Coronary Sinus Reducer Implantation in Patients With Ischaemia and Non-obstructed Coronary Arteries and Coronary Microvascular Dysfunction.

NARecruitingINTERVENTIONAL
Enrollment

54

Participants

Timeline

Start Date

April 17, 2023

Primary Completion Date

March 6, 2026

Study Completion Date

March 6, 2026

Conditions
Refractory AnginaMicrovascular AnginaMicrovascular Coronary Artery DiseaseCoronary DiseaseAngina Pectoris
Interventions
DEVICE

Coronary sinus reducer

The Neovasc coronary sinus reducer is an hourglass-shaped stainless steel device inserted percutaneously into the coronary sinus and currently indicated for the treatment of refractory angina.

OTHER

Sham-procedure

Implantation procedure with no device implanted

DIAGNOSTIC_TEST

Invasive coronary physiology

Invasive coronary physiology assessment as part of REMEDY-MECH mechanistic substudy

Trial Locations (1)

SW36NP

RECRUITING

National Heart and Lung Institute (Brompton Campus), Imperial College London, London

All Listed Sponsors
collaborator

Bradford Teaching Hospitals NHS Foundation Trust

OTHER_GOV

collaborator

East and North Hertfordshire NHS Trust

OTHER_GOV

collaborator

Epsom and St Helier University Hospitals NHS Trust

OTHER

collaborator

Guy's and St Thomas' NHS Foundation Trust

OTHER

collaborator

Imperial College Healthcare NHS Trust

OTHER

collaborator

Kingston Hospital NHS Trust

OTHER

collaborator

London North West Healthcare NHS Trust

OTHER

collaborator

Oxford University Hospitals NHS Trust

OTHER

collaborator

Royal Brompton & Harefield NHS Foundation Trust

OTHER

collaborator

St George's University Hospitals NHS Foundation Trust

OTHER

collaborator

Liverpool University Hospitals NHS Foundation Trust

OTHER_GOV

lead

Imperial College London

OTHER