Effect of Propofol and Desflurane on Nucleic Acid of Liver Circulating Tumor

PHASE2CompletedINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

December 1, 2020

Primary Completion Date

August 8, 2022

Study Completion Date

August 8, 2022

Conditions
Hepatocellular CarcinomaDesflurane Adverse ReactionPropofol Adverse ReactionCirculating Tumor Cells
Interventions
DRUG

Desflurane

Propofol general anesthesia group (P group) : intravenous propofol infusion was slowly pushed until consciousness disappeared, and then anesthesia was maintained at 4-8 mg/kg/h. In the general anesthesia group with desflurane (group D), intravenous propofol infusion was slowly pushed until consciousness disappeared, and then anesthesia was maintained with 4-6% desflurane. The analgesic and muscle relaxant regimens were the same in both groups except for sedative drugs. All patients were treated with no medication before operation, and the operation was completed under endotracheal intubation and general anesthesia. The amount of propofol or desflurane was adjusted according to BIS or MAC values and hemodynamic changes during operation. Add 10mg of rocuronium every half hour. Vasoactive drugs can be used to maintain hemodynamic stability during the operation, and corresponding records should be made

DRUG

Propofol

Propofol general anesthesia group (P group) : intravenous propofol infusion was slowly pushed until consciousness disappeared, and then anesthesia was maintained at 4-8 mg/kg/h.

Trial Locations (1)

310022

Zhejiang Cancer hospital, Hangzhou

All Listed Sponsors
lead

Zhejiang Cancer Hospital

OTHER

NCT05502458 - Effect of Propofol and Desflurane on Nucleic Acid of Liver Circulating Tumor | Biotech Hunter | Biotech Hunter