A Study to Give Treatment Inside the Eye to Treat Retinoblastoma

PHASE2RecruitingINTERVENTIONAL
Enrollment

26

Participants

Timeline

Start Date

November 4, 2022

Primary Completion Date

December 31, 2026

Study Completion Date

December 31, 2026

Conditions
Bilateral RetinoblastomaChildhood Intraocular RetinoblastomaGroup D RetinoblastomaStage I RetinoblastomaUnilateral Retinoblastoma
Interventions
PROCEDURE

Biospecimen Collection

Undergo aqueous humor, tissue, and blood sample collection

DRUG

Carboplatin

Given IV

DRUG

Etoposide

Given IV

PROCEDURE

Examination Under Anesthesia

Undergo imaging of the eye during EUA

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

DRUG

Melphalan

Given I-VITRE

PROCEDURE

Ultrasound Biomicroscopy

Undergo UBM during EUA

DRUG

Vincristine

Given IV

Trial Locations (19)

6009

RECRUITING

Perth Children's Hospital, Perth

27710

RECRUITING

Duke University Medical Center, Durham

30329

RECRUITING

Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta

35233

RECRUITING

Children's Hospital of Alabama, Birmingham

38105

RECRUITING

Saint Jude Children's Research Hospital, Memphis

44195

RECRUITING

Cleveland Clinic Foundation, Cleveland

44308

RECRUITING

Children's Hospital Medical Center of Akron, Akron

48109

RECRUITING

C S Mott Children's Hospital, Ann Arbor

53226

RECRUITING

Children's Hospital of Wisconsin, Milwaukee

63110

RECRUITING

Washington University School of Medicine, St Louis

75390

RECRUITING

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

77030

RECRUITING

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston

RECRUITING

M D Anderson Cancer Center, Houston

78723

RECRUITING

Dell Children's Medical Center of Central Texas, Austin

80045

RECRUITING

Children's Hospital Colorado, Aurora

84113

RECRUITING

Primary Children's Hospital, Salt Lake City

90027

RECRUITING

Children's Hospital Los Angeles, Los Angeles

94304

RECRUITING

Lucile Packard Children's Hospital Stanford University, Palo Alto

H3T 1C5

RECRUITING

Centre Hospitalier Universitaire Sainte-Justine, Montreal

All Listed Sponsors
lead

Children's Oncology Group

NETWORK