A Study to Evaluate the Efficacy, Safety, Pharmacokinetics (PK), and Pharmacodynamics (PD) of Satralizumab in Participants With Anti-N-methyl-D-aspartic Acid Receptor (NMDAR) or Anti-leucine-rich Glioma-inactivated 1 (LGI1) Encephalitis

PHASE3RecruitingINTERVENTIONAL
Enrollment

152

Participants

Timeline

Start Date

September 27, 2022

Primary Completion Date

December 16, 2026

Study Completion Date

December 14, 2029

Conditions
NMDAR Autoimmune EncephalitisLGI1 Autoimmune Encephalitis
Interventions
DRUG

Satralizumab

In Part 1, study drug will be administered after all other study-related procedures have been performed at a site visit at Weeks 0, 2, 4, and every 4 weeks (Q4W) thereafter. Participants will receive satralizumab according to body weight. Study drug will be administered by subcutaneous (SC) injection in the abdominal or femoral region after all other study-related procedures have been performed at a site visit. In Part 2, participants will be asked to choose from one of the following options: Option 1: continue on randomized, double-blind study drug; Option 2: start open-label satralizumab based on body weight; Option 3: stop study treatment and continue follow-up assessments.

OTHER

Placebo

Satralizumab placebo prefilled syringe (PFS) is identical in composition to satralizumab PFS, but does not contain the satralizumab active ingredient and will be identical in appearance and packaging to satralizumab. A PFS (assembled with an needle safety device \[NSD\] and extended finger flange) filled with 0.5 milliliters (mL) of solution, corresponding to 60 milligrams (mg) satralizumab, may be used in Part 2 once it becomes available at the study site.

Trial Locations (87)

333

RECRUITING

Chang Gung Memorial Hospital - Linkou, Taoyuan

1090

WITHDRAWN

Medizinische Universität Wien, Vienna

4020

RECRUITING

Kepler Universitätsklinikum GmbH - Neuromed Campus, Linz

5000

RECRUITING

Odense Universitetshospital, Neurologisk Afdeling N, Odense C

10016

RECRUITING

NYU-Langone Medical Center, New York

16132

RECRUITING

Irccs A.O.U.San Martino Ist, Genoa

19104

RECRUITING

Univ of Pennsylvania Med Ctr, Philadelphia

20132

RECRUITING

IRCCS Ospedale San Raffaele, Milan

20133

RECRUITING

Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan

21201

RECRUITING

University of Maryland Medical Center, Baltimore

21205

RECRUITING

Johns Hopkins Hospital, Baltimore

27100

RECRUITING

Fondazione Istituto Neurologico Mondino IRCCS, Pavia

28007

RECRUITING

Hospital General Universitario Gregorio Marañon, Madrid

29010

RECRUITING

Hospital Regional Universitario de Malaga ? Hospital General, Málaga

35233

RECRUITING

University of Alabama at Birmingham, Birmingham

37000

RECRUITING

CHRU - Hôpital Bretonneau, Tours

40402

RECRUITING

China Medical University Hospital, North Dist.

