Study of Subcutaneous Epcoritamab in Combination With Intravenous Rituximab and Oral Lenalidomide (R2) to Assess Adverse Events and Change in Disease Activity in Adult Participants With Follicular Lymphoma

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

549

Participants

Timeline

Start Date

September 20, 2022

Primary Completion Date

December 31, 2029

Study Completion Date

December 31, 2029

Conditions
Follicular Lymphoma (FL)
Interventions
DRUG

Epcoritamab

Subcutaneous Injection

DRUG

Rituximab

Intravenous Infusion

DRUG

Lenalidomide

Oral Capsules

Trial Locations (273)

704

National Cheng Kung University Hospital /ID# 227381, Tainan City

833

Kaohsiung Chang Gung Memorial Hospital /ID# 227384, Kaohsiung City

1070

Institut Jules Bordet /ID# 254676, Anderlecht

1085

Semmelweis Egyetem /ID# 229291, Budapest

1097

Del-pesti Centrumkorhaz Orszagos Hematologiai es Infektologiai Intezet /ID# 229286, Budapest

1114

Fundaleu /Id# 229700, Ciudad Autonoma de Buenos Aire

1122

Orszagos Onkologiai Intezet /ID# 229292, Budapest

1431

Duplicate_CEMIC /ID# 229697, Ciudad Autonoma de Buenos Aire

1864

Wits Clinical Research /ID# 228895, Johannesburg

2025

Aotearoa Clinical Trials /ID# 228509, Papatoetoe

2050

Royal Prince Alfred Hospital /ID# 239272, Camperdown

2300

AZ Turnhout - Campus Sint-Elisabeth /ID# 231628, Turnhout

2650

Uza /Id# 228521, Edegem

2747

Nepean Hospital /ID# 239093, Kingswood

3000

Clinica de Nefrologia, Urologia y Enfermedades Cardiovasculares /ID# 232124, Santa Fe

Universitair Ziekenhuis Leuven /ID# 247780, Leuven

3100

Universitaetsklinikum St. Poelten /ID# 234015, Sankt Pölten

3199

Peninsula Private Hospital /ID# 238796, Frankston

4000

Groupe Sante CHC - Clinique du MontLegia /ID# 230415, Liège

4010

Ordensklinikum Linz GmbH Elisabethinen /ID# 247510, Linz

4032

Debreceni Egyetem-Klinikai Kozpont /ID# 229287, Debrecen

4400

Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz /ID# 232203, Nyíregyháza

4442

Palmerston North Hospital /ID# 232352, Palmerston North

4814

Townsville University Hospital /ID# 231124, Douglas

5001

Kantonsspital Aarau AG /ID# 229113, Aarau

5016

Hospital Privado Universitario - Hospital Privado Centro Medico de Cordoba S.A. /ID# 229701, Córdoba

5020

Landeskrankenhaus Salzburg-Universitaetsklinikum der PMU (LKH) /ID# 228366, Salzburg

6000

Royal Perth Hospital /ID# 230456, Perth

6009

Hollywood Private Hospital /ID# 251789, Perth

6150

Fiona Stanley Hospital /ID# 231122, Murdoch

6500

EOC Ospedale Regionale di Bellinzona e Valli /ID# 228922, Bellinzona

6720

Szegedi Tudományegyetem /ID# 229289, Szeged

7000

Kantonsspital Graubünden /ID# 253862, Chur

7100

Hospital La Louviere Site Jolimont - Helora /ID# 228520, La Louvière

Sygehus Lillebalt, Vejle /ID# 227404, Vejle

7400

Regionshospitalet Godstrup /ID# 227466, Herning

Somogy Varmegyei Kaposi Mor Oktato Korhaz /ID# 246475, Kaposvár

7580

Haemalife Inc. /ID# 243392, Kuils River

7925

University of Cape Town /ID# 228900, Cape Town

9007

Kantonsspital St. Gallen /ID# 229117, Sankt Gallen

9100

Vitaz /Id# 228525, Sint-Niklaas

9700

Vas Varmegyei Markusovszky Egyetemi Oktatokorhaz /ID# 229290, Szombathely

10003

Hospital San Pedro de Alcantara /ID# 248845, Cáceres

10016

NYU Laura and Isaac Perlmutter Cancer Center /ID# 227322, New York

10029

Icahn School of Medicine at Mount Sinai /ID# 227181, New York

10060

Istituto di Candiolo Fondazione del Piemonte per l'Oncologia IRCCS /ID# 229602, Candiolo

