Finding the Invasive Haemodynamic Threshold for Symptom Relief in Stable Angina

RecruitingOBSERVATIONAL
Enrollment

58

Participants

Timeline

Start Date

September 1, 2022

Primary Completion Date

April 8, 2025

Study Completion Date

April 8, 2025

Conditions
Stable Angina
Interventions
DIAGNOSTIC_TEST

Rest-angina physiological assessment

The degree of stenosis required to cause angina at rest will be measured under double-blinded placebo controlled conditions using sequential intracoronary balloon inflations. This will then be correlated with various physiological indices, including FFR and NHPR.

DIAGNOSTIC_TEST

Exercise-angina physiological assessment

The degree of stenosis required to cause angina during exercise will be measured under double-blinded placebo controlled conditions using sequential intracoronary balloon inflations. This will then be correlated with various physiological indices, including FFR and NHPR.

Trial Locations (6)

Unknown

RECRUITING

Mid and South Essex NHS Foundation Trust, Basildon

RECRUITING

Royal Bournemouth and Christchurch Hospitals NHS Foundation Trust, Bournemouth

RECRUITING

Imperial College NHS Trust, London

RECRUITING

Royal Free Hospital NHS Foundation Trust, London

RECRUITING

St George's University Hospitals NHS Foundation Trust, London

RECRUITING

Portsmouth Hospitals NHS Trust, Portsmouth

All Listed Sponsors
collaborator

Royal Free Hospital NHS Foundation Trust

OTHER

collaborator

Mid and South Essex NHS Foundation Trust

OTHER

collaborator

St George's University Hospitals NHS Foundation Trust

OTHER

collaborator

Royal Bournemouth and Christchurch Hospitals NHS Foundation Trust

OTHER_GOV

collaborator

Portsmouth Hospitals NHS Trust

OTHER_GOV

lead

Imperial College London

OTHER