NCT05417555View on ClinicalTrials.gov

Low Intensity Focused Ultrasound for Mild Cognitive Impairment and Mild Alzheimer's Disease

NARecruitingINTERVENTIONAL
Enrollment

144

Participants

Timeline

Start Date

September 1, 2022

Primary Completion Date

July 31, 2026

Study Completion Date

July 31, 2026

Conditions
Mild Cognitive ImpairmentAmnestic Mild Cognitive DisorderDeep Brain StimulationMild Alzheimer's Disease
Interventions
DEVICE

Low-Intensity Focused Ultrasound Pulsation (LIFUP)

Low intensity focused ultrasound pulsation will be administered to the left entorhinal cortex at 650kHz, ispta.3 720mW/cm, pulse repetition frequency 100Hz, duty cycle 50%, duration 30s with 30s spacing between sonications, 6 sonications per dose (participants receive 0, 1, 2 or 3 doses depending on group assignment)

Trial Locations (1)

90024

RECRUITING

UCLA Semel Institute for Neuroscience and Behavior, Los Angeles

All Listed Sponsors
collaborator

National Institute on Aging (NIA)

NIH

lead

University of California, Los Angeles

OTHER