Testing the Use of Ado-Trastuzumab Emtansine Compared to the Usual Treatment (Chemotherapy With Docetaxel Plus Trastuzumab) or Trastuzumab Deruxtecan for Recurrent, Metastatic, or Unresectable HER2-Expressing Salivary Gland Cancers

PHASE2RecruitingINTERVENTIONAL
Enrollment

146

Participants

Timeline

Start Date

March 3, 2023

Primary Completion Date

July 31, 2028

Study Completion Date

July 31, 2028

Conditions
Metastatic Salivary Gland CarcinomaRecurrent Salivary Gland CarcinomaStage III Major Salivary Gland Cancer AJCC v8Stage IV Major Salivary Gland Cancer AJCC v8Unresectable Salivary Gland Carcinoma
Interventions
PROCEDURE

Biopsy Procedure

Undergo a biopsy

PROCEDURE

Biospecimen Collection

Undergo blood sample collection

PROCEDURE

Computed Tomography

Undergo a CT scan

DRUG

Docetaxel

Given IV

PROCEDURE

Echocardiography Test

Undergo ECHO

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

PROCEDURE

Multigated Acquisition Scan

Undergo MUGA

OTHER

Questionnaire Administration

Ancillary studies

BIOLOGICAL

Trastuzumab

Given IV

BIOLOGICAL

Trastuzumab Deruxtecan

Given IV

BIOLOGICAL

Trastuzumab Emtansine

Given IV

Trial Locations (132)

