Gedatolisib Plus Fulvestrant With or Without Palbociclib vs Standard-of-Care for the Treatment of Patients With Advanced or Metastatic HR+/HER2- Breast Cancer (VIKTORIA-1)

PHASE3RecruitingINTERVENTIONAL
Enrollment

701

Participants

Timeline

Start Date

December 8, 2022

Primary Completion Date

June 30, 2025

Study Completion Date

December 31, 2026

Conditions
Breast Cancer
Interventions
DRUG

Gedatolisib

Gedatolisib 180 mg IV given weekly for 3 weeks (Days 1, 8, 15) followed by 1 week off

DRUG

Palbociclib

Palbociclib 125 mg PO given daily for 3 weeks (21 days), followed by 1 week off

DRUG

Fulvestrant

Fulvestrant 500 mg IM (2 × 5 mL injections) given every 2 weeks during Cycle 1 (Days 1 and 15), then every 4 weeks beginning with Cycle 2 Day 1

DRUG

Alpelisib

Alpelisib 300 mg PO (2 × 150 mg tablets) given daily for 4 weeks (28 days)

Trial Locations (217)

10021

RECRUITING

Weill Cornell Medicine/New York-Presbyterian Hospital, New York

10467

RECRUITING

Montefiore Medical Center, The Bronx

10601

RECRUITING

White Plains Hospital, White Plains

11432

RECRUITING

Queens Hospital Cancer Center, Jamaica

12206

RECRUITING

New York Oncology Hematology, P.C. - Albany, Albany

13057

RECRUITING

Hematology/Oncology Associates of Central New York, Syracuse

14076

RECRUITING

Francois Baclesse Center, Caen

14642

NOT_YET_RECRUITING

University of Rochester Medical Center, Rochester

17403

COMPLETED

Cancer Care Associates of York, York

19008

COMPLETED

Consultants In Medical Oncology and Hematology, P.C., Broomall

19044

RECRUITING

Alliance Cancer Specialists PC, Horsham

20850

RECRUITING

Maryland Oncology Hematology, P.A. - Rockville, Rockville

22060

RECRUITING

Fort Belvoir Community Hospital, Fort Belvoir

23114

RECRUITING

Bon Secours St. Francis Medical Oncology Center, Midlothian

23219

RECRUITING

VCU Massey Cancer Center, Richmond

23502

RECRUITING

Virginia Oncology Associates - Newport News, Newport News

24014

RECRUITING

Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care - Roanoke, Roanoke

27403

RECRUITING

Cone Health Cancer Center at Alamance Regional, Hematology/Oncology, Greensboro

28359

RECRUITING

Southeast Regional Cancer Center, Lumberton

31792

RECRUITING

John D. Archbold Memorial Hospital, Thomasville

32256

RECRUITING

Cancer Specialists of North Florida - Jacksonville, Jacksonville

33021

RECRUITING

South Broward Hospital District d/b/a Memorial Healthcare System, Hollywood

33612

RECRUITING

H. Lee Moffitt Cancer Center & Research Institute, Tampa

33881

COMPLETED

Bond & Steele Clinic, P.A. d/b/a Bond Clinic, P.A., Winter Haven

35294

RECRUITING

University of Alabama at Birmingham, Birmingham

42003

RECRUITING

Mercy Health - Paducah, Paducah

43210

RECRUITING

The James Cancer Hospital and Solove Research Institute, Columbus

46845

RECRUITING

Fort Wayne Medical Oncology and Hematology, Fort Wayne

48202

RECRUITING

Henry Ford Hospital, Detroit

57104

RECRUITING

Sanford Gynecologic Oncology Clinic, Sioux Falls

60005

RECRUITING

Illinois Cancer Specialists - Arlington Heights, Arlington Heights

64460

RECRUITING

Filios High Medicine, Monterrey

68130

RECRUITING

Oncology Hematology West PC dba Nebraska Cancer Specialists, Omaha

68198

COMPLETED

University of Nebraska Medical Center, Omaha

68506

RECRUITING

Nebraska Hematology - Oncology, P.C., Lincoln

72205

RECRUITING

CARTI Cancer Center, Little Rock

72401

RECRUITING

St. Bernards Medical Center, Jonesboro

73104

RECRUITING

OU Health Stephenson Cancer Center, Oklahoma City

75071

COMPLETED

Texas Oncology - McKinney, McKinney

75230

COMPLETED

Texas Oncology P.A. - Dallas, Dallas

75246

RECRUITING

