Phase 1b Study of SL-172154 Administered with Combination Agent(s) in Subjects with Ovarian Cancers

PHASE1CompletedINTERVENTIONAL
Enrollment

86

Participants

Timeline

Start Date

August 18, 2022

Primary Completion Date

February 7, 2025

Study Completion Date

February 7, 2025

Conditions
Platinum-resistant Ovarian CancerFallopian Tube CancerEpithelial Ovarian CancerOvarian CancerPlatinum-Resistant Fallopian Tube CarcinomaPlatinum-Resistant Primary Peritoneal CarcinomaPrimary Peritoneal Carcinoma
Interventions
DRUG

Pegylated Liposomal Doxorubicin + SL-172154

The investigational product, SL-172154, is a novel fusion protein consisting of human SIRPα and CD40L (SIRPα -Fc-CD40L) linked via a human Fc.

DRUG

Mirvetuximab + SL-172154

The investigational product, SL-172154, is a novel fusion protein consisting of human SIRPα and CD40L (SIRPα -Fc-CD40L) linked via a human Fc.

Trial Locations (21)

17007

Hospital Universitario Dr. Josep Trueta - ICO de Girona, Servicio de Oncología Av. Francia s/n, Girona

28013

Hospital Universitari Vall D Hebron, Madrid

28040

Hospital Universitario Fundacion Jimenez Diaz START Madrid-FJD- Unidad de Ensayos Fase I, Madrid

30120

Hospital Universitario Virgen de la Arrixaca. Servicio de Oncología Ctra. Madrid-Cartagena, s/n, Murcia

49546

START Midwest, Grand Rapids

60611

Robert H.Lurie ComprehensiveCancer Center, Northwestern University, Chicago

72205

University of Arkansas for Medical sciences, Little Rock

73104

Stephenson Cancer Center, OU Health/ Sarah Cannon Research Institute, Oklahoma City

91010

City of Hope, Duarte

BC V5Z 4E6

BC Cancer Center, Vancouver

M5G 2M9

University health Network (UHN)-University of Toronto, Toronto

H4A 3J1

McGill University Health Care, Montreal

08916

Hospital Universitari Germans Trias i Pujol, Badalona

08028

Hospital Universitario Quirón-Dexeus Servicio de Oncologia Médica, Barcelona

08036

Hospital Clinic de Barcelona Servicio de Oncología, Esc. 2, Planta 5 dcha, Barcelona

PR2 9HT

Lancashire Teaching Hospitals NHS Foundation Trust, Preston

SE1 7EH

Guy's & St Thomas' NHS Foundation Trust, London

SW3 6JJ

The Royal Marsden NHS Foundation Trust, London

W1T 7HA

University College London Hospitals NHS Foundation Trust, London

M20 4BX

The Christie NHS Foundation Trust, Manchester

SM2 5PT

The Royal Marsden NHS Foundation Trust, Sutton

All Listed Sponsors
lead

Shattuck Labs, Inc.

INDUSTRY