10011

RECRUITING

Mount Sinai Chelsea, New York

10029

RECRUITING

Mount Sinai Hospital, New York

10065

RECRUITING

Memorial Sloan Kettering Cancer Center, New York

10604

RECRUITING

Memorial Sloan Kettering Westchester, Harrison

11553

RECRUITING

Memorial Sloan Kettering Nassau, Uniondale

11725

RECRUITING

Memorial Sloan Kettering Commack, Commack

15009

RECRUITING

UPMC-Heritage Valley Health System Beaver, Beaver

15065

RECRUITING

UPMC Cancer Center-Natrona Heights, Natrona Heights

15108

RECRUITING

UPMC Hillman Cancer Center in Coraopolis, Moon Township

15132

RECRUITING

UPMC Cancer Center at UPMC McKeesport, McKeesport

15146

RECRUITING

UPMC Hillman Cancer Center - Monroeville, Monroeville

15215

RECRUITING

UPMC-Saint Margaret, Pittsburgh

15219

RECRUITING

UPMC-Mercy Hospital, Pittsburgh

15232

RECRUITING

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

15237

RECRUITING

UPMC-Passavant Hospital, Pittsburgh

15243

RECRUITING

UPMC-Saint Clair Hospital Cancer Center, Pittsburgh

15301

RECRUITING

UPMC Cancer Center-Washington, Washington

15401

RECRUITING

UPMC Cancer Center-Uniontown, Uniontown

15601

RECRUITING

UPMC Cancer Centers - Arnold Palmer Pavilion, Greensburg

15642

RECRUITING

Arnold Palmer Cancer Center Medical Oncology Norwin, N. Huntingdon

15666

RECRUITING

UPMC Hillman Cancer Center - Part of Frick Hospital, Mount Pleasant

15701

RECRUITING

IRMC Cancer Center, Indiana

15901

RECRUITING

UPMC-Johnstown/John P. Murtha Regional Cancer Center, Johnstown

16001

RECRUITING

UPMC Hillman Cancer Center at Butler Health System, Butler

16066

RECRUITING

UPMC Hillman Cancer Center - Passavant - Cranberry, Cranberry Township

16105

RECRUITING

UPMC Hillman Cancer Center - New Castle, New Castle

16121

RECRUITING

UPMC Cancer Center at UPMC Horizon, Farrell

16346

RECRUITING

UPMC Cancer Center at UPMC Northwest, Seneca

16505

RECRUITING

UPMC Hillman Cancer Center Erie, Erie

16601

RECRUITING

UPMC Altoona, Altoona

17011

ACTIVE_NOT_RECRUITING

UPMC Camp Hill, Camp Hill

17015

RECRUITING

Carlisle Regional Cancer Center, Carlisle

17050

RECRUITING

UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion, Mechanicsburg

17109

RECRUITING

UPMC Pinnacle Cancer Center/Community Osteopathic Campus, Harrisburg

17408

RECRUITING

UPMC Memorial, York

17754

RECRUITING

Divine Providence Hospital, Williamsport

21502

RECRUITING

UPMC Western Maryland, Cumberland

23298

RECRUITING

VCU Massey Comprehensive Cancer Center, Richmond

29425

RECRUITING

Medical University of South Carolina, Charleston

30308

RECRUITING

Emory University Hospital Midtown, Atlanta

35233

ACTIVE_NOT_RECRUITING

University of Alabama at Birmingham Cancer Center, Birmingham

37232

RECRUITING

Vanderbilt University/Ingram Cancer Center, Nashville

40536

RECRUITING

University of Kentucky/Markey Cancer Center, Lexington

43210

ACTIVE_NOT_RECRUITING

Ohio State University Comprehensive Cancer Center, Columbus

43952

RECRUITING

Trinity's Tony Teramana Cancer Center, Steubenville

45069

RECRUITING

University of Cincinnati Cancer Center-West Chester, West Chester

45219

RECRUITING

University of Cincinnati Cancer Center-UC Medical Center, Cincinnati

48109

RECRUITING

University of Michigan Comprehensive Cancer Center, Ann Arbor

48201

ACTIVE_NOT_RECRUITING

Wayne State University/Karmanos Cancer Institute, Detroit

48334

ACTIVE_NOT_RECRUITING

Weisberg Cancer Treatment Center, Farmington Hills

50010

ACTIVE_NOT_RECRUITING

McFarland Clinic - Ames, Ames

50314

RECRUITING

Mercy Medical Center - Des Moines, Des Moines

53066

RECRUITING

ProHealth Oconomowoc Memorial Hospital, Oconomowoc

53149

RECRUITING

ProHealth D N Greenwald Center, Mukwonago

53188

RECRUITING

UW Cancer Center at ProHealth Care, Waukesha

53226

RECRUITING

Medical College of Wisconsin, Milwaukee

54449

RECRUITING

Marshfield Medical Center-Marshfield, Marshfield

54476

RECRUITING

Marshfield Medical Center - Weston, Weston

54482

RECRUITING

Marshfield Medical Center-River Region at Stevens Point, Stevens Point

54548

RECRUITING

Marshfield Medical Center - Minocqua, Minocqua

54701

RECRUITING

Marshfield Medical Center-EC Cancer Center, Eau Claire

54868

RECRUITING

Marshfield Medical Center-Rice Lake, Rice Lake

55101

RECRUITING

Regions Hospital, Saint Paul

55102

RECRUITING

United Hospital, Saint Paul

55407

RECRUITING

Abbott-Northwestern Hospital, Minneapolis

55415

RECRUITING

Hennepin County Medical Center, Minneapolis

55416

RECRUITING

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55433

RECRUITING

Mercy Hospital, Coon Rapids