10126

A.O.U. CITTA' DELLA SALUTE E DELLA SCIENZA DI TORINO - Ospedale Molinette /ID# 229820, Turin

10676

General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 226633, Athens

11501

NYU Langone Hospital - Long Island /ID# 253343, Mineola

11527

General Hospital of Athens Laiko /ID# 226626, Athens

11528

Alexandra General Hospital /ID# 226632, Athens

12462

University General Hospital Attikon /ID# 226629, Athens

13100

ZIV Medical Center /ID# 232257, Safed

13125

Helios Klinikum Berlin-Buch /ID# 229178, Berlin

13620

Seoul National University Bundang Hospital /ID# 228448, Seongnam-si

14004

Hospital Universitario Reina Sofia /ID# 228122, Córdoba

14033

CHU de CAEN - Hopital de la Cote de Nacre /ID# 245929, Caen

14263

Roswell Park Cancer Institute /ID# 239128, Buffalo

15100

Azienda Ospedaliero - Universitaria SS. Antonio e Biagio e Cesare Arrigo - Aless /ID# 227401, Alessandria

20132

IRCCS Ospedale San Raffaele /ID# 228669, Milan

20141

Istituto Europeo Di Oncologia /ID# 227396, Milan

21000

CHU Dijon /ID# 230354, Dijon

21200

Dicle Universitesi Tip /ID# 230087, Diyarbakır

21201

University of Maryland, Baltimore /ID# 227191, Baltimore

23219

Virginia Commonwealth University Medical Center Main Hospital /ID# 227211, Richmond

25123

ASST degli Spedali Civili di Brescia /ID# 227397, Brescia

27834

East Carolina University - Brody School of Medicine /ID# 227192, Greenville

28027

CLINICA UNIVERSIDAD DE NAVARRA-Madrid /ID# 229157, Madrid

28033

MD Anderson Madrid /ID# 229860, Madrid

28034

Hospital Universitario Ramon y Cajal /ID# 228113, Madrid

28040

Hospital Universitario Fundacion Jimenez Diaz /ID# 228110, Madrid

28041

Hospital Universitario 12 de Octubre /ID# 228109, Madrid

28100

Azienda Ospedaliero Universitaria Maggiore della Carita di Novara /ID# 227399, Novara

30029

CHU NIMES - Hopital Caremeau /ID# 230351, Nîmes

31008

Clinica Universidad de Navarra - Pamplona /ID# 228116, Pamplona

31059

IUCT Oncopole /ID# 233486, Toulouse

33081

Duplicate_Centro di Riferimento Oncologico /ID# 227395, Aviano

33604

Centre Hospitalier Universitaire de Bordeaux /ID# 230347, Pessac

34098

Istanbul Universitesi-Cerrahpasa Cerrahpasa Tip Fakultesi /ID# 248202, Istanbul

34125

Klinikum Kassel /ID# 229185, Kassel

34200

Istanbul Florence Nightingale Hastanesi /ID# 229546, Istanbul

34899

Duplicate_Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi /ID# 227855, Istanbul

