Stimulating Compassion UsingTranscutaneous Vagus Nerve Stimulation

NACompletedINTERVENTIONAL
Enrollment

120

Participants

Timeline

Start Date

June 27, 2022

Primary Completion Date

March 15, 2023

Study Completion Date

March 15, 2023

Conditions
Healthy Volunteers
Interventions
DEVICE

Active transcutaneous vagus nerve stimulation

TVNS is a non-invasive counterpart to surgical methods for stimulating the vagus. For the active condition, stimulator electrodes deliver a mild electrical current to the tragus. Stimulation parameters: stimulation of left tragus via two gold-plated electrodes, attached by ear-clip. Waveform: rectangular, frequency: 20 Hz, pulse width: 0.2 ms, individually adjusted intensity based on participant's perceptual threshold.

BEHAVIORAL

Active self-compassion imagery

Self-compassion imagery is both a meditative technique and a component of compassion-focused cognitive therapy. Here, self-compassionate imagery is delivered as standardized audio-recorded instructions.

DEVICE

Sham transcutaneous vagus nerve stimulation

TVNS is a non-invasive counterpart to surgical methods for stimulating the vagus. For the sham condition, stimulator electrodes deliver a mild electrical current to the earlobe. Stimulation parameters: stimulation of left earlobe via two gold-plated electrodes, attached by ear-clip. Waveform: rectangular, frequency: 20 Hz, pulse width: 0.2 ms, individually adjusted intensity based on participant's perceptual threshold.

BEHAVIORAL

Sham mental imagery

Draw-a-face-in-imagination is the sham/ control imagery condition. Here, control imagery instructions are delivered as a standardized audio-recording, well-matched to self-compassion imagery for number of words, complexity of language, and duration of the audio instructions.

Trial Locations (1)

WC1E 6BT

Clinical Psychopharmacology Unit, London

All Listed Sponsors
lead

University College, London

OTHER