Study to Compare Bictegravir/Lenacapavir Versus Current Therapy in People With HIV-1 Who Are Successfully Treated With a Complicated Regimen

PHASE2/PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

689

Participants

Timeline

Start Date

August 16, 2022

Primary Completion Date

September 29, 2025

Study Completion Date

July 31, 2028

Conditions
HIV-1-infection
Interventions
DRUG

Bictegravir

Tablets administered orally without regard to food

DRUG

Lenacapavir

Tablets administered orally without regard to food

DRUG

BIC/LEN FDC

Tablets administered orally without regard to food

DRUG

Stable Baseline Regimen

"SBR will include a combination of antiretroviral (ARV) regimen. ARV regimen may include the following, except for participants taking a single tablet regimen or taking a complete parenteral regimen (Cabenuva).~* Nucleos(t)ide Reverse Transcriptase Inhibitors:~ * Abacavir~ * Emtricitabine~ * Lamivudine~ * Tenofovir alafenamide~ * Tenofovir disoproxil fumarate~ * Zidovudine~* Non-Nucleosite Reverse Transcriptase Inhibitors:~ * Delavirdine~ * Efavirenz~ * Nevirapine~ * Rilpivirine~ * Doravirine~* Integrase Inhibitors:~ * Bictegravir~ * Cabotegravir~ * Dolutegravir~ * Elvitegravir~ * Raltegravir~* Protease Inhibitors:~ * Atazanavir~ * Darunavir~ * Fosamprenavir~ * Indinavir~ * Lopinavir~ * Nelfinavir~ * Saquinavir~ * Tipranavir~* Chemokine Co-receptor 5 (CCR5) Antagonist:~ * Maraviroc~* Fusion Inhibitors:~ * Enfuvirtide~* gp120 Attachment Inhibitor:~ * Fostemsavir~* Anti-CD4 Monoclonal Antibodies:~ * Ibalizumab-uiyk"

Trial Locations (94)