35000

CHU de Rennes - PONTCHAILLOU /ID# 230356, Rennes

35040

Ege University Medical Faculty /ID# 227792, Izmir

35392

Universitaetsklinikum Giessen /ID# 234245, Giessen

37075

Universitaetsmedizin Goettingen /ID# 230411, Göttingen

37711

Hospital Universitario de Salamanca /ID# 228117, Salamanca

39008

Hospital Universitario Marques de Valdecilla /ID# 228984, Santander

39120

Otto-von-Guericke-Universitaet /ID# 230144, Magdeburg

40447

China Medical University Hospital /ID# 227379, Taichung

40705

Taichung Veterans General Hospital /ID# 227383, Taichung

41013

Hospital Universitario Virgen del Rocio /ID# 228118, Seville

41380

Kocaeli University Med Faculty /ID# 227854, Köseköy

42601

Keimyung University Dongsan Hospital /ID# 229800, Daegu

44000

CHU de Nantes, Hotel Dieu -HME /ID# 245928, Nantes

45147

Universitaetsklinikum Essen /ID# 229180, Essen

45500

University General Hospital of Ioannina /ID# 226628, Ioannina

46526

Goshen Center for Cancer Care /ID# 227189, Goshen

47392

Inje University - Busan Paik Hospital /ID# 230293, Busan

48121

Ospedale Santa Maria Delle Croci /ID# 227394, Ravenna

48202

Henry Ford Hospital /ID# 227250, Detroit

49201

Dong-A University Medical Center /ID# 228638, Busan

49241

Pusan National University Hospital /ID# 229798, Busan

51092

CHU Reims - Hôpital Robert Debre /ID# 248710, Reims

53127

Universitaetsklinikum Bonn /ID# 249401, Bonn

54290

Klinikum Mutterhaus der Borromäerinnen /ID# 232354, Trier

54500

CHRU Nancy - Hopitaux de Brabois /ID# 241595, Vandœuvre-lès-Nancy

54636

General University Hospital of Thessaloniki AXEPA /ID# 226630, Thessaloniki

54639

Theageneio Anticancer Hospital /ID# 226627, Thessaloniki

54907

Jeonbuk National University Hospital /ID# 228908, Jeonju

55200

Ondokuz mayis University Facul /ID# 227794, Samsun

59037

CHRU Lille - Hopital Claude Huriez /ID# 230353, Lille

59102

Intermountain Health St. Vincent Regional Hospital - Cancer Centers of Montana /ID# 251220, Billings

63017

St. Luke's Hospital - Chesterfield /ID# 247817, Chesterfield

63100

CHU Clermont-Ferrand /ID# 238676, Clermont

69373

Centre Leon Berard /ID# 230348, Lyon

69495

HCL - Hopital Lyon Sud /ID# 231449, Pierre-Bénite

70124

Duplicate_I.R.C.C.S Istituto Tumori Giovanni Paolo II /ID# 227400, Bari

70300

Yitzhak Shamir Medical Center /ID# 228037, Ẕerifin

70808

Our Lady Of The Lake Regional Medical Center /ID# 251393, Baton Rouge

71013

Fondazione di Religione e di Culto Casa Sollievo della Sofferenza /ID# 228458, San Giovanni Rotondo

