A Study of Zilovertamab Vedotin (MK-2140) in Combination With Cyclophosphamide, Doxorubicin, and Prednisone Plus Rituximab or Rituximab Biosimilar (Truxima) (R-CHP) in Participants With Diffuse Large B-Cell Lymphoma (DLBCL) (MK-2140-007)

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

July 14, 2022

Primary Completion Date

April 26, 2029

Study Completion Date

April 26, 2029

Conditions
Lymphoma, Large B-Cell, Diffuse (DLBCL)
Interventions
BIOLOGICAL

Zilovertamab Vedotin

IV infusion

DRUG

Cyclophosphamide

IV infusion

DRUG

Doxorubicin

IV infusion

BIOLOGICAL

Rituximab

IV infusion

BIOLOGICAL

Rituximab Biosimilar

IV infusion

DRUG

Prednisone

IV or oral administration (per local guidelines)

DRUG

Prednisolone

IV or oral administration (per local guidelines)

Trial Locations (22)

15121

Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare -Azienda Ospedaliera Nazionale SS. Ant, Alessandria

20132

Ospedale San Raffaele-Unità Linfomi ( Site 0305), Milan

22030

Trakya University ( Site 0805), Edirne

28040

Hospital Universitario Fundación Jiménez Díaz-Oncology & Hematology ( Site 0700), Madrid

34214

Mega Medipol-Hematology ( Site 0808), Stanbul

41013

HOSPITAL UNIVERSITARIO VIRGEN DEL ROCIO-Hematology ( Site 0704), Seville

50134

Azienda Ospedaliera Universitaria Careggi-SOD Ematologia ( Site 0308), Florence

90146

Az. Osp. Ospedali Riuniti VILLA SOFIA-CERVELLO-EMATOLOGIA I ( Site 0307), Palermo

5265601

Sheba Medical Center-Hemato Oncology ( Site 0400), Ramat Gan

9112001

Hadassah Medical Center ( Site 0401), Jerusalem

V8R 6V5

BC Cancer Victoria-Clinical Trials Unit ( Site 0105), Victoria

L6R3J7

William Osler Health System ( Site 0106), Toronto

H4J 1C5

Hopital du Sacre-Coeur de Montreal ( Site 0108), Montreal

00168

Fondazione Policlinico Universitario Agostino Gemelli-ISTITUTO DI EMATOLOGIA ( Site 0306), Rome

02-781

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Kilinka Onkologii I Hematologii ( Site, Warsaw

80-214

Uniwersyteckie Centrum Kliniczne-Klinika Hematologii i Transplantologii ( Site 0504), Gdansk

44-101

Narodowy Instytut Onkologii - Oddzial w Gliwicach ( Site 0505), Gliwice

93-513

Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumat-Oddiał Hematologii Ogólnej ( Site 0503), Lodz

03080

Seoul National University Hospital ( Site 0201), Seoul

06351

Samsung Medical Center ( Site 0200), Seoul

08908

Instituto Catalan de Oncologia - Hospital Duran i Reynals-Haematology Department ( Site 0703), L'Hospitalet Del Llobregat

06620

Ankara Universitesi Tip Fakultesi Hastanesi-hematology ( Site 0801), Ankara

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY