A Study of Amivantamab in Participants With Advanced or Metastatic Solid Tumors Including Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer

PHASE2RecruitingINTERVENTIONAL
Enrollment

520

Participants

Timeline

Start Date

November 11, 2022

Primary Completion Date

August 17, 2027

Study Completion Date

August 17, 2027

Conditions
Carcinoma, Non-small-Cell Lung
Interventions
DRUG

Amivantamab

Amivantamab will be administered subcutaneously by manual injection.

DRUG

Lazertinib

Lazertinib will be administered as an oral tablet.

DRUG

Carboplatin

Carboplatin will be administrated by IV infusion.

DRUG

Pemetrexed

Pemetrexed will be administered by IV infusion.

DRUG

Direct Oral Anticoagulant (DOAC)

DOAC will be administered orally.

DRUG

Low Molecular Weight Heparin (LMWH)

LMWH will be administered subcutaneously.

Trial Locations (110)

8908

RECRUITING

Inst. Cat. Doncologia-H Duran I Reynals, Barcelona

10408

RECRUITING

National Cancer Center, Goyang-si

13057

COMPLETED

Hematology-Oncology Associates of CNY, East Syracuse

13125

COMPLETED

Evangelische Lungenklinik Berlin, Berlin

13620

RECRUITING

Seoul National University Bundang Hospital, Seongnam-si

14076

RECRUITING

Centre Francois Baclesse, Caen

15006

RECRUITING

Hosp Univ A Coruna, A Coruña

16132

RECRUITING

Policlinico Hospital San Martino- IRCCS for Oncology, Genova

20016

RECRUITING

Johns Hopkins Office of Capital Region Research - Sibley Memorial Hospital, Washington D.C.