72076

Universitaetsklinikum Tuebingen /ID# 229663, Tübingen

72205

University of Arkansas for Medical Sciences /ID# 227198, Little Rock

75010

Hôpital Saint-Louis /ID# 232067, Paris

75013

Hopital Pitie Salpetriere /ID# 230360, Paris

75246

Baylor Sammons Cancer Center /ID# 261584, Dallas

75702

Texas Oncology - Northeast Texas /ID# 265890, Tyler

80131

Duplicate_Azienda Ospedaliera Universitaria Federico II /ID# 230403, Napoli

84143

Intermountain Healthcare LDS Hospital /ID# 259948, Salt Lake City

85000

CHD Vendée- La Roche-sur-Yon - Les Oudairies /ID# 234095, La Roche-sur-Yon

85719

The University of Arizona Cancer Center - North Campus /ID# 228862, Tucson

86000

CHU Poitiers - La miletrie /ID# 230357, Poitiers

87042

CHU Limoges - Dupuytren 1 /ID# 231450, Limoges

90033

University of Southern California /ID# 227195, Los Angeles

90067

Valkyrie Clinical Trials /ID# 268502, Los Angeles

90146

Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello /ID# 227402, Palermo

90211

Beverly Hills Cancer Center /ID# 231535, Beverly Hills

91120

Hadassah /ID# 227846, Jerusalem

94010

Hopitaux Universitaires Henri Mondor - Hopital Henri Mondor /ID# 230358, Créteil

94705

Alta Bates Summit Medical Center for Research /ID# 229428, Berkeley

96049

Sozialstiftung Bamberg /ID# 229184, Bamberg

97080

Universitaetsklinikum Wuerzburg /ID# 229278, Würzburg

100034

Peking University First Hospital /ID# 250517, Beijing

100191

Peking University Third Hospital /ID# 230885, Beijing

110001

The First Hospital of China Medical University /ID# 232509, Shenyang

200032

Fudan University Cancer Hospital /ID# 250475, Shanghai

215006

The First Affiliated Hospital of Soochow University /ID# 232511, Suzhou

221006

The Affiliated Hospital of Xuzhou Medical College /ID# 232513, Xuzhou

300000

Tianjin Cancer Hospital /ID# 230876, Tianjin

310003

The First Affiliated Hospital, Zhejiang University School of Medicine /ID# 230390, Hangzhou

310009

The second affiliated hospital of Zhejiang University school of medicine /ID# 231250, Hangzhou

310022

Zhejiang Cancer hospital /ID# 231389, Hangzhou

330006

The First Affiliated Hospital of Nanchang University /ID# 231047, Nanchang

330029

Jiangxi Provincial Cancer Hospital /ID# 232507, Nanchang

350001

Fujian Medical University Union Hospital /ID# 233919, Fuzhou

361003

The First Affiliated Hospital of Xiamen University /ID# 238427, Xiamen

410006

Hunan Cancer Hospital /ID# 232153, Changsha

430022

Union Hospital affiliated to Tongji Medical College of Huazhong University of Sc /ID# 234153, Wuhan

430079

Hubei Cancer Hospital /ID# 232255, Wuhan

450008

Henan Cancer Hospital /ID# 230459, Zhengzhou

510060

Sun Yat-Sen University Cancer Center /ID# 231463, Guangzhou

510120

Guangdong Provincial Peoples Hospital(Huifu Campus) /ID# 232512, Guangzhou

510515

Nanfang Hospital of Southern Medical University /ID# 230383, Guangzhou

650118

Yunnan Cancer Hospital /ID# 232062, Kunming

710032

Xijing Hospital /ID# 238650, Xi'an

3109601

Rambam Health Care Campus /ID# 227849, Haifa

4941492

Rabin Medical Center /ID# 228043, Petah Tikva

5265601

The Chaim Sheba Medical Center /ID# 228322, Ramat Gan

6423906

Tel Aviv Sourasky Medical Center /ID# 228529, Tel Aviv

9808574

Tohoku University Hospital /ID# 232303, Sendai

90806-1701

Long Beach Memorial Medical Ct /ID# 228997, Long Beach

30322-1013

Duplicate_Emory University /ID# 227299, Atlanta

96813-4920

Hawaii Cancer Care - Waterfront Plaza /ID# 262448, Honolulu

60611-2927

Northwestern University Feinberg School of Medicine /ID# 227248, Chicago

46250-2042

Community Health Network, Inc. /ID# 259756, Indianapolis

02114

Massachusetts General Hospital /ID# 245233, Boston

01605

UMass Memorial Medical Center /ID# 227323, Worcester

07960-6136

Morristown Medical Center /ID# 231427, Morristown

10065-6007

Memorial Sloan Kettering Cancer Center-Koch Center /ID# 227193, New York

73104-5418

University of Oklahoma, Stephenson Cancer Center /ID# 227325, Oklahoma City

80060-900

Hospital de Clinicas da Universidade Federal do Parana /ID# 228123, Curitiba

20231-050

Instituto Nacional de Cancer (INCA) /ID# 228706, Rio de Janeiro

18618-686

Upeclin Fmb - Unesp /Id# 252912, Botucatu

17210-070

Hospital Amaral Carvalho - Fundacao Doutor Amaral Carvalho /ID# 228129, Jaú

01323-001

Real e Benemérita Associação Portuguesa de Beneficência /ID# 228121, São Paulo

01401-002

Instituto D'Or de Pesquisa e Ensino - Regional Sao Paulo /ID# 252918, São Paulo

01509-900

Fundacao Antonio Prudente - AC Camargo Cancer Center /ID# 228130, São Paulo

04039-901

Instituto de Assistencia Medica ao Servidor Publico Estadual /ID# 230182, São Paulo

