozin tablet)"

DRUG

Part A: zibotentan (dose B) + dapagliflozin

"zibotentan capsule~dapagliflozin tablet"

DRUG

Part B: Placebo (matching zibotentan capsule & matching dapagliflozin tablet)

"placebo capsule (matching zibotentan capsule)~placebo tablet (matching dapagliflozin tablet)"

DRUG

Part B: placebo (matching zibotentan capsule) + dapagliflozin

"placebo capsule (matching zibotentan capsule)~dapagliflozin tablet"

DRUG

Part B: zibotentan (dose A) + dapagliflozin

"zibotentan capsule~dapagliflozin tablet"

DRUG

Part B: zibotentan (dose B) + dapagliflozin

"zibotentan capsule~dapagliflozin tablet"

DRUG

Part B: zibotentan (dose C) + dapagliflozin

"zibotentan capsule~dapagliflozin tablet"

Trial Locations (50)

112

Research Site, Taipei

1090

Research Site, Vienna

2650

Research Site, Edegem

Research Site, Hvidovre

3010

Research Site, Bern

3084

Research Site, Heidelberg

4600

Research Site, Køge

6000

Research Site, Lucerne

6700

Research Site, Esbjerg

6900

Research Site, Lugano

8200

Research Site, Aarhus N

10002

Research Site, Taipei

10467

Research Site, The Bronx

22903

Research Site, Charlottesville

23249

Research Site, Richmond

28007

Research Site, Madrid

28034

Research Site, Madrid

28222

Research Site, Majadahonda

29425

Research Site, Charleston

31059

Research Site, Toulouse

35233

Research Site, Birmingham

39008

Research Site, Santander

48149

Research Site, Münster

49933

Research Site, Angers

53226

Research Site, Milwaukee

55131

Research Site, Mainz

55905

Research Site, Rochester

65189

Research Site, Wiesbaden

75246

Research Site, Dallas

75651

Research Site, Paris

84034

Research Site, Landshut

90048

Research Site, West Hollywood

91105

Research Site, Pasadena

92110

Research Site, Clichy

94115

Research Site, San Francisco

100057

Research Site, Beijing

310000

Research Site, Hangzhou

400162

Research Site, Cluj-Napoca

510515

Research Site, Guangzhou

610000

Research Site, Chengdu

128 00

Research Site, Prague

169 02

Research Site, Prague

01307

Research Site, Dresden

1081 HV

Research Site, Amsterdam

08035

Research Site, Barcelona

08036

Research Site, Barcelona

08041

Research Site, Barcelona

B9 5SS

Research Site, Birmingham

CB2 0XY

Research Site, Cambridge

SE5 9RS

Research Site, London

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AstraZeneca

INDUSTRY

NCT05516498 - Zibotentan and Dapagliflozin Combination, EvAluated in Liver Cirrhosis (ZEAL Study) | Biotech Hunter | Biotech Hunter