A Study of Coformulated Favezelimab/Pembrolizumab (MK-4280A) Versus Physician's Choice Chemotherapy in PD-(L)1-refractory, Relapsed or Refractory Classical Hodgkin Lymphoma (MK-4280A-008)

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

203

Participants

Timeline

Start Date

October 18, 2022

Primary Completion Date

September 3, 2025

Study Completion Date

January 8, 2026

Conditions
Hodgkin Lymphoma
Interventions
BIOLOGICAL

favezelimab/pembrolizumab

Coformulated favezelimab/pembrolizumab (800 mg/200 mg), IV infusion

DRUG

bendamustine

IV infusion

DRUG

gemcitabine

IV infusion

Trial Locations (105)

3000

UZ Leuven-Hematology ( Site 0101), Leuven

3021

Western Health-Sunshine & Footscray Hospitals-Cancer Services-Cancer Research ( Site 0002), St Albans

4814

The Townsville Hospital ( Site 0006), Townsville

5000

Royal Adelaide Hospital ( Site 0005), Adelaide

5530

Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant-Godinne - Site Godi, Namur

6000

Royal Perth Hospital-Haematology ( Site 0004), Perth

6501

Ospedale Regionale Bellinzona e Valli-IOSI ( Site 1600), Bellinzona

14263

Roswell Park Cancer Institute ( Site 2220), Buffalo

15006

CHUAC-Complejo Hospitalario Universitario A Coruña ( Site 1812), A Coruña

15224

AHN West Penn Hospital ( Site 2213), Pittsburgh

15232

UPMC Hillman Cancer Center ( Site 2205), Pittsburgh

21201

University of Maryland-Greenebaum Comprehensive Cancer Center ( Site 2210), Baltimore

21231

Johns Hopkins University-The Sidney Kimmel Comprehensive Cancer Center ( Site 2206), Baltimore

22185

Skånes Universitetssjukhus Lund ( Site 1901), Lund

28041

Hospital Universitario 12 de Octubre-Hemathology and hemotherapy ( Site 1810), Madrid

29010

Hospital Universitario Virgen de la Victoria ( Site 1808), Málaga

31059

Institut Universitaire du Cancer Toulouse - Oncopole - CHU de TOULOUSE ( Site 0706), Toulouse

33612

Moffitt Cancer Center ( Site 2200), Tampa

34214

Mega Medipol-Hematology ( Site 2005), Stanbul

35016

Hospital Insular de Gran Canaria-Oncology ( Site 1807), Las Palmas de Gran Canaria

35033

Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou-haematology ( Site 0707), Rennes

35100

Ege Universitesi Hastanesi ( Site 2001), Izmir

37007

Hospital Universitario de Salamanca - Complejo Asistencial U-Servicio de Hematologia ( Site 1801), Salamanca

39008

Hospital Universitario Marqués de Valdecilla ( Site 1805), Santander

40536

University of Kentucky Chandler Medical Center ( Site 2201), Lexington

41380

Kocaeli Üniversitesi-Hematology ( Site 2009), Kocaeli

44106

University Hospitals Cleveland Medical Center ( Site 2214), Cleveland

44195

Cleveland Clinic-Taussig Cancer Center ( Site 2203), Cleveland

45147

Universitaetsklinikum Essen ( Site 0807), Essen

48109

University of Michigan ( Site 2215), Ann Arbor

48149

Universitätsklinikum Münster - Albert Schweitzer Campus ( Site 0806), Münster

49241

Pusan National University Hospital-Internal Medicine ( Site 1704), Busan

49503

Cancer and Hematology Centers of Western Michigan ( Site 2222), Grand Rapids

50937

Universitaetsklinikum Koeln-Klinik I für Innere Medizin ( Site 0801), Cologne

69008

CENTRE LEON BERARD-Medical oncology ( Site 0703), Lyon

70174

Klinikum Stuttgart - Katharinenhospital ( Site 0804), Stuttgart

72424

Unidad Médica Onco-hematológica ( Site 2507), Puebla City

85719

The University of Arizona Cancer Center - North Campus ( Site 2216), Tucson

87042

Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren ( Site 0704), Limoges

89081

Universitaetsklinikum Ulm-Department of Internal Medicine III ( Site 0805), Ulm

90404

UCLA Hematology/Oncology - Santa Monica ( Site 2208), Los Angeles

90502

Lundquist Institute for Biomedical Innovation at Harbor-UCLA-Hematology and Medical Oncology ( Site, Torrance

92210

Institut Curie - site Saint-Cloud ( Site 0708), Saint-Cloud

94000

HENRI MONDOR HOSPITAL ( Site 0702), Créteil

98109

Fred Hutchinson Cancer Center ( Site 2212), Seattle

100005

Beijing Hospital ( Site 0514), Beijing

100091

Peking University Third Hospital-Hematology ( Site 0519), Beijing

130021

The First Hospital of Jilin University-Hematology ( Site 0516), Changchun

200032

Fudan University Shanghai Cancer Center ( Site 0520), Shanghai

230031

Anhui Provincial Cancer Hospital ( Site 0501), Hefei

300060

Tianjin Medical University Cancer Institute & Hospital-lymphoma ( Site 0506), Tianjin