05403-000

Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao /ID# 228127, São Paulo

T6G 1Z2

Cross Cancer Institute /ID# 249080, Edmonton

V8R 6V5

BC Cancer - Victoria /ID# 228850, Victoria

G6V 3Z1

CSSS Alphonse-Desjardins, CHAU de Levis /ID# 229896, Lévis

G1J 1Z4

CHUQ- Hôpital de l'Enfant-Jesus /ID# 231537, Québec

G5L 5T1

CISSSBSL -Hopital regional de Rimouski /ID# 229894, Rimouski

050011

Fourth Hospital of Hebei Medical University /ID# 238657, Shijiazhuang

500 05

Fakultní nemocnice Hradec Králové - Sokolská /ID# 228269, Hradec Králové

128 00

Všeobecná Fakultní Nemocnice v Praze /ID# 228565, Prague

100 34

Fakultni nemocnice Kralovske Vinohrady /ID# 228564, Prague

150 00

Duplicate_Fakultni Nemocnice v Motole /ID# 228272, Prague

01307

Universitaetsklinikum Carl Gustav Carus Dresden /ID# 229754, Dresden

04103

Universitaetsklinikum Leipzig /ID# 242907, Leipzig

07747

Universitaetsklinikum Jena /ID# 232064, Jena

00168

Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Università Cattolica /ID# 230402, Rome

