Comparing the Addition of Radiation Either Before or After Surgery for Patients With Brain Metastases

PHASE3RecruitingINTERVENTIONAL
Enrollment

236

Participants

Timeline

Start Date

October 24, 2022

Primary Completion Date

March 16, 2027

Study Completion Date

March 16, 2027

Conditions
Metastatic Malignant Neoplasm in the Brain
Interventions
PROCEDURE

Brain Surgery

Undergo surgery per standard of care

OTHER

Quality-of-Life Assessment

Ancillary studies

OTHER

Questionnaire Administration

Ancillary studies

RADIATION

Stereotactic Radiosurgery

Undergo stereotactic radiosurgery

Trial Locations (215)

10011

ACTIVE_NOT_RECRUITING

Mount Sinai Chelsea, New York

10019

ACTIVE_NOT_RECRUITING

Mount Sinai West, New York

10029

ACTIVE_NOT_RECRUITING

Mount Sinai Hospital, New York

10032

ACTIVE_NOT_RECRUITING

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York

10065

RECRUITING

Manhattan Eye Ear and Throat Hospital, New York

RECRUITING

NYP/Weill Cornell Medical Center, New York

10075

RECRUITING

Lenox Hill Hospital, New York

10461

RECRUITING

Montefiore Medical Center-Einstein Campus, The Bronx

RECRUITING

Montefiore Medical Center-Weiler Hospital, The Bronx

10467

RECRUITING

Montefiore Medical Center - Moses Campus, The Bronx

10549

RECRUITING

Northern Westchester Hospital, Mount Kisco

11215

RECRUITING

New York-Presbyterian/Brooklyn Methodist Hospital, Brooklyn

11355

SUSPENDED

The New York Hospital Medical Center of Queens, Flushing

11794

RECRUITING

Stony Brook University Medical Center, Stony Brook

11795

RECRUITING

Good Samaritan University Hospital, West Islip

13210

RECRUITING

State University of New York Upstate Medical University, Syracuse

14263

ACTIVE_NOT_RECRUITING

Roswell Park Cancer Institute, Buffalo

14642

ACTIVE_NOT_RECRUITING

University of Rochester, Rochester

15213

RECRUITING

UPMC-Presbyterian Hospital, Pittsburgh

15232

RECRUITING

UPMC-Shadyside Hospital, Pittsburgh

18512

ACTIVE_NOT_RECRUITING

Northeast Radiation Oncology Center, Dunmore

19107

ACTIVE_NOT_RECRUITING

Thomas Jefferson University Hospital, Philadelphia

20774

RECRUITING

UM Capital Region Medical Center, Largo

21014

RECRUITING

UM Upper Chesapeake Medical Center, Bel Air

21061

RECRUITING

UM Baltimore Washington Medical Center/Tate Cancer Center, Glen Burnie

21201

RECRUITING

University of Maryland/Greenebaum Cancer Center, Baltimore

22031

RECRUITING

Inova Schar Cancer Institute, Fairfax

23229

RECRUITING

Henrico Doctor's Hospital, Richmond

23235

RECRUITING

CJW Medical Center - Johnston-Willis Campus, Richmond

23298

RECRUITING

VCU Massey Comprehensive Cancer Center, Richmond

24033

RECRUITING

Carilion Roanoke Memorial Hospital, Roanoke

27157

RECRUITING

Wake Forest University Health Sciences, Winston-Salem

28025

RECRUITING

Atrium Health Cabarrus/LCI-Concord, Concord

28054

RECRUITING

CaroMont Regional Medical Center, Gastonia

28203

RECRUITING

Carolinas Medical Center/Levine Cancer Institute, Charlotte

28401

RECRUITING

Novant Health Cancer Institute Radiation Oncology - Wilmington, Wilmington

29303

RECRUITING

Spartanburg Medical Center, Spartanburg

29341

RECRUITING

Gibbs Cancer Center-Gaffney, Gaffney

29379

RECRUITING

SMC Center for Hematology Oncology Union, Union

29425

RECRUITING

Medical University of South Carolina, Charleston

29651

RECRUITING

Gibbs Cancer Center-Pelham, Greer

30303

RECRUITING

Grady Health System, Atlanta

30308

RECRUITING

Emory University Hospital Midtown, Atlanta

30309

RECRUITING

Piedmont Hospital, Atlanta

30322

RECRUITING

Emory University Hospital/Winship Cancer Institute, Atlanta

30342

RECRUITING

Emory Saint Joseph's Hospital, Atlanta

33136

RECRUITING

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33146

