Mirvetuximab Soravtansine (MIRV) With Carboplatin in Second-line Treatment of Folate Receptor Alpha (FRα) Expressing, Platinum-sensitive Epithelial Ovarian Cancer

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

125

Participants

Timeline

Start Date

September 28, 2022

Primary Completion Date

November 30, 2026

Study Completion Date

November 30, 2026

Conditions
High Grade Ovarian CancerPrimary Peritoneal CancerFallopian Tube Cancer
Interventions
DRUG

Mirvetuximab soravtansine

Mirvetuximab Soravtansine (MIRV) is an investigational antibody drug conjugate designed to selectively kill cancer cells. The antibody (protein) part of MIRV targets tumors by delivering a cell-killing drug to the tumor cells carrying a tumor-associated protein called FRα. It is being developed for the treatment of participants with recurrent platinum-sensitive, high grade epithelial ovarian, primary peritoneal, or fallopian tube cancers with FRα expression. FRα positivity will be defined by the Ventana FOLR1 Assay.

DRUG

Carboplatin

Carboplatin is considered to be the treatment agent of choice in relapsed PSOC.

Trial Locations (69)

1200

Cliniques Universitaires UCL Saint-Luc /ID# 268916, Brussels

3000

Universitair Ziekenhuis Leuven /ID# 268914, Leuven

4000

Duplicate_CHU de Liege /ID# 268918, Liège

10032

Columbia University Irving Medical Center /ID# 268887, New York

11040

Long Island Jewish Medical Center /ID# 268909, New Hyde Park

14004

Hospital Universitario Reina Sofia /ID# 269657, Córdoba

15006

Complejo Hospitalario Universitario A Coruña /ID# 268930, A Coruña

25198

Hospital Universitario Arnau de Vilanova de Lleida /ID# 268939, Lleida

27514

University of North Carolina Medical Center /ID# 268963, Chapel Hill

27607

Duke Cancer Center Macon Pond /ID# 268910, Raleigh

28027

Clinica Universidad de Navarra - Madrid /ID# 268935, Madrid

28040

Hospital Universitario Fundación Jiménez Díaz /ID# 268938, Madrid

28041

Hospital Universitario 12 de Octubre /ID# 268936, Madrid

28050

Hospital Universitario HM Sanchinarro /ID# 268932, Madrid

29425

MUSC Hollings Cancer Center /ID# 268892, Charleston

30322

Winship Cancer Institute of Emory University /ID# 268913, Atlanta

31008

Clinica Universidad de Navarra - Pamplona /ID# 268940, Pamplona

32803

AdventHealth Orlando /ID# 268920, Orlando

33612

Moffitt Cancer Center /ID# 269089, Tampa

34239

Sarasota Memorial Hospital /ID# 268882, Sarasota

46010

Hospital Clínico Universitario de Valencia /ID# 268933, Valencia

48201

Karmanos Cancer Institute - Detroit /ID# 268890, Detroit

63130

Washington University School of Medicine - St. Louis /ID# 268897, St Louis

70433

Women'S Cancer Care /ID# 268898, Covington

73104

Ou Health - Stephenson Cancer Center /ID# 268878, Oklahoma City

75235

University of Texas - Southwestern Medical Center /ID# 268891, Dallas

85704

University of Arizona Cancer Center /ID# 268906, Tucson

87102

University of New Mexico Comprehensive Cancer Center /ID# 268961, Albuquerque

87124

Presbyterian Rust Medical Center /ID# 278582, Rio Rancho

89511

The Center Of Hope /ID# 268884, Reno

90033

University of Southern California /ID# 268964, Los Angeles

90095

University of California Los Angeles Medical Center /ID# 268883, Los Angeles

92037

Moores Cancer Center /ID# 268888, La Jolla

92103

Scripps Md Anderson - Prebys Cancer Center /ID# 268966, San Diego

92663

Hoag Memorial Hospital Presbyterian /ID# 268907, Newport Beach

93710

Women'S Cancer Research Network - Cogi /ID# 268912, Fresno

94109

California Pacific Medical Center - Van Ness Campus /ID# 268886, San Francisco

95817

UC Davis Comprehensive Cancer Center /ID# 269085, Sacramento

99336

Duplicate_Kadlec Clinic Heme-Onc /ID# 268580, Kennewick

92835-3826

Providence - St. Jude Medical /ID# 268911, Fullerton

06519-1110

Smilow Cancer Hospital at Yale New Haven /ID# 268889, New Haven

60611-3015

Northwestern University- Robert H. Lurie Comprehensive Cancer Center /ID# 268957, Chicago

02114

Massachusetts General Hospital /ID# 268879, Boston

02215

Dana-Farber Cancer Institute /ID# 268881, Boston

08103

Md Anderson Cancer Center At Cooper /ID# 268885, Camden

07666

Holy Name Medical Center /ID# 268903, Teaneck

02905

Women & Infants Hospital /ID# 268895, Providence

V5Z 4E6

BC Cancer - Vancouver /ID# 268901, Vancouver

H1T 2M4

Universite de Montreal - Hopital Maisonneuve-Rosemont /ID# 268902, Montreal

H2X 3E4

Centre Hospitalier De L'Universite De Montreal - Hopital Saint-Luc /ID# 268899, Montreal

H4A 3J1

McGill University Health Centre - Glen Site /ID# 269084, Montreal

J1G 2E8

Centre Hospitalier Universite De Sherbrooke - Hôtel-Dieu Hospital /ID# 268900, Sherbrooke

0102

American Hospital Tbilisi /ID# 268947, Tbilisi

0103

High Technology Hospital MedCenter /ID# 268946, Tbilisi

0112

Israeli-Georgian Medical Research Clinic Helsicore /ID# 268950, Tbilisi

0159

Caraps Medline /ID# 268948, Tbilisi

0168

Duplicate_Consilium Medulla Multiprofile Clinic /ID# 268951, Tbilisi

08916

Institut Català d'Oncologia (ICO) - Badalona /ID# 268929, Badalona

06010

Complejos Hospitalario Universitario de Badajoz /ID# 268937, Badajoz

08028

Usp Instituto Universitario Dexeus /ID# 268931, Barcelona

08035

Hospital Universitario Vall de Hebron /ID# 268926, Barcelona

W12 0HS

Hammersmith Hospital /ID# 268945, London

SE1 9RT

Guy's Hospital /ID# 269083, London

SW3 6JJ

The Royal Marsden - Chelsea /ID# 268943, London

HA6 2RN

Mount Vernon Hospital /ID# 268942, Northwood

NG3 6AA

Nottinghamshire Healthcare NHS Foundation Trust /ID# 269087, Nottingham

TA1 5DA

Musgrove Park Hospital /ID# 269088, Taunton

SM2 5PT

The Royal Marsden - Sutton /ID# 268941, Sutton

M20 4BX

The Christie /ID# 268944, Manchester

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