A Study Comparing Talquetamab in Combination With Daratumumab or in Combination With Daratumumab and Pomalidomide Versus Daratumumab in Combination With Pomalidomide and Dexamethasone in Participants With Multiple Myeloma That Returns After Treatment or is Resistant to Treatment

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

864

Participants

Timeline

Start Date

October 13, 2022

Primary Completion Date

February 6, 2026

Study Completion Date

June 30, 2029

Conditions
Relapsed or Refractory Multiple Myeloma
Interventions
DRUG

Talquetamab

Talquetamab will be administered subcutaneously.

DRUG

Daratumumab

Daratumumab will be administered subcutaneously.

DRUG

Pomalidomide

Pomalidomide will be administered orally.

DRUG

Dexamethasone

Dexamethasone will be administered orally or intravenously.

Trial Locations (216)

704

National Cheng Kung University Hospital, Tainan City

1090

UZ Brussel, Brussels

1340

Clinique Saint Pierre, Ottignies

2650

UZA, Edegem

3015

Erasmus MC, Rotterdam

3500

Virga Jessa Ziekenhuis, Hasselt

4000

CHC MontLegia, Liège

5530

UCL Mont Godinne, Yvoir

10016

NYU Langone Health, New York

10048

National Taiwan University Hospital, Taipei

10126

A.O.U. Città della Salute e della Scienza, Torino

10408

National Cancer Center, Gyeonggi-do

11407

Hosp. de Jerez de La Frontera, Jerez de la Frontera

12203

Charite Campus Benjamin Franklin, Berlin

13100

Ziv Medical Center, Safed

13210

SUNY Upstate Medical University, Syracuse

20007

MedStar Georgetown University Hospital, Washington D.C.

20037

George Washington University, Washington D.C.

20090

Centrum Onkologii Ziemi Lubelskiej im sw Jana z Dukli, Lublin

20133

Fondazione IRCCS Istituto Nazionale dei Tumori, Milan

20162

ASST Grande Ospedale Metropolitano Niguarda, Milan

21000

CHU Dijon, Dijon

21205

Johns Hopkins University, Baltimore

21565

Gachon University Gil Medical Center, Incheon

22100

Galilee Medical Center, Nahariya

22763

Asklepios Klinik Altona, Hamburg

22903

University of Virginia, Charlottesville

23298

Virginia Commonwealth University - Massey Cancer Center, Richmond

24071

Hosp. de Leon, León

25123

Azienda Ospedaliera Spedali Civili di Brescia, Brescia

27100

Fondazione IRCCS Policlinico San Matteo, Pavia

27103

Novant Health, Winston-Salem

27157

Wake Forest Baptist Medical Center, Winston-Salem

27599

University of North Carolina, Chapel Hill

28006

Hosp. Univ. de La Princesa, Madrid

28034

Hosp. Univ. Ramon Y Cajal, Madrid

28041

Hosp. Univ. 12 de Octubre, Madrid

28050

Hosp Univ Hm Sanchinarro, Madrid

28204

Levine Cancer Institute, Carolinas HealthCare System, Charlotte

Novant Health, Charlotte

29010

Hosp Virgen de La Victoria, Málaga

30120

Hosp. Univ. Virgen de La Arrixaca, El Palmar

31008

Clinica Univ. de Navarra, Pamplona

31048

Bnai Zion Medical Center, Haifa

31059

Institut Universitaire du cancer de Toulouse-Oncopole, Toulouse

31096

Rambam Medical Center, Haifa

33021

Memorial Healthcare System, Hollywood

33136

University of Miami Health System, Miami

33604

CHRU - Hôpital du Haut Lévêque - Centre François Magendie, Pessac

34093

Istanbul University Istanbul Medical Faculty, Istanbul

34153

Istanbul University Cerrahpasa Medical Faculty, Istanbul

34214

Medipol Mega University Hospital, Istabul

34295

CHU de Montpellier - Hopital Saint-Eloi, Montpellier

34362

Carmel Medical Center, Haifa

35128

Azienda Ospedaliera Universitaria di Padova, Padua

35330

Dokuz Eylul University Medical Faculty, Izmir

37007

Hosp Clinico Univ de Salamanca, Salamanca

38120

Baptist Cancer Center, Memphis

38320

Hosp. Univ. de Canarias, San Cristóbal de La Laguna

39216

University of Mississippi Medical Center, Jackson

40138

Azienda Ospedaliera Policlinico S. Orsola-Malpighi, Bologna

40447

China Medical University Hospital, Taichung

42123

Arcispedale Santa Maria Nuova - IRCCS, Reggio Emilia

43210

The Ohio State University Wexner Medical Center - James Cancer Hospital, Columbus