Texas Oncology - Baylor Charles A. Sammons Cancer Center, Dallas

75702

RECRUITING

Texas Oncology - Tyler, Tyler

77030

RECRUITING

Oncology Consultants, Houston

RECRUITING

University of Texas MD Anderson Cancer Center, Houston

77479

RECRUITING

Texas Oncology - Gulf Coast, Sugar Land

78234

RECRUITING

Brooke Army Medical Center, Houston

78745

RECRUITING

Texas Oncology - Austin, Austin

79920

RECRUITING

William Beaumont Army Medical Center, El Paso

85395

COMPLETED

Arizona Oncology (US Oncology/McKesson) - Goodyear, Goodyear

85925

RECRUITING

La Roche-sur-Yon Hospital, La Roche-sur-Yon

90505

RECRUITING

Torrance Memorial Physician Network - Cancer Care, Torrance

90710

COMPLETED

Kaiser Permanente South Bay Medical Center, Harbor City

90720

RECRUITING

Cancer and Blood Specialty Clinic, Los Alamitos

90904

RECRUITING

UCLA Hematology/Oncology-Santa Monica, Santa Monica

92373

RECRUITING

Redlands Hematology Oncology, Redlands

92801

COMPLETED

Pacific Cancer Medical Center Inc, Anaheim

92868

RECRUITING

University of California, Irvine Medical Center, Orange

93030

COMPLETED

Ventura County Hematology Oncology Specialists, Oxnard

93940

RECRUITING

Pacific Cancer Care, Monterey

94589

RECRUITING

Kaiser Permanente Medical Center - Vallejo, Vallejo

97223

COMPLETED

Northwest Cancer Specialists, PC - Tigard, Tigard

97301

RECRUITING

Oregon Oncology Specialists, Salem

98405

RECRUITING

Northwest Medical Specialties, PLLC - Tacoma, Tacoma

90602-1006

COMPLETED

PIH Health Hospital Whittier, Whittier

06520-8028

RECRUITING

Yale Cancer Center - New Haven, New Haven

40536-0293

RECRUITING

University of Kentucky Medical Center, Lexington

20817-7847

RECRUITING

American Oncology Partners of Maryland, PA, Bethesda

02215-5450

RECRUITING

Dana Farber Cancer Institute, Boston

02215

RECRUITING

Beth Israel Deaconess Medical Center, Boston

10021-5302

RECRUITING

Coleman, Pasmantier & Decter, MDs, New York

44106-1716

RECRUITING

University Hospitals Cleveland Medical Center, Cleveland

98109-1023

RECRUITING

Fred Hutchinson Cancer Center, Seattle

Unknown

RECRUITING

Alexander Fleming Institute, Buenos Aires

RECRUITING

Buenos Aires British Hospital, Buenos Aires

RECRUITING

CENIT Foundation, Buenos Aires

RECRUITING

Center for Medical Education and Clinical Research (CEMIC), Buenos Aires

RECRUITING

Fleischer Medical Center, Buenos Aires

RECRUITING

Medical Center Austral, Buenos Aires

NOT_YET_RECRUITING

Pergamino Clinic, Buenos Aires

RECRUITING

Cordoba Oncology Institute (IONC), Córdoba

RECRUITING

Center of Nuclear and Molecular Medicine of Entre Rios (CEMENER), Paraná

RECRUITING

CEDIT Diagnostic and treatment center, Salta

RECRUITING

CER San Juan, San Juan

RECRUITING

9 of July Sanatorium, San Miguel de Tucumán

RECRUITING

Rosario's Oncology Institute and Medical Specialities (IOR), Santa Fe

RECRUITING

Adelaide Oncology & Haematology, Adelaide

RECRUITING

St Vincent's Hospital (Melbourne) Ltd, Fitzroy

COMPLETED

Peninsula & South Eastern Hematology and Oncology Group (PSEHOG), Frankston

RECRUITING

Hollywood Private Hospital, Breast Cancer Research Centre, Nedlands

RECRUITING

Mater Hospital Brisbane, Mater Cancer Care Centre, South Brisbane

RECRUITING

Icon Cancer Centre- Southport, Southport

RECRUITING

Sydney Adventist Hospital, Wahroonga

RECRUITING

The Queen Elizabeth Hospital, Woodville

RECRUITING

University Hospital Graz, Department of Gynecology and Obstetrics, Graz

RECRUITING

University Hospital Innsbruck - Tyrolean Hospital, Department of Gynaecology and Obstetrics, Innsbruck

RECRUITING

Order Hospital Linz Ltd. - Hospital of Sisters of Mercy, Department of Internal Medicine I, Linz