42055

RECRUITING

CHU Saint Etienne - Hôpital Nord, Saint-Etienne

44106

RECRUITING

University Hospitals of Cleveland, Cleveland

44915

RECRUITING

Cleveland Clinic Foundation, Cleveland

52242

RECRUITING

University of Iowa Hospitals & Clinics, Iowa City

53226

RECRUITING

Medical College of Wisconsin, Milwaukee

55905

RECRUITING

Mayo Clinic - Rochester, Rochester

69677

ACTIVE_NOT_RECRUITING

Hopital neurologique Pierre Wertheimer - CHU Lyon, Bron

75651

RECRUITING

Hopital Pitié Salpétrière - CHU, Paris

77030

RECRUITING

University of Texas at Houston, Houston

80045

RECRUITING

University of Colorado, Aurora

80131

RECRUITING

A. O. U. Federico II, Napoli

80138

RECRUITING

AOU Seconda Università degli Studi, Napoli

90129

RECRUITING

AOU Policlinico Giaccone, Palermo

92037

RECRUITING

UC San Diego, La Jolla

92658

RECRUITING

Hoag Memorial Hospital, Newport Beach

94158

RECRUITING

UCSF- Multiple Sclerosis Centre, San Francisco

98122

WITHDRAWN

Swedish Neuroscience Institute, Seattle

100045

RECRUITING

Beijing Children's Hospital, Capital Medical University, Beijing

100730

RECRUITING

Beijing Tongren Hospital, Beijing

119074

RECRUITING

National University Hospital (NUH), Singapore

130021

RECRUITING

The First Hospital of Jilin University, Changchun

200040

RECRUITING

Huashan Hospital, Fudan University, Shanghai

272029

RECRUITING

Affiliated Hospital of Jining Medical University, Jining

325035

ACTIVE_NOT_RECRUITING

The First Affiliated Hospital of Wenzhou Medical University, Wenzhou

350001

RECRUITING

Fujian Medical University Union Hospital, Fuzhou

410011

RECRUITING

The Second Xiangya Hospital of Central South University, Changsha

430030

RECRUITING

Tongji Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan

510180

RECRUITING

Guangzhou First Municipal People's Hospital, Guangzhou

610047

RECRUITING

West China Hospital - Sichuan University, Chengdu

6500047

RECRUITING

Hyogo prefectural Kobe Children's Hospital, Hyogoken

02115

RECRUITING

Brigham and Women's Hospital Department of Neurology, Boston

C1221ADC

ACTIVE_NOT_RECRUITING

Hospital Ramos Mejía, CABA

C1280AEB

RECRUITING

Hospital Britanico, Ciudad Autonoma Bs As

T4000IDK

RECRUITING

Sanatorio del Sur S.A., San Miguel de Tucumán

60175-295

RECRUITING

Hospital Geral de Fortaleza, Fortaleza

29055-450

RECRUITING

CEDOES - Diagnóstico e Pesquisa, Vitória

81210-310

RECRUITING

Instituto de Neurologia de Curitiba, Curitiba

01228-200

ACTIVE_NOT_RECRUITING

Centro de Pesquisas Clinicas, São Paulo

05652-000

RECRUITING

Hospital Israelita Albert Einstein, São Paulo

Unknown

RECRUITING

Beijing Tiantan Hospital,Capital Medical University, Beijing

RECRUITING

Komfo Anokye Teaching Hospital, Kumasi

030001

RECRUITING

The First Hospital of Shanxi Medical University, Taiyuan

500 05

RECRUITING

Fakultni nemocnice Hradec Kralove, Hradec Králové

150 06

RECRUITING

Fakultni nemocnice v Motole, Prague

00165

WITHDRAWN

Ospedale Pediatrico Bambino Gesù, Rome

470-1192

RECRUITING

Fujita Health University Hospital, Aichi

260-8677

ACTIVE_NOT_RECRUITING

Chiba University Hospital, Chiba

812-8582

ACTIVE_NOT_RECRUITING

Kyushu University Hospital, Fukuoka

814-0180

RECRUITING

Fukuoka University Hospital, Fukuoka

501-1194

ACTIVE_NOT_RECRUITING

Gifu University Hospital, Gifu

060-8648

ACTIVE_NOT_RECRUITING

Hokkaido University Hospital, Hokkaido

650-0017

RECRUITING

Kobe University Hospital, Hyōgo

890-8760

RECRUITING

Kagoshima City Hospital, Kagoshima

216-8511

COMPLETED

St.Marianna University School of Medicine hospital, Kanagawa

252-0375

ACTIVE_NOT_RECRUITING

Kitasato University Hospital, Kanagawa

259-1193

RECRUITING

Tokai University Hospital, Kanagawa

980-8574

RECRUITING

Tohoku University Hospital, Miyagi

565-0871

RECRUITING

The University of Osaka Hospital, Osaka

589-8511

RECRUITING

Kindai University Hospital, Ōsaka-sayama

362-8588

RECRUITING

Ageo Central General Hospital, Saitama

113-8431

RECRUITING

Juntendo University Hospital, Tokyo

173-8610

ACTIVE_NOT_RECRUITING

Nihon University Itabashi Hospital, Tokyo

3015 GD

RECRUITING

Erasmus MC, Rotterdam

86-300

WITHDRAWN

Regionalny Szpital Specjalistyczny im. W. Bieganskiego, Grudzi?dz

30-688

COMPLETED

Szpital Uniwersytecki w Krakowie, Krakow

02-957

RECRUITING

Instytut Psychiatrii i Neurologii II Klinika Neurologiczna, Warsaw

41-800

RECRUITING

SPSK nr 1, Zabrze

03080

RECRUITING

Seoul National University Hospital, Seoul

DUMMY_VALUE

RECRUITING

Hospital Alvaro Cunqueiro, Vigo

00833

RECRUITING

Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Chugai Pharmaceutical

INDUSTRY

lead

Hoffmann-La Roche

INDUSTRY