RECRUITING

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables

33176

RECRUITING

Miami Cancer Institute, Miami

33324

RECRUITING

UM Sylvester Comprehensive Cancer Center at Plantation, Plantation

33442

RECRUITING

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

33544

RECRUITING

Moffitt Cancer Center at Wesley Chapel, Wesley Chapel

33607

RECRUITING

Moffitt Cancer Center-International Plaza, Tampa

33612

RECRUITING

Moffitt Cancer Center - McKinley Campus, Tampa

RECRUITING

Moffitt Cancer Center, Tampa

37203

RECRUITING

The Children's Hospital at TriStar Centennial, Nashville

43015

RECRUITING

Delaware Health Center-Grady Cancer Center, Delaware

RECRUITING

Grady Memorial Hospital, Delaware

43210

RECRUITING

Ohio State University Comprehensive Cancer Center, Columbus

43214

RECRUITING

Riverside Methodist Hospital, Columbus

43215

RECRUITING

Grant Medical Center, Columbus

43551

RECRUITING

Mercy Health - Perrysburg Hospital, Perrysburg

44106

RECRUITING

Case Western Reserve University, Cleveland

45429

RECRUITING

Kettering Medical Center, Kettering

45431

RECRUITING

Indu and Raj Soin Medical Center, Beavercreek

46260

RECRUITING

Ascension Saint Vincent Indianapolis Hospital, Indianapolis

48073

RECRUITING

Corewell Health William Beaumont University Hospital, Royal Oak

48085

RECRUITING

Corewell Health Beaumont Troy Hospital, Troy

48109

RECRUITING

University of Michigan Comprehensive Cancer Center, Ann Arbor

48201

NOT_YET_RECRUITING

Wayne State University/Karmanos Cancer Institute, Detroit

48334

ACTIVE_NOT_RECRUITING

Weisberg Cancer Treatment Center, Farmington Hills

50023

RECRUITING

UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny

50263

RECRUITING

UI Health Care Mission Cancer and Blood - Waukee Clinic, Waukee

50309

RECRUITING

Iowa Methodist Medical Center, Des Moines

RECRUITING

UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines

50314

RECRUITING

UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines

50325

RECRUITING

UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive

53022

RECRUITING

Aurora Health Care Germantown Health Center, Germantown

53024

RECRUITING

Aurora Cancer Care-Grafton, Grafton

53038

RECRUITING

University of Wisconsin Carbone Cancer Center - Johnson Creek, Johnson Creek

53066

RECRUITING

Aurora Medical Center in Summit, Summit

53081

RECRUITING

Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan

53105

RECRUITING

Aurora Cancer Care-Southern Lakes VLCC, Burlington

53142

RECRUITING

Aurora Cancer Care-Kenosha South, Kenosha

53188

RECRUITING

UW Cancer Center at ProHealth Care, Waukesha

53209

RECRUITING

Aurora Cancer Care-Milwaukee, Milwaukee

53215

RECRUITING

Aurora Saint Luke's Medical Center, Milwaukee

53226

RECRUITING

Medical College of Wisconsin, Milwaukee

RECRUITING

Aurora Cancer Care-Milwaukee West, Wauwatosa

53227

RECRUITING

Aurora West Allis Medical Center, West Allis

53233

RECRUITING

Aurora Sinai Medical Center, Milwaukee

53406

RECRUITING

Aurora Cancer Care-Racine, Racine

53718

RECRUITING

University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison

53792

RECRUITING

University of Wisconsin Carbone Cancer Center - University Hospital, Madison

54311

RECRUITING

Aurora BayCare Medical Center, Green Bay

54401

RECRUITING

Aspirus Regional Cancer Center, Wausau

54481

RECRUITING

Aspirus Cancer Care - Stevens Point, Stevens Point

54494

RECRUITING

Aspirus Cancer Care - Wisconsin Rapids, Wisconsin Rapids

54501

RECRUITING

Aspirus Cancer Care - James Beck Cancer Center, Rhinelander

54801

RECRUITING

Essentia Health-Spooner Clinic, Spooner

54806

RECRUITING

Duluth Clinic Ashland, Ashland

RECRUITING