310022

Zhejiang Cancer Hospital ( Site 0510), Hangzhou

315010

Ningbo First Hospital ( Site 0518), Ningbo

361003

The First Affiliated hospital of Xiamen University ( Site 0512), Xiamen

410008

Xiangya Hospital Central South University ( Site 0513), Changsha

410013

Hunan Cancer Hospital ( Site 0503), Changsha

430010

Union Hospital Tongji Medical College Huazhong University of Science and Technology ( Site 0509), Wuhan

450008

Henan Cancer Hospital ( Site 0515), Zhengzhou

510060

Sun Yat-sen University Cancer Center ( Site 0500), Guangzhou

610041

West China Hospital of Sichuan University-Head and Neck Oncology ( Site 0502), Chengdu

3109601

Rambam Health Care Campus ( Site 1004), Haifa

3436212

Carmel Hospital ( Site 1007), Haifa

4910021

Rabin Medical Center-Hemato-Oncology ( Site 1001), Petah Tikva

5265601

Sheba Medical Center-Hemato Oncology ( Site 1005), Ramat Gan

6423906

Sourasky Medical Center ( Site 1002), Tel Aviv

7500921

FALP-UIDO ( Site 0400), Santiago

7580206

Clínica Inmunocel ( Site 0407), Santiago

9112001

Hadassah Medical Center-Hemato-Oncology ( Site 1000), Jerusalem

14784400

Fundação Pio XII - Hospital de Câncer de Barretos ( Site 0202), Barretos

08903

Rutgers Cancer Institute of New Jersey ( Site 2217), New Brunswick

C1118AAT

Hospital Aleman-oncohematologic diseases ( Site 2302), Buenos Aires

M5500AYB

Fundacion Centro Oncologico de Integración Regional-Medical Oncology ( Site 2301), Mendoza

01321-001

Hospital Paulistano-Americas Oncologia ( Site 0207), São Paulo

T6G 1Z2

Cross Cancer Institute ( Site 0313), Edmonton

M5G 2M9

Princess Margaret Cancer Centre ( Site 0310), Toronto

H3T 1E2

Jewish General Hospital ( Site 0309), Montreal

H4A 3J1

McGill University Health Centre ( Site 0314), Montreal

625 00

Fakultní nemocnice Brno Bohunice-Interni hematologicka a onkologicka klinika ( Site 0901), Brno

500 05

Fakultni nemocnice Hradec Kralove-IV. interni hematologicka klinika ( Site 0902), Hradec Králové

128 08

Vseobecna fakultni nemocnice v Praze-I. Interní klinika - klinika hematologie ( Site 0903), Prague

01307

Universitaetsklinikum Carl Gustav Carus Dresden-University Cancer Center Early Clinical Trial Unit (, Dresden

04103

Universitätsklinikum Leipzig ( Site 0803), Leipzig

03100

Centro de Infusion Superare ( Site 2503), Mexico City

31-826

Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie-Oncology Department ( Site 1406), Krakow

50-556

Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckieg-Klinika Hematologii, Nowotworów Krwi i, Wroclaw

02-781

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Kilinka Onkologii I Hematologii ( Site, Warsaw

80-214

Uniwersyteckie Centrum Kliniczne-Klinika Hematologii i Transplantologii ( Site 1402), Gdansk

25-734

Swietokrzyskie Centrum Onkologii, Samodzielny Publiczny Zakl-Klinika Hematologii i Transplantacji S, Kielce

03080

Seoul National University Hospital ( Site 1701), Seoul

03722

Severance Hospital, Yonsei University Health System-Medical oncology ( Site 1702), Seoul

05505

Asan Medical Center-Department of Oncology ( Site 1703), Seoul

06351

Samsung Medical Center ( Site 1700), Seoul

08035

Hospital Universitari Vall d'Hebron ( Site 1803), Barcelona

03010

Hospital General Universitario de Alicante ( Site 1806), Alicante

751 85

Akademiska sjukhuset-Blod- och tumörsjukdomar ( Site 1900), Uppsala

06100

Ankara Universitesi Tip Fakultesi Hastanesi-hematology ( Site 2000), Ankara

06230

Hacettepe Universite Hastaneleri-Department of Hematology ( Site 2006), Ankara

07100

Antalya Egitim ve Arastırma Hastanesi ( Site 2011), Antalya

Pl6 8DH

Derriford Hospital ( Site 2107), Plymouth

G12 0YN

The Beatson West of Scotland Cancer Centre ( Site 2110), Glasgow

EC1A 7BE

St Bartholomew's Hospital-Centre for Experimental Cancer Medicine ( Site 2105), London

OX4 6LB

GenesisCare - Oxford ( Site 2104), Oxford

LS9 7TF

St James's University Hospital ( Site 2109), Leeds

LE1 5WW

Leicester Royal Infirmary ( Site 2100), Leicester

L7 8YA

Clatterbridge Cancer Centre - Liverpool-Heamatology ( Site 2108), Liverpool

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY