A Study of Zilovertamab Vedotin (MK-2140) as Monotherapy and in Combination in Participants With Aggressive and Indolent B-cell Malignancies (MK-2140-006)

PHASE2RecruitingINTERVENTIONAL
Enrollment

223

Participants

Timeline

Start Date

July 21, 2022

Primary Completion Date

March 13, 2029

Study Completion Date

May 17, 2029

Conditions
Chronic Lymphocytic LeukemiaMantle Cell LymphomaFollicular LymphomaRichter Transformation Lymphoma
Interventions
BIOLOGICAL

Zilovertamab vedotin

IV infusion

DRUG

Nemtabrutinib

Oral tablet

Trial Locations (109)

10029

COMPLETED

Icahn School of Medicine at Mount Sinai ( Site 0023), New York

13419

COMPLETED

North Estonia Medical Centre Foundation ( Site 0401), Tallinn

15038

RECRUITING

INSTITUTO NACIONAL DE ENFERMEDADES NEOPLASICAS ( Site 1700), Lima

15121

COMPLETED

Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare -Azienda Ospedaliera Nazionale SS. Ant ( Site 0803), Alessandria

20089

RECRUITING

Humanitas-U.O di Oncologia medica ed Ematologia ( Site 0802), Rozzano

21201

RECRUITING

Greenebaum Comprehensive Cancer Center-Hematology & Multiple Myeloma ( Site 0010), Baltimore

22030

RECRUITING

Trakya University ( Site 6005), Edirne

22185

RECRUITING

Skånes Universitetssjukhus Lund ( Site 5000), Lund

28033

RECRUITING

MD Anderson Cancer Center ( Site 4006), Madrid

31008

RECRUITING

Clinica Universidad de Navarra ( Site 4005), Pamplona

34214

RECRUITING

Mega Medipol-Hematology ( Site 6009), Stanbul

35100

RECRUITING

Ege Universitesi Hastanesi ( Site 6002), Izmir

37007

RECRUITING

Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca-Hematology ( Site 4001), Salamanca

40138

RECRUITING

IRCCS - AOU di Bologna-SSD: Diagnosi e terapie dei linfomi e delle sindromi linfoproliferative cron ( Site 0800), Bologna

40207

RECRUITING

Norton Women's and Children's Hospital-Norton Cancer Institute - St. Matthews ( Site 0007), Saint Matthews

43210

RECRUITING

The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive C ( Site 0004), Columbus

48109

RECRUITING

University of Michigan ( Site 0009), Ann Arbor

48202

RECRUITING

Henry Ford Hospital ( Site 0035), Detroit

50937

RECRUITING

Universitaetsklinikum Koeln ( Site 0506), Cologne

53226

COMPLETED

MEDICAL COLLEGE OF WISCONSIN ( Site 0021), Milwaukee

53792

RECRUITING

University of Wisconsin Hospitals and Clinics-Carbone Cancer Center ( Site 0030), Madison

55139

RECRUITING

Ondokuz Mayıs Universitesi-Oncology department ( Site 6004), Samsun

57105

RECRUITING

Avera Cancer Institute- Research ( Site 0011), Sioux Falls

58122

COMPLETED

Sanford Fargo Medical Center-Roger Maris Cancer Center ( Site 0014), Fargo

62526

COMPLETED

Cancer Care Specialists of Illinois ( Site 0031), Decatur

66205

COMPLETED

University of Kansas Medical Center-Division of Hematologic Malignancies and Cellular Therapeutics ( Site 0038), Fairway

80045

RECRUITING

University of Colorado Anschutz Medical Campus-The Center for Cancer and Blood Disorders ( Site 0008), Aurora

85006

RECRUITING

Banner MD Anderson Cancer Center - University Medical Center Phoenix-Medical Oncology ( Site 0036), Phoenix

85234

RECRUITING

Banner MD Anderson Cancer Center ( Site 0040), Gilbert

89081

RECRUITING

Universitaetsklinikum Ulm. ( Site 0502), Ulm

99208

RECRUITING

Medical Oncology Associates, PS ( Site 0005), Spokane

99508

RECRUITING

Alaska Oncology and Hematology ( Site 0037), Anchorage

100142

RECRUITING

Beijing Cancer hospital ( Site 1200), Beijing

130012

COMPLETED

Jilin Province Tumor Hospital-oncology department ( Site 1220), Chuangchun

168583

RECRUITING

National Cancer Centre Singapore ( Site 1500), Singapore

200032

RECRUITING

Fudan University Shanghai Cancer Center ( Site 1208), Shanghai

215006

COMPLETED

The First Affiliated Hospital of Soochow University-hematology department ( Site 1218), Suzhou

