The Management of Metastatic Neck Nodes in N2/3 Hypopharyngeal Squamous Cell Carcinoma

NARecruitingINTERVENTIONAL
Enrollment

111

Participants

Timeline

Start Date

November 1, 2022

Primary Completion Date

November 30, 2025

Study Completion Date

November 30, 2025

Conditions
Hypopharyngeal Carcinoma
Interventions
DRUG

Docetaxel

60 mg/m2 i.v. day 1

DRUG

Cisplatin

60 mg/m2 i.v. day 1-3

DRUG

Capecitabine

750 mg/m2 po bid day 1-14

RADIATION

Concomitant chemoradiotherapy

"Radiotherapy: using intensity-modulated radiation therapy (IMRT)~Gross tumor volume (GTV) for primary tumor: 66-70 Gy in total, 2.0\~2.2 Gy per day, 5 days per week~Clinical target volume (CTV) for lesions closely related to the primary lesion and metastatic lymph nodes: 65\~70 Gy in total, 1.7\~2.0 Gy per day, 5 days per week~Prophylactic irradiation for sites of suspected subclinical spread: 50\~60 Gy in total, 1.7\~2.0 Gy per day, 5 days per week~Concurrent chemotherapy: cisplatin 80 mg/m2 on days 1-3 every 3 weeks."

PROCEDURE

Surgery

Neck dissection and primary tumor resection

Trial Locations (3)

150000

NOT_YET_RECRUITING

Harbin Medical University Cancer Hospital, Harbin

200031

RECRUITING

Eye & ENT Hospital, Fudan University, Shanghai

250012

NOT_YET_RECRUITING

Shandong Provincial ENT Hospital, Cheeloo College of Medicine, Shandong University, Jinan

All Listed Sponsors
collaborator

Shandong Provincial Hospital

OTHER_GOV

collaborator

Harbin Medical University Third Affiliated Hospital

OTHER

lead

Eye & ENT Hospital of Fudan University

OTHER