Oral Itraconazole Versus Combination of Systemic Glucorticoids and Oral Itraconazole in CPA-ABPA Overlap Syndrome

NARecruitingINTERVENTIONAL
Enrollment

104

Participants

Timeline

Start Date

June 15, 2022

Primary Completion Date

December 31, 2024

Study Completion Date

December 31, 2025

Conditions
Chronic Pulmonary AspergillosisAllergic Bronchopulmonary Aspergillosis
Interventions
DRUG

Prednisone tablet and Itraconazole

Oral prednisolone 0.5 mg/Kg body weight tapered over 4 months and oral itraconazole (400 mg/day). The dose of itraconazole will be adjusted according to therapeutic drug monitoring to achieve a serum trough level of 0.5 microgram/mL. traconazole will be given for 12 months

DRUG

Oral itraconazole

Oral itraconazole (400 mg/day). The dose of itraconazole will be adjusted according to therapeutic drug monitoring to achieve a serum trough level of 0.5 microgram/mL. Itraconazole will be given for 12 months

Trial Locations (2)

160012

ACTIVE_NOT_RECRUITING

Chest clinic, PGIMER, Chandigarh

RECRUITING

Chest clinic, Chandigarh

All Listed Sponsors
lead

Post Graduate Institute of Medical Education and Research, Chandigarh

OTHER