Investigating Speech Sequencing in Neurotypical Speakers and Persons With Disordered Speech

NARecruitingINTERVENTIONAL
Enrollment

2

Participants

Timeline

Start Date

April 3, 2023

Primary Completion Date

May 31, 2026

Study Completion Date

May 31, 2026

Conditions
Stuttering, DevelopmentalAphasia, Primary Progressive
Interventions
BEHAVIORAL

Learning of non-native phoneme combinations: 6 training sessions

Each trial of the training sessions will follow a simple reaction time protocol in which a nonsense syllable containing novel consonant clusters (e.g., GDADK) is produced as quickly and accurately as possible after an auditory prompt presented via earphones. During each training session, the participant will practice producing a set of 8 stimuli (the Fully Learned stimuli). Each of the 8 Fully Learned stimuli will be produced 60 times over the 6 training sessions.

BEHAVIORAL

Learning of non-native phoneme combinations: 1 training session

Each trial of the training sessions will follow a simple reaction time protocol in which a nonsense syllable containing novel consonant clusters (e.g., GDADK) is produced as quickly and accurately as possible after an auditory prompt presented via earphones. During the training session, the participant will practice producing a set of 3 stimuli (the Fully Learned stimuli). Each of the 3 Fully Learned stimuli will be produced 60 times.

BEHAVIORAL

Learning of novel multisyllabic nonwords

Each trial of the training sessions (total of 6 training sessions over 2 days) will follow a simple reaction time protocol in which a nonword stimulus formed by 2 or 3 syllables that are legal in American English is presented auditorily to the participant, who then produces the stimulus as quickly and accurately as possible. During training, each participant will repeatedly produce 6 nonwords, with each nonword produced a total of 60 times over the 6 training sessions.

DEVICE

Anodal tDCS

Continuous anodal tDCS is delivered to a speech processing area of the brain during a 19-minute speech training session. The tDCS stimulation will ramp up to its maximum value (2 milliamperes) in the minute prior to the training session and maintained at that level throughout the session.

DEVICE

Sham tDCS

Sham tDCS stimulation is delivered to a speech processing area of the brain during a 19-minute speech training session. During the minute prior to training onset, the tDCS stimulator is ramped up to 2 milliamperes and then back down to 0.

BEHAVIORAL

Learning of non-native phoneme combinations: 8 training sessions

Each trial of the training sessions will follow a simple reaction time protocol in which a nonsense syllable containing novel consonant clusters (e.g., GDADK) is produced as quickly and accurately as possible after an auditory prompt presented via earphones. During each training session, the participant will practice producing a set of 3 stimuli (the Fully Learned stimuli). Each of the 3 Fully Learned stimuli will be produced 120 times over the 8 training sessions.

Trial Locations (3)

48109

RECRUITING

University of Michigan, Ann Arbor

02129

RECRUITING

Massachusetts General Hospital, Boston

02215

RECRUITING

Boston University, Boston

All Listed Sponsors
collaborator

National Institute on Deafness and Other Communication Disorders (NIDCD)

NIH

collaborator

University of Michigan

OTHER

collaborator

Massachusetts General Hospital

OTHER

lead

Boston University Charles River Campus

OTHER