Northwest Wisconsin Cancer Center, Ashland

54843

RECRUITING

Essentia Health-Hayward Clinic, Hayward

54880

RECRUITING

Essentia Health Saint Mary's Hospital - Superior, Superior

54904

RECRUITING

Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh

54911

RECRUITING

ThedaCare Regional Cancer Center, Appleton

55072

RECRUITING

Essentia Health Sandstone, Sandstone

55746

RECRUITING

Essentia Health Hibbing Clinic, Hibbing

55792

RECRUITING

Essentia Health Virginia Clinic, Virginia

55805

RECRUITING

Essentia Health Cancer Center, Duluth

RECRUITING

Essentia Health Saint Mary's Medical Center, Duluth

RECRUITING

Miller-Dwan Hospital, Duluth

56303

RECRUITING

Coborn Cancer Center at Saint Cloud Hospital, Saint Cloud

56401

RECRUITING

Essentia Health Saint Joseph's Medical Center, Brainerd

56636

RECRUITING

Essentia Health - Deer River Clinic, Deer River

57104

RECRUITING

Sanford Cancer Center Oncology Clinic, Sioux Falls

58122

RECRUITING

Sanford Broadway Medical Center, Fargo

RECRUITING

Sanford Roger Maris Cancer Center, Fargo

59101

RECRUITING

Billings Clinic Cancer Center, Billings

59405

RECRUITING

Benefis Sletten Cancer Institute, Great Falls

60010

RECRUITING

Advocate Good Shepherd Hospital, Barrington

60014

RECRUITING

AMG Crystal Lake - Oncology, Crystal Lake

60048

RECRUITING

AMG Libertyville - Oncology, Libertyville

60068

RECRUITING

Advocate Lutheran General Hospital, Park Ridge

60126

SUSPENDED

Elmhurst Memorial Hospital, Elmhurst

60429

RECRUITING

Advocate South Suburban Hospital, Hazel Crest

60451

SUSPENDED

UC Comprehensive Cancer Center at Silver Cross, New Lenox

60506

RECRUITING

Advocate Outpatient Center - Aurora, Aurora

60515

RECRUITING

Advocate Good Samaritan Hospital, Downers Grove

60540

SUSPENDED

Edward Hospital/Cancer Center, Naperville

60555

RECRUITING

Northwestern Medicine Cancer Center Warrenville, Warrenville

60611

RECRUITING

Northwestern University, Chicago

60637

SUSPENDED

University of Chicago Comprehensive Cancer Center, Chicago

61801

RECRUITING

Carle Cancer Center, Urbana

61832

RECRUITING

Carle at The Riverfront, Danville

61938

RECRUITING

Carle Physician Group-Mattoon/Charleston, Mattoon

62269

SUSPENDED

Cancer Care Center of O'Fallon, O'Fallon

62401

RECRUITING

Carle Physician Group-Effingham, Effingham

RECRUITING

Crossroads Cancer Center, Effingham

62526

RECRUITING

Cancer Care Specialists of Illinois - Decatur, Decatur

RECRUITING

Decatur Memorial Hospital, Decatur

62702

RECRUITING

Southern Illinois University School of Medicine, Springfield

RECRUITING

Springfield Clinic, Springfield

62781

RECRUITING

Springfield Memorial Hospital, Springfield

62801

RECRUITING

Centralia Oncology Clinic, Centralia

63080

RECRUITING

Missouri Baptist Sullivan Hospital, Sullivan

63127

RECRUITING

BJC Outpatient Center at Sunset Hills, Sunset Hills

63131

RECRUITING

Missouri Baptist Medical Center, St Louis

63640

RECRUITING

Parkland Health Center - Farmington, Farmington

63670

RECRUITING

Sainte Genevieve County Memorial Hospital, Sainte Genevieve

64111

RECRUITING

Saint Luke's Hospital of Kansas City, Kansas City

65804

RECRUITING

Mercy Hospital Springfield, Springfield

73104

RECRUITING

University of Oklahoma Health Sciences Center, Oklahoma City

78229

WITHDRAWN

University of Texas Health Science Center at San Antonio, San Antonio

79410

SUSPENDED

Covenant Medical Center-Lakeside, Lubbock

84112

ACTIVE_NOT_RECRUITING

Huntsman Cancer Institute/University of Utah, Salt Lake City

85013

RECRUITING

Saint Joseph's Hospital and Medical Center, Phoenix

85719

RECRUITING

Banner University Medical Center - Tucson, Tucson

RECRUITING

University of Arizona Cancer Center-North Campus, Tucson

89502

RECRUITING