RECRUITING

Salzburg Regional Hospital, Department of Internal Medicine III, Salzburg

RECRUITING

University Hospital St. Poelten, Department of Internal Medicine I, Sankt Pölten

RECRUITING

Hospital Hietzing, Department of Gynecology, Vienna

RECRUITING

Medical University Vienna, Department of Gynecology and Obstetrics, Vienna

RECRUITING

Saint Luc University Hospital, Brussels

RECRUITING

Charleroi Grand Hospital (GHDC), Charleroi

RECRUITING

University Hospital Antwerp (UZA), Edegem

RECRUITING

AZ Groeninge, Kortrijk

RECRUITING

University Hospitals Leuven, Campus Gasthuisberg, Leuven

RECRUITING

Citadelle Regional Hospital Center, Liège

RECRUITING

VITAZ, Sint-Niklaas

RECRUITING

Centre Hospitalier Peltzer-la-Tourelle, Verviers

RECRUITING

UCL Mont-Godinne University Hospitals, Yvoir

RECRUITING

Oncology Treatment Center, Belém

RECRUITING

Pronutrir, Fortaleza

RECRUITING

ONCOSITE - Clinical Research Center in Oncology, Ijuí

RECRUITING

Juiz de Fora Eurolatino Research Center, Minas Gerais

RECRUITING

Bahia Oncology Center, Salvador

RECRUITING

D'OR Institute, São Paulo

RECRUITING

Hospital A.C.Camargo, São Paulo

RECRUITING

Multiprofile Hospital for Active Treatment - Uni Hospital, Panagyurishte, Panagyurishte

RECRUITING

"MHAT for Women's Health Nadezhda", Sofia

RECRUITING

"Multiprofile Hospital for Active Treatment Serdika, Sofia", Sofia

RECRUITING

Specialized Hospital for Active Treatment in Oncology, Clinic of Medicial Oncology (Chemotherapy), Sofia

RECRUITING

"University Multiprofile Hospital for Active Treatment Sveta Marina", Varna

NOT_YET_RECRUITING

BC Cancer - Vancouver, Medical Oncology, Vancouver

RECRUITING

CIUSSS du Saguenay Lac St-Jean, Chicoutimi

NOT_YET_RECRUITING

Hospital Notre-Dame, Montreal

RECRUITING

Maisonneuve-Rosemont Hospital, Montreal

RECRUITING

University Hospital Olomouc, Clinic of Oncology, Olomouc

RECRUITING

Thomayer University Hospital, Clinic of Oncology, Prague

RECRUITING

University Hospital Bulovka, Institute of Radiation Oncology, Prague

RECRUITING

University Hospital Motol, Clinic of Oncology, Prague

RECRUITING

Bergonie Institute, Bordeaux

RECRUITING

CHU La Timone - La Timone Children's Hospital, Marseille

RECRUITING

University Hospital Center of Poitiers, Poitiers

RECRUITING

Saint Anne Clinic, Strasbourg

RECRUITING

Gustave Roussy, Villejuif

RECRUITING

Hospital Bayreuth, Bayreuth

RECRUITING

Vivantes Hospital Am Urban, Berlin

RECRUITING

Hospital Suedstadt Rostock, Dorf Mecklenburg

RECRUITING

Private Practice with Focus on Oncology, Lübeck

RECRUITING

University Hospital Johannes Gutenberg - University of Mainz, Mainz

RECRUITING

University Hospital Muenster, Münster

RECRUITING

Caritas Klinikum, Saarbrücken

RECRUITING

Helios Clinic Wuppertal, Wuppertal

RECRUITING

Alexandra General Hospital, Athens

RECRUITING

University General Hospital of Ioannina, Ioannina

RECRUITING

IASO Thessaly SA, Larissa

RECRUITING

EUROMEDICA General Clinic of Thessaloniki, Thessaloniki

RECRUITING

Theageneio Anticancer Hospital of Thessaloniki, Thessaloniki

RECRUITING

University of Debrecen Clinical Center, Institute of Oncology, Debrecen

RECRUITING

Bacs-Kiskun County Hospital, Center for Oncoradiology, Kecskemét

RECRUITING

Szabolcs-Szatmar-Bereg County Hospitals and University Teaching Hospital, Department of Oncology, Nyíregyháza

NOT_YET_RECRUITING

HCG Cancer Centre, Bangalore

NOT_YET_RECRUITING

Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh

COMPLETED

Tata Medical Center, Kolkata

COMPLETED

Tata Memorial Hospital, Navi Mumbai

NOT_YET_RECRUITING

Christian Medical College, Department of Medical Oncology, Vellore

RECRUITING

European Institute of Oncology (IEO), IRCCS, Milan

RECRUITING

University Polyclinic Hospital of Modena, Modena

RECRUITING

Local Healthcare Company of Monza (ASST Monza), Monza

RECRUITING

University Hospital of Parma, Parma

RECRUITING

New Hospital of Prato (NOP), Prato

RECRUITING

University Hospital Campus Bio-Medico, Rome

RECRUITING

"University Polyclinic Foundation Agostino Gemelli - IRCCS", Rome

RECRUITING

Santa Maria della Misericordia University Hospital of Udine, Udine

RECRUITING

Clinical Research Center Chapultepec Mexico City, Mexico City

RECRUITING

CRYPTEX, Mexico City

RECRUITING

ProcliniQ Clinical Research, Mexico City

RECRUITING

Administrative Society of Health Services, SC, Morelia

RECRUITING

Avix Clinical Research, Nuevo León

RECRUITING

Zambrano Hellion Medical Center, Nuevo León

COMPLETED

Inbiomedyc, Querétaro

RECRUITING

ONCOR Life Medical Center, Saltillo

RECRUITING

Prof. Franciszek Lukaszczyk Oncology Center in Bydgoszcz, Chemotherapy Outpatient Clinic, Bydgoszcz