460-0001

Duplicate_NHO Nagoya Medical Center /ID# 230678, Nagoya

464-8681

Aichi Cancer Center Hospital /ID# 230134, Nagoya

470-1192

Fujita Health University Hospital /ID# 264541, Toyoake

277-8577

National Cancer Center Hospital East /ID# 232423, Kashiwa-shi

790-8524

Matsuyama Red Cross Hospital /ID# 251866, Matsuyama

811-1395

National Hospital Organization Kyushu Cancer Center /ID# 252245, Fukuoka

812-8582

Kyushu University Hospital /ID# 230136, Fukuoka

960-1295

Fukushima Medical University Hospital /ID# 251839, Fukushima

060-8648

Hokkaido University Hospital /ID# 231443, Sapporo

650-0047

Kobe City Medical Center General Hospital /ID# 251945, Kobe

890-8520

Kagoshima University Hospital /ID# 232251, Kagoshima

259-1193

Tokai University Hospital /ID# 252135, Isehara

252-0375

Kitasato University Hospital /ID# 264668, Sagamihara-shi

606-8507

Kyoto University Hospital /ID# 231156, Kyoto

514-8507

Mie University Hospital /ID# 251944, Tsu

390-8621

Shinshu University Hospital /ID# 252246, Matsumoto-shi

700-8558

Okayama University Hospital /ID# 232009, Okayama

534-0021

Osaka City General Hospital /ID# 264670, Osaka

589-8511

Kindai University Hospital /ID# 232152, Osakasayama-shi

104-0045

National Cancer Center Hospital /ID# 230004, Chuo-ku

135-8550

The Cancer Institute Hospital Of JFCR /ID# 230271, Koto-ku

990-9585

Yamagata University Hospital /ID# 230005, Yamagata

400-0027

Yamanashi Prefectural Central Hospital /ID# 263715, Kofu

6532 SZ

Canisius-Wilhelmina Ziekenhuis /ID# 248138, Nijmegen

4818 CK

Amphia Ziekenhuis /ID# 247739, Breda

1091 AC

Olvg /Id# 247899, Amsterdam

1624 NP

Dijklander Ziekenhuis /ID# 248993, Hoorn

7512 KZ

Medisch Spectrum Twente /ID# 247854, Enschede

9713 GZ

Universitair Medisch Centrum Groningen /ID# 247741, Groningen

3318 AT

Albert Schweitzer Ziekenhuis /ID# 247740, Dordrecht

2333 ZA

Leids Universitair Medisch Centrum /ID# 247742, Leiden

3045 PM

Franciscus Gasthuis & Vlietland, Locatie Gasthuis /ID# 248139, Rotterdam

3435 CM

St. Antonius Ziekenhuis /ID# 248644, Nieuwegein

4462 RA

Admiraal de Ruyter Ziekenhuis /ID# 247692, Goes

7416 SE

Deventer Ziekenhuis /ID# 247853, Deventer

0622

North Shore Hospital /ID# 228508, Takapuna

64-920

ARS-MEDICAL Sp. z o.o. /ID# 229601, Piła

60-185

Aidport Sp. z o.o. /ID# 229299, Skórzewo

30-727

Pratia MCM Krakow /ID# 229121, Krakow

81-519

Szpitale Pomorskie Sp. z o.o /ID# 229122, Gdynia

25-734

Swietokrzyskie Centrum Onkologii Samodzielny Publiczny Zaklad Opieki Zdrowotnej /ID# 229362, Kielce

00674

Hematology and Oncology Institute /ID# 230056, Manatí

00935

Pan American Center for Oncology Trials, LLC /ID# 230055, Rio Piedras

00918

Auxilio Mutuo Cancer Center /ID# 248721, San Juan

833 10

Narodny onkologicky ustav /ID# 239510, Bratislava

0044

Alberts Cellular Therapy /ID# 228896, Pretoria

03080

Seoul National University Hospital /ID# 228446, Seoul

05505

Asan Medical Center /ID# 228444, Seoul

06351

Samsung Medical Center /ID# 228445, Seoul

06591

The Catholic University of Korea, Seoul St. Marys Hospital /ID# 228447, Seoul

08916

Instituto Catalan de Oncologia (ICO) Badalona /ID# 228108, Badalona

08003

Hospital Parc de Salut del Mar /ID# 228106, Barcelona

08041

Hospital Santa Creu i Sant Pau /ID# 229859, Barcelona

08907

Institut Català d'Oncologia (ICO) - L'Hospitalet /ID# 228107, L'Hospitalet de Llobregat

971 80

Sunderby sjukhus /ID# 228165, Luleå

501 82

Sodra Alvsborgs sjukhus /ID# 228886, Borås

581 85

Linkoping University Hospital /ID# 233520, Linköping

06620

Ankara Universitesi Fakultesi /ID# 227790, Ankara

07059

Akdeniz Universitesi Tip Fakul /ID# 227791, Antalya

B15 2TH

University Hospitals Birmingham NHS Foundation Trust /ID# 230043, Birmingham

PL6 8DH

Derriford Hospital and the Royal Eye Infirmary /ID# 230038, Plymouth

G12 0YN

Gartnavel General Hospital /ID# 230027, Glasgow

E1 2ES

Disc_Barts Health NHS Trust - The Royal London Hospital /ID# 230028, London

L7 8YA

Clatterbridge Cancer Centre - Liverpool /ID# 230036, Liverpool

NE3 3HD

The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 230123, Newcastle upon Tyne

OX3 9DU

Oxford University Hospitals NHS Foundation Trust /ID# 230035, Oxford

LS9 7TF

Leeds Teaching Hospitals NHS Trust /ID# 230471, Leeds

CO4 5JL

East Suffolk and North Essex NHS Foundation Trust /ID# 230040, Colchester

M20 4BX

The Christie Hospital /ID# 230124, Manchester

PO6 3LY

Portsmouth Hospitals University NHS Trust /ID# 230044, Portsmouth

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

AbbVie

INDUSTRY

lead

Genmab

INDUSTRY