568
Participants
Start Date
August 29, 2022
Primary Completion Date
March 5, 2025
Study Completion Date
April 9, 2025
Semaglutide
Participants will receive once-weekly semaglutide s.c. for 40 weeks. Semaglutide 0.25 mg will be given at week 0 and then the dose will be escalated at weeks 4, 8 and 12 to 0.5 mg, 1 mg, 2 mg respectively.
Insuline glargine U100 (reduced)
Participants will receive insulin glargine U100 s.c. once-daily. Insulin glargine dose will be reduced by 10 U at initiation of semaglutide and then again at each semaglutide dose escalation up to 40 weeks. The dose will be adjusted based on the mean of three pre-breakfast SMPG values (target SMPG: 4.4-7.2 mmol/L).
Insuline glargine U100 (titrated)
Participants will receive titrated insulin glargine U100 s.c. once-daily up to 40 weeks. The dose will be adjusted based on the mean of three pre-breakfast SMPG values (target SMPG: 4.4-7.2 mmol/L).
Diabetes Care Centre & CDE Centre, Benoni
East Rand Physicians, Benoni
East Rand Physicians, Johannesburg
Centre for Diabetes, Johannesburg
Dr T Padayachee, eMkhomazi
Dr J Reddy, Durban
Dr Pillay's Rooms, Durban
"Laiko General Hospital of Athens", Athens
Alexandra General Hospital, Therapeutic Clinic, Athens
Albany Medical College - Endo, Albany
University Hospital of Athens ATTIKON, Athens
ResTrial s.r.o., Prague
Thomas Jefferson University, Philadelphia
Istituto Scientifico San Raffaele, Milan
Endo And Metab Cons, Rockville
Azienda Ospedaliera Papa Giovanni XXIII, Bergamo
ASST degli Spedali Civili di Brescia-Presidio Ospedaliero di Montichiari, Montichiari
Hospital Infanta Leonor, Madrid
Carteret Medical Group, Morehead City
Lucas Research Inc., Morehead City
Coastal Heritage Clinical Research, Hinesville
Northeast Res Inst. Inc., Jacksonville
Jacksonville Ctr For Clin Res, Jacksonville
Encore Medical Research LLC, Hollywood
Elite Research Center, Miami
Reyes Clinical Research, Inc, Miami
Renstar Medical Research, Ocala
Suncoast Clin Res Port Richey, New Port Richey
Suncoast Clinical Research, Inc._New Port Richey, New Port Richey
Holston Medical Group, Kingsport
Accellacare US Inc., d/b/a Accellacare of Knoxville, Knoxville
Hospital Infanta Luisa, Seville
Advanced Med Res Maumee, Maumee
University of Toledo Medical Center, Toledo
University of Toledo_Toledo, Toledo
Diab & Endo Assoc of Stark Co, Canton
Arcturus HC PLC Troy Med Res, Troy
Northern Pines Hlth Ctr, PC, Buckley
Iowa Diab & Endo Res Center, West Des Moines
Iowa Diab & Endo Res Center, West Des Moines
AHEPA General University Hospital, Thessaloniki
EUROMEDICA Gen Clinic The/ki, Endocrin,Metabolism,Diabetes, Thessaloniki
Ospedale Civile Campo di Marte, Lucca
"Thermi Private Hosital", Thessaloniki
Lillestol Research LLC, Fargo
Mercury Str Med Grp, PLLC, Butte
Cedar-Crosse Research Center, Chicago
Cotton O'Neil Diab & Endo Ctr, Topeka
University Hospital of Alexandroupolis, Alexandroupoli
Ileana J. Tandron, MD APMC (a private medical office), Slidell
Thyroid Endocrinology & Diabetes PA, Dallas
Velocity Clinical Res-Dallas, Dallas
Diabetes Glandular Diseases Clinic, San Antonio
Consano Clinical Research, LLC, Shavano Park
Diabetes Glandular Diseases Clinic, San Antonio
Amarillo Med Spec LLP, Amarillo
"A.O.U. Università Studi della Campania Luigi Vanvitelli", Napoli
"A.O.U. Università Studi della Campania Luigi Vanvitelli", Napoli
MediTask, s.r.o, Bratislava
Olympus Family Medicine, Salt Lake City
Chrysalis Clinical Research, St. George
Policlinico Mater Domini Università di Catanzaro, Catanzaro
Palm Research Center Inc-Vegas, Las Vegas
Velocity Clin Res Los Angeles, Los Angeles
San Fernando Valley Hlth Inst, LLC, Canoga Park
Valley Clinical Trials, Inc., Northridge
Wetlin Research Associates, Inc., San Diego
Loma Linda Univ Hlth Cr Endo, Loma Linda
Diabetologicka ambulancia DIA-MAX s.r.o., Levice
First Valley Medical Group, Lancaster
Valley Research, Fresno
DIA - CLARUS s.r.o., Bojnice
Novus Medical Clinica SRL, Ploieşti
Spitalul Judetean de Urgenta Targoviste, Târgovişte
Centrul Medical Sfantul Stefan, Timișoara
Medical Practice SRL, Oradea
SC Grand Med SRL, Oradea
CMI Dr Pop Lavinia, Baia Mare
Clinica Korall S.R.L. Satu Mare, Satu Mare
Centrul Medical de Diagnostic si Tratament Ambulatoriu Neomed, Brasov
SC Consultmed SRL, Iași
Clinic of Diabetes Constanta, Constanța
Joslin Diabetes Center, Boston
Southern New Hampshire Diabetes and Endocrinology, Nashua
Arlington Family Res. Ctr Inc, Arlington
EDUMED s.r.o. Nachod, Náchod
Diahelp - diabetologie, Pardubice
MUDr. Jitka Zemanova diabetologie a interna, Plzen - Vychodni Predmesti
Diabet2 s.r.o., Prague
MUDr. Michala Pelikanova, Prague
Alexandra General Hospital, Therapeutic Clinic, Athens
General Hospital of Nikaia, Nikaia
"Thermi Private Hosital", Thessaloniki
Ospedale Santa Maria Goretti - UOD Diabetologia, Latina
Azienda Ospedaliera di Perugia;Ospedale S. Maria della Misericordia, Perugia
Policlinico A. Gemelli, Rome
Unidade Local De Saude De Matosinhos E.P.E., Senhora Da Hora, Matosinhos
Unidade Local De Saude De Almada-Seixal E.P.E. - Hospital Garcia de Orta, Almada
Unidade de Local de Saúde de Braga, Braga
Unidade Local De Saude Do Oeste E.P.E., Caldas da Rainha
Unidade Local De Saude Da Regiao De Leiria E.P.E.- Hospital de Santo André, Leiria
Unidade Local de Saúde de São José EPE - Hospital Curry Cabral, Lisbon
Unidade Local De Saude De Lisboa Ocidental E.P.E. - Hospital Egas Moniz, Lisbon
Unidade Local de Saúde do Alto Minho E.P.E. - Viana do Castelo, Viana do Castelo
MEDISPEKTRUM s.r.o., Bratislava
IN-DIA s.r.o., Lučenec
FUNKYSTUFF s.r.o, Nové Zámky
Diakom, spol. s r.o., Poprad
DIALIPID, s.r.o., Prešov
Tatratrial s.r.o., Rožňava
BENROD s.r.o., Štúrovo
ABS La Roca del Vallés, La Roca Del Vallés
Hospital Son Espases, Palma de Mallorca
Lead Sponsor
Novo Nordisk A/S
INDUSTRY