221000

RECRUITING

The Affiliated Hospital of Xuzhou Medical College ( Site 1223), Xuzhou

310003

RECRUITING

The First Affiliated Hospital, Zhejiang University ( Site 1211), Hangzhou

310005

COMPLETED

Zhejiang Cancer Hospital ( Site 1214), Hangzhou

330006

RECRUITING

The First Affiliated Hospital of Nanchang University ( Site 1204), Nanchang

330029

RECRUITING

Jiangxi Provincial Cancer Hospital ( Site 1213), Nanchang

430023

COMPLETED

Union Hospital Tongji Medical College Huazhong University of Science and Technology ( Site 1210), Wuhan

430030

COMPLETED

Tongji Hospital Tongji Medical,Science & Technology ( Site 1221), Wuhan

450003

RECRUITING

Henan Cancer Hospital-hematology department ( Site 1212), Zhengzhou

510280

RECRUITING

Zhujiang Hospital ( Site 1207), Guangzhou

510515

RECRUITING

Southern Medical University Nanfang Hospital ( Site 1202), Guangzhou

510700

RECRUITING

Sun Yat-sen University Cancer Center ( Site 1201), Guangzhou

610041

COMPLETED

West China Hospital of Sichuan University-Head and Neck Oncology ( Site 1206), Chengdu

1720430

RECRUITING

IC La Serena Research ( Site 1909), La Serena

1834111

COMPLETED

Emek Medical Center-Hematology Unit ( Site 0705), Afula

2210001

COMPLETED

Galilee Medical Center ( Site 0710), Nahariya

3109601

COMPLETED

Rambam Health Care Campus-Hematology and Bone Marrow Transplantation ( Site 0706), Haifa

3436212

RECRUITING

Carmel Hospital ( Site 0709), Haifa

5265601

RECRUITING

Sheba Medical Center-Hemato Oncology ( Site 0700), Ramat Gan

7500653

RECRUITING

Centro de Estudios Clínicos SAGA-CECSAGA ( Site 1907), Santiago

7580206

RECRUITING

Clínica Inmunocel ( Site 1910), Santiago

7650568

RECRUITING

Clínica Alemana de Santiago ( Site 1903), Santiago

8410101

RECRUITING

Soroka Medical Center-Hematology Department ( Site 0707), Beersheba

9112001

RECRUITING

Hadassah Medical Center ( Site 0701), Jerusalem

02111

RECRUITING

Tufts Medical Center ( Site 0024), Boston

02114

RECRUITING

Massachusetts General Hospital ( Site 0018), Boston

02215

RECRUITING

Dana-Farber Cancer Institute-Lymphoma ( Site 0026), Boston

59075-740

RECRUITING

Liga Norte Riograndense Contra o Câncer-Centro de Pesquisa Clínica ( Site 1807), Natal

20231-050

RECRUITING

Instituto Nacional de Câncer - INCA-Divisão de Pesquisa Clínica e Desenvolvimento Tecnológico HC1 ( Site 1809), Rio de Janeiro

01246-000

RECRUITING

ICESP - INSTITUTO DO CÂNCER DO ESTADO DE SÃO PAULO ( Site 1808), São Paulo

01321-001

RECRUITING

Hospital Paulistano-Americas Oncologia ( Site 1805), São Paulo

V5Z 4E6

RECRUITING

BC Cancer Vancouver-Clinical Trials Unit ( Site 0201), Vancouver

E1C 6Z8

RECRUITING

The Moncton Hospital-Oncology ( Site 0211), Moncton

B3H 2Y9

RECRUITING

QEII Health Sciences Centre - Victoria General Site ( Site 0213), Halifax

N6A 5W9

RECRUITING

Lawson Health Research Institute - London Health Sciences Ce-London Regional Cancer Program ( Site 0203), London

M5G 2M9

RECRUITING

Princess Margaret Cancer Centre-Division of Medical Oncology and Hematology ( Site 0200), Toronto