RECRUITING

"Medical Clinic Komed", Konin

RECRUITING

Maria Sklodowska-Curie Institute of Oncology, Branch in Krakow, Krakow

RECRUITING

Polish Mother's Memorial Hospital-Research Institute, Lodz

RECRUITING

Independent Public Healthcare Facility Prof. Tadeusz Koszarowski Opole Oncology Center in Opole, Clinical Oncology Department and Day Hospitalization Unit, Opole

RECRUITING

St. John Paul 2nd Mazovian Provincial Hospital in Siedlce Limited Liability Company, Siedlce Oncology Centre, Siedlce

RECRUITING

West Pomeranian Oncology Center, Szczecin

RECRUITING

LUX MED Oncology LLC, Szamocka Hospital, Department of Clinical Oncology/Chemotherapy, Warsaw

RECRUITING

Maria Sklodowska-Curie - National Research Institute of Oncology, Warsaw

RECRUITING

Provincial Specialist Hospital in Wroclaw, Department of Chemotherapy, Wroclaw

RECRUITING

S.C. Oncopremium-Team SRL, Baia Mare

RECRUITING

Prof. Dr. Alexandru Trestioreanu Institute of Oncology, Bucharest

COMPLETED

Prof. Dr. Ion Chiricuta Institute of Oncology, Cluj-Napoca

RECRUITING

Onco Clinic Consult S.A., Craiova

RECRUITING

"Oncology Center Sf. Nectarie", Craiova

RECRUITING

S.C. Topmed Medical Center SRL, Târgu Mureş

RECRUITING

Curie Oncology, Singapore

RECRUITING

ICON SOC Farrer Park Medical Clinic, Singapore

RECRUITING

OncoCare Cancer Centre, Singapore

RECRUITING

Raffles Hospital, Singapore

RECRUITING

Tan Tock Seng Hospital, Singapore

RECRUITING

Asan Medical Center, Seoul

RECRUITING

Gangnam Severance Hospital, Soeul

RECRUITING

Korea University Anam Hospital, Soeul

RECRUITING

Samsung Medical Center, Soeul

RECRUITING

Severance Hospital, Yonsei University Health System, Soeul

RECRUITING

Ulsan University Hospital, Ulsan

RECRUITING

Infanta Cristina Hospital, Badajoz

RECRUITING

Catalan Institute of Oncology, Hospital Duran i Reynals, Barcelona

RECRUITING

Caceres Hospital Complex - San Pedro de Alcantara General Hospital, Cáceres

RECRUITING

Hospital Ruber Internacional, Madrid

RECRUITING

University Hospital Foundation Jimenez Diaz, Madrid

RECRUITING

University Clinical Hospital Virgen de la Arrixaca, Department of Oncology, Murcia

RECRUITING

University Hospital Complex of Santiago (CHUS), Department of Oncology, Santiago de Compostela

RECRUITING

Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City

NOT_YET_RECRUITING

Taipei Medical University - Shuang Ho Hospital, New Taipei City

NOT_YET_RECRUITING

China Medical University Hospital, Taichung

RECRUITING

National Cheng Kung University Hospital, Tainan City

RECRUITING

National Taiwan University Hospital, Taipei

NOT_YET_RECRUITING

Taipei Veterans General Hospital, Taipei

NOT_YET_RECRUITING

Royal United Hospital, Department of Oncology/Hematology, Bath

NOT_YET_RECRUITING

Velindre Cancer Centre, Cardiff

NOT_YET_RECRUITING

Guy's Hospital, London

NOT_YET_RECRUITING

Royal Marsden Hospital - London, Department of Medical Oncology, London

NOT_YET_RECRUITING

The Christie NHS Foundation Trust, Manchester

NOT_YET_RECRUITING

Nottingham City Hospital, Nottingham

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Celcuity Inc

INDUSTRY

NCT05501886 - Gedatolisib Plus Fulvestrant With or Without Palbociclib vs Standard-of-Care for the Treatment of Patients With Advanced or Metastatic HR+/HER2- Breast Cancer (VIKTORIA-1) | Biotech Hunter | Biotech Hunter