208

Sefako Makgatho Health Sciences University, Ga-Rankuwa

1072

Hospital General de Agudos J.M Ramon Mejia, Buenos Aires

1202

Fundación Huésped, Buenos Aires

1425

Helios Salud, Buenos Aires

2010

St.Vincent's Hospital Sydney, Darlinghurst

Holdsworth House Medical Practice, Sydney

2011

Taylor Square Private Clinic, Darlinghurst

2193

Ezintsha, Johannesburg

3004

Alfred Health, Melbourne

4103

Hospital Universitario Virgen del Rocio, Seville

6202

CHU Nice-Hôpital l'Archet, Nice

7925

Desmond Tutu Health Foundation Clinical Trials Unit, Cape Town

10001

Ricky K. Hsu, MD, PC, New York

10149

ASL Città di Torino, Torino

10439

zibp Zentrum für Infektiologie Berlin Prenzlauer Berg GmbH, Berlin

11355

New York Presbyterian Hospital, Flushing

19107

Philadelphia FIGHT, Philadelphia

20127

IRCCS Ospedale San Raffaele, Milan

20146

ICH Study Center GmbH & Co. KG, Hamburg

20157

ASST Fatebenefratelli Sacco, Milan

22060

Far Eastern Memorial Hospital, New Taipei City

27514

University of North Carolina - Chapel Hill, Chapel Hill

27858

East Carolina University, Greenville

28034

Hospital Ramon y Cajal, Madrid, Madrid

28040

Hospital Clinico San Carlos, Madrid

28046

Hospital Universitario La Paz, Madrid

29425

Medical University of South Carolina (MUSC) Research NEXUS, Charleston

30309

Atlanta ID Group, Atlanta

31201

Mercer University School of Medicine, Macon

32720

Midland Florida Clinical Research Center, LLC, DeLand

32803

Orlando Immunology Center, Orlando

Therapeutic Concepts, PA, Orlando

33004

Taoyuan General Hospital, Taoyuan

33016

Floridian Clinical Research, Miami Lakes

33136

Schiff Center for liver Diseases/University of Miami, Miami

33308

Therafirst Medical Centers, Fort Lauderdale

33316

Gary Richmond, MD, PA, Inc., Fort Lauderdale

33407

Triple O Research Institute PA, West Palm Beach

34982

Midway Immunology & Research Center, LLC, Ft. Pierce

35015

Chungnam National University Hospital, Daejeon

40124

Azienda Ospedaliero-Universitaria di Modena, Modena

41944

Kyungpook National University Hospital, Daegu

48072

Be Well Medical Center, Berkeley

53127

Universitatsklinikum Bonn, Bonn

60596

Infektio Research GmbH & Co.KG, Frankfurt

60613

Howard Brown Health Center, Chicago

63139

Southampton Healthcare, Inc., St Louis

64111

Kansas City Care Clinic, Kansas City

75010

Hospital Saint Louis, Paris

75018

Groupe Hospitalier Bichat Claude Bernard, Paris

75208

AIDS Arms, Inc., DBA Prism Health North Texas, Dallas

75246

North Texas Infectious Diseases Consultants, Dallas

75605

Diagnostic Clinic of Longview - Center for Clinical Research, Longview

75651

Höpital de la Pitié Salpêtrière, Paris

76104

Texas Centers for Infectious Disease Associates, Fort Worth

77098

Gordon E. Crofoot MD PA, Houston

77401

St. Hope Foundation, Bellaire

78705

Central Texas Clinical Research, Austin

80204

Denver Health Medical Center, Denver

80756

Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City

81362

Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City

87505

AXCES Research Group, Santa Fe

90036

Ruane Clinical Research Group, Inc, Los Angeles

90046

The Men's Health Foundation, West Hollywood

90211

Pacific Oaks Medical Group, Beverly Hills

90502

Lundquist Institute for Biomedical Innovation at Harbor - UCLA Medical Center, Torrance

92103

University of California San Diego (UCSD), San Diego

92262

Bios Clinical Research, Palm Springs

94609

Alta Bates Summit Medical Center, Summit Campus, East Bay Advanced Care, Oakland

98104

Peter Shalit, MD, Seattle

06510

Yale University; School of Medicine; AIDS Program, New Haven

07102

Saint Michael's Medical Center, Newark

H4A 3J1

Chronic Viral Illness Service / McGill University Health Centre (MUHC), Decarie Montreal

H2L 0B1

Clinique Medicale du Quartier Latin, Montreal

K1H 8L6

The Ottawa Hospital - General Campus, Ottawa

S4P 0W5

ID Clinic, Regina

M5G 1K2

Maple Leaf Research, Toronto

V6Z 2T1

Spectrum Health, Vancouver

Unknown

Instituto Dominicano de Estudio Virologicos - IDEV, Santo Domingo

MVZ München am Goetheplatz, München

National Hospital Organization Nagoya Medical Center, Nagoya

00149

"Istituto Nazionale Malattie Infettive Lazzaro Spallanzani IRCCS", Roma

540-0006

National Hospital Organization Osaka National Hospital, Osaka

162-0052

Center Hospital of the National Center for Global Health and Medicine, Tokyo

00909

Hope Clinical Research, San Juan

00935

Proyecto ACTU, San Juan

03722

Yonsei University Severance Hospital, Seoul

06591

The Catholic University of Korea Seoul St. Mary's Hospital, Seoul

08036

Hospital Clinic Provincial de Barcelona, Barcelona

B9 5SS

Department of HIV & Sexual Medicine, Birmingham

BN2 3EW

Brighton and Sussex University Hospitals NHS Trust, Brighton

E1 1BB.

Barts Health NHS Trust, London

SE5 9RS

HIV medicine and infectious diseases, London

SW109NH

St.Stephen's AIDS Trust, Clinical Trials Unit, 1st Floor, St.Stephen's Centre, London

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Gilead Sciences

INDUSTRY

NCT05502341 - Study to Compare Bictegravir/Lenacapavir Versus Current Therapy in People With HIV-1 Who Are Successfully Treated With a Complicated Regimen | Biotech Hunter | Biotech Hunter