H3T 1E2

RECRUITING

Jewish General Hospital ( Site 0202), Montreal

S4T 7T1

COMPLETED

Allan Blair Cancer Centre-Care Services ( Site 0208), Regina

625 00

ACTIVE_NOT_RECRUITING

Fakultní nemocnice Brno Bohunice-Interni hematologicka a onkologicka klinika ( Site 0300), Brno

708 52

COMPLETED

Fakultni nemocnice Ostrava-Klinika Hematoonkologie ( Site 0301), Ostrava

128 08

COMPLETED

Vseobecna fakultni nemocnice v Praze-I. Interní klinika - klinika hematologie ( Site 0302), Prague

D08 E9P6

RECRUITING

St. James's Hospital ( Site 0600), Dublin

00168

RECRUITING

Fondazione Policlinico Universitario Agostino Gemelli IRCCS -ISTITUTO DI EMATOLOGIA ( Site 0804), Roma

460-0001

RECRUITING

National Hospital Organization Nagoya Medical Center ( Site 1108), Nagoya

060-8648

RECRUITING

Hokkaido University Hospital ( Site 1104), Sapporo

259-1193

RECRUITING

Tokai University Hospital ( Site 1100), Isehara

980-8574

RECRUITING

Tohoku University Hospital ( Site 1106), Sendai

589-8511

RECRUITING

Kindai University Hospital ( Site 1102), Sayama

104-0045

RECRUITING

National Cancer Center Hospital ( Site 1103), Chuo-ku

135-8550

RECRUITING

Cancer Institute Hospital of JFCR ( Site 1101), Koto

812-8582

RECRUITING

Kyushu University Hospital ( Site 1105), Fukuoka

700-8558

RECRUITING

Okayama University Hospital ( Site 1107), Okayama

04001

RECRUITING

Centro Medico Monte Carmelo ( Site 1702), Arequipa

30-727

RECRUITING

Pratia MCM Krakow ( Site 1001), Krakow

20-090

RECRUITING

Centrum Onkologii Ziemi Lubelskiej-Oddzial Hematologiczny ( Site 1006), Lublin

02-781

RECRUITING

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworów Układu Chłonnego ( Site 1002), Warsaw

10-228

RECRUITING

Samodzielny Publiczny Zakład Opieki Zdrowotnej MSWiA w Olsztynie-Oddzial Kliniczny Hematologii ( Site 1007), Olsztyn

93-513

COMPLETED

Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumat-Oddiał Hematologii Ogólnej ( Site 1008), Lodz

25-734

RECRUITING

Swietokrzyskie Centrum Onkologii, Samodzielny Publiczny Zakl-Klinika Hematologii i Transplantacji S ( Site 1010), Kielce

1400-038

RECRUITING

Champalimaud Foundation ( Site 2002), Lisbon

4710-243

RECRUITING

Unidade Local de Saude de Braga - Hospital de Braga ( Site 2001), Braga

4200-072

RECRUITING

Instituto Português de Oncologia do Porto Francisco Gentil, EPE ( Site 2000), Porto

03080

RECRUITING

Seoul National University Hospital ( Site 1300), Seoul

06351

RECRUITING

Samsung Medical Center ( Site 1301), Seoul

08908

COMPLETED

Instituto Catalan de Oncologia - Hospital Duran i Reynals-Haematology Department ( Site 4003), L'Hospitalet Del Llobregat

08035

RECRUITING

Hospital Universitari Vall d'Hebron ( Site 4004), Barcelona

751 85

RECRUITING

Akademiska sjukhuset-Blod- och tumörsjukdomar ( Site 5002), Uppsala

413 45

RECRUITING

Sahlgrenska Universitetssjukhuset ( Site 5003), Gothenburg

06100

RECRUITING

Ankara Universitesi Tip Fakultesi Hastanesi-hematology ( Site 6001), Ankara

TR1 3LJ

RECRUITING

The Royal Cornwall Hospital-Haematology ( Site 7006), Truro

NW1 2PG

RECRUITING

University College London Hospital ( Site 7001), London

OX3 7LE

RECRUITING

The Churchill Hospital ( Site 7002), Oxford

m20 4bx

RECRUITING

The Christie NHS Foundation Trust ( Site 7007), Manchester

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY