Testing Olaparib and Temozolomide Versus the Usual Treatment for Uterine Leiomyosarcoma After Chemotherapy Has Stopped Working

PHASE2/PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

190

Participants

Timeline

Start Date

March 30, 2023

Primary Completion Date

March 9, 2030

Study Completion Date

March 9, 2030

Conditions
Locally Advanced Uterine Corpus LeiomyosarcomaMetastatic Uterine Corpus LeiomyosarcomaStage III Uterine Corpus Leiomyosarcoma AJCC v8Stage IV Uterine Corpus Leiomyosarcoma AJCC v8Unresectable Uterine Corpus Leiomyosarcoma
Interventions
PROCEDURE

Biospecimen Collection

Undergo collection of blood samples

PROCEDURE

Bone Scan

Undergo bone scan

PROCEDURE

Computed Tomography

Undergo CT scan

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

PROCEDURE

Multigated Acquisition Scan

Undergo MUGA

DRUG

Olaparib

Given PO

DRUG

Pazopanib

Given PO

DRUG

Temozolomide

Given PO

DRUG

Trabectedin

Given IV

PROCEDURE

Transthoracic Echocardiography Test

Undergo TTE

Trial Locations (145)

10065

Memorial Sloan Kettering Cancer Center, New York

10604

Memorial Sloan Kettering Westchester, Harrison

11042

Northwell Health/Center for Advanced Medicine, Lake Success

11553

Memorial Sloan Kettering Nassau, Uniondale

11725

Memorial Sloan Kettering Commack, Commack

14263

Roswell Park Cancer Institute, Buffalo

19090

Asplundh Cancer Pavilion, Willow Grove

19107

Thomas Jefferson University Hospital, Philadelphia

19111

Fox Chase Cancer Center, Philadelphia

20010

MedStar Washington Hospital Center, Washington D.C.