43214

OhioHealth, Columbus

44093

CHU de Nantes hotel Dieu, Nantes

44106

University Hospitals Cleveland Medical Center, Cleveland

46017

Hosp. Univ. Dr. Peset, Valencia

48109

University of Michigan Health System, Ann Arbor

49100

Beilinson medical center, Petah Tikva

50937

Universitaetsklinikum Koelnt, Cologne

52621

Sheba Medical Center, Ramat Gan

54907

Jeonbuk National University Hospital, Jeonju

55131

Universitätsmedizin der Johannes Gutenberg Universität, Mainz

55139

Ondokuz Mayis University, Samsun

55455

University Of Minnesota, Minneapolis

58128

Chonnam National University Hwasun Hospital, Jeollanam-do

60126

A.O. Universitaria Ospedali Riuniti di Ancona, Ancona

60612

University Of Illinois, Chicago

66205

University of Kansas, Westwood

69008

Centre Leon Berard, Lyon

69120

Universitaetsklinikum Heidelberg, Heidelberg

70112

Tulane University Hospital & Clinics, New Orleans

70124

Policlinico di Bari, Bari

70300

Shamir Medical Center Assaf Harofeh, Be’er Ya‘aqov

71013

IRCCS Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo

72205

University of Arkansas for Medical Sciences, Little Rock

75571

CHU Hopital Saint Antoine, Paris

77030

Houston Methodist Hospital, Houston

MD Anderson Cancer Center, Houston

79410

Joe Arrington Cancer Research Treatment Center, Lubbock

80756

Kaohsiung Medical University Chung Ho Memorial Hospital, Kaohsiung City

83301

Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City

84112

Huntsman Cancer Institute, Salt Lake City

85719

The University of Arizona Cancer Center, Tucson

90146

Ospedale Villa Sofia-Cervello, Palermo

94010

APHP - Hopital Henri Mondor, Créteil

95123

PO G.Rodolico, AOU Policlinico-Vittorio Emanuele Catania, Catania

97080

Universitaetsklinikum Wuerzburg, Würzburg

98109

Fred Hutchinson Cancer Research Center, Seattle

100006

Peking Union Medical College Hospital, Beijing

100020

Beijing Chaoyang Hospital, Chaoyang District

100034

Peking University First Hospital, Beijing

130021

The First Hospital of Jilin University, Changchun

200065

Tongji Hospital of Tongji University, Shanghai

200434

Shanghai Fourth People s Hospital, Shanghai

210008

Nanjing Drum Tower Hospital, Nanjing

215006

First Affiliated Hospital SooChow University, Suzhou

300060

Tianjin cancer hospital, Tianjin

300320

Institute of Hematology & Blood Disease Hospital Chinese Academy of Medical Science, Tianjin

310003

The First Affiliated Hospital Zhejiang University College of Medicine, Hangzhou

350001

Fujian Medical University Union Hospital, Fuzhou

410000

The second Xiangya Hospital of Central South University, Changsha

430030

Tongji Hospital, Tongji Medical College of HUST, Wuhan

450008

Henan Cancer Hospital, Zhengzhou

510080

Guangdong Provincial People's Hospital, Guangzhou

510710

Sun Yat Sen University Cancer Center, Guangzhou

518036

Peking University Shenzhen Hospital, Shenzhen

610072

Sichuan Academy of Medical Science Sichuan Provincial People's Hospital, Chengdu

1834111

Ha'Emek Medical Center, Afula

3810101

Hillel Yaffe Medical Center, Hadera

6423906

Sourasky (Ichilov) Medical Center, Tel Aviv

9103102

Shaare Zedek Medical Center, Jerusalem

06850

Norwalk Hospital-oncology, Norwalk

70121-2429

Ochsner Health System, New Orleans

02114

Massachusetts General, Boston

02118

Boston University Medical Center, Boston

01655

University of Massachusetts Medical School, Worcester

63110-1032

Washington University School Of Medicine, St Louis

08901

Rutgers Cancer Institute of New Jersey, New Brunswick

19107-4215

Thomas Jefferson University, Philadelphia

29425-8900

Medical University of South Carolina, Charleston

14784 400

Fundacao Pio XII, Barretos

30150-221

Santa Casa de Misericordia de Belo Horizonte, Belo Horizonte

70390-140

Hospitais Integradaos da Gavea S/A - DF Star, Brasília

95070 560

Fundacao Universidade de Caxias do Sul, Caxias do Sul

81520 060

Liga Paranaense de Combate ao Cancer, Curitiba

88034 000

Centro de Pesquisa e Ensino em Oncologia de Santa Catarina CEPEN, Florianópolis

59062-000

Liga Norte Riograndense Contra O Cancer, Natal

90050-170

Irmandade Santa Casa de Misericordia de Porto Alegre, Porto Alegre

14051 140

Hospital Das Clinicas Da Faculdade De Medicina De RPUSP HCRP, Ribeirão Preto

22775 001

Instituto de Educacao, Pesquisa e Gestao em Saude Instituto Americas (COI), Rio de Janeiro

