First Live Birth Rate With eSET After Preimplantation Methylome Screening (PIMS) Versus Conventional In-vitro Fertilization

NARecruitingINTERVENTIONAL
Enrollment

1,146

Participants

Timeline

Start Date

September 16, 2022

Primary Completion Date

June 1, 2024

Study Completion Date

May 31, 2025

Conditions
Reproductive Techniques, AssistedDNA Methylation
Interventions
OTHER

Using DNA methylome to select embryos

DNA methylation level Embryo with methylation level closest to the optimal level (from one couple patients) is the one for embryonic transfer to uterus

OTHER

Using morphologic score to select embryos

blastocyst will transferred according to morphologic score or blastocysts will be biopsied on trophectoderm, sequenced with next-generation sequencing (NGS). Euploidy will transferred one by one according to morphologic score.

Trial Locations (28)

200135

RECRUITING

Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine,Shanghai Jiao Tong University, Shanghai

250012

RECRUITING

Center for Reproductive Medicine, Shandong University, Jinan

410008

RECRUITING

Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-XIANGYA, Changsha

Unknown

RECRUITING

Shandong University, Jinan

RECRUITING

Center for Reproductive Medicine, Center for Prenatal Diagnosis First Hospital, Jilin University, Changchun

RECRUITING

900 th Hospital of Joint Logistics Support Force, Fuzhou

RECRUITING

Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou

RECRUITING

Guangzhou Womenand Children's Medical Center, Guanzhou

NOT_YET_RECRUITING

The Sixth Affiliated Hospital of Sun Yat-sen University, Guanzhou

RECRUITING

Center for Reproductive Medicine, The Affiliated Hospital of Guizhou Medical University, Guiyang

RECRUITING

The first affiliated hospital of Hainan Medical University, Haikou

RECRUITING

Assisted Reproduction Unit, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou

RECRUITING

The First Affiliated Hospital of Anhui Medical University, Hefei

RECRUITING

Affiliated Hospital of Jining Medical University, Jining

RECRUITING

Liuzhou Hospital of Guangzhou Women and Children's Medical Center, Liuzhou

RECRUITING

Department of Reproductive Medicine, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing

RECRUITING

The First Affiliated Hospital with Nanjing Medical University, Nanjing

NOT_YET_RECRUITING

Changhai Hospital, Shanghai

NOT_YET_RECRUITING

International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai

NOT_YET_RECRUITING

Reproductive Medical Center of Ruijin Hospital, School of Medicine,Shanghai Jiao Tong University, Shanghai

NOT_YET_RECRUITING

Shanghai Ji Ai Genetics and IVF Institute, Obstetrics and Gynecology Hospital, Fudan University, Shanghai

RECRUITING

Shenzhen Maternity & Child Healthcare Hospital, Shenzhen

RECRUITING

The Second Hospital of Hebei Medical University, Shijiazhuang

RECRUITING

Center for reproduction and genetics,suzhou municipal hospital, Suzhou

RECRUITING

The General Hospital of Ningxia Medical University, Yinchuan

RECRUITING

Department of Reproductive Medicine, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou

RECRUITING

Reproductive Medical Center, Henan Provincial People's Hospital, Zhengzhou

NOT_YET_RECRUITING

Siriraj hospital, Mahidol university, Bangkok

All Listed Sponsors
collaborator

RenJi Hospital

OTHER

collaborator

Reproductive & Genetic Hospital of CITIC-Xiangya

OTHER

collaborator

Nanjing Maternity and Child Health Care Hospital

OTHER

collaborator

ShangHai Ji Ai Genetics & IVF Institute

OTHER

collaborator

Suzhou Municipal Hospital

OTHER

collaborator

The First Hospital of Jilin University

OTHER

collaborator

Sir Run Run Shaw Hospital

OTHER

collaborator

The Affiliated Hospital Of Guizhou Medical University

OTHER

collaborator

The Second Hospital of Hebei Medical University

OTHER

collaborator

Third Affiliated Hospital of Zhengzhou University

OTHER

collaborator

Ruijin Hospital

OTHER

collaborator

International Peace Maternity and Child Health Hospital

OTHER

collaborator

Henan Provincial People's Hospital

OTHER

collaborator

The First Affiliated Hospital of Hainan Medical University

OTHER_GOV

collaborator

The First Affiliated Hospital of Anhui Medical University

OTHER

collaborator

Fujian Maternity and Child Health Hospital

OTHER

collaborator

General Hospital of Ningxia Medical University

OTHER

collaborator

The First Affiliated Hospital with Nanjing Medical University

OTHER

collaborator

900 Hospital of Joint Logistics Support Force of PLA

OTHER

collaborator

Guangzhou Womenand Children's Medical Center

UNKNOWN

collaborator

Changhai Hospital

OTHER

collaborator

Shenzhen Maternity & Child Healthcare Hospital

OTHER

collaborator

Sixth Affiliated Hospital, Sun Yat-sen University

OTHER

collaborator

Liuzhou Hospital of Guangzhou Women and Children's Medical Center

UNKNOWN

collaborator

Jining Medical University

OTHER

collaborator

Siriraj Hospital

OTHER

lead

Shandong University

OTHER