Renown Regional Medical Center, Reno

90027

RECRUITING

Kaiser Permanente Los Angeles Medical Center, Los Angeles

90706

RECRUITING

Kaiser Permanente-Bellflower, Bellflower

91761

RECRUITING

Kaiser Permanente-Ontario, Ontario

92612

RECRUITING

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine

92806

RECRUITING

Kaiser Permanente-Anaheim, Anaheim

92868

RECRUITING

Saint Joseph Hospital - Orange, Orange

RECRUITING

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange

94115

SUSPENDED

California Pacific Medical Center-Pacific Campus, San Francisco

94143

RECRUITING

UCSF Medical Center-Parnassus, San Francisco

94304

RECRUITING

Stanford Cancer Institute Palo Alto, Palo Alto

94589

RECRUITING

Sutter Solano Medical Center/Cancer Center, Vallejo

95355

RECRUITING

Memorial Medical Center, Modesto

95403

RECRUITING

Sutter Pacific Medical Foundation, Santa Rosa

95602

RECRUITING

Sutter Auburn Faith Hospital, Auburn

95603

RECRUITING

Sutter Cancer Centers Radiation Oncology Services-Auburn, Auburn

95661

RECRUITING

Sutter Cancer Centers Radiation Oncology Services-Roseville, Roseville

RECRUITING

Sutter Roseville Medical Center, Roseville

95816

RECRUITING

Sutter Medical Center Sacramento, Sacramento

95817

RECRUITING

University of California Davis Comprehensive Cancer Center, Sacramento

96701

RECRUITING

Hawaii Cancer Care - Westridge, ‘Aiea

RECRUITING

Pali Momi Medical Center, ‘Aiea

96706

RECRUITING

The Queen's Medical Center - West Oahu, ‘Ewa Beach

96734

RECRUITING

Castle Medical Center, Kailua

96766

RECRUITING

Wilcox Memorial Hospital and Kauai Medical Clinic, Lihue

96813

RECRUITING

Hawaii Cancer Care Inc - Waterfront Plaza, Honolulu

RECRUITING

Queen's Cancer Cenrer - POB I, Honolulu

RECRUITING

Queen's Medical Center, Honolulu

RECRUITING

Straub Clinic and Hospital, Honolulu

RECRUITING

University of Hawaii Cancer Center, Honolulu

96817

RECRUITING

Queen's Cancer Center - Kuakini, Honolulu

RECRUITING

The Cancer Center of Hawaii-Liliha, Honolulu

96826

RECRUITING

Kapiolani Medical Center for Women and Children, Honolulu

32224-9980

RECRUITING

Mayo Clinic in Florida, Jacksonville

60453-2699

RECRUITING

Advocate Christ Medical Center, Oak Lawn

03756

RECRUITING

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon

08103

RECRUITING

Cooper Hospital University Medical Center, Camden

07302

RECRUITING

Jersey City Medical Center, Jersey City

07039

RECRUITING

Saint Barnabas Medical Center, Livingston

08903

RECRUITING

Rutgers Cancer Institute of New Jersey, New Brunswick

07112

RECRUITING

Newark Beth Israel Medical Center, Newark

07652

RECRUITING

The Valley Hospital - Luckow Pavilion, Paramus

08534

RECRUITING

Capital Health Medical Center-Hopewell, Pennington

07450

RECRUITING

Valley Health System Ridgewood Campus, Ridgewood

08755

RECRUITING

Community Medical Center, Toms River

07675

SUSPENDED

Valley Health System-Hematology/Oncology, Westwood

17033-0850

RECRUITING

Penn State Milton S Hershey Medical Center, Hershey

57117-5134

RECRUITING

Sanford USD Medical Center - Sioux Falls, Sioux Falls

H2X 3E4

RECRUITING

CHUM - Centre Hospitalier de l'Universite de Montreal, Montreal

H3H 2R9

RECRUITING

The Research Institute of the McGill University Health Centre (MUHC), Montreal

G1R 2J6

RECRUITING

CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ), Québec

060-8648

RECRUITING

Hokkaido University Hospital, Sapporo

371-8511

RECRUITING

Gunma University Hospital, Gunma

606-8507

RECRUITING

Kyoto University Hospital, Kyoto

466-0065

RECRUITING

Nagoya University Hospital, Showa-Ku Nagoya

104 0045

RECRUITING

National Cancer Center Hospital, Tokyo

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

NRG Oncology

OTHER