41253-190

Hospital Sao Rafael, Salvador

01308 901

Sociedade Beneficente de Senhoras Hospital Sirio Libanes, São Paulo

01321-001

Real e Benemerita Associacao Portuguesa de Beneficencia, São Paulo

01323-000

Hospital Paulistano, São Paulo

01401 002

Instituto D Or de Pesquisa e Ensino IDOR, São Paulo

01455 010

Clinica Sao Germano, São Paulo

01509 900

Fundacao Antonio Prudente A C Camargo Cancer Center, São Paulo

625 00

Fakultni nemocnice Brno, Brno

500 05

Fakultni nemocnice Hradec Kralove, Hradec Králové

779 00

Fakultni nemocnice Olomouc, Olomouc

708 52

Fakultni Nemocnice Ostrava, Ostrava - Poruba

100 34

Fakultni nemocnice Kralovske Vinohrady, Prague

128 08

Vseobecna fakultni nemocnice v Praze - I. interni klinika - klinika hematologie, Prague

06202

CHU HOPITAL DE L'ARCHET - Hematology, Nice

04103

Universitaetsklinikum Leipzig, Leipzig

115 28

Alexandra General Hospital of Athens, Athens Attica

546 39

Anticancer Hospital of Thessaloniki Theageneio, Thessaloniki

570 10

G Papanikolaou Hospital of Thessaloniki, Thessalonikis

00193

Presidio Ospedaliero Santo Spirito in Sassia, Roma

113 8519

Institute of Science Tokyo Hospital, Bunkyō City

260-8717

Chiba Cancer Center, Chiba

814-0180

Fukuoka University Hospital, Fukuoka

503-8502

Ogaki Municipal Hospital, Gifu

371-0034

Gunma University Hospital, Gunma

573 1191

Kansai Medical University Hospital, Hirakata

663-8501

Hyogo Medical University Hospital, Hyôgo

670-8540

Japanese Red Cross Society Himeji Hospital, Hyōgo

247-8533

Shonan Kamakura General Hospital, Kamakura-shi

277 8577

National Cancer Center Hospital East, Kashiwa

343-8555

Dokkyo Medical University Saitama Medical Center, Koshigaya

860-8556

Kumamoto University Hospital, Kumamoto

603-8151

Kyoto Kuramaguchi Medical Center, Kyoto

399-8701

National Hospital Organization Matsumoto Medical Center, Matsumoto

951-8566

Niigata Cancer Center Hospital, Niigata

739-0696

National Hospital Organization Hiroshima-Nishi Medical Center, Ōtake

060-8648

Hokkaido University Hospital, Sapporo

980 8574

Tohoku University Hospital, Sendai

028-3695

Iwate Medical University Hospital, Shiwa-gun

565 0871

The University of Osaka Hospital, Suita

135 8550

The Cancer Institute Hospital of JFCR, Tokyo

3318 AT

Albert Schweitzer ziekenhuis-lokatie Dordwijk, Dordrecht

5631 BM

Maxima Medisch Centrum, Eindhoven

36-200

Szpital Specjalistyczny w Brzozowie Podkarpacki Osrodek Onkologiczny im Ks B Markiewicza, Brzozów

80 214

Uniwersyteckie Centrum Kliniczne, Gdansk

40 519

Pratia Onkologia Katowice, Katowice

25 734

Swietokrzyskie Centrum Onkologii SPZOZ w Kielcach, Kielce

30 688

Szpital Uniwersytecki w Krakowie, Krakow

10-228

Szpital Kliniczny MSWiA z Warminsko Mazurskim Centrum Onkologii w Olsztynie Oddzial Hematologii, Olsztyn

71-252

Uniwersytecki Szpital Kliniczny Nr 1 PUM im prof Tadeusza Sokolowskiego w Szczecinie, Szczecin

87 100

Wojewodzki Szpital Zespolony im L Rydygiera w Toruniu, Torun

02-781

Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut Badawczy, Warsaw

50 367

Uniwersytecki Szpital Kliniczny im Jana Mikulicza Radeckiego we Wroclawiu, Wroclaw

602 812

Dong-A University Hospital, Busan

03080

Seoul National University Hospital, Seoul

03722

Severance Hospital Yonsei University Health System, Seoul

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

06591

The Catholic University of Korea Seoul St Marys Hospital, Seoul

08916

Hosp. Univ. Germans Trias I Pujol, Badalona

08025

Hosp. de La Santa Creu I Sant Pau, Barcelona

08035

Hosp Univ Vall D Hebron, Barcelona

08036

Hosp Clinic de Barcelona, Barcelona

06200

Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, Hematology Unit, Ankara

06590

Ankara University Medical Faculty, Ankara

06680

Liv Hospital Ankara, Ankara

07100

Antalya Training And Research Hospital, Antalya

FY3 8NR

Blackpool Victoria Hospital, Blackpool

DD1 9SY

Ninewells Hospital & Medical School, Dundee

W12 0HS

Hammersmith Hospital, London

NE7 7DN

Newcastle Freeman Hospital, Newcastle upon Tyne

NG5 1PB

Nottingham City Hospital, Nottingham

PL6 8DH

University Hospitals Plymouth NHS Trust, Plymouth

SM2 5PT

Royal Marsden Hospital, Sutton

WV10 0QP

New Cross Hospital, Wolverhampton

All Listed Sponsors
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