Studying Conditioning Regimen In Pediatric Transplantation - AML , SCRIPT-AML

PHASE3RecruitingINTERVENTIONAL
Enrollment

170

Participants

Timeline

Start Date

June 7, 2022

Primary Completion Date

December 31, 2029

Study Completion Date

December 31, 2031

Conditions
Acute Myeloid Leukemia (AML) in RemissionStem Cell Transplantation
Interventions
DRUG

busulfan, cyclophosphamide and melphalan, BuCyMel

a three alkylator combination of busulfan, cyclophosphamide and melphalan (BuCyMel, standard arm)

DRUG

clofarabine, fludarabine and busulfan, CloFluBu

combination of clofarabine, fludarabine and busulfan in which two alkylators are replaced by antimetabolites (CloFluBu, experimental arm)

Trial Locations (17)

1020

NOT_YET_RECRUITING

L'Hôpital Universitaire des Enfants Reine Fabiola (HUDERF), Brussels

1200

NOT_YET_RECRUITING

Cliniques Universitaires Saint-Luc (CUSL), Brussels

3000

NOT_YET_RECRUITING

University Hospital Leuven, Leuven

4000

NOT_YET_RECRUITING

Centre Hospitalier Régional de la Citadelle (CHR)/CHU Liège, Liège

9000

NOT_YET_RECRUITING

Department of Pediatric Hematology, Oncology and SCT, Ghent University Hospital, Ghent

28009

NOT_YET_RECRUITING

Stemcelltransplant unit Hospital Niño Jesús, Madrid

41685

RECRUITING

Queen Silvia Children's Hospital, Sahlgrenska University Hospital, Gothenburg

4920235

NOT_YET_RECRUITING

Schneider Children's Medical Center of Israel, Petah Tikva

DK-2100

RECRUITING

Paediatric Stem Cell Transplant and Immune Deficiency, Department of Pediatric and Adolescent Medicine, Section 4072, Rigshospitalet University Hospital of Copenhagen, Copenhagen

FIN-00290

RECRUITING

Division of Hematology, Oncology, and Stem Cell Transplantation, The New Children's Hospital, Helsinki University Hospital, Helsinki

Unknown

NOT_YET_RECRUITING

Department of Pediatrics and Adolescent Medicine, Hong King Children's Hospital, Hong Kong

08661

NOT_YET_RECRUITING

Vilnius University Hospital Santaros Klinikos Center for Pediatric Oncology and Hematology, Vilnius

3584CS

RECRUITING

Princess Máxima Center for Pediatric Oncology, Utrecht

0424

RECRUITING

Department of Pediatric Hematology and Oncology, Oslo University HospitalOslo University Hospital, Oslo

SE- 221 85

RECRUITING

Barncancercentrum, avdelning 64, Skane University Hospital, Lund

141 86

NOT_YET_RECRUITING

Pediatric Hematology immunology and stem cell transplantation Astrid Lindgren children's Hospital Huddinge K86-88, Stockholm

SE-751 85

NOT_YET_RECRUITING

Childrens department for Blood and tumor diseases Uppsala University Hospital, Uppsala

All Listed Sponsors
lead

Vastra Gotaland Region

OTHER_GOV