20090

RECRUITING

Azienda Ospedaliera San Gerardo, Monza

20132

RECRUITING

Ospedale San Raffaele, Milan

20162

RECRUITING

ASST Grande Ospedale Metropolitano Niguarda, Milan

21079

COMPLETED

Centre Georges-François Leclerc, Dijon

21224

RECRUITING

Sidney Kimmel Cancer Center - Bayview Campus, Baltimore

22031

RECRUITING

Virginia Cancer Specialists, Fairfax

22927

RECRUITING

LungenClinic Grosshansdorf GmbH, Grosshandorf

25100

RECRUITING

Hospital Tengku Ampuan Afzan, Kuantan

27106

COMPLETED

Novant Health, Winston-Salem

28007

RECRUITING

Hosp. Gral. Univ. Gregorio Maranon, Madrid

28034

RECRUITING

Hosp. Univ. Ramon Y Cajal, Madrid

28041

RECRUITING

Hosp. Univ. 12 de Octubre, Madrid

28046

RECRUITING

Hosp. Univ. La Paz, Madrid

28204

COMPLETED

Novant Health, Charlotte

29010

RECRUITING

Hosp Regional Univ de Malaga, Málaga

30029

RECRUITING

Institut de Cancérologie du Gard, Nîmes

32804

RECRUITING

AdventHealth, Orlando

33140

RECRUITING

Mount Sinai Medical Center, Miami Beach

33486

COMPLETED

Baptist Lynn Cancer Institute, Boca Raton

33612

COMPLETED

H. Lee Moffitt Cancer & Research Institute, Tampa

34376

RECRUITING

Lungenfachklinik Immenhausen, Immenhausen

41009

RECRUITING

Hosp. Virgen Macarena, Seville

44111

COMPLETED

Cleveland Clinic, Cleveland

44122

COMPLETED

Cleveland Clinic, Warrensville Heights

44124

COMPLETED

Cleveland Clinic, Mayfield Heights

44195

COMPLETED

Cleveland Clinic, Cleveland

44281

RECRUITING

Meir Medical Center, Kfar Saba

44805

RECRUITING

Institut de cancerologie de l'ouest, Saint-Herblain

46010

RECRUITING

Hosp. Clinico Univ. de Valencia, Valencia

46014

RECRUITING

Hosp. Gral. Univ. Valencia, Valencia

46050

RECRUITING

Beacon Hospital Sdn Bhd, Petaling Jaya

50937

RECRUITING

Universitaetsklinikum Koelnt, Cologne

52621

RECRUITING

Sheba Medical Center, Ramat Gan

59100

RECRUITING

University Malaya Medical Centre, Kuala Lumpur

63110

RECRUITING

Washington University School Of Medicine, St Louis

66205

RECRUITING

University of Kansas Cancer Center, Westwood

75248

RECRUITING

Institut Curie, Paris

80131

RECRUITING

Azienda Ospedaliera Specialistica dei Colli, Naples

84112

COMPLETED

The Huntsman Cancer Institute, Salt Lake City

86015

RECRUITING

Instituto do Cancer de Londrina Hospital do Cancer de Londrina, Londrina

92093

RECRUITING

University of California at San Diego, La Jolla

92868

RECRUITING

University of California Irvine, Orange

93586

RECRUITING

Hospital Umum Sarawak, Kuching

94305

RECRUITING

Stanford Cancer Institute, Stanford

94800

RECRUITING

Gustave Roussy, Villejuif

97074

RECRUITING

Klinikum Würzburg Mitte gGmbH Standort Missioklinik, Würzburg

98101

COMPLETED

Virginia Mason Medical Center, Seattle

98104

RECRUITING

Swedish Cancer Institute, Seattle

98201

COMPLETED

Providence Regional Cancer Partnership, Everett

130000

RECRUITING

Jilin cancer hospital, Changchun

150000

RECRUITING

Harbin medical university cancer hospital, Harbin

200032

RECRUITING

Fudan University Shanghai Cancer Center, Shanghai

214122

COMPLETED

Hospital of Jiangnan University, Wuxi

264000

COMPLETED

Yantai Yuhuangding Hospital, Yantai

300052

RECRUITING

Tianjin Medical University General Hospital, Tianjin

310003

RECRUITING

The First Affiliated Hospital Zhejiang University College of Medicine, Hangzhou

310016

RECRUITING

Sir Run Run Shaw Hospital Zhejiang University School of Medicine, Hangzhou

325000

RECRUITING

The First Affiliated Hospital of Wenzhou Medical University, Wenzhou

400038

RECRUITING

The First Affiliated Hospital of PLA Army Medical University, Chongqing

430022

RECRUITING

Union Hospital Tongji Medical College of Huazhong University of Science and Technology, Wuhan

510060

RECRUITING

The First Affiliated Hospital Sun Yat sen University, Guangzhou

516001

RECRUITING

Huizhou Municipal Central Hospital, Huizhou

545006

COMPLETED

Liuzhou people's Hospital, Liuzhou

610041

RECRUITING

Sichuan Cancer Hospital, Chengdu

610047

RECRUITING

West China Hospital Sichuan University, Chengdu

710061

RECRUITING

The First Affiliated Hospital of Xian Jiaotong University, Xi'an

3109601

RECRUITING

Rambam Medical Center, Haifa

4941492

RECRUITING

Rabin Medical Center, Petah Tikva

9103102

RECRUITING

Shaare Zedek Medical Center, Jerusalem

02118

RECRUITING

Boston Medical Center, Boston

07601

RECRUITING

Hackensack University Medical Center, Hackensack

08901

RECRUITING

Rutgers Cancer Institute of New Jersey, New Brunswick

14784-400

RECRUITING

Fundacao Pio XII, Barretos

30130 090

RECRUITING

PERSONAL Oncologia de Precisao e Personalizada, Belo Horizonte

90035-001

RECRUITING

Associacao Hospitalar Moinhos de Vento, Porto Alegre

22281 100

RECRUITING

Instituto D Or de Pesquisa e Ensino IDOR, Rio de Janeiro

41253-190

RECRUITING

Instituto D Or de Pesquisa e Ensino IDOR, Salvador

01327 001

RECRUITING

Hospital Alemao Oswaldo Cruz, São Paulo

01409-001

RECRUITING

Impar Servicos Hospitalares SA Hospital Nove de Julho, São Paulo

01509 900

RECRUITING

Fundacao Antonio Prudente A C Camargo Cancer Center, São Paulo

071051

RECRUITING

Affiliated Hospital of Hebei University, Baoding

670-8520

ACTIVE_NOT_RECRUITING

National Hospital Organization Himeji Medical Center, Himeji

515-8544

ACTIVE_NOT_RECRUITING

Matsusaka Municipal Hospital, Matsusaka

951-8566

ACTIVE_NOT_RECRUITING

Niigata Cancer Center Hospital, Niigata

411 8777

ACTIVE_NOT_RECRUITING

Shizuoka Cancer Center, Shizuoka

135 8550

ACTIVE_NOT_RECRUITING

The Cancer Institute Hospital of JFCR, Tokyo

641 8510

ACTIVE_NOT_RECRUITING

Wakayama Medical University Hospital, Wakayama

03080

RECRUITING

Seoul National University Hospital, Seoul

03722

RECRUITING

Severance Hospital Yonsei University Health System, Seoul

05505

COMPLETED

Asan Medical Center, Seoul

03010

RECRUITING

General University Hospital of Alicantet, Alicante

08003

RECRUITING

Hosp. Del Mar, Barcelona

08025

RECRUITING

Hosp. de La Santa Creu I Sant Pau, Barcelona

08035

RECRUITING

Hosp Univ Vall D Hebron, Barcelona

GL53 7AN

COMPLETED

Cheltenham General Hospital, Cheltenham

TQ2 7AA

RECRUITING

Torbay Hospital-Devon, Devon

EH4 2XU

RECRUITING

Edinburgh Cancer Centre Western General, Edinburgh

LE1 5WW

RECRUITING

Leicester Royal Infirmary, Leicester

NW1 2PG

RECRUITING

University College London Hospitals, London

NG5 1PB

RECRUITING

Nottingham City Hospital, Nottingham

PO6 3LY

RECRUITING

Queen Alexandra Hospital, Portsmouth

All Listed Sponsors
lead

Janssen Research & Development, LLC

INDUSTRY