23235

VCU Massey Cancer Center at Stony Point, Richmond

23298

VCU Massey Comprehensive Cancer Center, Richmond

25304

West Virginia University Charleston Division, Charleston

27599

UNC Lineberger Comprehensive Cancer Center, Chapel Hill

27710

Duke University Medical Center, Durham

27834

ECU Health Medical Center, Greenville

29425

Medical University of South Carolina, Charleston

29910

Saint Joseph's/Candler - Bluffton Campus, Bluffton

31405

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler, Savannah

33136

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33324

UM Sylvester Comprehensive Cancer Center at Plantation, Plantation

33442

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

35233

University of Alabama at Birmingham Cancer Center, Birmingham

37232

Vanderbilt University/Ingram Cancer Center, Nashville

40503

Baptist Health Lexington, Lexington

44011

UH Seidman Cancer Center at UH Avon Health Center, Avon

44106

Case Western Reserve University, Cleveland

44111

Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland

44122

UHHS-Chagrin Highlands Medical Center, Beachwood

44124

Hillcrest Hospital Cancer Center, Mayfield Heights

44195

Cleveland Clinic Foundation, Cleveland

48109

University of Michigan Comprehensive Cancer Center, Ann Arbor

49007

Bronson Methodist Hospital, Kalamazoo

West Michigan Cancer Center, Kalamazoo

49009

Beacon Kalamazoo Cancer Center, Kalamazoo

49017

Bronson Battle Creek, Battle Creek

49085

Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph

49444

Trinity Health Muskegon Hospital, Muskegon

Cancer and Hematology Centers of Western Michigan - Norton Shores, Norton Shores

49503

Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids

Trinity Health Grand Rapids Hospital, Grand Rapids

49519

University of Michigan Health - West, Wyoming

49677

Corewell Health Reed City Hospital, Reed City

49684

Munson Medical Center, Traverse City

50010

Mary Greeley Medical Center, Ames

McFarland Clinic - Ames, Ames

50036

McFarland Clinic - Boone, Boone

50129

McFarland Clinic - Jefferson, Jefferson

50158

McFarland Clinic - Marshalltown, Marshalltown

50314

Mercy Medical Center - Des Moines, Des Moines

50501

McFarland Clinic - Trinity Cancer Center, Fort Dodge

51503

Heartland Oncology and Hematology LLP, Council Bluffs

52242

University of Iowa/Holden Comprehensive Cancer Center, Iowa City

53226

Medical College of Wisconsin, Milwaukee

54449

Marshfield Medical Center-Marshfield, Marshfield

54476

Marshfield Medical Center - Weston, Weston

54482

Marshfield Medical Center-River Region at Stevens Point, Stevens Point

54548

Marshfield Medical Center - Minocqua, Minocqua

54701

Marshfield Medical Center-EC Cancer Center, Eau Claire

54868

Marshfield Medical Center-Rice Lake, Rice Lake

55101

Regions Hospital, Saint Paul

55102

United Hospital, Saint Paul

55407

Abbott-Northwestern Hospital, Minneapolis

55416

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55433

Mercy Hospital, Coon Rapids

55435

Fairview Southdale Hospital, Edina

55905

Mayo Clinic in Rochester, Rochester

60026

NorthShore University HealthSystem-Glenbrook Hospital, Glenview

60035

NorthShore University HealthSystem-Highland Park Hospital, Highland Park

60045

Northwestern Medicine Lake Forest Hospital, Lake Forest

60115

Northwestern Medicine Cancer Center Kishwaukee, DeKalb

60134

Northwestern Medicine Cancer Center Delnor, Geneva

60201

NorthShore University HealthSystem-Evanston Hospital, Evanston

60555

Northwestern Medicine Cancer Center Warrenville, Warrenville

60611

Northwestern University, Chicago

60612

University of Illinois, Chicago

61801

Carle Cancer Center, Urbana

61832

Carle at The Riverfront, Danville

61938

Carle Physician Group-Mattoon/Charleston, Mattoon

62401

Carle Physician Group-Effingham, Effingham

63110

Washington University School of Medicine, St Louis

63129

Siteman Cancer Center-South County, St Louis

63141

Siteman Cancer Center at West County Hospital, Creve Coeur

Mercy Hospital Saint Louis, St Louis

68114

Nebraska Cancer Specialists/Oncology Hematology West PC - MECC, Omaha

Nebraska Methodist Hospital, Omaha

Oncology Associates PC, Omaha

70112

University Medical Center New Orleans, New Orleans

70817

Our Lady of the Lake Medical Oncology, Baton Rouge

73104

University of Oklahoma Health Sciences Center, Oklahoma City

80045

UCHealth University of Colorado Hospital, Aurora

80524

Poudre Valley Hospital, Fort Collins

80528

Cancer Care and Hematology-Fort Collins, Fort Collins

80538

Medical Center of the Rockies, Loveland

80631

UCHealth Greeley Hospital, Greeley

80909

UCHealth Memorial Hospital Central, Colorado Springs

80920

Memorial Hospital North, Colorado Springs

83301

Saint Luke's Cancer Institute - Twin Falls, Twin Falls

83619

Saint Luke's Cancer Institute - Fruitland, Fruitland

83642

Saint Luke's Cancer Institute - Meridian, Meridian

83687

Saint Luke's Cancer Institute - Nampa, Nampa

83712

Saint Luke's Cancer Institute - Boise, Boise

85054

Mayo Clinic Hospital in Arizona, Phoenix

91010

City of Hope Comprehensive Cancer Center, Duarte

92618

City of Hope at Irvine Lennar, Irvine

94568

Epic Care-Dublin, Dublin

94597

Epic Care Cyberknife Center, Walnut Creek

94608

Epic Care Partners in Cancer Care, Emeryville

97015

Clackamas Radiation Oncology Center, Clackamas

97030

Legacy Mount Hood Medical Center, Gresham

97045

Providence Willamette Falls Medical Center, Oregon City

97062

Legacy Meridian Park Hospital, Tualatin

97132

Providence Newberg Medical Center, Newberg

97210

Legacy Good Samaritan Hospital and Medical Center, Portland

97213

Providence Portland Medical Center, Portland

97225

Providence Saint Vincent Medical Center, Portland

97239

Oregon Health and Science University, Portland

98109

Fred Hutchinson Cancer Center, Seattle

98195

University of Washington Medical Center - Montlake, Seattle

98684

Legacy Cancer Institute Medical Oncology and Day Treatment, Vancouver

98686

Legacy Salmon Creek Hospital, Vancouver

99508

Alaska Women's Cancer Care, Anchorage

94553-3156

Contra Costa Regional Medical Center, Martinez

06418

Smilow Cancer Hospital-Derby Care Center, Derby

06824

Smilow Cancer Hospital Care Center-Fairfield, Fairfield

06033

Smilow Cancer Hospital Care Center at Glastonbury, Glastonbury

06830

Smilow Cancer Hospital Care Center at Greenwich, Greenwich

06437

Smilow Cancer Hospital Care Center - Guilford, Guilford

06105

Smilow Cancer Hospital Care Center at Saint Francis, Hartford

06520

Yale University, New Haven

06473

Yale-New Haven Hospital North Haven Medical Center, North Haven

06902

Smilow Cancer Hospital Care Center at Long Ridge, Stamford

06790

Smilow Cancer Hospital-Torrington Care Center, Torrington

06611

Smilow Cancer Hospital Care Center-Trumbull, Trumbull

06708

Smilow Cancer Hospital-Waterbury Care Center, Waterbury

06385

Smilow Cancer Hospital Care Center - Waterford, Waterford

32224-9980

Mayo Clinic in Florida, Jacksonville

04074

MaineHealth Maine Medical Center- Scarborough, Scarborough

02215

Dana-Farber Cancer Institute, Boston

07920

Memorial Sloan Kettering Basking Ridge, Basking Ridge

07748

Memorial Sloan Kettering Monmouth, Middletown

07645

Memorial Sloan Kettering Bergen, Montvale

02905

Women and Infants Hospital, Providence

02891

Smilow Cancer Hospital Care Center - Westerly, Westerly

00927

Centro Comprensivo de Cancer de UPR, San Juan

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH