435
Participants
Start Date
March 15, 2023
Primary Completion Date
June 30, 2026
Study Completion Date
June 30, 2026
Biospecimen Collection
Undergo collection of blood
Bone Marrow Aspiration
Undergo bone marrow aspiration
Busulfan
Given intravenously (IV)
Cyclophosphamide
Given IV
Echocardiography Test
Undergo ECHO
Fludarabine
Given IV
Haploidentical Hematopoietic Cell Transplantation
Undergo haploHCT
Lapine T-Lymphocyte Immune Globulin
Given IV
Lumbar Puncture
Undergo lumbar puncture
Matched Unrelated Donor Hematopoietic Cell Transplantation
Undergo MUD-HCT
Melphalan
Given IV
Methotrexate
Given IV
Multigated Acquisition Scan
Undergo MUGA
Mycophenolate Mofetil
Given IV
Myeloablative Conditioning
Receive myeloablative conditioning regimen
Quality-of-Life Assessment
Ancillary studies
Questionnaire Administration
Ancillary studies
Rituximab
Given IV
T-Cell Depletion Therapy
Undergo haploHCT with alpha beta T cell depletion
Tacrolimus
Given IV
Thiotepa
Given IV
Total-Body Irradiation
Undergo TBI
The Children's Hospital at Westmead, Westmead
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York
Montefiore Medical Center - Moses Campus, The Bronx
New York Medical College, Valhalla
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park
Roswell Park Cancer Institute, Buffalo
University of Rochester, Rochester
Penn State Children's Hospital, Hershey
Alfred I duPont Hospital for Children, Wilmington
Children's National Medical Center, Washington D.C.
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore
VCU Massey Comprehensive Cancer Center, Richmond
Duke University Medical Center, Durham
Carolinas Medical Center/Levine Cancer Institute, Charlotte
Medical University of South Carolina, Charleston
Nemours Children's Clinic-Jacksonville, Jacksonville
University of Florida Health Science Center - Gainesville, Gainesville
AdventHealth Orlando, Orlando
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami
Nicklaus Children's Hospital, Miami
Johns Hopkins All Children's Hospital, St. Petersburg
Children's Hospital of Alabama, Birmingham
The Children's Hospital at TriStar Centennial, Nashville
Vanderbilt University/Ingram Cancer Center, Nashville
University of Mississippi Medical Center, Jackson
Norton Children's Hospital, Louisville
Cleveland Clinic Foundation, Cleveland
Riley Hospital for Children, Indianapolis
C S Mott Children's Hospital, Ann Arbor
Children's Hospital of Michigan, Detroit
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids
University of Iowa/Holden Comprehensive Cancer Center, Iowa City
University of Wisconsin Carbone Cancer Center - University Hospital, Madison
Mayo Clinic in Rochester, Rochester
Lurie Children's Hospital-Chicago, Chicago
University of Chicago Comprehensive Cancer Center, Chicago
Washington University School of Medicine, St Louis
Children's Mercy Hospitals and Clinics, Kansas City
Children's Hospital New Orleans, New Orleans
University of Oklahoma Health Sciences Center, Oklahoma City
Medical City Dallas Hospital, Dallas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas
Cook Children's Medical Center, Fort Worth
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston
Methodist Children's Hospital of South Texas, San Antonio
Children's Hospital Colorado, Aurora
Primary Children's Hospital, Salt Lake City
Phoenix Childrens Hospital, Phoenix
Children's Hospital Los Angeles, Los Angeles
City of Hope Comprehensive Cancer Center, Duarte
Loma Linda University Medical Center, Loma Linda
UCSF Medical Center-Mission Bay, San Francisco
Lucile Packard Children's Hospital Stanford University, Palo Alto
UCSF Benioff Children's Hospital Oakland, Oakland
Arkansas Children's Hospital, Little Rock
Yale University, New Haven
Hackensack University Medical Center, Hackensack
Alberta Children's Hospital, Calgary
British Columbia Children's Hospital, Vancouver
CancerCare Manitoba, Winnipeg
Hospital for Sick Children, Toronto
Centre Hospitalier Universitaire Sainte-Justine, Montreal
Children's Oncology Group
NETWORK