55435

RECRUITING

Fairview Southdale Hospital, Edina

55905

RECRUITING

Mayo Clinic in Rochester, Rochester

56601

RECRUITING

Sanford Joe Lueken Cancer Center, Bemidji

57104

RECRUITING

Sanford Cancer Center Oncology Clinic, Sioux Falls

58122

RECRUITING

Sanford Broadway Medical Center, Fargo

RECRUITING

Sanford Roger Maris Cancer Center, Fargo

58501

RECRUITING

Sanford Bismarck Medical Center, Bismarck

61801

SUSPENDED

Carle Cancer Center, Urbana

61832

SUSPENDED

Carle at The Riverfront, Danville

61938

SUSPENDED

Carle Physician Group-Mattoon/Charleston, Mattoon

62401

SUSPENDED

Carle Physician Group-Effingham, Effingham

63110

RECRUITING

Washington University School of Medicine, St Louis

63129

RECRUITING

Siteman Cancer Center-South County, St Louis

63136

RECRUITING

Siteman Cancer Center at Christian Hospital, St Louis

63141

RECRUITING

Siteman Cancer Center at West County Hospital, Creve Coeur

63376

RECRUITING

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

64064

RECRUITING

University of Kansas Cancer Center - Lee's Summit, Lee's Summit

64108

RECRUITING

University Health Truman Medical Center, Kansas City

64154

RECRUITING

University of Kansas Cancer Center - North, Kansas City

66061

RECRUITING

The University of Kansas Cancer Center - Olathe, Olathe

66160

RECRUITING

University of Kansas Cancer Center, Kansas City

66205

RECRUITING

University of Kansas Hospital-Westwood Cancer Center, Westwood

66210

RECRUITING

University of Kansas Cancer Center-Overland Park, Overland Park

66211

RECRUITING

University of Kansas Hospital-Indian Creek Campus, Overland Park

67601

RECRUITING

HaysMed, Hays

73104

RECRUITING

University of Oklahoma Health Sciences Center, Oklahoma City

73505

RECRUITING

Cancer Centers of Southwest Oklahoma Research, Lawton

80045

RECRUITING

UCHealth University of Colorado Hospital, Aurora

80129

RECRUITING

UCHealth Highlands Ranch Hospital, Highlands Ranch

83301

RECRUITING

Saint Luke's Cancer Institute - Twin Falls, Twin Falls

83619

RECRUITING

Saint Luke's Cancer Institute - Fruitland, Fruitland

83642

RECRUITING

Saint Luke's Cancer Institute - Meridian, Meridian

83687

RECRUITING

Saint Luke's Cancer Institute - Nampa, Nampa

83712

RECRUITING

Saint Luke's Cancer Institute - Boise, Boise

87106

RECRUITING

University of New Mexico Cancer Center, Albuquerque

91010

ACTIVE_NOT_RECRUITING

City of Hope Comprehensive Cancer Center, Duarte

92618

ACTIVE_NOT_RECRUITING

City of Hope at Irvine Lennar, Irvine

93720

RECRUITING

Kaiser Permanente-Fresno, Fresno

94080

RECRUITING

Kaiser Permanente-South San Francisco, South San Francisco

94115

RECRUITING

Kaiser Permanente-San Francisco, San Francisco

94158

RECRUITING

UCSF Medical Center-Mission Bay, San Francisco

94304

RECRUITING

Stanford Cancer Institute Palo Alto, Palo Alto

94538

RECRUITING

Kaiser Permanente-Fremont, Fremont

94568

RECRUITING

Kaiser Permanente Dublin, Dublin

94577

RECRUITING

Kaiser Permanente San Leandro, San Leandro

94589

RECRUITING

Kaiser Permanente-Vallejo, Vallejo

94596

RECRUITING

Kaiser Permanente-Walnut Creek, Walnut Creek

94611

RECRUITING

Kaiser Permanente-Oakland, Oakland

94903

RECRUITING

Kaiser San Rafael-Gallinas, San Rafael

95051

RECRUITING

Kaiser Permanente Medical Center - Santa Clara, Santa Clara

95119

RECRUITING

Kaiser Permanente-Santa Teresa-San Jose, San Jose

95356

RECRUITING

Kaiser Permanente-Modesto, Modesto

95403

RECRUITING

Kaiser Permanente-Santa Rosa, Santa Rosa

95661

RECRUITING

Kaiser Permanente-Roseville, Roseville

95814

RECRUITING

Kaiser Permanente Downtown Commons, Sacramento

95823

RECRUITING

Kaiser Permanente-South Sacramento, Sacramento

96819

RECRUITING

Kaiser Permanente Moanalua Medical Center, Honolulu

98109

RECRUITING

Fred Hutchinson Cancer Center, Seattle

03756

RECRUITING

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon

07920

RECRUITING

Memorial Sloan Kettering Basking Ridge, Basking Ridge

07748

RECRUITING

Memorial Sloan Kettering Monmouth, Middletown

07645

RECRUITING

Memorial Sloan Kettering Bergen, Montvale

57117-5134

RECRUITING

Sanford USD Medical Center - Sioux Falls, Sioux Falls

05819

SUSPENDED

Dartmouth Cancer Center - North, Saint Johnsbury

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

NRG Oncology

OTHER

NCT05408845 - Testing the Use of Ado-Trastuzumab Emtansine Compared to the Usual Treatment (Chemotherapy With Docetaxel Plus Trastuzumab) or Trastuzumab Deruxtecan for Recurrent, Metastatic, or Unresectable HER2-Expressing Salivary Gland Cancers | Biotech Hunter | Biotech Hunter