754
Participants
Start Date
June 22, 2023
Primary Completion Date
April 30, 2029
Study Completion Date
December 31, 2029
Revascularization by PCI
"Contemporary, State-of-the-art PCI techniques will be encouraged in STICH3C, based on the most recent evidence and clinical practice guidelines recommendations. The best practices to be followed include the use of physiological and intravascular guidance, new-generation drug-eluting stents or scaffolds, rotational or orbital atherectomy for extensive calcifications, recommended bifurcation techniques, chronic total occlusion for viable segments by experienced operators, and trans-radial access.Planned temporary ventricular support is permitted by experienced operators when deemed indicated."
Revascularization by CABG
The surgical revascularization strategy will be tailored according to the individual patient's coronary anatomy, left ventricular remodeling, aortic atherosclerosis, co-morbidities, local expertise, and surgical judgement. An internal thoracic artery will be used to graft the left anterior descending in all cases. Multi-arterial grafting may be considered in patients without significant co-morbidities and with expected limited vasopressor use, or in patients without saphenous conduits. Choice of on- vs. off-pump surgery is influenced by LV size, associated valvular disease, and aortic atherosclerosis, as well as surgeon experience, but on-pump surgery is recommended routinely. The use of adjunctive intra-aortic balloon support or other cardiac support is not routinely recommended in stable patients; the intra-aortic balloon support is the first line mechanical support.
RECRUITING
Clinical Hospital Dubrava, Sušak
RECRUITING
John Hopkins Hospital, Baltimore
RECRUITING
Hospital Clínico Universitario Virgen de la Arrixaca, El Palmar
RECRUITING
Hospital Universitario de Navarra, Pamplona
RECRUITING
UofL Health, Inc, Louisville
RECRUITING
University Hospital Dusseldorf, Düsseldorf
RECRUITING
University Hospitals Cleveland Medical Center, Cleveland
RECRUITING
Mayo Clinic, Rochester
RECRUITING
Cedars-Sinai, Los Angeles
RECRUITING
Jilin Heart Hospital, Jilin
RECRUITING
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai
RECRUITING
G Kuppuswamy Naidu Memorial Hospital (GKNM), Palayam
RECRUITING
Yale University, New Haven
RECRUITING
Medical University of Vienna, Vienna
RECRUITING
Instituto Mexicano del Seguro Social (IMSS), Mexico City
ACTIVE_NOT_RECRUITING
Medical University of Silesia, Katowice
RECRUITING
Dedinje Cardiovascular Institute, Belgrade
RECRUITING
Hospital del Vinalopó, Alicante
RECRUITING
Heart Institute, Medical School of the University of Sao Paulo_INCOR, São Paulo
RECRUITING
University of Calgary; Libin Cardiovascular Institute, Calgary
RECRUITING
Mackenzie Health Sciences Center, Edmonton
WITHDRAWN
Fraser Health; Royal Columbian Hospital, New Westminster
RECRUITING
Providence Health, Vancouver
RECRUITING
Queen Elizabeth II Hospital, Halifax
RECRUITING
Hamilton General Hospital, Hamilton
RECRUITING
London Health Sciences Center, University Hospital, London
RECRUITING
Southlake Regional HC, Newmarket
RECRUITING
Ottawa Heart Institute, Ottawa
RECRUITING
Sunnybrook Health Sciences Center, Toronto
RECRUITING
St. Michael's, Toronto
RECRUITING
Toronto General Hospital, Toronto
RECRUITING
Center Hospitalier Universitaire de Montreal, Montreal
RECRUITING
Montreal Heart Institute, Montreal
RECRUITING
Hospital Sacre-Coeur, Montreal
RECRUITING
Institut de Cardiologie Quebec (QC) - Laval, Québec
RECRUITING
European Hospital, Via Portuense, Roma
RECRUITING
Unidade Local de Saude Lisboa Ocidental (ULSLO), Lisbon
RECRUITING
Centro Hospitalar e Universitário Sao João, Porto
RECRUITING
Hospital Clinic de Barcelona (ICCV), Barcelona
Canadian Institutes of Health Research (CIHR)
OTHER_GOV
Weill Medical College of Cornell University
OTHER
Sunnybrook Health Sciences Centre
OTHER